Bovine lactoferrin supplementation for prevention of late-onset sepsis in very low-birth-weight neonates: a randomized trial.

PubWeight™: 3.34‹?› | Rank: Top 1%

🔗 View Article (PMID 19809023)

Published in JAMA on October 07, 2009

Authors

Paolo Manzoni1, Matteo Rinaldi, Silvia Cattani, Lorenza Pugni, Mario Giovanni Romeo, Hubert Messner, Ilaria Stolfi, Lidia Decembrino, Nicola Laforgia, Federica Vagnarelli, Luigi Memo, Linda Bordignon, Onofrio Sergio Saia, Milena Maule, Elena Gallo, Michael Mostert, Cristiana Magnani, Michele Quercia, Lina Bollani, Roberto Pedicino, Livia Renzullo, Pasqua Betta, Fabio Mosca, Fabrizio Ferrari, Rosario Magaldi, Mauro Stronati, Daniele Farina, Italian Task Force for the Study and Prevention of Neonatal Fungal Infections, Italian Society of Neonatology

Author Affiliations

1: Neonatology and Neonatal Intensive Care Unit, S. Anna Hospital, Azienda Ospedaliera Regina Margherita-S. Anna, C. Spezia 60, 10126 Torino, Italy. paolomanzoni@hotmail.com

Associated clinical trials:

Lactoferrin for Prevention of Sepsis in Infants (NEOLACTO) | NCT01525316

Pilot Study: Lactoferrin for Prevention of Neonatal Sepsis (NEOLACTO) | NCT01264536

Bovine Lactoferrin as a Natural Regimen of Selective Decontamination of the Digestive Tract in Patients With Prolonged Mechanical Ventilation (LFasSDD) | NCT01535170

Lactoferrin in Treatment of Fe Deficient Anemia In Cirrhosis | NCT04335058

Articles citing this

Human milk composition: nutrients and bioactive factors. Pediatr Clin North Am (2013) 2.39

Probiotics and the gut microbiota in intestinal health and disease. Nat Rev Gastroenterol Hepatol (2010) 2.22

Time for a neonatal-specific consensus definition for sepsis. Pediatr Crit Care Med (2014) 1.56

Neonatal infectious diseases: evaluation of neonatal sepsis. Pediatr Clin North Am (2013) 1.47

Role of innate host defenses in susceptibility to early-onset neonatal sepsis. Clin Perinatol (2010) 1.39

Ontogeny of early life immunity. Trends Immunol (2014) 1.35

Preterm birth and childhood wheezing disorders: a systematic review and meta-analysis. PLoS Med (2014) 1.33

Neonatal sepsis due to coagulase-negative staphylococci. Clin Dev Immunol (2013) 1.16

Role of innate immunity in neonatal infection. Am J Perinatol (2013) 1.16

Neonatal severe bacterial infection impairment estimates in South Asia, sub-Saharan Africa, and Latin America for 2010. Pediatr Res (2013) 1.15

Human milk for the premature infant. Pediatr Clin North Am (2012) 1.12

New concepts of microbial translocation in the neonatal intestine: mechanisms and prevention. Clin Perinatol (2010) 1.08

Immune responses in neonates. Expert Rev Clin Immunol (2014) 1.06

Influence of iron status on risk of maternal or neonatal infection and on neonatal mortality with an emphasis on developing countries. Nutr Rev (2013) 1.00

Paneth cells and necrotizing enterocolitis: a novel hypothesis for disease pathogenesis. Neonatology (2012) 1.00

Randomized double-blind controlled trial of bovine lactoferrin for prevention of diarrhea in children. J Pediatr (2012) 0.96

Immunomodulatory effects of lactoferrin. Acta Pharmacol Sin (2014) 0.90

Human breast milk and the gastrointestinal innate immune system. Clin Perinatol (2014) 0.86

Therapeutic use of prebiotics, probiotics, and postbiotics to prevent necrotizing enterocolitis: what is the current evidence? Clin Perinatol (2013) 0.86

Late-onset neonatal sepsis: recent developments. Arch Dis Child Fetal Neonatal Ed (2014) 0.85

Prevention of necrotizing enterocolitis with probiotics: a systematic review and meta-analysis. PeerJ (2016) 0.84

