Published in Biochim Biophys Acta on October 07, 2009
Neuroprotective effects of estrogens and androgens in CNS inflammation and neurodegeneration. Front Neuroendocrinol (2011) 1.26
Estrogen mediates neuroprotection and anti-inflammatory effects during EAE through ERα signaling on astrocytes but not through ERβ signaling on astrocytes or neurons. J Neurosci (2013) 1.12
Estradiol for treatment-resistant schizophrenia: a large-scale randomized-controlled trial in women of child-bearing age. Mol Psychiatry (2014) 1.03
Estrogen neuroprotection and the critical period hypothesis. Front Neuroendocrinol (2011) 1.03
Neuroprotective effects of 17β-estradiol rely on estrogen receptor membrane initiated signals. Front Physiol (2012) 1.01
The MRL/lpr mouse strain as a model for neuropsychiatric systemic lupus erythematosus. J Biomed Biotechnol (2011) 0.97
Neuroprotective actions of estradiol and novel estrogen analogs in ischemia: translational implications. Front Neuroendocrinol (2010) 0.95
Gender differences in brain susceptibility to oxidative stress are mediated by levels of paraoxonase-2 expression. Free Radic Biol Med (2013) 0.93
Estrogens regulate neuroinflammatory genes via estrogen receptors α and β in the frontal cortex of middle-aged female rats. J Neuroinflammation (2011) 0.92
Estrogens as neuroprotectants: Estrogenic actions in the context of cognitive aging and brain injury. Prog Neurobiol (2016) 0.90
Tamoxifen and estradiol improved locomotor function and increased spared tissue in rats after spinal cord injury: their antioxidant effect and role of estrogen receptor alpha. Brain Res (2014) 0.89
Estriol preserves synaptic transmission in the hippocampus during autoimmune demyelinating disease. Lab Invest (2012) 0.88
Estrogen receptors are found in glia and at extranuclear neuronal sites in the dorsal striatum of female rats: evidence for cholinergic but not dopaminergic colocalization. Endocrinology (2012) 0.88
17β-Estradiol prevents cell death and mitochondrial dysfunction by an estrogen receptor-dependent mechanism in astrocytes after oxygen-glucose deprivation/reperfusion. Free Radic Biol Med (2012) 0.87
Medial prefrontal cortical estradiol rapidly alters memory system bias in female rats: ultrastructural analysis reveals membrane-associated estrogen receptors as potential mediators. Endocrinology (2014) 0.85
Impact of aromatase genetic variation on hormone levels and global outcome after severe TBI. J Neurotrauma (2013) 0.85
Age-related changes in neuroactive steroid levels in 3xTg-AD mice. Neurobiol Aging (2012) 0.85
Estrogen receptors in the central nervous system and their implication for dopamine-dependent cognition in females. Horm Behav (2015) 0.84
Estrogen, astrocytes and the neuroendocrine control of metabolism. Rev Endocr Metab Disord (2013) 0.84
Oestrogen signalling and neuroprotection in cerebral ischaemia. J Neuroendocrinol (2012) 0.83
Paraoxonase-2 (PON2) in brain and its potential role in neuroprotection. Neurotoxicology (2013) 0.81
Neuroinflammation induces glial aromatase expression in the uninjured songbird brain. J Neuroinflammation (2011) 0.80
The role of oestrogen and other hormones in the pathophysiology and treatment of schizophrenia. Schizophr Res Treatment (2012) 0.80
The Relationship between Nutrition in Infancy and Cognitive Performance during Adolescence. Front Nutr (2015) 0.80
17β-estradiol increases expression of the oxidative stress response and DNA repair protein apurinic endonuclease (Ape1) in the cerebral cortex of female mice following hypoxia. J Steroid Biochem Mol Biol (2013) 0.79
Significant association of estrogen receptor binding site variation with bipolar disorder in females. PLoS One (2012) 0.79
White matter development and tobacco smoking in young adults: A systematic review with recommendations for future research. Drug Alcohol Depend (2016) 0.79
Menopause leads to elevated expression of macrophage-associated genes in the aging frontal cortex: rat and human studies identify strikingly similar changes. J Neuroinflammation (2012) 0.79
Early manipulation of juvenile hormone has sexually dimorphic effects on mature adult behavior in Drosophila melanogaster. Horm Behav (2013) 0.79
