Expression of chimeric antigen receptors in natural killer cells with a regulatory-compliant non-viral method.

PubWeight™: 1.32‹?› | Rank: Top 10%

🔗 View Article (PMC 2821468)

Published in Cancer Gene Ther on September 11, 2009

Authors

L Li1, L N Liu, S Feller, C Allen, R Shivakumar, J Fratantoni, L A Wolfraim, H Fujisaki, D Campana, N Chopas, S Dzekunov, M Peshwa

Author Affiliations

1: MaxCyte Inc, Gaithersburg, MD 20878, USA. linhongl@maxcyte.com

Articles citing this

Multiple injections of electroporated autologous T cells expressing a chimeric antigen receptor mediate regression of human disseminated tumor. Cancer Res (2010) 2.64

Cytotoxicity of activated natural killer cells against pediatric solid tumors. Clin Cancer Res (2010) 2.51

Treatment of advanced leukemia in mice with mRNA engineered T cells. Hum Gene Ther (2011) 1.87

Natural killer cell biology: an update and future directions. J Allergy Clin Immunol (2013) 1.56

The future is now: chimeric antigen receptors as new targeted therapies for childhood cancer. Clin Cancer Res (2012) 1.37

Advantages and clinical applications of natural killer cells in cancer immunotherapy. Cancer Immunol Immunother (2013) 1.22

Regimen-specific effects of RNA-modified chimeric antigen receptor T cells in mice with advanced leukemia. Hum Gene Ther (2013) 1.21

Natural killer cell engineering for cellular therapy of cancer. Tissue Antigens (2011) 1.18

Therapeutic approaches to enhance natural killer cell cytotoxicity against cancer: the force awakens. Nat Rev Drug Discov (2015) 1.14

Engineering lymph node homing of ex vivo-expanded human natural killer cells via trogocytosis of the chemokine receptor CCR7. Blood (2012) 1.07

NK cells and cancer: you can teach innate cells new tricks. Nat Rev Cancer (2015) 1.04

Advantages and applications of CAR-expressing natural killer cells. Front Pharmacol (2015) 1.03

A practical approach to immunotherapy of hepatocellular carcinoma using T cells redirected against hepatitis B virus. Mol Ther Nucleic Acids (2013) 0.99

Are natural killer cells superior CAR drivers? Oncoimmunology (2014) 0.99

Hematopoietic stem cells for cancer immunotherapy. Immunol Rev (2014) 0.95

Cell surface receptor FPR2 promotes antitumor host defense by limiting M2 polarization of macrophages. Cancer Res (2012) 0.89

Comparison of mRNA and lentiviral based transfection of natural killer cells with chimeric antigen receptors recognizing lymphoid antigens. Leuk Lymphoma (2011) 0.87

Utilizing chimeric antigen receptors to direct natural killer cell activity. Front Immunol (2015) 0.85

Genetic Manipulation of NK Cells for Cancer Immunotherapy: Techniques and Clinical Implications. Front Immunol (2015) 0.84

Rigorous optimization and validation of potent RNA CAR T cell therapy for the treatment of common epithelial cancers expressing folate receptor. Oncotarget (2015) 0.83

Efficient large volume lentiviral vector production using flow electroporation. Hum Gene Ther (2011) 0.83

Efficient mRNA-Based Genetic Engineering of Human NK Cells with High-Affinity CD16 and CCR7 Augments Rituximab-Induced ADCC against Lymphoma and Targets NK Cell Migration toward the Lymph Node-Associated Chemokine CCL19. Front Immunol (2016) 0.80

Enhanced cytotoxicity of natural killer cells following the acquisition of chimeric antigen receptors through trogocytosis. PLoS One (2014) 0.78

Cellular therapies in acute lymphoblastic leukemia. Hematol Oncol Clin North Am (2011) 0.78

Current translational and clinical practices in hematopoietic cell and gene therapy. Cytotherapy (2012) 0.77

