Published in J Am Chem Soc on September 23, 2009
Turning gene function ON and OFF using sense and antisense photo-morpholinos in zebrafish. Development (2012) 1.19
Photocaged morpholino oligomers for the light-regulation of gene function in zebrafish and Xenopus embryos. J Am Chem Soc (2010) 1.16
Activation and deactivation of DNAzyme and antisense function with light for the photochemical regulation of gene expression in mammalian cells. J Am Chem Soc (2010) 1.09
Spatiotemporal resolution of the Ntla transcriptome in axial mesoderm development. Nat Chem Biol (2012) 1.01
Light-controlled synthetic gene circuits. Curr Opin Chem Biol (2012) 0.94
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Photoactivatable fluorophores and techniques for biological imaging applications. Photochem Photobiol Sci (2012) 0.89
Photomodulating RNA cleavage using photolabile circular antisense oligodeoxynucleotides. Nucleic Acids Res (2010) 0.89
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Optochemical control of deoxyoligonucleotide function via a nucleobase-caging approach. Acc Chem Res (2013) 0.87
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Oligonucleotide-based tools for studying zebrafish development. Zebrafish (2010) 0.84
Nitrodibenzofuran: A One- and Two-Photon Sensitive Protecting Group That Is Superior to Brominated Hydroxycoumarin for Thiol Caging in Peptides. J Am Chem Soc (2016) 0.80
Cellular delivery and photochemical activation of antisense agents through a nucleobase caging strategy. ACS Chem Biol (2013) 0.80
Unraveling the mechanism of the photodeprotection reaction of 8-bromo- and 8-chloro-7-hydroxyquinoline caged acetates. Chemistry (2012) 0.79
Spatiotemporal control of embryonic gene expression using caged morpholinos. Methods Cell Biol (2011) 0.79
Caged circular antisense oligonucleotides for photomodulation of RNA digestion and gene expression in cells. Nucleic Acids Res (2012) 0.78
Photocleavable peptide-oligonucleotide conjugates for protein kinase assays by MALDI-TOF MS. Mol Biosyst (2012) 0.78
Ruthenium-Caged Antisense Morpholinos for Regulating Gene Expression in Zebrafish Embryos. Chem Sci (2015) 0.78
Site-specific promoter caging enables optochemical gene activation in cells and animals. J Am Chem Soc (2014) 0.78
Gene knockdown by morpholino-modified oligonucleotides in the zebrafish (Danio rerio) model: applications for developmental toxicology. Methods Mol Biol (2012) 0.77
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Nitroreductase-activatable morpholino oligonucleotides for in vivo gene silencing. ACS Chem Biol (2014) 0.75
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New caged coumarin fluorophores with extraordinary uncaging cross sections suitable for biological imaging applications. J Am Chem Soc (2004) 1.74
Polaris and Polycystin-2 in dorsal forerunner cells and Kupffer's vesicle are required for specification of the zebrafish left-right axis. Dev Biol (2005) 1.69
Regulating gene expression in zebrafish embryos using light-activated, negatively charged peptide nucleic acids. J Am Chem Soc (2007) 1.62
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The zebrafish T-box genes no tail and spadetail are required for development of trunk and tail mesoderm and medial floor plate. Development (2002) 1.41
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Regulating gene expression in human leukemia cells using light-activated oligodeoxynucleotides. Nucleic Acids Res (2007) 1.17
Targeted gene knockdown in zebrafish using negatively charged peptide nucleic acid mimics. Dev Dyn (2003) 1.13
8-Bromo-7-hydroxyquinoline as a photoremovable protecting group for physiological use: mechanism and scope. J Am Chem Soc (2006) 1.08
