| Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
|
1
|
The burden of selected digestive diseases in the United States.
|
Gastroenterology
|
2002
|
6.79
|
|
2
|
The protein kinase Akt induces epithelial mesenchymal transition and promotes enhanced motility and invasiveness of squamous cell carcinoma lines.
|
Cancer Res
|
2003
|
3.58
|
|
3
|
Evolutionary origins of eukaryotic sodium/proton exchangers.
|
Am J Physiol Cell Physiol
|
2005
|
2.82
|
|
4
|
Molecular physiology of intestinal Na+/H+ exchange.
|
Annu Rev Physiol
|
2005
|
2.58
|
|
5
|
Na(+)/H(+ ) exchanger regulatory factor 2 directs parathyroid hormone 1 receptor signalling.
|
Nature
|
2002
|
1.94
|
|
6
|
Akt as a mediator of cell death.
|
Proc Natl Acad Sci U S A
|
2003
|
1.73
|
|
7
|
Ca2+-dependent inhibition of NHE3 requires PKC alpha which binds to E3KARP to decrease surface NHE3 containing plasma membrane complexes.
|
Am J Physiol Cell Physiol
|
2003
|
1.53
|
|
8
|
Human Na(+)/H(+) exchanger isoform 6 is found in recycling endosomes of cells, not in mitochondria.
|
Am J Physiol Cell Physiol
|
2002
|
1.41
|
|
9
|
Ca(2+)-dependent inhibition of Na+/H+ exchanger 3 (NHE3) requires an NHE3-E3KARP-alpha-actinin-4 complex for oligomerization and endocytosis.
|
J Biol Chem
|
2002
|
1.38
|
|
10
|
Lysophosphatidic acid stimulates brush border Na+/H+ exchanger 3 (NHE3) activity by increasing its exocytosis by an NHE3 kinase A regulatory protein-dependent mechanism.
|
J Biol Chem
|
2003
|
1.36
|
|
11
|
The NHE3 juxtamembrane cytoplasmic domain directly binds ezrin: dual role in NHE3 trafficking and mobility in the brush border.
|
Mol Biol Cell
|
2006
|
1.34
|
|
12
|
Lysophosphatidic acid stimulates the intestinal brush border Na(+)/H(+) exchanger 3 and fluid absorption via LPA(5) and NHERF2.
|
Gastroenterology
|
2009
|
1.33
|
|
13
|
The glycosphingolipid globotriaosylceramide in the metastatic transformation of colon cancer.
|
Proc Natl Acad Sci U S A
|
2005
|
1.32
|
|
14
|
Differential roles of NHERF1, NHERF2, and PDZK1 in regulating CFTR-mediated intestinal anion secretion in mice.
|
J Clin Invest
|
2009
|
1.30
|
|
15
|
Na+/H+ exchanger NHE3 activity and trafficking are lipid Raft-dependent.
|
J Biol Chem
|
2006
|
1.29
|
|
16
|
cGMP inhibition of Na+/H+ antiporter 3 (NHE3) requires PDZ domain adapter NHERF2, a broad specificity protein kinase G-anchoring protein.
|
J Biol Chem
|
2005
|
1.29
|
|
17
|
The lateral mobility of NHE3 on the apical membrane of renal epithelial OK cells is limited by the PDZ domain proteins NHERF1/2, but is dependent on an intact actin cytoskeleton as determined by FRAP.
|
J Cell Sci
|
2004
|
1.27
|
|
18
|
Carbachol regulation of rabbit ileal brush border Na+-H+ exchanger 3 (NHE3) occurs through changes in NHE3 trafficking and complex formation and is Src dependent.
|
J Physiol
|
2004
|
1.27
|
|
19
|
Downregulation of sodium transporters and NHERF proteins in IBD patients and mouse colitis models: potential contributors to IBD-associated diarrhea.
|
Inflamm Bowel Dis
|
2009
|
1.26
|
|
20
|
Mutations in TTC37 cause trichohepatoenteric syndrome (phenotypic diarrhea of infancy).
|
Gastroenterology
|
2010
|
1.20
|
|
21
|
D-glucose acts via sodium/glucose cotransporter 1 to increase NHE3 in mouse jejunal brush border by a Na+/H+ exchange regulatory factor 2-dependent process.