Gene-modified hematopoietic stem cells for cancer immunotherapy. Hum Vaccin Immunother (2014) 0.76

Formyl peptide receptor suppresses melanoma development and promotes NK cell migration. Inflammation (2014) 0.76

Engineering Natural Killer Cells for Cancer Immunotherapy. Mol Ther (2017) 0.76

Current perspectives on natural killer cell education and tolerance: emerging roles for inhibitory receptors. Immunotargets Ther (2015) 0.75

LZTFL1 Upregulated by All-Trans Retinoic Acid during CD4+ T Cell Activation Enhances IL-5 Production. J Immunol (2015) 0.75

Redirected Primary Human Chimeric Antigen Receptor Natural Killer Cells As an "Off-the-Shelf Immunotherapy" for Improvement in Cancer Treatment. Front Immunol (2017) 0.75

Synthetic Immunology: Hacking Immune Cells to Expand Their Therapeutic Capabilities. Annu Rev Immunol (2017) 0.75

Articles cited by this

Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants. Science (2002) 12.75

Successful adoptive transfer and in vivo expansion of human haploidentical NK cells in patients with cancer. Blood (2005) 7.28

Graft-versus-leukemia effect of donor lymphocyte transfusions in marrow grafted patients. Blood (1995) 5.34

Genetically targeted T cells eradicate systemic acute lymphoblastic leukemia xenografts. Clin Cancer Res (2007) 4.42

CD28 costimulation provided through a CD19-specific chimeric antigen receptor enhances in vivo persistence and antitumor efficacy of adoptively transferred T cells. Cancer Res (2006) 4.06

Chimeric receptors with 4-1BB signaling capacity provoke potent cytotoxicity against acute lymphoblastic leukemia. Leukemia (2004) 3.59

Genetic modification of primary natural killer cells overcomes inhibitory signals and induces specific killing of leukemic cells. Blood (2005) 2.81

Activation of resting human primary T cells with chimeric receptors: costimulation from CD28, inducible costimulator, CD134, and CD137 in series with signals from the TCR zeta chain. J Immunol (2004) 2.49

Addition of the CD28 signaling domain to chimeric T-cell receptors enhances chimeric T-cell resistance to T regulatory cells. Leukemia (2006) 2.35

Natural killer cell receptors: new biology and insights into the graft-versus-leukemia effect. Blood (2002) 2.20

High-efficiency transfection of primary human and mouse T lymphocytes using RNA electroporation. Mol Ther (2005) 2.04

Modification of antigen-encoding RNA increases stability, translational efficacy, and T-cell stimulatory capacity of dendritic cells. Blood (2006) 2.00

Purified donor NK-lymphocyte infusion to consolidate engraftment after haploidentical stem cell transplantation. Leukemia (2004) 1.97

Electrical breakdown, electropermeabilization and electrofusion. Rev Physiol Biochem Pharmacol (1986) 1.93

Emerging clinical applications of RNA. Nature (2002) 1.76

Donor leukocyte infusions in acute lymphocytic leukemia. Bone Marrow Transplant (2000) 1.62

Allogeneic hematopoietic stem cell transplantation for chronic myeloid leukemia in Europe 2006: transplant activity, long-term data and current results. An analysis by the Chronic Leukemia Working Party of the European Group for Blood and Marrow Transplantation (EBMT). Haematologica (2006) 1.59

Manufacturing of gene-modified cytotoxic T lymphocytes for autologous cellular therapy for lymphoma. Cytotherapy (2006) 1.57

Good manufacturing practices production of natural killer cells for immunotherapy: a six-year single-institution experience. Transfusion (2007) 1.49

Study of mechanisms of electric field-induced DNA transfection. I. DNA entry by surface binding and diffusion through membrane pores. Biophys J (1990) 1.47

The T-body approach: redirecting T cells with antibody specificity. Handb Exp Pharmacol (2008) 1.41

Natural killer cell alloreactivity in allogeneic hematopoietic transplantation. Curr Opin Oncol (2007) 1.27