Current management of late onset neonatal bacterial sepsis in five European countries. Eur J Pediatr (2014) 0.84

Probiotics for prevention of necrotizing enterocolitis in preterm infants: systematic review and meta-analysis. Ital J Pediatr (2015) 0.84

Randomized controlled trial of lactoferrin for prevention of sepsis in peruvian neonates less than 2500 g. Pediatr Infect Dis J (2015) 0.84

The human milk oligosaccharide 2'-fucosyllactose attenuates the severity of experimental necrotising enterocolitis by enhancing mesenteric perfusion in the neonatal intestine. Br J Nutr (2016) 0.83

Clinical applications of bioactive milk components. Nutr Rev (2015) 0.83

Lactoferrin supplementation to prevent nosocomial infections in preterm infants. JAMA (2009) 0.83

Influence of oral lactoferrin on Mycobacterium tuberculosis induced immunopathology. Tuberculosis (Edinb) (2011) 0.83

TGF-β2, a protective intestinal cytokine, is abundant in maternal human milk and human-derived fortifiers but not in donor human milk. Breastfeed Med (2013) 0.83

Challenges in the diagnosis and management of neonatal sepsis. J Trop Pediatr (2015) 0.83

An update on necrotizing enterocolitis: pathogenesis and preventive strategies. Korean J Pediatr (2011) 0.82

Persistent coagulase-negative staphylococci bacteremia in very-low-birth-weight infants. Eur J Pediatr (2011) 0.81

Antimicrobial protein and Peptide concentrations and activity in human breast milk consumed by preterm infants at risk of late-onset neonatal sepsis. PLoS One (2015) 0.81

Lactoferrin for prevention of neonatal sepsis. Biometals (2014) 0.81

Executive summary of the workshop "Nutritional Challenges in the High Risk Infant". J Pediatr (2012) 0.81

Lactoferrin modulation of mycobacterial cord factor trehalose 6-6'-dimycolate induced granulomatous response. Transl Res (2010) 0.81

Late-Onset Bloodstream Infection and Perturbed Maturation of the Gastrointestinal Microbiota in Premature Infants. PLoS One (2015) 0.80

Novel recombinant human lactoferrin: differential activation of oxidative stress related gene expression. J Biotechnol (2013) 0.79

Lactoferrin Suppresses Neutrophil Extracellular Traps Release in Inflammation. EBioMedicine (2016) 0.79

The effect of UV-C pasteurization on bacteriostatic properties and immunological proteins of donor human milk. PLoS One (2013) 0.79

Effects of recombinant human prolactin on breast milk composition. Pediatrics (2011) 0.79

Incidence of Late Onset Neonatal Sepsis in Very Low Birth Weight Infants in a Tertiary Hospital: An ongoing challenge. Sultan Qaboos Univ Med J (2010) 0.78

Evidence-based feeding strategies before and after the development of necrotizing enterocolitis. Expert Rev Clin Immunol (2014) 0.78

Necrotizing enterocolitis: new insights into pathogenesis and mechanisms. Nat Rev Gastroenterol Hepatol (2016) 0.78

Bovine lactoferrin induces interleukin-11 production in a hepatitis mouse model and human intestinal myofibroblasts. Eur J Nutr (2011) 0.78

Stability of lactoferrin in stored human milk. J Perinatol (2014) 0.78

Lactoferrin and necrotizing enterocolitis. Clin Perinatol (2013) 0.78

Oropharyngeal administration of mother's colostrum, health outcomes of premature infants: study protocol for a randomized controlled trial. Trials (2015) 0.78

Probiotics for Preventing Late-Onset Sepsis in Preterm Neonates: A PRISMA-Compliant Systematic Review and Meta-Analysis of Randomized Controlled Trials. Medicine (Baltimore) (2016) 0.78

Sustained Reduction in Bloodstream Infections in Infants at a Large Tertiary Care Neonatal Intensive Care Unit. Adv Neonatal Care (2016) 0.77

Antimicrobial Proteins and Peptides in Early Life: Ontogeny and Translational Opportunities. Front Immunol (2016) 0.77

