Clara cell: progenitor for the bronchiolar epithelium.

β-catenin in the alveolar epithelium protects from lung fibrosis after intratracheal bleomycin. Am J Respir Crit Care Med (2013) 1.89

Stem cells and cell therapies in lung biology and lung diseases. Proc Am Thorac Soc (2011) 1.66

Neuroepithelial body microenvironment is a niche for a distinct subset of Clara-like precursors in the developing airways. Proc Natl Acad Sci U S A (2012) 1.31

RNA-Seq quantification of the human small airway epithelium transcriptome. BMC Genomics (2012) 1.28

Regeneration of alveolar type I and II cells from Scgb1a1-expressing cells following severe pulmonary damage induced by bleomycin and influenza. PLoS One (2012) 1.13

Localizations of Na(+)-D-glucose cotransporters SGLT1 and SGLT2 in human kidney and of SGLT1 in human small intestine, liver, lung, and heart. Pflugers Arch (2014) 1.01

Repair of tracheal epithelium by basal cells after chlorine-induced injury. Respir Res (2012) 0.99

Major shifts in the spatio-temporal distribution of lung antioxidant enzymes during influenza pneumonia. PLoS One (2012) 0.94

Direct and indirect roles for β-catenin in facultative basal progenitor cell differentiation. Am J Physiol Lung Cell Mol Physiol (2012) 0.91

Lung cancer stem cells: progress and prospects. Cancer Lett (2012) 0.90

Chemosensory brush cells of the trachea. A stable population in a dynamic epithelium. Am J Respir Cell Mol Biol (2013) 0.89

Stem cells, cell therapies, and bioengineering in lung biology and diseases. Comprehensive review of the recent literature 2010-2012. Ann Am Thorac Soc (2013) 0.88

In vivo disruption of TGF-beta signaling by Smad7 in airway epithelium alleviates allergic asthma but aggravates lung carcinogenesis in mouse. PLoS One (2010) 0.87

Bone marrow cells expressing clara cell secretory protein increase epithelial repair after ablation of pulmonary clara cells. Mol Ther (2013) 0.87

Exacerbation of lung radiation injury by viral infection: the role of Clara cells and Clara cell secretory protein. Radiat Res (2013) 0.86

Isolation of epithelial, endothelial, and immune cells from lungs of transgenic mice with oncogene-induced lung adenocarcinomas. Am J Respir Cell Mol Biol (2015) 0.86

Polydatin up-regulates Clara cell secretory protein to suppress phospholipase A2 of lung induced by LPS in vivo and in vitro. BMC Cell Biol (2011) 0.85

Regenerative pulmonary medicine: potential and promise, pitfalls and challenges. Eur J Clin Invest (2012) 0.84

Regulation of transplanted mesenchymal stem cells by the lung progenitor niche in rats with chronic obstructive pulmonary disease. Respir Res (2014) 0.83

Tracheal dysplasia precedes bronchial dysplasia in mouse model of N-nitroso trischloroethylurea induced squamous cell lung cancer. PLoS One (2015) 0.83

Tissue-dependent consequences of Apc inactivation on proliferation and differentiation of ciliated cell progenitors via Wnt and notch signaling. PLoS One (2013) 0.83

Diversity of epithelial stem cell types in adult lung. Stem Cells Int (2015) 0.80

Aging exacerbates damage and delays repair of alveolar epithelia following influenza viral pneumonia. Respir Res (2014) 0.80

E-cadherin controls bronchiolar progenitor cells and onset of preneoplastic lesions in mice. Neoplasia (2012) 0.79

Deletion of airway cilia results in noninflammatory bronchiectasis and hyperreactive airways. Am J Physiol Lung Cell Mol Physiol (2013) 0.79

Neonatal hyperoxic exposure persistently alters lung secretoglobins and annexin A1. Biomed Res Int (2013) 0.78

Jaagsiekte sheep retrovirus infects multiple cell types in the ovine lung. J Virol (2011) 0.78

