Published in PLoS Med on September 29, 2009
Recent advances in the utility and use of the General Practice Research Database as an example of a UK Primary Care Data resource. Ther Adv Drug Saf (2012) 4.71
Thiazolidinedione use and the longitudinal risk of fractures in patients with type 2 diabetes mellitus. J Clin Endocrinol Metab (2010) 1.36
Bone loss in diabetes: use of antidiabetic thiazolidinediones and secondary osteoporosis. Curr Osteoporos Rep (2010) 1.18
Hospitalised hip fracture risk with rosiglitazone and pioglitazone use compared with other glucose-lowering drugs. Diabetologia (2012) 1.08
Thiazolidinediones and fractures: evidence from translating research into action for diabetes. J Clin Endocrinol Metab (2010) 1.05
Comparing pioglitazone to insulin with respect to cancer, cardiovascular and bone fracture endpoints, using propensity score weights. Clin Drug Investig (2013) 0.98
Effect of rosiglitazone on bone quality in a rat model of insulin resistance and osteoporosis. Diabetes (2011) 0.89
Medication-induced osteoporosis: screening and treatment strategies. Ther Adv Musculoskelet Dis (2014) 0.87
Risk of fracture with thiazolidinediones: disease or drugs? Calcif Tissue Int (2012) 0.86
Pharmacoepidemiology. Br J Clin Pharmacol (2012) 0.85
Risk of fracture with thiazolidinediones: an individual patient data meta-analysis. Front Endocrinol (Lausanne) (2013) 0.85
Oral anti-diabetic drugs and fracture risk, cut to the bone: safe or dangerous? A narrative review. Osteoporos Int (2015) 0.83
Real-world data in the United Kingdom: opportunities and challenges. BMC Med (2016) 0.83
The skeletal effects of thiazolidinedione and metformin on insulin-resistant mice. J Bone Miner Metab (2012) 0.82
Safety of Anti-Diabetic Therapies on Bone. Clin Rev Bone Miner Metab (2012) 0.81
Cellular and molecular effects of thiazolidinediones on bone cells: a review. Int J Biochem Mol Biol (2011) 0.80
Predictors of the rate of BMD loss in older men: findings from the CHAMP study. Osteoporos Int (2012) 0.79
Effects of TZD Use and Discontinuation on Fracture Rates in ACCORD Bone Study. J Clin Endocrinol Metab (2015) 0.79
A self-controlled case series to assess the effectiveness of beta blockers for heart failure in reducing hospitalisations in the elderly. BMC Med Res Methodol (2011) 0.78
Type 2 diabetes: uses of thiazolidinediones and insulin. Diabetes Care (2011) 0.77
Intensive glycemic control and thiazolidinedione use: effects on cortical and trabecular bone at the radius and tibia. Calcif Tissue Int (2013) 0.77
Association between oral fluoroquinolones and seizures: A self-controlled case series study. Neurology (2016) 0.77
Bone effects of rosiglitazone in HIV-infected patients with lipoatrophy. HIV Clin Trials (2012) 0.75
LT175 is a novel PPARα/γ ligand with potent insulin-sensitizing effects and reduced adipogenic properties. J Biol Chem (2014) 0.75
Is there a biological basis for treatment of fibrodysplasia ossificans progressiva with rosiglitazone? Potential benefits and undesired effects. PPAR Res (2010) 0.75
The use of relative incidence ratios in self-controlled case series studies: an overview. BMC Med Res Methodol (2016) 0.75
Review article: effects of type 2 diabetes therapies on bone metabolism. Diabetol Metab Syndr (2017) 0.75
Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes. N Engl J Med (2007) 33.21
Glycemic durability of rosiglitazone, metformin, or glyburide monotherapy. N Engl J Med (2006) 19.09
Rosiglitazone evaluated for cardiovascular outcomes in oral agent combination therapy for type 2 diabetes (RECORD): a multicentre, randomised, open-label trial. Lancet (2009) 8.54
Rosiglitazone evaluated for cardiovascular outcomes--an interim analysis. N Engl J Med (2007) 7.86
Epidemiology of fractures in England and Wales. Bone (2001) 5.76
The General Practice Research Database. Scientific and Ethical Advisory Group. QJM (1998) 4.67
Thiazolidinediones and cardiovascular outcomes in older patients with diabetes. JAMA (2007) 4.25
Tutorial in biostatistics: the self-controlled case series method. Stat Med (2006) 4.12
Thiazolidinediones and heart failure: a teleo-analysis. Diabetes Care (2007) 3.62