Current perspectives in zebrafish reverse genetics: moving forward. Dev Dyn (2008) 1.05
Light controllable siRNAs regulate gene suppression and phenotypes in cells. Biochim Biophys Acta (2006) 1.04
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Brominated hydroxyquinoline as a photolabile protecting group with sensitivity to multiphoton excitation. Org Lett (2002) 1.01
Light-induced formation of G-quadruplex DNA secondary structures. Chembiochem (2005) 0.99
RNA bandages for photoregulating in vitro protein synthesis. Bioorg Med Chem Lett (2008) 0.98
Imaging dynamic cell-cell junctional coupling in vivo using Trojan-LAMP. Nat Methods (2008) 0.97
Spatial regulation of floating head expression in the developing notochord. Dev Dyn (1997) 0.96
Infrared-LAMP: two-photon uncaging and imaging of gap junctional communication in three dimensions. Nat Methods (2006) 0.94
Chemical technologies for probing embryonic development. Chem Soc Rev (2008) 0.84
A rapid and versatile method to label receptor ligands using "click" chemistry: Validation with the muscarinic M1 antagonist pirenzepine. Bioconjug Chem (2006) 0.82
Medulloblastoma growth inhibition by hedgehog pathway blockade. Science (2002) 6.53
Purmorphamine activates the Hedgehog pathway by targeting Smoothened. Nat Chem Biol (2005) 3.49
Lipidomics reveals that adiposomes store ether lipids and mediate phospholipid traffic. J Lipid Res (2007) 2.92
Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade. Proc Natl Acad Sci U S A (2009) 2.41
A small molecule that binds Hedgehog and blocks its signaling in human cells. Nat Chem Biol (2009) 2.21
Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2. Science (2004) 2.19
Small-molecule inhibitors of the AAA+ ATPase motor cytoplasmic dynein. Nature (2012) 2.16
The BAH domain of ORC1 links H4K20me2 to DNA replication licensing and Meier-Gorlin syndrome. Nature (2012) 2.07
The role of inositol 1,4,5-trisphosphate receptors in Ca(2+) signalling and the generation of arrhythmias in rat atrial myocytes. J Physiol (2002) 2.05
Light-controlled gene silencing in zebrafish embryos. Nat Chem Biol (2007) 2.02
Small-molecule regulation of zebrafish gene expression. Nat Chem Biol (2007) 2.00
A crucial requirement for Hedgehog signaling in small cell lung cancer. Nat Med (2011) 1.97
LAMP, a new imaging assay of gap junctional communication unveils that Ca2+ influx inhibits cell coupling. Nat Methods (2004) 1.78
New caged coumarin fluorophores with extraordinary uncaging cross sections suitable for biological imaging applications. J Am Chem Soc (2004) 1.74
A cAMP and Ca2+ coincidence detector in support of Ca2+-induced Ca2+ release in mouse pancreatic beta cells. J Physiol (2005) 1.40
Smoothened signal transduction is promoted by G protein-coupled receptor kinase 2. Mol Cell Biol (2006) 1.38
Phosphorylation of type-1 inositol 1,4,5-trisphosphate receptors by cyclic nucleotide-dependent protein kinases: a mutational analysis of the functionally important sites in the S2+ and S2- splice variants. J Biol Chem (2003) 1.37
A small-molecule smoothened agonist prevents glucocorticoid-induced neonatal cerebellar injury. Sci Transl Med (2011) 1.35
ET-1 activates Ca2+ sparks in PASMC: local Ca2+ signaling between inositol trisphosphate and ryanodine receptors. Am J Physiol Lung Cell Mol Physiol (2003) 1.34
Lipotoxicity disrupts incretin-regulated human β cell connectivity. J Clin Invest (2013) 1.27
Improved orange and red Ca²± indicators and photophysical considerations for optogenetic applications. ACS Chem Neurosci (2013) 1.26
