Published in Arch Pharm Res on November 08, 2009
Human chromosomal translocations at CpG sites and a theoretical basis for their lineage and stage specificity. Cell (2008) 3.31
Roles of nonhomologous DNA end joining, V(D)J recombination, and class switch recombination in chromosomal translocations. DNA Repair (Amst) (2006) 2.52
Synthesis and characterization of novel 6-fluoro-4-piperidinyl-1,2-benzisoxazole amides and 6-fluoro-chroman-2-carboxamides: antimicrobial studies. Bioorg Med Chem (2005) 2.32
An inhibitor of nonhomologous end-joining abrogates double-strand break repair and impedes cancer progression. Cell (2012) 1.81
Chromosomal translocations in cancer. Biochim Biophys Acta (2008) 1.38
Formation of a G-quadruplex at the BCL2 major breakpoint region of the t(14;18) translocation in follicular lymphoma. Nucleic Acids Res (2010) 1.30
Synthesis of pharmaceutically important condensed heterocyclic 4,6-disubstituted-1,2,4-triazolo-1,3,4-thiadiazole derivatives as antimicrobials. Eur J Med Chem (2006) 1.22
Synthesis of novel isoxazolidine derivatives and studies for their antifungal properties. Eur J Med Chem (2003) 1.16
1-Benzhydryl-4-(4-chloro-phenyl-sulfonyl)piperazine. Acta Crystallogr Sect E Struct Rep Online (2008) 1.15
Synthesis of new bioactive venlafaxine analogs: novel thiazolidin-4-ones as antimicrobials. Bioorg Med Chem (2005) 1.15
How does DNA break during chromosomal translocations? Nucleic Acids Res (2011) 1.14
Methyl angolensate, a natural tetranortriterpenoid induces intrinsic apoptotic pathway in leukemic cells. FEBS Lett (2008) 1.09
Synthesis and biological evaluation of novel 2-aralkyl-5-substituted-6-(4'-fluorophenyl)-imidazo[2,1-b][1,3,4]thiadiazole derivatives as potent anticancer agents. Eur J Med Chem (2011) 1.08
Phytochemical and Antimicrobial Studies of Methyl Angolensate and Luteolin-7-O-glucoside Isolated from Callus Cultures of Soymida febrifuga. Int J Biomed Sci (2007) 1.07
Synthesis and biological evaluation of novel 1-(4-methoxyphenethyl)-1H-benzimidazole-5-carboxylic acid derivatives and their precursors as antileukemic agents. Bioorg Med Chem Lett (2009) 1.03
Synthesis of novel isoxazolidine derivatives and their antifungal and antibacterial properties. Arch Pharm (Weinheim) (2003) 1.03
A small oxazine compound as an anti-tumor agent: a novel pyranoside mimetic that binds to VEGF, HB-EGF, and TNF-α. Cancer Lett (2010) 1.02
Anti-tumor activity of a novel HS-mimetic-vascular endothelial growth factor binding small molecule. PLoS One (2012) 0.99
Efficiency of nonhomologous DNA end joining varies among somatic tissues, despite similarity in mechanism. Cell Mol Life Sci (2010) 0.98
Extracts of strawberry fruits induce intrinsic pathway of apoptosis in breast cancer cells and inhibits tumor progression in mice. PLoS One (2012) 0.97
Novel derivatives of spirohydantoin induce growth inhibition followed by apoptosis in leukemia cells. Biochem Pharmacol (2008) 0.97
Synthesis and in vitro antiproliferative activity of novel 1-benzhydrylpiperazine derivatives against human cancer cell lines. Eur J Med Chem (2008) 0.97
Potential G-quadruplex formation at breakpoint regions of chromosomal translocations in cancer may explain their fragility. Genomics (2012) 0.93
A novel DNA intercalator, 8-methoxy pyrimido[4',5':4,5]thieno (2,3-b)quinoline-4(3H)-one induces apoptosis in cancer cells, inhibits the tumor progression and enhances lifespan in mice with tumor. Mol Carcinog (2011) 0.93