Use of thiazolidinediones and fracture risk. Arch Intern Med (2008) 2.99
Relative incidence estimation from case series for vaccine safety evaluation. Biometrics (1995) 2.55
Use of statins and risk of fractures. JAMA (2001) 2.47
Inhaled corticosteroids and hip fracture: a population-based case-control study. Am J Respir Crit Care Med (2002) 1.87
The use of a large pharmacoepidemiological database to study exposure to oral corticosteroids and risk of fractures: validation of study population and results. Pharmacoepidemiol Drug Saf (2000) 1.70
Effects of thiazolidinediones on bone loss and fracture. Ann Pharmacother (2007) 1.01
Transcatheter aortic-valve implantation for aortic stenosis in patients who cannot undergo surgery. N Engl J Med (2010) 22.04
Validation and validity of diagnoses in the General Practice Research Database: a systematic review. Br J Clin Pharmacol (2010) 10.70
Effects of candesartan on mortality and morbidity in patients with chronic heart failure: the CHARM-Overall programme. Lancet (2003) 9.98
Effect of inhibitors of the renin-angiotensin system and other antihypertensive drugs on renal outcomes: systematic review and meta-analysis. Lancet (2005) 6.59
Hypertension in sub-saharan Africa: a systematic review. Hypertension (2007) 6.14
Transcatheter aortic-valve replacement for inoperable severe aortic stenosis. N Engl J Med (2012) 4.47
Exposure to antipsychotics and risk of stroke: self controlled case series study. BMJ (2008) 4.09
NICE guidance. Chest pain of recent onset: assessment and diagnosis of recent onset chest pain or discomfort of suspected cardiac origin. Heart (2010) 3.90
Renal function as a predictor of outcome in a broad spectrum of patients with heart failure. Circulation (2006) 3.85
Association between C reactive protein and coronary heart disease: mendelian randomisation analysis based on individual participant data. BMJ (2011) 3.65
Homocysteine and stroke: evidence on a causal link from mendelian randomisation. Lancet (2005) 3.60
Invasive dental treatment and risk for vascular events: a self-controlled case series. Ann Intern Med (2010) 3.59
A road map for efficient and reliable human genome epidemiology. Nat Genet (2006) 3.21
Insulin glargine and malignancy: an unwarranted alarm. Lancet (2009) 3.19
Cessation of dual antiplatelet treatment and cardiac events after percutaneous coronary intervention (PARIS): 2 year results from a prospective observational study. Lancet (2013) 3.17
Non-communicable diseases in low and middle-income countries: a priority or a distraction? Int J Epidemiol (2005) 3.06
Research capacity. Enabling the genomic revolution in Africa. Science (2014) 3.05
Influenza as a trigger for acute myocardial infarction or death from cardiovascular disease: a systematic review. Lancet Infect Dis (2009) 2.97
Influence of nonfatal hospitalization for heart failure on subsequent mortality in patients with chronic heart failure. Circulation (2007) 2.95
Clopidogrel and interaction with proton pump inhibitors: comparison between cohort and within person study designs. BMJ (2012) 2.88
Can we improve the statistical analysis of stroke trials? Statistical reanalysis of functional outcomes in stroke trials. Stroke (2007) 2.86
Measuring performance and missing the point? BMJ (2007) 2.83
Moving beyond single and dual diagnosis in general practice: many patients have multiple morbidities, and their needs have to be addressed. BMJ (2003) 2.81
Bivalirudin started during emergency transport for primary PCI. N Engl J Med (2013) 2.80
The Myocardial Ischaemia National Audit Project (MINAP). Heart (2010) 2.80
Influence of ejection fraction on cardiovascular outcomes in a broad spectrum of heart failure patients. Circulation (2005) 2.78
Data resource profile: cardiovascular disease research using linked bespoke studies and electronic health records (CALIBER). Int J Epidemiol (2012) 2.75
Circulating influenza virus, climatic factors, and acute myocardial infarction: a time series study in England and Wales and Hong Kong. J Infect Dis (2011) 2.64
Estimation of bias in nongenetic observational studies using "mendelian triangulation". Ann Epidemiol (2006) 2.57
Time series regression studies in environmental epidemiology. Int J Epidemiol (2013) 2.52