|
Gastroenterology
|
2010
|
1.16
|
|
22
|
Genome-wide analysis reveals the vacuolar pH-stat of Saccharomyces cerevisiae.
|
PLoS One
|
2011
|
1.13
|
|
23
|
Cystic fibrosis transmembrane conductance regulator activation is reduced in the small intestine of Na+/H+ exchanger 3 regulatory factor 1 (NHERF-1)- but Not NHERF-2-deficient mice.
|
J Biol Chem
|
2007
|
1.11
|
|
24
|
Pharmacological properties of N-(3,5-diamino-6-chloropyrazine-2-carbonyl)-N'-4-[4-(2,3-dihydroxypropoxy)phenyl]butyl-guanidine methanesulfonate (552-02), a novel epithelial sodium channel blocker with potential clinical efficacy for cystic fibrosis lung disease.
|
J Pharmacol Exp Ther
|
2008
|
1.11
|
|
25
|
Casein kinase 2 binds to the C terminus of Na+/H+ exchanger 3 (NHE3) and stimulates NHE3 basal activity by phosphorylating a separate site in NHE3.
|
Mol Biol Cell
|
2008
|
1.10
|
|
26
|
Macropinocytosis in Shiga toxin 1 uptake by human intestinal epithelial cells and transcellular transcytosis.
|
Am J Physiol Gastrointest Liver Physiol
|
2008
|
1.09
|
|
27
|
NHERF1 and NHERF2 are necessary for multiple but usually separate aspects of basal and acute regulation of NHE3 activity.
|
Am J Physiol Cell Physiol
|
2010
|
1.09
|
|
28
|
Akt2, phosphatidylinositol 3-kinase, and PTEN are in lipid rafts of intestinal cells: role in absorption and differentiation.
|
Gastroenterology
|
2004
|
1.08
|
|
29
|
ClC-5: role in endocytosis in the proximal tubule.
|
Am J Physiol Renal Physiol
|
2005
|
1.07
|
|
30
|
The spatial organization of proton and lactate transport in a rat brain tumor.
|
PLoS One
|
2011
|
1.05
|
|
31
|
Loss of PDZ-adaptor protein NHERF2 affects membrane localization and cGMP- and [Ca2+]- but not cAMP-dependent regulation of Na+/H+ exchanger 3 in murine intestine.
|
J Physiol
|
2010
|
1.04
|
|
32
|
Fractionation of subcellular membrane vesicles of epithelial and nonepithelial cells by OptiPrep density gradient ultracentrifugation.
|
Methods Mol Biol
|
2008
|
1.02
|
|
33
|
NHERF2 is necessary for basal activity, second messenger inhibition, and LPA stimulation of NHE3 in mouse distal ileum.
|
Am J Physiol Cell Physiol
|
2011
|
1.00
|
|
34
|
NHERF3 (PDZK1) contributes to basal and calcium inhibition of NHE3 activity in Caco-2BBe cells.
|
J Biol Chem
|
2009
|
0.99
|
|
35
|
Lysophosphatidic acid induces exocytic trafficking of Na(+)/H(+) exchanger 3 by E3KARP-dependent activation of phospholipase C.
|
Biochim Biophys Acta
|
2004
|
0.98
|
|
36
|
Proteome of murine jejunal brush border membrane vesicles.
|
J Proteome Res
|
2007
|
0.97
|
|
37
|
PTH transiently increases the percent mobile fraction of Npt2a in OK cells as determined by FRAP.
|
Am J Physiol Renal Physiol
|
2009
|
0.97
|
|
38
|
The epithelial brush border Na+/H+ exchanger NHE3 associates with the actin cytoskeleton by binding to ezrin directly and via PDZ domain-containing Na+/H+ exchanger regulatory factor (NHERF) proteins.
|
Clin Exp Pharmacol Physiol
|
2008
|
0.97
|
|
39
|
Does the proteome encode organellar pH?
|
FEBS Lett
|
2006
|
0.95
|
|
40
|
Elevated intracellular calcium stimulates NHE3 activity by an IKEPP (NHERF4) dependent mechanism.
|
Cell Physiol Biochem
|
2008
|
0.94
|
|
41
|
NHE3 mobility in brush borders increases upon NHERF2-dependent stimulation by lyophosphatidic acid.