Multiple strains probiotics appear to be the most effective probiotics in the prevention of necrotizing enterocolitis and mortality: An updated meta-analysis. PLoS One (2017) 0.77

Randomized Controlled Trial of Talactoferrin Oral Solution in Preterm Infants. J Pediatr (2016) 0.77

Mechanisms Affecting the Gut of Preterm Infants in Enteral Feeding Trials. Front Nutr (2017) 0.77

Characterization of recombinant human lactoferrin N-glycans expressed in the milk of transgenic cows. PLoS One (2017) 0.76

Probiotics and Time to Achieve Full Enteral Feeding in Human Milk-Fed and Formula-Fed Preterm Infants: Systematic Review and Meta-Analysis. Nutrients (2016) 0.76

Comparison of lactoferrin activity in fresh and stored human milk. J Perinatol (2015) 0.76

Lactoferrin during lactation protects the immature hypoxic-ischemic rat brain. Ann Clin Transl Neurol (2014) 0.76

The Role of Mucosal Immunity in the Pathogenesis of Necrotizing Enterocolitis. Front Pediatr (2017) 0.75

Talactoferrin. Germs (2012) 0.75

Immunological Defects in Neonatal Sepsis and Potential Therapeutic Approaches. Front Pediatr (2017) 0.75

Pathogenesis of NEC: Role of the innate and adaptive immune response. Semin Perinatol (2016) 0.75

Prevention and treatment of neonatal nosocomial infections. Matern Health Neonatol Perinatol (2017) 0.75

Prevention of nosocomial infections in critically ill patients with lactoferrin (PREVAIL study): study protocol for a randomized controlled trial. Trials (2016) 0.75

Lactoferrin: A Modulator for Immunity against Tuberculosis Related Granulomatous Pathology. Mediators Inflamm (2015) 0.75

Radioprotection of mice by lactoferrin against irradiation with sublethal X-rays. J Radiat Res (2014) 0.75

Bovine lactoferrin prevents invasive fungal infections in very low birth weight infants: a randomized controlled trial. J Clin Neonatol (2012) 0.75

Bovine lactoferrin appears to decrease the incidence of sepsis in very low-birth weight infants. J Pediatr (2010) 0.75

Bifidobacterium adolescentis protects against necrotizing enterocolitis and upregulates TOLLIP and SIGIRR in premature neonatal rats. BMC Pediatr (2017) 0.75

The impact of lactoferrin with different levels of metal saturation on the intestinal epithelial barrier function and mucosal inflammation. Biometals (2016) 0.75

pH Dependent Antimicrobial Peptides and Proteins, Their Mechanisms of Action and Potential as Therapeutic Agents. Pharmaceuticals (Basel) (2016) 0.75

Lactoferrin concentration in breast milk of mothers of low-birth-weight newborns. J Perinatol (2017) 0.75

Lactoferrin and prematurity: a promising milk protein? Biochem Cell Biol (2016) 0.75

Probiotic supplementation in preterm infants does not affect the risk of retinopathy of prematurity: a meta-analysis of randomized controlled trials. Sci Rep (2017) 0.75

Articles by these authors

A multicenter, randomized trial of prophylactic fluconazole in preterm neonates. N Engl J Med (2007) 4.72

Prevalence of the congenital long-QT syndrome. Circulation (2009) 4.32

Clinical and molecular phenotype of Aicardi-Goutieres syndrome. Am J Hum Genet (2007) 2.81

Tirofiban and sirolimus-eluting stent vs abciximab and bare-metal stent for acute myocardial infarction: a randomized trial. JAMA (2005) 2.74

Loss-of-function mutations in TGFB2 cause a syndromic presentation of thoracic aortic aneurysm. Nat Genet (2012) 2.44

Short-term, long-term and paracrine effect of human umbilical cord-derived stem cells in lung injury prevention and repair in experimental bronchopulmonary dysplasia. Thorax (2012) 1.95

Circulating endothelial progenitor cells in preterm infants with bronchopulmonary dysplasia. Am J Respir Crit Care Med (2009) 1.92

Important source of marine secondary organic aerosol from biogenic amines. Environ Sci Technol (2008) 1.88

Prophylactic fluconazole is effective in preventing fungal colonization and fungal systemic infections in preterm neonates: a single-center, 6-year, retrospective cohort study. Pediatrics (2005) 1.74