Murine CLCA5 is uniquely expressed in distinct niches of airway epithelial cells. Histochem Cell Biol (2014) 0.78

Immunohistochemical detection and regulation of α5 nicotinic acetylcholine receptor (nAChR) subunits by FoxA2 during mouse lung organogenesis. Respir Res (2011) 0.78

A distinct regulatory region of the Bmp5 locus activates gene expression following adult bone fracture or soft tissue injury. Bone (2015) 0.78

Depletion of bone marrow CCSP-expressing cells delays airway regeneration. Mol Ther (2014) 0.77

Serum pneumoproteins in tunnel construction workers. Int Arch Occup Environ Health (2015) 0.76

Intratracheal Administration of Mesenchymal Stem Cells Modulates Tachykinin System, Suppresses Airway Remodeling and Reduces Airway Hyperresponsiveness in an Animal Model. PLoS One (2016) 0.76

Persistent effects of chlorine inhalation on respiratory health. Ann N Y Acad Sci (2016) 0.76

Cartilage rings contribute to the proper embryonic tracheal epithelial differentiation, metabolism and expression of inflammatory genes. Am J Physiol Lung Cell Mol Physiol (2016) 0.75

Engineering airway epithelium. J Biomed Biotechnol (2012) 0.75

Syndecan 4 Mediates Nrf2-dependent Expansion of Bronchiolar Progenitors That Protect Against Lung Inflammation. Mol Ther (2015) 0.75

New Role of Adult Lung c-kit(+) Cells in a Mouse Model of Airway Hyperresponsiveness. Mediators Inflamm (2016) 0.75

Involvement of Igf1r in Bronchiolar Epithelial Regeneration: Role during Repair Kinetics after Selective Club Cell Ablation. PLoS One (2016) 0.75

Protective phenotypes of club cells and alveolar macrophages are favored as part of endotoxin-mediated prevention of asthma. Exp Biol Med (Maywood) (2014) 0.75

The role of club cell phenoconversion and migration in idiopathic pulmonary fibrosis. Aging (Albany NY) (2016) 0.75

The role and importance of club cells (Clara cells) in the pathogenesis of some respiratory diseases. Kardiochir Torakochirurgia Pol (2016) 0.75

Depletion of club cells attenuates bleomycin-induced lung injury and fibrosis in mice. J Inflamm (Lond) (2017) 0.75

Analysis of Cell Turnover in the Bronchiolar Epithelium Through the Normal Aging Process. Lung (2016) 0.75

Identification of bronchioalveolar stem cells in normal lung and lung cancer. Cell (2005) 15.06

The role of Scgb1a1+ Clara cells in the long-term maintenance and repair of lung airway, but not alveolar, epithelium. Cell Stem Cell (2009) 6.44

Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma. Nat Med (2002) 4.65

Neuroepithelial bodies of pulmonary airways serve as a reservoir of progenitor cells capable of epithelial regeneration. Am J Pathol (2000) 3.13

Basic helix-loop-helix transcription factors regulate the neuroendocrine differentiation of fetal mouse pulmonary epithelium. Development (2000) 2.73

Mucin is produced by clara cells in the proximal airways of antigen-challenged mice. Am J Respir Cell Mol Biol (2004) 2.50

Stem cells are dispensable for lung homeostasis but restore airways after injury. Proc Natl Acad Sci U S A (2009) 2.28

Conditional stabilization of beta-catenin expands the pool of lung stem cells. Stem Cells (2008) 2.16

Maintenance and repair of the bronchiolar epithelium. Proc Am Thorac Soc (2008) 2.15

Endogenous fibroblastic progenitor cells in the adult mouse lung are highly enriched in the sca-1 positive cell fraction. Stem Cells (2009) 1.74

Secretoglobins SCGB3A1 and SCGB3A2 define secretory cell subsets in mouse and human airways. Am J Respir Crit Care Med (2002) 1.57

Prospective isolation of bronchiolar stem cells based upon immunophenotypic and autofluorescence characteristics. Stem Cells (2009) 1.56

