The hematopoietic stem cell niche: low in oxygen but a nice place to be.

PubWeight™: 2.63‹?› | Rank: Top 1%

🔗 View Article (PMID 19725055)

Published in J Cell Physiol on January 01, 2010

Authors

Pernilla Eliasson1, Jan-Ingvar Jönsson

Author Affiliations

1: Department of Clinical and Experimental Medicine, Experimental Hematology Unit, Linköping University, Linköping, Sweden.

Articles citing this

(truncated to the top 100)

The distinct metabolic profile of hematopoietic stem cells reflects their location in a hypoxic niche. Cell Stem Cell (2010) 5.07

IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics. Nature (2012) 4.04

Cell cycle regulation in hematopoietic stem cells. J Cell Biol (2011) 2.48

Dynamic niches in the origination and differentiation of haematopoietic stem cells. Nat Rev Mol Cell Biol (2011) 2.34

Quantitative imaging of haematopoietic stem and progenitor cell localization and hypoxic status in the bone marrow microenvironment. Nat Cell Biol (2013) 2.34

The bone marrow at the crossroads of blood and immunity. Nat Rev Immunol (2011) 2.07

Hypoxia suppresses conversion from proliferative arrest to cellular senescence. Proc Natl Acad Sci U S A (2012) 1.83

AKR1C3 is a biomarker of sensitivity to PR-104 in preclinical models of T-cell acute lymphoblastic leukemia. Blood (2015) 1.52

Meis1 regulates the metabolic phenotype and oxidant defense of hematopoietic stem cells. Blood (2012) 1.45

Autophagy in stem cells. Autophagy (2013) 1.43

Effects of hypoxic culture conditions on umbilical cord-derived human mesenchymal stem cells. Cell Commun Signal (2010) 1.36

Hypoxia promotes satellite cell self-renewal and enhances the efficiency of myoblast transplantation. Development (2012) 1.31

Redox homeostasis: the linchpin in stem cell self-renewal and differentiation. Cell Death Dis (2013) 1.31

TNFalpha up-regulates SLUG via the NF-kappaB/HIF1alpha axis, which imparts breast cancer cells with a stem cell-like phenotype. J Cell Physiol (2010) 1.27

HIF1α is required for survival maintenance of chronic myeloid leukemia stem cells. Blood (2012) 1.26

Upregulation of nascent mitochondrial biogenesis in mouse hematopoietic stem cells parallels upregulation of CD34 and loss of pluripotency: a potential strategy for reducing oxidative risk in stem cells. Cell Cycle (2010) 1.25

Reactive oxygen species and hematopoietic stem cell senescence. Int J Hematol (2011) 1.24

Defining and redefining the nephron progenitor population. Pediatr Nephrol (2011) 1.23

Drosophila: a model for studying genetic and molecular aspects of haematopoiesis and associated leukaemias. Dis Model Mech (2011) 1.14

Energy metabolism and energy-sensing pathways in mammalian embryonic and adult stem cell fate. J Cell Sci (2012) 1.12

Selective enhancement of donor hematopoietic cell engraftment by the CXCR4 antagonist AMD3100 in a mouse transplantation model. PLoS One (2010) 1.12

Hypoxic culture conditions as a solution for mesenchymal stem cell based regenerative therapy. ScientificWorldJournal (2013) 1.10

Homeostatic and pathogenic extramedullary hematopoiesis. J Blood Med (2010) 1.10

Meis1 preserves hematopoietic stem cells in mice by limiting oxidative stress. Blood (2012) 1.09

Metabolism and the leukemic stem cell. J Exp Med (2010) 1.08

Reactive oxygen species in normal and tumor stem cells. Adv Cancer Res (2014) 1.06

Hypoxia in the regulation of neural stem cells. Cell Mol Life Sci (2011) 1.04

Roles of reactive oxygen species in the fate of stem cells. Antioxid Redox Signal (2012) 1.02

The Valley of Death in anticancer drug development: a reassessment. Trends Pharmacol Sci (2012) 1.00

Changing appetites: the adaptive advantages of fuel choice. Trends Cell Biol (2013) 1.00

Paracrine molecules of mesenchymal stem cells for hematopoietic stem cell niche. Bone Marrow Res (2011) 0.96

Tug of war in the haematopoietic stem cell niche: do myeloma plasma cells compete for the HSC niche? Blood Cancer J (2012) 0.96

Mimicking the functional hematopoietic stem cell niche in vitro: recapitulation of marrow physiology by hydrogel-based three-dimensional cultures of mesenchymal stromal cells. Haematologica (2011) 0.95

