Published in Neuromolecular Med on January 01, 2009
Coordination features and affinity of the Cu²+ site in the α-synuclein protein of Parkinson's disease. Biochemistry (2011) 1.20
N-terminal acetylation of α-synuclein induces increased transient helical propensity and decreased aggregation rates in the intrinsically disordered monomer. Protein Sci (2012) 1.01
Curcumin and its derivatives: their application in neuropharmacology and neuroscience in the 21st century. Curr Neuropharmacol (2013) 0.97
Divalent metal ions enhance DOPAL-induced oligomerization of alpha-synuclein. Neurosci Lett (2014) 0.90
Phosphorylation of α-Synuclein at Y125 and S129 alters its metal binding properties: implications for understanding the role of α-Synuclein in the pathogenesis of Parkinson's Disease and related disorders. ACS Chem Neurosci (2011) 0.90
Conserved C-terminal charge exerts a profound influence on the aggregation rate of α-synuclein. J Mol Biol (2011) 0.89
The effects of pdr1, djr1.1 and pink1 loss in manganese-induced toxicity and the role of α-synuclein in C. elegans. Metallomics (2014) 0.89
Implication of Alpha-Synuclein Phosphorylation at S129 in Synucleinopathies: What Have We Learned in the Last Decade? J Parkinsons Dis (2016) 0.87
Prolyl oligopeptidase enhances α-synuclein dimerization via direct protein-protein interaction. J Biol Chem (2015) 0.79
Exploring the accessible conformations of N-terminal acetylated α-synuclein. FEBS Lett (2013) 0.79
Genome-wide association study of neocortical Lewy-related pathology. Ann Clin Transl Neurol (2015) 0.76
Abnormal metal levels in the primary visual pathway of the DBA/2J mouse model of glaucoma. Biometals (2014) 0.76
Cu(II) promotes amyloid pore formation. Biochem Biophys Res Commun (2015) 0.75
From the Cover: Arsenic Induces Accumulation of α-Synuclein: Implications for Synucleinopathies and Neurodegeneration. Toxicol Sci (2016) 0.75
Metabolic Investigations of the Molecular Mechanisms Associated with Parkinson's Disease. Metabolites (2017) 0.75
Conformational equilibria in monomeric alpha-synuclein at the single-molecule level. PLoS Biol (2008) 1.37
Broken helix in vesicle and micelle-bound alpha-synuclein: insights from site-directed spin labeling-EPR experiments and MD simulations. J Am Chem Soc (2008) 1.36
Kinetic and structural analysis of the early oxidation products of dopamine: analysis of the interactions with alpha-synuclein. J Biol Chem (2007) 1.34
A topological model of the interaction between alpha-synuclein and sodium dodecyl sulfate micelles. Biochemistry (2005) 1.33
Structural insights on physiological functions and pathological effects of alpha-synuclein. FASEB J (2008) 1.32
Triggering of inflammasome by aggregated α-synuclein, an inflammatory response in synucleinopathies. PLoS One (2013) 1.11
Biochemical characterization of highly purified leucine-rich repeat kinases 1 and 2 demonstrates formation of homodimers. PLoS One (2012) 1.09
Pathogenic mutations shift the equilibria of alpha-synuclein single molecules towards structured conformers. Chembiochem (2009) 1.06
LRRK2 and neuroinflammation: partners in crime in Parkinson's disease? J Neuroinflammation (2014) 1.05
Structural and morphological characterization of aggregated species of α-synuclein induced by docosahexaenoic acid. J Biol Chem (2011) 1.02
GTPase activity regulates kinase activity and cellular phenotypes of Parkinson's disease-associated LRRK2. Hum Mol Genet (2012) 0.99
Molecular mapping of functionalities in the solution structure of reduced Grx4, a monothiol glutaredoxin from Escherichia coli. J Biol Chem (2005) 0.98
Exosomes-associated neurodegeneration and progression of Parkinson's disease. Am J Neurodegener Dis (2012) 0.92
Fly cryptochrome and the visual system. Proc Natl Acad Sci U S A (2013) 0.91
Green coffee oil analysis by high-resolution nuclear magnetic resonance spectroscopy. Talanta (2013) 0.91
MXAN analysis of the XANES energy region of a mononuclear copper complex: applications to bioinorganic systems. Inorg Chem (2005) 0.90
Structure and topology of the non-amyloid-beta component fragment of human alpha-synuclein bound to micelles: implications for the aggregation process. Protein Sci (2006) 0.89
Molecular characterization of dopamine-derived quinones reactivity toward NADH and glutathione: implications for mitochondrial dysfunction in Parkinson disease. Biochim Biophys Acta (2010) 0.89
Alpha-synuclein pore forming activity upon membrane association. Biochim Biophys Acta (2012) 0.89
Parkinson's disease and immune system: is the culprit LRRKing in the periphery? J Neuroinflammation (2012) 0.88
Dopamine quinones interact with alpha-synuclein to form unstructured adducts. Biochem Biophys Res Commun (2010) 0.88
Dopamine-derived quinones affect the structure of the redox sensor DJ-1 through modifications at Cys-106 and Cys-53. J Biol Chem (2012) 0.88
Molecular insights into the interaction between alpha-synuclein and docosahexaenoic acid. J Mol Biol (2009) 0.88
Ceftriaxone blocks the polymerization of α-synuclein and exerts neuroprotective effects in vitro. ACS Chem Neurosci (2013) 0.87
Solvent polarity controls the helical conformation of short peptides rich in Calpha-tetrasubstituted amino acids. Chemistry (2007) 0.87
Small molecules interacting with α-synuclein: antiaggregating and cytoprotective properties. Amino Acids (2013) 0.87