Inflammation and the neural diathesis-stress hypothesis of schizophrenia: a reconceptualization. Transl Psychiatry (2017) 0.78
Tamoxifen and Src kinase inhibitors as neuroprotective/neuroregenerative drugs after spinal cord injury. Neural Regen Res (2015) 0.78
Estrogen replacement therapy-induced neuroprotection against brain ischemia-reperfusion injury involves the activation of astrocytes via estrogen receptor β. Sci Rep (2016) 0.78
The role of hormones on Toxoplasma gondii infection: a systematic review. Front Microbiol (2014) 0.78
Use of estetrol with other steroids for attenuation of neonatal hypoxic-ischemic brain injury: to combine or not to combine? Oncotarget (2016) 0.78
17beta-estradiol counteracts neuropathic pain: a behavioural, immunohistochemical, and proteomic investigation on sex-related differences in mice. Sci Rep (2016) 0.78
A novel mouse model of Alzheimer's disease with chronic estrogen deficiency leads to glial cell activation and hypertrophy. J Aging Res (2011) 0.77
Sex differences in a Murine Model of Complex Regional Pain Syndrome. Neurobiol Learn Mem (2015) 0.77
TSPO PIGA Ligands Promote Neurosteroidogenesis and Human Astrocyte Well-Being. Int J Mol Sci (2016) 0.76
Obesity and sex interact in the regulation of Alzheimer's disease. Neurosci Biobehav Rev (2015) 0.76
Neuroprotective actions of the synthetic estrogen 17alpha-ethynylestradiol in the hippocampus. Cell Mol Neurobiol (2010) 0.76
Paraoxonases-1, -2 and -3: What are their functions? Chem Biol Interact (2016) 0.76
Sex Hormones Regulate Cytoskeletal Proteins Involved in Brain Plasticity. Front Psychiatry (2015) 0.76
Protecting the developing brain by 17β-estradiol. Oncotarget (2017) 0.75
Oxidative Stress as a Physiological Pain Response in Full-Term Newborns. Oxid Med Cell Longev (2017) 0.75
Neuroprotection by Estrogen and Progesterone in Traumatic Brain Injury and Spinal Cord Injury. Curr Neuropharmacol (2016) 0.75
Protecting the developing brain by 17βestradiol. Oncotarget (2017) 0.75
Neuronal differentiation dictates estrogen-dependent survival and ERK1/2 kinetic by means of caveolin-1. PLoS One (2014) 0.75
Administration of 17β-Estradiol Improves Motoneuron Survival and Down-regulates Inflammasome Activation in Male SOD1(G93A) ALS Mice. Mol Neurobiol (2016) 0.75
Effects of estrogen receptor modulators on cytoskeletal proteins in the central nervous system. Neural Regen Res (2017) 0.75
Microglial CB2 cannabinoid receptors are neuroprotective in Huntington's disease excitotoxicity. Brain (2009) 1.50
Reduced metabolites mediate neuroprotective effects of progesterone in the adult rat hippocampus. The synthetic progestin medroxyprogesterone acetate (Provera) is not neuroprotective. J Neurobiol (2006) 1.17
Interactions of estrogen and insulin-like growth factor-I in the brain: molecular mechanisms and functional implications. J Steroid Biochem Mol Biol (2002) 1.17
Aromatase expression by reactive astroglia is neuroprotective. Ann N Y Acad Sci (2003) 1.09
Diabetes-induced myelin abnormalities are associated with an altered lipid pattern: protective effects of LXR activation. J Lipid Res (2011) 1.08
Interactions of estradiol and insulin-like growth factor-I signalling in the nervous system: new advances. Prog Brain Res (2010) 1.07
Glia-neuron crosstalk in the neuroprotective mechanisms of sex steroid hormones. Brain Res Brain Res Rev (2005) 1.07
Aromatase: a neuroprotective enzyme. Prog Neurobiol (2003) 1.05
Testosterone decreases reactive astroglia and reactive microglia after brain injury in male rats: role of its metabolites, oestradiol and dihydrotestosterone. Eur J Neurosci (2007) 1.04
Estrogen receptor alpha forms estrogen-dependent multimolecular complexes with insulin-like growth factor receptor and phosphatidylinositol 3-kinase in the adult rat brain. Brain Res Mol Brain Res (2003) 1.04
Selective estrogen receptor modulators decrease reactive astrogliosis in the injured brain: effects of aging and prolonged depletion of ovarian hormones. Endocrinology (2009) 1.04
Ro5-4864, a peripheral benzodiazepine receptor ligand, reduces reactive gliosis and protects hippocampal hilar neurons from kainic acid excitotoxicity. J Neurosci Res (2005) 1.03