Centrosome repositioning in T cells is biphasic and driven by microtubule end-on capture-shrinkage. J Cell Biol (2013) 1.26
Functional consequences of phosphomimetic mutations at key cAMP-dependent protein kinase phosphorylation sites in the type 1 inositol 1,4,5-trisphosphate receptor. J Biol Chem (2004) 1.21
Features of 5'-splice-site efficiency derived from disease-causing mutations and comparative genomics. Genome Res (2007) 1.16
Lightweight genome viewer: portable software for browsing genomics data in its chromosomal context. BMC Bioinformatics (2007) 1.15
Cell membrane permeable esters of D-myo-inositol 1,4,5-trisphosphate. Cell Calcium (2007) 1.14
The decoupling of Smoothened from Galphai proteins has little effect on Gli3 protein processing and Hedgehog-regulated chick neural tube patterning. Dev Biol (2008) 1.13
Diacylglycerol promotes centrosome polarization in T cells via reciprocal localization of dynein and myosin II. Proc Natl Acad Sci U S A (2013) 1.12
C(a2+)-dependent glutamate release involves two classes of endoplasmic reticulum Ca(2+) stores in astrocytes. J Neurosci Res (2004) 1.10
Intercellular calcium signaling in a gap junction-coupled cell network establishes asymmetric neuronal fates in C. elegans. Development (2012) 1.10
Neuropilins are positive regulators of Hedgehog signal transduction. Genes Dev (2011) 1.07
Gene regulation by SMAR1: Role in cellular homeostasis and cancer. Biochim Biophys Acta (2010) 1.02
Spatiotemporal resolution of the Ntla transcriptome in axial mesoderm development. Nat Chem Biol (2012) 1.01
Perfidious gallbladders - a diagnostic dilemma with xanthogranulomatous cholecystitis. Ann R Coll Surg Engl (2007) 0.98
Imaging dynamic cell-cell junctional coupling in vivo using Trojan-LAMP. Nat Methods (2008) 0.97
A purine-like nickel(II) base pair for DNA. Angew Chem Int Ed Engl (2005) 0.94
Cyclic caged morpholinos: conformationally gated probes of embryonic gene function. Angew Chem Int Ed Engl (2012) 0.93
Capacity for stochastic self-renewal and differentiation in mammalian spermatogonial stem cells. J Cell Biol (2009) 0.93
Post-transcriptional mechanisms contribute to Etv2 repression during vascular development. Dev Biol (2013) 0.92
Inhibiting miRNA in Caenorhabditis elegans using a potent and selective antisense reagent. Silence (2010) 0.91
Converse conformational control of smoothened activity by structurally related small molecules. J Biol Chem (2009) 0.90
Propargyloxycarbonyl (Poc) amino acid chlorides as efficient coupling reagents for the synthesis of 100% diastereopure peptides and resin bound tetrathiomolybdate as an effective deblocking agent for the Poc group. Chem Commun (Camb) (2002) 0.90
Photoactivatable fluorophores and techniques for biological imaging applications. Photochem Photobiol Sci (2012) 0.89
Tumor suppressor SMAR1 represses IkappaBalpha expression and inhibits p65 transactivation through matrix attachment regions. J Biol Chem (2008) 0.89
A new class of macrocyclic lanthanide complexes for cell labeling and magnetic resonance imaging applications. J Am Chem Soc (2005) 0.88
Sequential gene silencing using wavelength-selective caged morpholino oligonucleotides. Angew Chem Int Ed Engl (2014) 0.88
Controlling destiny through chemistry: small-molecule regulators of cell fate. ACS Chem Biol (2010) 0.88
General method for regulating protein stability with light. ACS Chem Biol (2013) 0.88
Temporal and spatial regulation of microRNA activity with photoactivatable cantimirs. ACS Chem Biol (2011) 0.87
Nuclear matrix protein SMAR1 represses HIV-1 LTR mediated transcription through chromatin remodeling. Virology (2010) 0.87
5-propynyluracil.diaminopurine: an efficient base-pair for non-enzymatic transcription of DNA. Chem Commun (Camb) (2002) 0.86