Efficient gene transfer into the human natural killer cell line, NKL, using the Amaxa nucleofection system. J Immunol Methods (2004) 1.17

Gene transfer into human T lymphocytes and natural killer cells by Ad5/F35 chimeric adenoviral vectors. Exp Hematol (2004) 1.17

Synthetic messenger RNA as a tool for gene therapy. Hum Gene Ther (2006) 1.13

In vitro and in vivo electric field-mediated permeabilization, gene transfer, and expression. Methods (2004) 1.07

Gene transfection and expression in resting and activated murine CD4 T cell subsets. J Immunol Methods (2003) 1.07

Interleukin-4 induces programmed cell death (apoptosis) in cases of high-risk acute lymphoblastic leukemia. Blood (1994) 1.03

Rapid and highly efficient gene transfer into natural killer cells by nucleofection. J Immunol Methods (2003) 1.02

High transfection efficiency, gene expression, and viability of monocyte-derived human dendritic cells after nonviral gene transfer. J Leukoc Biol (2007) 1.01

Chimeric T-cell receptors: new challenges for targeted immunotherapy in hematologic malignancies. Haematologica (2007) 1.00

High-level transgene expression in primary human T lymphocytes and adult bone marrow CD34+ cells via electroporation-mediated gene delivery. Gene Ther (2000) 0.99

Activating and inhibitory NK cell receptors. Adv Exp Med Biol (1998) 0.96

mRNA but not plasmid DNA is efficiently transfected in murine J774A.1 macrophages. Biochem Biophys Res Commun (2005) 0.95

Natural killer cell-based immunotherapeutic strategies. Cytotherapy (2005) 0.94

The analysis of costimulatory receptor signaling cascades in normal T lymphocytes using in vitro gene transfer and reporter gene analysis. Nat Med (2001) 0.92

Highly efficient, large volume flow electroporation. Technol Cancer Res Treat (2002) 0.91

The biology of natural killer cells and implications for therapy of human disease. J Hematother Stem Cell Res (2001) 0.87

Activating KIRs exert a crucial role on relapse and overall survival after HLA-identical sibling transplantation. Mol Immunol (2008) 0.86

High-efficiency electrotransfection of human primary hematopoietic stem cells. FASEB J (2001) 0.84

Apoptosis induced by DNA uptake limits transfection efficiency. Exp Cell Res (1999) 0.83

Recent advances in chronic lymphocytic leukemia. Cancer Invest (2006) 0.82

Donor leukocyte infusions for recurrent hematologic malignancies after allogeneic bone marrow transplantation: impact of infused and residual donor T cells. Bone Marrow Transplant (1998) 0.81

Rapid and efficient nonviral gene delivery of CD154 to primary chronic lymphocytic leukemia cells. Cancer Gene Ther (2006) 0.81

Novel approaches to immunotherapy for B-cell malignancies. Curr Hematol Rep (2005) 0.79

Articles by these authors

(truncated to the top 100)

Relation of tumor size, lymph node status, and survival in 24,740 breast cancer cases. Cancer (1989) 8.07

Structural polarity and directional growth of microtubules of Chlamydomonas flagella. J Mol Biol (1974) 4.80

Microtubule assembly in vitro. Fed Proc (1974) 3.82

Chimeric receptors with 4-1BB signaling capacity provoke potent cytotoxicity against acute lymphoblastic leukemia. Leukemia (2004) 3.59

Immunological detection of minimal residual disease in children with acute lymphoblastic leukaemia. Lancet (1998) 3.07

Clinical importance of minimal residual disease in childhood acute lymphoblastic leukemia. Blood (2000) 2.92

The maximum oxygen intake. An international reference standard of cardiorespiratory fitness. Bull World Health Organ (1968) 2.87

Human leptin levels are pulsatile and inversely related to pituitary-adrenal function. Nat Med (1997) 2.73

Cell cycle regulation of the cyclin A, cdc25C and cdc2 genes is based on a common mechanism of transcriptional repression. EMBO J (1995) 2.67