Ligand for translocator protein reverses pathology in a mouse model of Alzheimer's disease. J Neurosci (2013) 1.02
Classical androgen receptors in non-classical sites in the brain. Horm Behav (2008) 1.01
Selective oestrogen receptor (ER) modulators reduce microglia reactivity in vivo after peripheral inflammation: potential role of microglial ERs. J Endocrinol (2008) 0.98
Cross-talk between estrogen receptors and insulin-like growth factor-I receptor in the brain: cellular and molecular mechanisms. Front Neuroendocrinol (2006) 0.98
Prenatal stress causes alterations in the morphology of microglia and the inflammatory response of the hippocampus of adult female mice. J Neuroinflammation (2012) 0.97
Sex differences in the inflammatory response of primary astrocytes to lipopolysaccharide. Biol Sex Differ (2011) 0.95
Aromatase distribution in the monkey temporal neocortex and hippocampus. Brain Res (2008) 0.95
Sex hormones and brain aging. Exp Gerontol (2004) 0.95
Interdependence of oestrogen and insulin-like growth factor-I in the brain: potential for analysing neuroprotective mechanisms. J Endocrinol (2005) 0.95
Neuroprotective actions of selective estrogen receptor modulators. Psychoneuroendocrinology (2009) 0.95
An antagonist of estrogen receptors blocks the induction of adult neurogenesis by insulin-like growth factor-I in the dentate gyrus of adult female rat. Eur J Neurosci (2003) 0.94
Selective estrogen receptor modulators protect hippocampal neurons from kainic acid excitotoxicity: differences with the effect of estradiol. J Neurobiol (2004) 0.93
Interaction of estrogen receptors with insulin-like growth factor-I and Wnt signaling in the nervous system. Steroids (2009) 0.93
CX3CL1 promotes breast cancer via transactivation of the EGF pathway. Cancer Res (2013) 0.93
Endogenous estrogen formation is neuroprotective in model of cerebellar ataxia. Endocrine (2003) 0.93
Selective estrogen receptor modulators as brain therapeutic agents. J Mol Endocrinol (2011) 0.93
Translocator protein 18 kDa is involved in the regulation of reactive gliosis. Glia (2007) 0.93
Aromatase, the enzyme responsible for estrogen biosynthesis, is expressed by human and rat glioblastomas. Neurosci Lett (2004) 0.93
Neuroprotective actions of estradiol revisited. Trends Endocrinol Metab (2011) 0.92
Population control of resident and immigrant microglia by mitosis and apoptosis. Am J Pathol (2007) 0.92
Progesterone and its derivatives dihydroprogesterone and tetrahydroprogesterone reduce myelin fiber morphological abnormalities and myelin fiber loss in the sciatic nerve of aged rats. Neurobiol Aging (2003) 0.91
Neuroactive steroids prevent peripheral myelin alterations induced by diabetes. Neurosci Lett (2006) 0.91
Sex differences, developmental changes, response to injury and cAMP regulation of the mRNA levels of steroidogenic acute regulatory protein, cytochrome p450scc, and aromatase in the olivocerebellar system. J Neurobiol (2006) 0.91
Growth hormone prevents neuronal loss in the aged rat hippocampus. Neurobiol Aging (2005) 0.89
Neuroprotection by the steroids pregnenolone and dehydroepiandrosterone is mediated by the enzyme aromatase. J Neurobiol (2003) 0.88
Neuroprotective and neurotoxic effects of estrogens. Brain Res (2003) 0.88
Extragonadal synthesis of estradiol is protective against kainic acid excitotoxic damage to the hippocampus. Neuroreport (2005) 0.87
Androgen receptor immunoreactivity in forebrain axons and dendrites in the rat. Endocrinology (2003) 0.87
Prenatal stress increases the expression of proinflammatory cytokines and exacerbates the inflammatory response to LPS in the hippocampal formation of adult male mice. Brain Behav Immun (2012) 0.87
Role of astroglia in the neuroplastic and neuroprotective actions of estradiol. Eur J Neurosci (2010) 0.87
Gender differences in the long-term effects of chronic prenatal stress on the HPA axis and hypothalamic structure in rats. Psychoneuroendocrinology (2010) 0.87
Blockade of cannabinoid CB(1) receptor function protects against in vivo disseminating brain damage following NMDA-induced excitotoxicity. J Neurochem (2002) 0.87
Aromatase expression in the normal and epileptic human hippocampus. Brain Res (2009) 0.87