Germ cell migration in zebrafish is cyclopamine-sensitive but Smoothened-independent. Dev Biol (2009) 0.86
The imidazopyridine derivative JK184 reveals dual roles for microtubules in Hedgehog signaling. Angew Chem Int Ed Engl (2009) 0.86
Upregulation of CPE promotes cell proliferation and tumorigenicity in colorectal cancer. BMC Cancer (2013) 0.84
Chemical technologies for probing embryonic development. Chem Soc Rev (2008) 0.84
Fish 'n clicks. Nat Chem Biol (2008) 0.84
Synthetic strategies for studying embryonic development. Chem Biol (2010) 0.84
Oligonucleotide-based tools for studying zebrafish development. Zebrafish (2010) 0.84
Roles of Hedgehog pathway components and retinoic acid signalling in specifying zebrafish ventral spinal cord neurons. Development (2011) 0.84
Photoactivatable and water soluble FRET dyes with high uncaging cross section. J Am Chem Soc (2007) 0.84
Development of larval Schistosoma japonicum blocked in Oncomelania hupensis by pre-infection with larval Exorchis sp. J Parasitol (2009) 0.83
Protective role of curcumin against nicotine-induced genotoxicity on rat liver under restricted dietary protein. Eur J Pharmacol (2008) 0.83
Gene regulation technologies in zebrafish. Mol Biosyst (2008) 0.82
Stem cells: The right neighbour. Nature (2012) 0.82
LIM protein JUB promotes epithelial-mesenchymal transition in colorectal cancer. Cancer Sci (2014) 0.82
Effect of microbial treatment on the prevention and removal of paraffin deposits on stainless steel surfaces. Bioresour Technol (2012) 0.81
Assaying dynamic cell-cell junctional communication using noninvasive and quantitative fluorescence imaging techniques: LAMP and infrared-LAMP. Nat Protoc (2009) 0.81
Chemical 'Jekyll and Hyde's: small-molecule inhibitors of developmental signaling pathways. Chem Soc Rev (2011) 0.80
Lineage labeling of zebrafish cells with laser uncagable fluorescein dextran. J Vis Exp (2011) 0.80
Retracted Zebrafish caspase-3: molecular cloning, characterization, crystallization and phylogenetic analysis. Protein Pept Lett (2006) 0.80
Local Ca2+ rise near store operated Ca2+ channels inhibits cell coupling during capacitative Ca2+ influx. Cell Commun Adhes (2006) 0.80
Crafting new cages. Nat Methods (2006) 0.79
Hedgehog and retinoic acid signaling cooperate to promote motoneurogenesis in zebrafish. Development (2011) 0.79
Spatiotemporal control of embryonic gene expression using caged morpholinos. Methods Cell Biol (2011) 0.79
Tumor Necrosis Factor alpha (TNFalpha) regulates CD40 expression through SMAR1 phosphorylation. Biochem Biophys Res Commun (2009) 0.77
Improved protocol for the synthesis of flexibly protected morpholino monomers from unprotected ribonucleosides. Nucleosides Nucleotides Nucleic Acids (2012) 0.77
Cytoplasmic Dynein Antagonists with Improved Potency and Isoform Selectivity. ACS Chem Biol (2015) 0.77
Functional inhibition of UQCRB suppresses angiogenesis in zebrafish. Biochem Biophys Res Commun (2013) 0.77
Nitroreductase-activatable morpholino oligonucleotides for in vivo gene silencing. ACS Chem Biol (2014) 0.75
2-Benz-yloxy-1-naphthaldehyde. Acta Crystallogr Sect E Struct Rep Online (2009) 0.75
Stabilization of SMAR1 mRNA by PGA2 involves a stem loop structure in the 5' UTR. Nucleic Acids Res (2007) 0.75
Synthesis of optically active 2- and 3- indolylglycine derivatives and their oxygen analogues. J Org Chem (2012) 0.75
Emerging technologies in molecular imaging: new windows into biology. Curr Opin Chem Biol (2013) 0.75
Photophysical studies and submicron ring formation of morpholino U-nucleoside monomers. Chem Commun (Camb) (2013) 0.75