Focal therapy for localized prostate cancer: a phase I/II trial. J Urol (2011) 2.43

Sporadic medulloblastomas contain oncogenic beta-catenin mutations. Cancer Res (1998) 2.33

No to BDA. Br Dent J (2010) 2.31

Long-term results of St Jude Total Therapy Studies 11, 12, 13A, 13B, and 14 for childhood acute lymphoblastic leukemia. Leukemia (2009) 2.24

Paranoid Psychosis Successfully Treated by Adrenalectomy. Br Med J (1945) 2.23

Microtuble assembly: some possible regulatory mechanisms. J Supramol Struct (1974) 2.21

Targeted testicular excision biopsy: when and how should we try to avoid radical orchidectomy? Clin Radiol (2009) 2.11

Proceedings: A more uniform measurement of factor VIII inhibitors. Thromb Diath Haemorrh (1975) 2.10

Mutations in the mu heavy-chain gene in patients with agammaglobulinemia. N Engl J Med (1996) 2.10

Acupuncture-point stimulation for chemotherapy-induced nausea or vomiting. Cochrane Database Syst Rev (2006) 2.03

Long-term results of Total Therapy studies 11, 12 and 13A for childhood acute lymphoblastic leukemia at St Jude Children's Research Hospital. Leukemia (2000) 1.94

Video-rate scanning two-photon excitation fluorescence microscopy and ratio imaging with cameleons. Biophys J (1999) 1.93

Rapamycin causes poorly reversible inhibition of mTOR and induces p53-independent apoptosis in human rhabdomyosarcoma cells. Cancer Res (1999) 1.89

Clinical significance of minimal residual disease in childhood acute lymphoblastic leukemia after first relapse. Leukemia (2004) 1.87

Sharing care: the psychiatrist in the family physician's office. Can J Psychiatry (1997) 1.85

Mechanisms of GDF-5 action during skeletal development. Development (1999) 1.83

The p150,95 molecule is a marker of human mononuclear phagocytes: comparison with expression of class II molecules. Eur J Immunol (1986) 1.82

A region of consistent deletion in neuroblastoma maps within human chromosome 1p36.2-36.3. Proc Natl Acad Sci U S A (1995) 1.82

High-intensity-focused ultrasound in the treatment of primary prostate cancer: the first UK series. Br J Cancer (2009) 1.78

ATPase activities and actin-binding properties of subfragments of Acanthamoeba myosin IA. J Biol Chem (1986) 1.78

Diet and risk of chronic diseases: results from the first 8 years of follow-up in the EPIC-Potsdam study. Eur J Clin Nutr (2013) 1.71

IgG rheumatoid factor, complement and immune complexes in rheumatoid synovitis and vasculitis: comparative and serial studies during cytotoxic therapy. Clin Exp Immunol (1981) 1.66

Comparative analysis of flow cytometry and polymerase chain reaction for the detection of minimal residual disease in childhood acute lymphoblastic leukemia. Leukemia (2004) 1.65

An essential role for BLNK in human B cell development. Science (1999) 1.64

The spv genes on the Salmonella dublin virulence plasmid are required for severe enteritis and systemic infection in the natural host. Infect Immun (1997) 1.61

A novel monoclonal antibody BI-3C5 recognises myeloblasts and non-B non-T lymphoblasts in acute leukaemias and CGL blast crises, and reacts with immature cells in normal bone marrow. Leuk Res (1985) 1.61

A multi-centre prospective development study evaluating focal therapy using high intensity focused ultrasound for localised prostate cancer: The INDEX study. Contemp Clin Trials (2013) 1.61

Blastomycosis in six dogs in New York state. J Am Vet Med Assoc (1997) 1.60

Cytokine production regulating Th1 and Th2 cytokines in hemophagocytic lymphohistiocytosis. Blood (1997) 1.60