Steroidogenic acute regulatory protein in the rat brain: cellular distribution, developmental regulation and overexpression after injury. Eur J Neurosci (2003) 0.86
Long-term ovariectomy enhances anxiety and depressive-like behaviors in mice submitted to chronic unpredictable stress. Horm Behav (2010) 0.86
Insulin-like growth factor-I gene delivery to astrocytes reduces their inflammatory response to lipopolysaccharide. J Neuroinflammation (2011) 0.85
Age-related changes in neuroactive steroid levels in 3xTg-AD mice. Neurobiol Aging (2012) 0.85
Role of estrogen receptor alpha in membrane-initiated signaling in neural cells: interaction with IGF-1 receptor. J Steroid Biochem Mol Biol (2009) 0.84
Sex-dependent long-term effects of adolescent exposure to THC and/or MDMA on neuroinflammation and serotoninergic and cannabinoid systems in rats. Br J Pharmacol (2014) 0.84
Response of transcription factor NFATc3 to excitotoxic and traumatic brain insults: identification of a subpopulation of reactive astrocytes. Glia (2010) 0.84
Molecular mechanisms involved in the regulation of neuritogenesis by estradiol: Recent advances. J Steroid Biochem Mol Biol (2011) 0.83
Estradiol and soy extract increase the production of new cells in the dentate gyrus of old rats. Exp Gerontol (2005) 0.83
A lovastatin-elicited genetic program inhibits M2 macrophage polarization and enhances T cell infiltration into spontaneous mouse mammary tumors. Oncotarget (2013) 0.83
Therapeutic approaches to peripheral neuropathy based on neuroactive steroids. Expert Rev Neurother (2006) 0.82
G protein-coupled estrogen receptor is required for the neuritogenic mechanism of 17β-estradiol in developing hippocampal neurons. Mol Cell Endocrinol (2013) 0.82
Gonadal hormones and the control of reactive gliosis. Horm Behav (2012) 0.81
Behavioral effects of estradiol therapy in ovariectomized rats depend on the age when the treatment is initiated. Exp Gerontol (2011) 0.81
Regulation of the phosphoinositide-3 kinase and mitogen-activated protein kinase signaling pathways by progesterone and its reduced metabolites in the rat brain. J Neurosci Res (2009) 0.81
Pubertal maturation modifies the regulation of insulin-like growth factor-I receptor signaling by estradiol in the rat prefrontal cortex. Dev Neurobiol (2008) 0.81
Effects of progesterone and its reduced metabolites, dihydroprogesterone and tetrahydroprogesterone, on the expression and phosphorylation of glycogen synthase kinase-3 and the microtubule-associated protein tau in the rat cerebellum. Dev Neurobiol (2007) 0.81
Estrogen receptor ligands counteract cognitive deficits caused by androgen deprivation in male rats. Horm Behav (2011) 0.80
Neuroprotective effects of soy phytoestrogens in the rat brain. Gynecol Endocrinol (2006) 0.80
Estradiol and testosterone regulate arginine-vasopressin expression in SH-SY5Y human female neuroblastoma cells through estrogen receptors-α and -β. Endocrinology (2013) 0.80
Estradiol meets notch signaling in developing neurons. Front Endocrinol (Lausanne) (2011) 0.79
Estradiol decreases cortical reactive astrogliosis after brain injury by a mechanism involving cannabinoid receptors. Cereb Cortex (2011) 0.79
Leptin accumulation in hypothalamic and dorsal raphe neurons is inversely correlated with brain serotonin content. Brain Res (2010) 0.79
Sex-dimorphic effects of progesterone and its reduced metabolites on gene expression of myelin proteins by rat Schwann cells. J Peripher Nerv Syst (2006) 0.79
Antidepressive and anxiolytic activity of selective estrogen receptor modulators in ovariectomized mice submitted to chronic unpredictable stress. Behav Brain Res (2011) 0.78
Estrogen receptor alpha is involved in the estrogenic regulation of arginine vasopressin immunoreactivity in the supraoptic and paraventricular nuclei of ovariectomized rats. Neurosci Lett (2010) 0.78
The weight gain response to stress during adulthood is conditioned by both sex and prenatal stress exposure. Psychoneuroendocrinology (2009) 0.78
Progesterone regulates the phosphorylation of protein phosphatases in the brain. J Neurosci Res (2010) 0.78
Selective transcriptional regulation of aromatase gene by vitamin D, dexamethasone, and mifepristone in human glioma cells. Endocrine (2008) 0.78