Glucose availability in hypoxia regulates the selection of chronic myeloid leukemia progenitor subsets with different resistance to imatinib-mesylate. Haematologica (2010) 0.95

Development and maintenance of cancer stem cells under chronic inflammation. J Nippon Med Sch (2011) 0.95

Autophagy-mediated regulation of macrophages and its applications for cancer. Autophagy (2013) 0.94

Hypoxia and metabolic properties of hematopoietic stem cells. Antioxid Redox Signal (2013) 0.94

Evidence that growth factor independence 1b regulates dormancy and peripheral blood mobilization of hematopoietic stem cells. Blood (2010) 0.94

NADPH oxidase 2 regulates bone marrow microenvironment following hindlimb ischemia: role in reparative mobilization of progenitor cells. Stem Cells (2012) 0.94

Hypoxia selects bortezomib-resistant stem cells of chronic myeloid leukemia. PLoS One (2011) 0.93

Haematopoietic stem cell niches: new insights inspire new questions. EMBO J (2013) 0.93

Surviving change: the metabolic journey of hematopoietic stem cells. Trends Cell Biol (2014) 0.93

Stress and stem cells. Wiley Interdiscip Rev Dev Biol (2012) 0.93

Meat Science and Muscle Biology Symposium: stem cell niche and postnatal muscle growth. J Anim Sci (2011) 0.92

To breathe or not to breathe: the haematopoietic stem/progenitor cells dilemma. Br J Pharmacol (2013) 0.91

Bone marrow endosteal mesenchymal progenitors depend on HIF factors for maintenance and regulation of hematopoiesis. Stem Cell Reports (2014) 0.90

Hypoxia and senescence: the impact of oxygenation on tumor suppression. Mol Cancer Res (2011) 0.89

Stem cell-based tissue engineering approaches for musculoskeletal regeneration. Curr Pharm Des (2013) 0.88

Redox Regulation in Cancer Stem Cells. Oxid Med Cell Longev (2015) 0.88

The gap junction as a "Biological Rosetta Stone": implications of evolution, stem cells to homeostatic regulation of health and disease in the Barker hypothesis. J Cell Commun Signal (2010) 0.87

Reactive oxygen species in vascular formation and development. Oxid Med Cell Longev (2013) 0.87

Genome integrity, stem cells and hyaluronan. Aging (Albany NY) (2012) 0.87

Phase I/II study of the hypoxia-activated prodrug PR104 in refractory/relapsed acute myeloid leukemia and acute lymphoblastic leukemia. Haematologica (2015) 0.87

Initial testing of the hypoxia-activated prodrug PR-104 by the pediatric preclinical testing program. Pediatr Blood Cancer (2010) 0.87

CXCL12/CXCR4 signaling and other recruitment and homing pathways in fracture repair. Bonekey Rep (2013) 0.87

Cited2 is required for the maintenance of glycolytic metabolism in adult hematopoietic stem cells. Stem Cells Dev (2013) 0.85

The Effect of Hypoxia on Mesenchymal Stem Cell Biology. Adv Pharm Bull (2015) 0.85

Mesenchymal precursor cells maintain the differentiation and proliferation potentials of breast epithelial cells. Breast Cancer Res (2014) 0.85

Chromosomal instability in in vitro cultured mouse hematopoietic cells associated with oxidative stress. Am J Blood Res (2012) 0.84

Heme oxygenase-1 derived carbon monoxide permits maturation of myeloid cells. Cell Death Dis (2014) 0.84

Mesenchymal stem cells: roles and relationships in vascularization. Tissue Eng Part B Rev (2014) 0.84

Bone marrow mesenchymal stem cells for improving hematopoietic function: an in vitro and in vivo model. Part 2: Effect on bone marrow microenvironment. PLoS One (2011) 0.84

Hypoxia-sensitive epigenetic regulation of an antisense-oriented lncRNA controls WT1 expression in myeloid leukemia cells. PLoS One (2015) 0.83

The Key Role of the Blood Supply to Bone. Bone Res (2013) 0.83

The cardiac hypoxic niche: emerging role of hypoxic microenvironment in cardiac progenitors. Cardiovasc Diagn Ther (2012) 0.83

Severe hypoxia exerts parallel and cell-specific regulation of gene expression and alternative splicing in human mesenchymal stem cells. BMC Genomics (2014) 0.83

Regulation of cell proliferation by hypoxia-inducible factors. Am J Physiol Cell Physiol (2015) 0.83

Salidroside stimulates DNA repair enzyme Parp-1 activity in mouse HSC maintenance. Blood (2012) 0.83

