A novel form of 4-1BBL has better immunomodulatory activity than an agonistic anti-4-1BB Ab without Ab-associated severe toxicity.

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Published in Vaccine on October 29, 2009

Authors

Rich-Henry Schabowsky1, Kutlu G Elpek, Shravan Madireddi, Rajesh K Sharma, Esma S Yolcu, Laura Bandura-Morgan, Robert Miller, Kathryn J MacLeod, Robert S Mittler, Haval Shirwan

Author Affiliations

1: Institute for Cellular Therapeutics, Department of Microbiology and Immunology, and James Brown Cancer Center, University of Louisville, KY 40202, United States.

Associated clinical trials:

Study of BMS-663513 in Patients With Advanced Cancer | NCT00309023

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