|
J Cell Sci
|
2010
|
0.94
|
|
42
|
Phospholipase C-gamma binds directly to the Na+/H+ exchanger 3 and is required for calcium regulation of exchange activity.
|
J Biol Chem
|
2009
|
0.93
|
|
43
|
Human enteroids: preclinical models of non-inflammatory diarrhea.
|
Stem Cell Res Ther
|
2013
|
0.88
|
|
44
|
Regulation of intestinal electroneutral sodium absorption and the brush border Na+/H+ exchanger by intracellular calcium.
|
Ann N Y Acad Sci
|
2009
|
0.88
|
|
45
|
Elevated calcium acutely regulates dynamic interactions of NHERF2 and NHE3 proteins in opossum kidney (OK) cell microvilli.
|
J Biol Chem
|
2011
|
0.86
|
|
46
|
Latrunculin B facilitates Shiga toxin 1 transcellular transcytosis across T84 intestinal epithelial cells.
|
Biochim Biophys Acta
|
2008
|
0.85
|
|
47
|
NHERF2 protein mobility rate is determined by a unique C-terminal domain that is also necessary for its regulation of NHE3 protein in OK cells.
|
J Biol Chem
|
2013
|
0.85
|
|
48
|
NHERF2 increases platelet-derived growth factor-induced proliferation through PI-3-kinase/Akt-, ERK-, and Src family kinase-dependent pathway.
|
Cell Signal
|
2004
|
0.84
|
|
49
|
NHE3 activity is dependent on direct phosphoinositide binding at the N terminus of its intracellular cytosolic region.
|
J Biol Chem
|
2010
|
0.84
|
|
50
|
Farnesoid X receptor agonists attenuate colonic epithelial secretory function and prevent experimental diarrhoea in vivo.
|
Gut
|
2013
|
0.82
|
|
51
|
Urine electrolyte, mineral, and protein excretion in NHERF-2 and NHERF-1 null mice.
|
Am J Physiol Renal Physiol
|
2008
|
0.82
|
|
52
|
Calmodulin kinase II constitutively binds, phosphorylates, and inhibits brush border Na+/H+ exchanger 3 (NHE3) by a NHERF2 protein-dependent process.
|
J Biol Chem
|
2012
|
0.82
|
|
53
|
Refractory lymphocytic enterocolitis and tumor necrosis factor antagonist therapy.
|
Clin Gastroenterol Hepatol
|
2009
|
0.82
|
|
54
|
Fractionation of subcellular membrane vesicles of epithelial and non-epithelial cells by OptiPrep™ density gradient ultracentrifugation.
|
Methods Mol Biol
|
2014
|
0.81
|
|
55
|
PLC-γ directly binds activated c-Src, which is necessary for carbachol-mediated inhibition of NHE3 activity in Caco-2/BBe cells.
|
Am J Physiol Cell Physiol
|
2013
|
0.80
|
|
56
|
Chloride channel (Clc)-5 is necessary for exocytic trafficking of Na+/H+ exchanger 3 (NHE3).
|
J Biol Chem
|
2011
|
0.79
|
|
57
|
AKT and GSK-3 are necessary for direct ezrin binding to NHE3 as part of a C-terminal stimulatory complex: role of a novel Ser-rich NHE3 C-terminal motif in NHE3 activity and trafficking.
|
J Biol Chem
|
2014
|
0.79
|
|
58
|
Shiga toxin 1 interaction with enterocytes causes apical protein mistargeting through the depletion of intracellular galectin-3.
|
Exp Cell Res
|
2009
|
0.78
|
|
59
|
Differential association of the Na+/H+ Exchanger Regulatory Factor (NHERF) family of adaptor proteins with the raft- and the non-raft brush border membrane fractions of NHE3.
|
Cell Physiol Biochem
|
2013
|
0.77
|
|
60
|
Insulin-like growth factor 1 (IGF-1) enhances the protein expression of CFTR.
|
PLoS One
|
2013
|
0.76
|
|
61
|
Erratum: A primary human macrophage-enteroid co-culture model to investigate mucosal gut physiology and host-pathogen interactions.
|
Sci Rep
|
2017
|
0.75
|
|
62
|
Corrigendum: Functional Coupling of Human Microphysiology Systems: Intestine, Liver, Kidney Proximal Tubule, Blood-Brain Barrier and Skeletal Muscle.
|
Sci Rep
|
2017
|
0.75
|