Tyrosinase exacerbates dopamine toxicity but is not genetically associated with Parkinson's disease. J Neurochem (2005) 0.87
Designed hairpin peptides interfere with amyloidogenesis pathways: fibril formation and cytotoxicity inhibition, interception of the preamyloid state. Biochemistry (2011) 0.86
Rapid authentication of coffee blends and quantification of 16-O-methylcafestol in roasted coffee beans by nuclear magnetic resonance. J Agric Food Chem (2014) 0.86
Antamanide, a derivative of Amanita phalloides, is a novel inhibitor of the mitochondrial permeability transition pore. PLoS One (2011) 0.86
Alpha-synuclein overexpression increases dopamine toxicity in BE2-M17 cells. BMC Neurosci (2010) 0.85
Molecular evolution and phylogeny of sipunculan hemerythrins. J Mol Evol (2005) 0.85
Human SOD2 modification by dopamine quinones affects enzymatic activity by promoting its aggregation: possible implications for Parkinson's disease. PLoS One (2012) 0.85
Leucine-rich repeat kinase 2 and alpha-synuclein: intersecting pathways in the pathogenesis of Parkinson's disease? Mol Neurodegener (2011) 0.85
Cuprizone neurotoxicity, copper deficiency and neurodegeneration. Neurotoxicology (2010) 0.84
Quaternary structure and functional properties of Penaeus monodon hemocyanin. FEBS J (2005) 0.84
Structural characterization of a high affinity mononuclear site in the copper(II)-α-synuclein complex. J Am Chem Soc (2010) 0.84
Tyrosinase-catalyzed oxidation of fluorophenols. J Biol Chem (2002) 0.84
Structural features that govern enzymatic activity in carbonic anhydrase from a low-temperature adapted fish, Chionodraco hamatus. Biophys J (2007) 0.84
Interaction of bombolitin II with a membrane-mimetic environment: an NMR and molecular dynamics simulation approach. Biophys Chem (2002) 0.83
Dysfunction of dopamine homeostasis: clues in the hunt for novel Parkinson's disease therapies. FASEB J (2013) 0.83
The 11-mer repeats of human alpha-synuclein in vesicle interactions and lipid composition discrimination: a cooperative role. Biopolymers (2006) 0.83
α-Synuclein oligomers induced by docosahexaenoic acid affect membrane integrity. PLoS One (2013) 0.82
DJ-1 is a copper chaperone acting on SOD1 activation. J Biol Chem (2014) 0.81
Molecular characterization of a ligand-tethered parathyroid hormone receptor. Biophys Chem (2002) 0.81
Seasonal variation of trehalose and glycerol concentrations in winter snow-active insects. Cryo Letters (2009) 0.81
Structure elucidation of the dye Acid Red 131: complete (1)H, (13)C and (15)N NMR data assignment. Magn Reson Chem (2011) 0.80
Human leucine-rich repeat kinase 1 and 2: intersecting or unrelated functions? Biochem Soc Trans (2012) 0.80
Molecular basis of the Bohr effect in arthropod hemocyanin. J Biol Chem (2008) 0.80
Conformational studies of a bombolitin III-derived peptide mimicking the four-helix bundle structural motif of proteins. J Am Chem Soc (2003) 0.80
Human tyrosinase produced in insect cells: a landmark for the screening of new drugs addressing its activity. Mol Biotechnol (2015) 0.80
The reaction of alpha-synuclein with tyrosinase: possible implications for Parkinson disease. J Biol Chem (2008) 0.80
Structural basis and mechanism of the inhibition of the type-3 copper protein tyrosinase from Streptomyces antibioticus by halide ions. J Biol Chem (2002) 0.80
Trapping tyrosinase key active intermediate under turnover. Dalton Trans (2009) 0.79
Identification of the production chain of Asiago d'Allevo cheese by nuclear magnetic resonance spectroscopy and principal component analysis. J Agric Food Chem (2008) 0.79
Copper(I)-α-synuclein interaction: structural description of two independent and competing metal binding sites. Inorg Chem (2013) 0.79
Investigation of Streptomyces antibioticus tyrosinase reactivity toward chlorophenols. Arch Biochem Biophys (2010) 0.79
Covalent α-synuclein dimers: chemico-physical and aggregation properties. PLoS One (2012) 0.79
Unsymmetrical binding modes of the HOPNO inhibitor of tyrosinase: from model complexes to the enzyme. Chemistry (2013) 0.78
A rigid helical peptide axle for a [2]rotaxane molecular machine. Angew Chem Int Ed Engl (2009) 0.78
Paramagnetic properties of the halide-bound derivatives of oxidised tyrosinase investigated by 1H NMR spectroscopy. Chemistry (2006) 0.78
Backbone dynamics of human parathyroid hormone (1-34): flexibility of the central region under different environmental conditions. Biopolymers (2006) 0.78
Worm-like Ising model for protein mechanical unfolding under the effect of osmolytes. Biophys J (2012) 0.78
Single-molecule-level evidence for the osmophobic effect. Angew Chem Int Ed Engl (2011) 0.78
Recognition of lysine-rich peptide ligands by murine cortactin SH3 domain: CD, ITC, and NMR studies. Biopolymers (2010) 0.78
Observing the osmophobic effect in action at the single molecule level. Proteins (2011) 0.78
A novel prion protein-tyrosine hydroxylase interaction. CNS Neurol Disord Drug Targets (2014) 0.77
Synthesis and structural characterisation as 12-helix of the hexamer of a beta-amino acid tethered to a pyrrolidin-2-one ring. Chem Commun (Camb) (2006) 0.77
Cloning, expression, purification, and spectroscopic analysis of the fragment 57-102 of human alpha-synuclein. Protein Expr Purif (2005) 0.77