An analysis of engraftment kinetics as a function of the CD34 content of peripheral blood progenitor cell collections in 692 patients after the administration of myeloablative chemotherapy. Blood (1995) 1.58

Rationale and design of Total Therapy Study XV for newly diagnosed childhood acute lymphoblastic leukemia. Ann Hematol (2004) 1.57

Monomeric Acanthamoeba myosins I support movement in vitro. J Biol Chem (1985) 1.56

Mutations in the human lambda5/14.1 gene result in B cell deficiency and agammaglobulinemia. J Exp Med (1998) 1.55

Postprandial bloating after laparoscopic Nissen fundoplication. Can J Surg (2001) 1.53

Psychosocial and psychosomatic diagnoses in primary care of children. Pediatrics (1980) 1.52

PITSLRE protein kinase activity is associated with apoptosis. Mol Cell Biol (1995) 1.51

Hyperactivation of p21(ras) and the hematopoietic-specific Rho GTPase, Rac2, cooperate to alter the proliferation of neurofibromin-deficient mast cells in vivo and in vitro. J Exp Med (2001) 1.50

Lipid-altering efficacy of ezetimibe/simvastatin 10/40 mg compared with doubling the statin dose in patients admitted to the hospital for a recent coronary event: the INFORCE study. Int J Clin Pract (2008) 1.50

TP53 gene mutation is frequent in patients with acute myeloid leukemia and complex karyotype, and is associated with very poor prognosis. Leukemia (2008) 1.50

Intrastromal noninflammatory bacterial colonization of a corneal graft. Arch Ophthalmol (1983) 1.49

Childhood acute lymphoblastic leukaemia--current status and future perspectives. Lancet Oncol (2001) 1.48

Influence of avilamycin administration and its subsequent withdrawal on emergence and disappearance of antimicrobial resistance in enterococci in the intestine of broiler chickens. J Appl Microbiol (2007) 1.45

Integrating mental health services within primary care. A Canadian program. Gen Hosp Psychiatry (1997) 1.43

Bone marrow-derived stromal cells prevent apoptotic cell death in B-lineage acute lymphoblastic leukemia. Blood (1992) 1.42

Human B cell development. I. Phenotypic differences of B lymphocytes in the bone marrow and peripheral lymphoid tissue. J Immunol (1985) 1.41

Treatment of obesity by exercise in the cold. Can Med Assoc J (1977) 1.41

Endocrine pancreatic tumors: factors correlated with survival. Ann Oncol (2005) 1.41

Studies on the mechanism of resistance to rapamycin in human cancer cells. Mol Pharmacol (1998) 1.41

PAMELA measurements of cosmic-ray proton and helium spectra. Science (2011) 1.39

"Cytoplasmic" expression of nuclear antigens. Leukemia (1989) 1.38

Hypnotic drugs and their effectiveness. All-night EEG studies of insomniac subjects. Arch Gen Psychiatry (1970) 1.38

Ralstonia solanacearum needs motility for invasive virulence on tomato. J Bacteriol (2001) 1.36

Analysis of PTCH/SMO/SHH pathway genes in medulloblastoma. Genes Chromosomes Cancer (2000) 1.36

IL-2 adenovector-transduced autologous tumor cells induce antitumor immune responses in patients with neuroblastoma. Blood (1998) 1.33

Combination of cladribine and cytarabine is effective for childhood acute myeloid leukemia: results of the St Jude AML97 trial. Leukemia (2009) 1.33

Mutations in Igalpha (CD79a) result in a complete block in B-cell development. J Clin Invest (1999) 1.32

The interaction between Pseudomonas aeruginosa and the corneal epithelium. An electron microscopic study. Arch Ophthalmol (1985) 1.32

Hypnotics and altered sleep-dream patterns. I. All-night EEG studies of glutethimide, methyprylon, and pentobarbital. Arch Gen Psychiatry (1970) 1.31

Experimental evidence for the contractile activities of Acanthamoeba myosins IA and IB. J Biol Chem (1985) 1.30