Role of inflammation in mouse lung tumorigenesis: a review. Exp Lung Res (2005) 1.38

Ontogeny of Clara cell-specific protein and its mRNA: their association with neuroepithelial bodies in human fetal lung and in bronchopulmonary dysplasia. J Histochem Cytochem (1996) 1.32

The role of CC10 in pulmonary carcinogenesis: from a marker to tumor suppression. Ann N Y Acad Sci (2000) 1.10

Epithelial stem/progenitor cells in lung postnatal growth, maintenance, and repair. Cold Spring Harb Symp Quant Biol (2008) 1.09

Neuroepithelial bodies stimulate proliferation of airway epithelium in fetal hamster lung. Am J Physiol (1991) 1.02

Bombesin-like peptide receptor gene expression, regulation, and function in fetal murine lung. Am J Physiol Lung Cell Mol Physiol (2003) 0.99

Proximal airway mucous cells of ovalbumin-sensitized and -challenged Brown Norway rats accumulate the neuropeptide calcitonin gene-related peptide. Am J Physiol Lung Cell Mol Physiol (2004) 0.83

Analysis of orthologous gene expression between human pulmonary adenocarcinoma and a carcinogen-induced murine model. Am J Pathol (2005) 2.39

Effect of silibinin on the growth and progression of primary lung tumors in mice. J Natl Cancer Inst (2006) 1.55

Differential polarization of alveolar macrophages and bone marrow-derived monocytes following chemically and pathogen-induced chronic lung inflammation. J Leukoc Biol (2010) 1.35

Relative amounts of antagonistic splicing factors, hnRNP A1 and ASF/SF2, change during neoplastic lung growth: implications for pre-mRNA processing. Mol Carcinog (2004) 1.32

Manipulation of pulmonary prostacyclin synthase expression prevents murine lung cancer. Cancer Res (2002) 1.31

Toll-like receptor 4 in butylated hydroxytoluene-induced mouse pulmonary inflammation and tumorigenesis. J Natl Cancer Inst (2005) 1.21

Tumor progression stage and anatomical site regulate tumor-associated macrophage and bone marrow-derived monocyte polarization. Am J Pathol (2010) 1.16

Genetic ablation of inducible nitric oxide synthase decreases mouse lung tumorigenesis. Cancer Res (2002) 1.16

Decreased lung tumorigenesis in mice genetically deficient in cytosolic phospholipase A2. Carcinogenesis (2004) 1.16

Tumor signaling to the bone marrow changes the phenotype of monocytes and pulmonary macrophages during urethane-induced primary lung tumorigenesis in A/J mice. Am J Pathol (2007) 1.13

Susceptibility to neoplastic and non-neoplastic pulmonary diseases in mice: genetic similarities. Am J Physiol Lung Cell Mol Physiol (2004) 1.05

Fine mapping and identification of candidate pulmonary adenoma susceptibility 1 genes using advanced intercross lines. Cancer Res (2003) 1.03

Growth inhibition and regression of lung tumors by silibinin: modulation of angiogenesis by macrophage-associated cytokines and nuclear factor-kappaB and signal transducers and activators of transcription 3. Cancer Prev Res (Phila) (2009) 1.02

Silibinin modulates TNF-α and IFN-γ mediated signaling to regulate COX2 and iNOS expression in tumorigenic mouse lung epithelial LM2 cells. Mol Carcinog (2011) 1.02

Inhibition by erlotinib of primary lung adenocarcinoma at an early stage in male mice. Cancer Chemother Pharmacol (2007) 1.01

Induction of a high incidence of lung tumors in C57BL/6 mice with multiple ethyl carbamate injections. Cancer Lett (2003) 1.01

Silibinin prevents lung tumorigenesis in wild-type but not in iNOS-/- mice: potential of real-time micro-CT in lung cancer chemoprevention studies. Clin Cancer Res (2010) 1.00

A macrophage gene expression signature defines a field effect in the lung tumor microenvironment. Cancer Res (2008) 0.99