Lactobacillus GG improves recovery in infants with blood in the stools and presumptive allergic colitis compared with extensively hydrolyzed formula alone. J Pediatr (2009) 1.74

Mapping the Wolf-Hirschhorn syndrome phenotype outside the currently accepted WHS critical region and defining a new critical region, WHSCR-2. Am J Hum Genet (2003) 1.67

Hand movements at 3 months predict later hemiplegia in term infants with neonatal cerebral infarction. Dev Med Child Neurol (2009) 1.56

Poor responsiveness to clopidogrel: drug-specific or class-effect mechanism? Evidence from a clopidogrel-to-ticlopidine crossover study. J Am Coll Cardiol (2007) 1.55

Two-year clinical follow-up after sirolimus-eluting versus bare-metal stent implantation assisted by systematic glycoprotein IIb/IIIa Inhibitor Infusion in patients with myocardial infarction: results from the STRATEGY study. J Am Coll Cardiol (2007) 1.54

Infant sex, obstetric risk factors, and 2-year neurodevelopmental outcome among preterm infants. Dev Med Child Neurol (2009) 1.52

Germline BRAF mutations in Noonan, LEOPARD, and cardiofaciocutaneous syndromes: molecular diversity and associated phenotypic spectrum. Hum Mutat (2009) 1.49

Do prebiotics reduce the number of fever episodes in healthy children in their first year of life: a randomised controlled trial. Br J Nutr (2011) 1.49

Breast milk-acquired cytomegalovirus infection in very low birth weight infants. J Matern Fetal Neonatal Med (2012) 1.47

Prophylactic or early selective surfactant combined with nCPAP in very preterm infants. Pediatrics (2010) 1.47

Congenital aggressive variant of Langerhans cells histiocytosis with CD56+/E-Cadherin- phenotype. Pediatr Blood Cancer (2009) 1.42

Voluminous mycetoma in a newborn with Down Syndrome: role of echocardiography. Eur J Echocardiogr (2005) 1.39

Vitamin K prophylaxis: leaving the old route for the new one? Acta Paediatr Suppl (2005) 1.38

Similar qualitative and quantitative changes of mitochondrial respiration following strength and endurance training in normoxia and hypoxia in sedentary humans. Am J Physiol Regul Integr Comp Physiol (2011) 1.38

Probabilistic diffusion tractography of the optic radiations and visual function in preterm infants at term equivalent age. Brain (2008) 1.26

Haploinsufficiency of COQ4 causes coenzyme Q10 deficiency. J Med Genet (2012) 1.16

Human rhinovirus and human respiratory enterovirus (EV68 and EV104) infections in hospitalized patients in Italy, 2008-2009. Diagn Microbiol Infect Dis (2012) 1.16

Self-biased 215 MHz magnetoelectric NEMS resonator for ultra-sensitive DC magnetic field detection. Sci Rep (2013) 1.14

Group B streptococcus late-onset disease: 2003-2010. Pediatrics (2013) 1.13

Multicity Italian study of congenital cytomegalovirus infection. Pediatr Infect Dis J (2006) 1.13

Safety and immunogenicity of a 13-valent pneumococcal conjugate vaccine compared to those of a 7-valent pneumococcal conjugate vaccine given as a three-dose series with routine vaccines in healthy infants and toddlers. Clin Vaccine Immunol (2010) 1.12

Canonical transient receptor potential 3 channel triggers vascular endothelial growth factor-induced intracellular Ca2+ oscillations in endothelial progenitor cells isolated from umbilical cord blood. Stem Cells Dev (2013) 1.11

Case-control study of high risk occupations for bladder cancer in New Zealand. Int J Cancer (2008) 1.09

Magnetic resonance imaging assessment of brain maturation in preterm neonates with punctate white matter lesions. Neuroradiology (2006) 1.08

Immunogenicity, safety and tolerability of heptavalent pneumococcal conjugate vaccine administered at 3, 5 and 11 months post-natally to pre- and full-term infants. Vaccine (2005) 1.07

Group B streptococcal infections in a northern region of Italy. Pediatrics (2007) 1.06