Identification of malignant plasma cell precursors in the bone marrow of multiple myeloma. J Clin Invest (1985) 1.30

Overexpression of human RAD51 and RAD52 reduces double-strand break-induced homologous recombination in mammalian cells. Nucleic Acids Res (2001) 1.26

p53/p21(CIP1) cooperate in enforcing rapamycin-induced G(1) arrest and determine the cellular response to rapamycin. Cancer Res (2001) 1.26

Formulation of drugs in block copolymer micelles: drug loading and release. Curr Pharm Des (2006) 1.26

Features of synovial membrane identified with monoclonal antibodies. Clin Exp Immunol (1985) 1.25

Incidence of decompression illness in amateur scuba divers. Health Trends (1995) 1.25

Clinical relevance of BCL-2 overexpression in childhood acute lymphoblastic leukemia. Blood (1996) 1.24

Endothelin ETA receptor antagonist blocks cardiac hypertrophy provoked by hemodynamic overload. Circulation (1994) 1.24

Case report: retrocaval ureter: MR appearances. Br J Radiol (2002) 1.24

Expression of T-cell receptors TcR1 (gamma/delta) and TcR2 (alpha/beta) in the human intestinal mucosa. Immunology (1989) 1.24

Standardization of submaximal exercise tests. Bull World Health Organ (1968) 1.23

IgG antiglobulins in rheumatoid arthritis and other arthritides: relationship with clinical features and other parameters. Ann Rheum Dis (1981) 1.23

Molecular genetic analysis of familial neuroblastoma. Eur J Cancer (1997) 1.23

Prostate MRI: who, when, and how? Report from a UK consensus meeting. Clin Radiol (2013) 1.23

Evidence that haploinsufficiency of Ptch leads to medulloblastoma in mice. Genes Chromosomes Cancer (2000) 1.22

Predictors, prodromes and incidence of postpartum depression. J Psychosom Obstet Gynaecol (2001) 1.21

Recruiting African-American older adults for a community-based health promotion intervention: which strategies are effective? Am J Prev Med (1998) 1.20

Interferon gamma inhibits apoptotic cell death in B cell chronic lymphocytic leukemia. J Exp Med (1993) 1.20

Natural killer cell engineering for cellular therapy of cancer. Tissue Antigens (2011) 1.18

LaTulippe--a case study of a one hundred and sixty kilometre runner. Br J Sports Med (1977) 1.17

Use of molecular probes to assess geographic distribution of Pfiesteria species. Environ Health Perspect (2001) 1.17

Noninvasive positive-pressure ventilation: a utilization review of use in a teaching hospital. CMAJ (2000) 1.15

Adhesion-dependent survival of normal and leukemic human B lymphoblasts on bone marrow stromal cells. Blood (1994) 1.14

Stroma-supported culture in childhood B-lineage acute lymphoblastic leukemia cells predicts treatment outcome. J Clin Invest (1996) 1.14

The isolation of immune complexes containing IgM rheumatoid factor and recovery of IgG rheumatoid factor from the complexes. J Immunol Methods (1980) 1.14

Comparative cytotoxicity of dexamethasone and prednisolone in childhood acute lymphoblastic leukemia. J Clin Oncol (1996) 1.14

Time-dependent changes in striatal glutamate synapses following a 6-hydroxydopamine lesion. Neuroscience (1999) 1.12

Monoclonal antibody 5.5 reacts with p8,14, a myeloid molecule associated with some vascular endothelium. Eur J Immunol (1989) 1.12

Requirement for two or more Erwinia carotovora subsp. carotovora pectolytic gene products for maceration of potato tuber tissue by Escherichia coli. J Bacteriol (1986) 1.11

Familial predisposition to neuroblastoma does not map to chromosome band 1p36. Cancer Res (1996) 1.11

Infection with E.B. virus and rheumatoid arthritis. Lancet (1979) 1.10

ECK, a human EPH-related gene, maps to 1p36.1, a common region of alteration in human cancers. Genomics (1997) 1.10