J-shaped relationship between blood pressure and mortality in hypertensive patients: new insights from a meta-analysis of individual-patient data. Ann Intern Med (2002) 2.45
There is no evidence of an inverse relationship between TH2-mediated atopy and TH1-mediated autoimmune disorders: Lack of support for the hygiene hypothesis. J Allergy Clin Immunol (2003) 2.34
Pragmatic randomised trials using routine electronic health records: putting them to the test. BMJ (2012) 2.33
Effect of statin treatment on short term mortality after pneumonia episode: cohort study. BMJ (2011) 2.32
Validation of the diagnosis of autism in general practitioner records. BMC Public Health (2004) 2.22
The Society for Clinical Trials supports United States legislation mandating trials registration. Position paper. Clin Trials (2004) 2.21
Limits to causal inference based on Mendelian randomization: a comparison with randomized controlled trials. Am J Epidemiol (2006) 2.16
Critical appraisal of CRP measurement for the prediction of coronary heart disease events: new data and systematic review of 31 prospective cohorts. Int J Epidemiol (2008) 2.14
The end of age: but not for the worse off. Age Ageing (2002) 2.04
A comparison of cost effectiveness using data from randomized trials or actual clinical practice: selective cox-2 inhibitors as an example. PLoS Med (2009) 1.99
Incidence of systemic lupus erythematosus in the United Kingdom, 1990-1999. Arthritis Rheum (2007) 1.98
Liver function abnormalities and outcome in patients with chronic heart failure: data from the Candesartan in Heart Failure: Assessment of Reduction in Mortality and Morbidity (CHARM) program. Eur J Heart Fail (2009) 1.93
Risk of stroke following herpes zoster: a self-controlled case-series study. Clin Infect Dis (2014) 1.91
The effects of hourly differences in air pollution on the risk of myocardial infarction: case crossover analysis of the MINAP database. BMJ (2011) 1.88
Inhaled corticosteroids and hip fracture: a population-based case-control study. Am J Respir Crit Care Med (2002) 1.87
Preparedness of Tanzanian health facilities for outpatient primary care of hypertension and diabetes: a cross-sectional survey. Lancet Glob Health (2014) 1.81
Herpes zoster vaccine effectiveness against incident herpes zoster and post-herpetic neuralgia in an older US population: a cohort study. PLoS Med (2013) 1.79
CKD and mortality risk in older people: a community-based population study in the United Kingdom. Am J Kidney Dis (2009) 1.74
Orlistat and the risk of acute liver injury: self controlled case series study in UK Clinical Practice Research Datalink. BMJ (2013) 1.74
Comparative analysis of genome-wide association studies signals for lipids, diabetes, and coronary heart disease: Cardiovascular Biomarker Genetics Collaboration. Eur Heart J (2011) 1.73
Influenza infection and risk of acute myocardial infarction in England and Wales: a CALIBER self-controlled case series study. J Infect Dis (2012) 1.73
The efficiency of cardiovascular risk assessment: do the right patients get statin treatment? Heart (2013) 1.73
Tackling non-communicable diseases in low- and middle-income countries: is the evidence from high-income countries all we need? PLoS Med (2013) 1.67
Endothelial nitric oxide synthase gene polymorphisms and cardiovascular disease: a HuGE review. Am J Epidemiol (2006) 1.66
Design of the liraglutide effect and action in diabetes: evaluation of cardiovascular outcome results (LEADER) trial. Am Heart J (2013) 1.62
Differences in cardiovascular risk factors in rural, urban and rural-to-urban migrants in Peru. Heart (2011) 1.60
2014 ESC/ESA Guidelines on non-cardiac surgery: cardiovascular assessment and management: The Joint Task Force on non-cardiac surgery: cardiovascular assessment and management of the European Society of Cardiology (ESC) and the European Society of Anaesthesiology (ESA). Eur J Anaesthesiol (2014) 1.59
Association of HIV and ART with cardiometabolic traits in sub-Saharan Africa: a systematic review and meta-analysis. Int J Epidemiol (2013) 1.57
Representativeness and optimal use of body mass index (BMI) in the UK Clinical Practice Research Datalink (CPRD). BMJ Open (2013) 1.57