Cancer risk associated with STK11/LKB1 germline mutations in Peutz-Jeghers syndrome patients: results of an Italian multicenter study. Dig Liver Dis (2013) 1.06

Galacto-oligosaccharides and long-chain fructo-oligosaccharides as prebiotics in infant formulas: a review. Acta Paediatr Suppl (2005) 1.06

Short-term and long-term sequelae in intrauterine growth retardation (IUGR). J Matern Fetal Neonatal Med (2012) 1.06

The pathophysiology of retinopathy of prematurity: an update of previous and recent knowledge. Acta Ophthalmol (2013) 1.05

High-energy phosphate metabolism during incremental calf exercise in patients with unilaterally symptomatic peripheral arterial disease measured by phosphor 31 magnetic resonance spectroscopy. J Vasc Surg (2006) 1.04

The HIV protease inhibitors nelfinavir and saquinavir, but not a variety of HIV reverse transcriptase inhibitors, adversely affect human proteasome function. Antivir Ther (2005) 1.03

Reduced occurrence of early atopic dermatitis because of immunoactive prebiotics among low-atopy-risk infants. J Allergy Clin Immunol (2010) 1.03

Neonatal onset intestinal failure: an Italian Multicenter Study. J Pediatr (2008) 1.02

Routine use of fluconazole prophylaxis in a neonatal intensive care unit does not select natively fluconazole-resistant Candida subspecies. Pediatr Infect Dis J (2008) 1.02

Differentiation and migration properties of human foetal umbilical cord perivascular cells: potential for lung repair. J Cell Mol Med (2011) 1.02

Bovine lactoferrin prevents invasive fungal infections in very low birth weight infants: a randomized controlled trial. Pediatrics (2011) 1.02

Association between hypermethylated tumor and paired surgical margins in head and neck squamous cell carcinomas. Clin Cancer Res (2007) 1.02

Apparent diffusion coefficient determination in normal fetal brain: a prenatal MR imaging study. AJNR Am J Neuroradiol (2003) 1.00

Genotype-phenotype relationship in three cases with overlapping 19p13.12 microdeletions. Eur J Hum Genet (2010) 1.00

Diffusion tensor imaging in preterm infants with punctate white matter lesions. Pediatr Res (2011) 0.99

Inter-society consensus document on treatment and prevention of bronchiolitis in newborns and infants. Ital J Pediatr (2014) 0.99

Assessment of prenatal exposure to ethanol by meconium analysis: results of an Italian multicenter study. Alcohol Clin Exp Res (2011) 0.99

Increase of faecal bifidobacteria due to dietary oligosaccharides induces a reduction of clinically relevant pathogen germs in the faeces of formula-fed preterm infants. Acta Paediatr Suppl (2005) 0.99

Neonatal neuroimaging: going beyond the pictures. Early Hum Dev (2009) 0.99

Human parechovirus infections in patients admitted to hospital in Northern Italy, 2008-2010. J Med Virol (2012) 0.99

Water apparent diffusion coefficient and T2 changes in the acute stage of maple syrup urine disease: evidence of intramyelinic and vasogenic-interstitial edema. J Neuroimaging (2003) 0.98

The human 26S proteasome is a target of antiretroviral agents. AIDS (2002) 0.98

Severe hypertriglyceridemia in a newborn with monogenic lipoprotein lipase deficiency: an unconventional therapeutic approach with exchange transfusion. JIMD Rep (2013) 0.98

Oral propranolol for retinopathy of prematurity: risks, safety concerns, and perspectives. J Pediatr (2013) 0.97

Natural history and long-term outcome of cardiac rhabdomyomas detected prenatally. Prenat Diagn (2004) 0.97

Rapid recovery of fat mass in small for gestational age preterm infants after term. PLoS One (2011) 0.97

Attitudes and knowledge regarding influenza vaccination among hospital health workers caring for women and children. Vaccine (2007) 0.97

Lutein and zeaxanthin supplementation in preterm very low-birth-weight neonates in neonatal intensive care units: a multicenter randomized controlled trial. Am J Perinatol (2012) 0.97

Longitudinal body composition data in exclusively breast-fed infants: a multicenter study. Obesity (Silver Spring) (2011) 0.97