Quantitative analysis of early chemically-induced pulmonary lesions in mice of varying susceptibilities to lung tumorigenesis. Cancer Lett (2005) 0.97

Mutation-selective tumor remission with Ras-targeted, whole yeast-based immunotherapy. Cancer Res (2004) 0.96

Celecoxib reduces pulmonary inflammation but not lung tumorigenesis in mice. Carcinogenesis (2002) 0.90

BAC consensus conference, November 4-6, 2004: epidemiology, pathogenesis, and preclinical models. J Thorac Oncol (2006) 0.90

Proteomic analysis of a neoplastic mouse lung epithelial cell line whose tumorigenicity has been abrogated by transfection with the gap junction structural gene for connexin 43, Gja1. Carcinogenesis (2003) 0.90

Tnfa and Il-10 deficiencies have contrasting effects on lung tumor susceptibility: gender-dependent modulation of IL-10 haploinsufficiency. Mol Carcinog (2003) 0.89

BARD1: an independent predictor of survival in non-small cell lung cancer. Int J Cancer (2011) 0.88

Prostaglandin E2 receptor subtype 2 (EP2) null mice are protected against murine lung tumorigenesis. Anticancer Res (2006) 0.88

Attenuation of the pulmonary inflammatory response following butylated hydroxytoluene treatment of cytosolic phospholipase A2 null mice. Am J Physiol Lung Cell Mol Physiol (2006) 0.87

Lung tumor growth is stimulated in IFN-gamma-/- mice and inhibited in IL-4Ralpha-/- mice. Anticancer Res (2009) 0.85

Misexpression of MIA disrupts lung morphogenesis and causes neonatal death. Dev Biol (2008) 0.84

Stimulation of neoplastic mouse lung cell proliferation by alveolar macrophage-derived, insulin-like growth factor-1 can be blocked by inhibiting MEK and PI3K activation. Mol Cancer (2011) 0.84

Specific chromosomal aberrations in mouse lung adenocarcinoma cell lines detected by spectral karyotyping: a comparison with human lung adenocarcinoma. Cancer Res (2002) 0.84

Epistatic interactions govern chemically-induced lung tumor susceptibility and Kras mutation site in murine C57BL/6J-ChrA/J chromosome substitution strains. Int J Cancer (2010) 0.84

Lung epithelial healing: a modified seed and soil concept. Proc Am Thorac Soc (2012) 0.83

Cytokines differentially regulate the synthesis of prostanoid and nitric oxide mediators in tumorigenic versus non-tumorigenic mouse lung epithelial cell lines. Carcinogenesis (2005) 0.83

Altered expression of splicing factor, heterogeneous nuclear ribonucleoprotein A2/B1, in mouse lung neoplasia. Mol Carcinog (2007) 0.81

The Kras mutational spectra of chemically induced lung tumors in different inbred mice mimics the spectra of KRAS mutations in adenocarcinomas in smokers versus nonsmokers. J Thorac Oncol (2010) 0.80

Morphological assessment of apoptosis in human lung cells. Methods Mol Med (2003) 0.79

Serum levels of surfactant protein D are increased in mice with lung tumors. Cancer Res (2003) 0.79

Lung toxicity and tumor promotion by hydroxylated derivatives of 2,6-di-tert-butyl-4-methylphenol (BHT) and 2-tert-butyl-4-methyl-6-iso-propylphenol: correlation with quinone methide reactivity. Chem Res Toxicol (2002) 0.79

Regulation of cytokine-induced prostanoid and nitric oxide synthesis by extracellular signal–regulated kinase 1/2 in lung epithelial cells. Exp Lung Res (2010) 0.78

Gap junctional intercellular communication in cells isolated from urethane-induced tumors in A/J mice. DNA Cell Biol (2003) 0.78

Responses of tumorigenic and non-tumorigenic mouse lung epithelial cell lines to electrophilic metabolites of the tumor promoter butylated hydroxytoluene. Chem Biol Interact (2003) 0.77