Low hematocrit predicts contrast-induced nephropathy after percutaneous coronary interventions. Kidney Int (2005) 1.57
Exposure to tricyclic and selective serotonin reuptake inhibitor antidepressants and the risk of hip fracture. Am J Epidemiol (2003) 1.57
Randomised controlled trials in primary care: scope and application. Br J Gen Pract (2002) 1.54
Addressing geographical variation in the progression of non-communicable diseases in Peru: the CRONICAS cohort study protocol. BMJ Open (2012) 1.52
Chickenpox and risk of stroke: a self-controlled case series analysis. Clin Infect Dis (2013) 1.51
Contribution of changes in incidence and mortality to trends in the prevalence of coronary heart disease in the UK: 1996 2005. Eur Heart J (2007) 1.49
The effect on cardiovascular risk factors of migration from rural to urban areas in Peru: PERU MIGRANT Study. BMC Cardiovasc Disord (2009) 1.46
Hormone replacement therapy and acute myocardial infarction: a large observational study exploring the influence of age. Int J Epidemiol (2006) 1.46
Autoimmune diseases co-occurring within individuals and within families: a systematic review. Epidemiology (2006) 1.45
Bayesian meta-analysis of genetic association studies with different sets of markers. Am J Hum Genet (2008) 1.44
Fulfilling the promise of personalized medicine? Systematic review and field synopsis of pharmacogenetic studies. PLoS One (2009) 1.43
Incidence of community-acquired lower respiratory tract infections and pneumonia among older adults in the United Kingdom: a population-based study. PLoS One (2013) 1.43
Could NICE guidance on the choice of blood pressure lowering drugs be simplified? BMJ (2012) 1.41
The Prevalence of Huntington's Disease. Neuroepidemiology (2016) 1.40
Vision screening. Br J Ophthalmol (2009) 1.38
Genetics of ischaemic stroke among persons of non-European descent: a meta-analysis of eight genes involving approximately 32,500 individuals. PLoS Med (2007) 1.38
Detecting chronic kidney disease in older people; what are the implications? Age Ageing (2007) 1.30
Prevalence of adult Huntington's disease in the UK based on diagnoses recorded in general practice records. J Neurol Neurosurg Psychiatry (2013) 1.30
Validity of the Clock-Drawing Test as a screening tool for cognitive impairment in the elderly. Am J Epidemiol (2004) 1.30
Improving the response rates to questionnaires. BMJ (2002) 1.28
Factors associated with depression in a representative sample of 14 217 people aged 75 and over in the United Kingdom: results from the MRC trial of assessment and management of older people in the community. Int J Geriatr Psychiatry (2003) 1.28
Clinical correlates and consequences of anemia in a broad spectrum of patients with heart failure: results of the Candesartan in Heart Failure: Assessment of Reduction in Mortality and Morbidity (CHARM) Program. Circulation (2006) 1.28
Coping with missing data in clinical trials: a model-based approach applied to asthma trials. Stat Med (2002) 1.27
Genetic variation in complement factor H and risk of coronary heart disease: eight new studies and a meta-analysis of around 48,000 individuals. Atherosclerosis (2010) 1.27
Prevalence of cognitive impairment: results from the MRC trial of assessment and management of older people in the community. Age Ageing (2005) 1.24
Are individuals with an autoimmune disease at higher risk of a second autoimmune disorder? Am J Epidemiol (2009) 1.23
Biomarkers of inflammation predict both vascular and non-vascular mortality in older men. Eur Heart J (2008) 1.22
Separating the mechanism-based and off-target actions of cholesteryl ester transfer protein inhibitors with CETP gene polymorphisms. Circulation (2009) 1.20
Setting the RECORD straight: developing a guideline for the REporting of studies Conducted using Observational Routinely collected Data. Clin Epidemiol (2013) 1.19
Pulsatile blood pressure component as predictor of mortality in hypertension: a meta-analysis of clinical trial control groups. J Hypertens (2002) 1.18
Prognostic models for stable coronary artery disease based on electronic health record cohort of 102 023 patients. Eur Heart J (2013) 1.18