A concerted HIF-1α/MT1-MMP signalling axis regulates the expression of the 3BP2 adaptor protein in hypoxic mesenchymal stromal cells. PLoS One (2011) 0.82

The primary cilium as a biomarker in the hypoxic adaptation of bone marrow-derived mesenchymal stromal cells: a role for the secreted frizzled-related proteins. Biomark Insights (2011) 0.82

Intermittent hypoxia mobilizes hematopoietic progenitors and augments cellular and humoral elements of innate immunity in adult men. High Alt Med Biol (2011) 0.81

Optimization of pre-transplantation conditions to enhance the efficacy of mesenchymal stem cells. Int J Biol Sci (2015) 0.81

The Culture-Repopulating Ability assays and incubation in low oxygen: a simple way to test drugs on leukaemia stem or progenitor cells. Curr Pharm Des (2013) 0.81

Molecular signature and in vivo behavior of bone marrow endosteal and subendosteal stromal cell populations and their relevance to hematopoiesis. Exp Cell Res (2012) 0.81

Hypoxic metabolism in human hematopoietic stem cells. Cell Biosci (2015) 0.80

Targeting the leukemia-stroma interaction in acute myeloid leukemia: rationale and latest evidence. Ther Adv Hematol (2016) 0.80

AMP-activated Protein Kinase Stimulates Warburg-like Glycolysis and Activation of Satellite Cells during Muscle Regeneration. J Biol Chem (2015) 0.80

Oxidases and reactive oxygen species during hematopoiesis: a focus on megakaryocytes. J Cell Physiol (2012) 0.80

Stem cell niches and other factors that influence the sensitivity of bone marrow to radiation-induced bone cancer and leukaemia in children and adults. Int J Radiat Biol (2011) 0.79

Retracted Endocannabinoids are expressed in bone marrow stromal niches and play a role in interactions of hematopoietic stem and progenitor cells with the bone marrow microenvironment. J Biol Chem (2010) 0.79

Effect of low oxygen tension on the biological characteristics of human bone marrow mesenchymal stem cells. Cell Stress Chaperones (2016) 0.79

Adaptive and Pathogenic Responses to Stress by Stem Cells during Development. Cells (2012) 0.78

Mechanisms of apoptosis induction by simultaneous inhibition of PI3K and FLT3-ITD in AML cells in the hypoxic bone marrow microenvironment. Cancer Lett (2012) 0.78

Perspective beyond cancer genomics: bioenergetics of cancer stem cells. Yonsei Med J (2010) 0.78

Manipulating megakaryocytes to manufacture platelets ex vivo. J Thromb Haemost (2015) 0.78

Regulation of Stem Cell Fate by ROS-mediated Alteration of Metabolism. Int J Stem Cells (2015) 0.78

Proteomic analysis of murine bone marrow niche microenvironment identifies thioredoxin as a novel agent for radioprotection and for enhancing donor cell reconstitution. Exp Hematol (2013) 0.78

Suppression of cytochrome p450 reductase enhances long-term hematopoietic stem cell repopulation efficiency in mice. PLoS One (2013) 0.77

Redox signaling in cardiac renewal. Antioxid Redox Signal (2014) 0.77

Low oxygen alters mitochondrial function and response to oxidative stress in human neural progenitor cells. PeerJ (2015) 0.77

A multiscale model of the bone marrow and hematopoiesis. Math Biosci Eng (2011) 0.77

Hypoxia Inducible Factor-1α Regulates the Migration of Bone Marrow Mesenchymal Stem Cells via Integrin α 4. Stem Cells Int (2016) 0.77

Mitoquinone restores platelet production in irradiation-induced thrombocytopenia. Platelets (2014) 0.77

RepSox slows decay of CD34+ acute myeloid leukemia cells and decreases T cell immunoglobulin mucin-3 expression. Stem Cells Transl Med (2014) 0.76

Stratified control of IGF-I expression by hypoxia and stress hormones in osteoblasts. Gene (2014) 0.76

Differential hypoxic regulation of the microRNA-146a/CXCR4 pathway in normal and leukemic monocytic cells: impact on response to chemotherapy. Haematologica (2015) 0.76

Toxic stress prioritizes and imbalances stem cell differentiation: implications for new biomarkers and in vitro toxicology tests. Syst Biol Reprod Med (2012) 0.76

Early severe impairment of hematopoietic stem and progenitor cells from the bone marrow caused by CLP sepsis and endotoxemia in a humanized mice model. Stem Cell Res Ther (2015) 0.76

Hypoxic Niche-Mediated Regeneration of Hematopoiesis in the Engraftment Window Is Dominantly Affected by Oxygen Tension in the Milieu. Stem Cells Dev (2015) 0.75

Oxygen tension variation in ischemic gastrocnemius muscle, marrow, and different hypoxic conditions in vitro. Med Sci Monit (2014) 0.75

Articles by these authors

Hypoxia mediates low cell-cycle activity and increases the proportion of long-term-reconstituting hematopoietic stem cells during in vitro culture. Exp Hematol (2010) 2.40

The Q705K polymorphism in NLRP3 is a gain-of-function alteration leading to excessive interleukin-1β and IL-18 production. PLoS One (2012) 1.36

Stem cell factor promotes mast cell survival via inactivation of FOXO3a-mediated transcriptional induction and MEK-regulated phosphorylation of the proapoptotic protein Bim. Blood (2005) 1.24

Systemic reduction of functionally suppressive CD4dimCD25highFoxp3+ Tregs in human second trimester pregnancy is induced by progesterone and 17beta-estradiol. J Immunol (2009) 1.19

The BH3-only protein Puma plays an essential role in cytokine deprivation induced apoptosis of mast cells. Blood (2007) 1.18

The LIM-only protein LMO4 modulates the transcriptional activity of HEN1. Biochem Biophys Res Commun (2003) 1.09

BH3-only protein Bim more critical than Puma in tyrosine kinase inhibitor-induced apoptosis of human leukemic cells and transduced hematopoietic progenitors carrying oncogenic FLT3. Blood (2008) 0.97

Bcl11b mutations identified in murine lymphomas increase the proliferation rate of hematopoietic progenitor cells. BMC Cancer (2007) 0.92

The Lim-only protein LMO2 acts as a positive regulator of erythroid differentiation. Biochem Biophys Res Commun (2007) 0.92

Gd₂O₃ nanoparticles in hematopoietic cells for MRI contrast enhancement. Int J Nanomedicine (2011) 0.91

FLT3 ligand regulates apoptosis through AKT-dependent inactivation of transcription factor FoxO3. Biochem Biophys Res Commun (2004) 0.89

Lipopolysaccharide-induced fever depends on prostaglandin E2 production specifically in brain endothelial cells. Endocrinology (2012) 0.83

Interleukin-7-induced Stat-5 acts in synergy with Flt-3 signaling to stimulate expansion of hematopoietic progenitor cells. J Biol Chem (2010) 0.83

miR-20b regulates expression of proteinase-activated receptor-1 (PAR-1) thrombin receptor in melanoma cells. Pigment Cell Melanoma Res (2014) 0.82

ABCB1 haplotypes do not influence transport or efficacy of tyrosine kinase inhibitors in vitro. Pharmgenomics Pers Med (2013) 0.81

Inactivation of the forkhead transcription factor FoxO3 is essential for PKB-mediated survival of hematopoietic progenitor cells by kit ligand. Exp Hematol (2003) 0.81

Phosphatidylinositol 3-kinase is essential for kit ligand-mediated survival, whereas interleukin-3 and flt3 ligand induce expression of antiapoptotic Bcl-2 family genes. J Leukoc Biol (2003) 0.80

Absence of hot spot mutations of the PIK3CA gene in acute myeloid leukaemia. Eur J Haematol (2006) 0.79

Single-nucleotide polymorphisms of ABCG2 increase the efficacy of tyrosine kinase inhibitors in the K562 chronic myeloid leukemia cell line. Pharmacogenet Genomics (2014) 0.78

Irreversible pan-ERBB inhibitor canertinib elicits anti-leukaemic effects and induces the regression of FLT3-ITD transformed cells in mice. Br J Haematol (2011) 0.77

The pan-ErbB tyrosine kinase inhibitor canertinib induces caspase-mediated cell death in human T-cell leukemia (Jurkat) cells. Biochem Biophys Res Commun (2011) 0.77

Characterization of the mouse myeloid-associated differentiation marker (MYADM) gene: promoter analysis and protein localization. Mol Biol Rep (2005) 0.77

Deficiency of activating Fcγ-receptors reduces hepatic clearance and deposition of IC and increases CIC levels in mercury-induced autoimmunity. PLoS One (2010) 0.77

The pan-ErbB receptor tyrosine kinase inhibitor canertinib induces ErbB-independent apoptosis in human leukemia (HL-60 and U-937) cells. Biochem Biophys Res Commun (2010) 0.77

Hypoxic and normoxic in vitro cultures maintain similar numbers of long-term reconstituting hematopoietic stem cells from mouse bone marrow. Exp Hematol (2012) 0.77

Interleukin-6 primarily produced by non-hematopoietic cells mediates the lipopolysaccharide-induced febrile response. Brain Behav Immun (2013) 0.76