Time-dependent predominance of nonhomologous DNA end-joining pathways during embryonic development in mice. J Mol Biol (2012) 0.92
Mechanism of fragility at BCL2 gene minor breakpoint cluster region during t(14;18) chromosomal translocation. J Biol Chem (2012) 0.92
Anti-apoptotic protein BCL2 down-regulates DNA end joining in cancer cells. J Biol Chem (2010) 0.92
G-quadruplex structures formed at the HOX11 breakpoint region contribute to its fragility during t(10;14) translocation in T-cell leukemia. Mol Cell Biol (2013) 0.91
A novel structural derivative of natural alkaloid ellipticine, MDPSQ, induces necrosis in leukemic cells. Invest New Drugs (2010) 0.91
P1 nuclease cleavage is dependent on length of the mismatches in DNA. DNA Repair (Amst) (2008) 0.90
A novel DNA intercalator, butylamino-pyrimido[4',5':4,5]selenolo(2,3-b)quinoline, induces cell cycle arrest and apoptosis in leukemic cells. Invest New Drugs (2009) 0.90
Chromosomal translocations among the healthy human population: implications in oncogenesis. Cell Mol Life Sci (2012) 0.89
Role of recombination activating genes in the generation of antigen receptor diversity and beyond. Immunology (2012) 0.87
Nonhomologous DNA end joining in cell-free extracts. J Nucleic Acids (2010) 0.86
Prevalence and analysis of t(14;18) and t(11;14) chromosomal translocations in healthy Indian population. Ann Hematol (2009) 0.86
N-Substituted-2-butyl-5-chloro-3H-imidazole-4-carbaldehyde derivatives as anti-tumor agents against Ehrlich ascites tumor cells in vivo. Med Chem (2007) 0.86
Pro-apoptotic activity of imidazole derivatives mediated by up-regulation of Bax and activation of CAD in Ehrlich Ascites Tumor cells. Invest New Drugs (2007) 0.86
A natural compound, methyl angolensate, induces mitochondrial pathway of apoptosis in Daudi cells. Invest New Drugs (2010) 0.85
Telomere and telomerase in stem cells: relevance in ageing and disease. Front Biosci (Schol Ed) (2012) 0.84
Novel levamisole derivative induces extrinsic pathway of apoptosis in cancer cells and inhibits tumor progression in mice. PLoS One (2012) 0.84
Cytosines, but not purines, determine recombination activating gene (RAG)-induced breaks on heteroduplex DNA structures: implications for genomic instability. J Biol Chem (2010) 0.83
Mechanistic aspects of lymphoid chromosomal translocations. J Natl Cancer Inst Monogr (2008) 0.83
Effect of novel arecoline thiazolidinones as muscarinic receptor 1 agonist in Alzheimer's dementia models. Neurochem Int (2007) 0.82
Synthesis of 2-(5-((5-(4-chlorophenyl)furan-2-yl)methylene)-4-oxo-2-thioxothiazolidin-3-yl)acetic acid derivatives and evaluation of their cytotoxicity and induction of apoptosis in human leukemia cells. Bioorg Med Chem (2009) 0.82
Tamarind seed extract mitigates the liver oxidative stress in arthritic rats. Food Funct (2014) 0.81
Intercalating, cytotoxic, antitumour activity of 8-chloro and 4-morpholinopyrimido [4',5':4,5]thieno(2,3-b)quinolines. J Photochem Photobiol B (2008) 0.81
Synthesis, characterization and evaluation of benzimidazole derivative and its precursors as inhibitors of MDA-MB-231 human breast cancer cell proliferation. Bioorg Med Chem Lett (2007) 0.81
Screening of quinoline, 1,3-benzoxazine, and 1,3-oxazine-based small molecules against isolated methionyl-tRNA synthetase and A549 and HCT116 cancer cells including an in silico binding mode analysis. Org Biomol Chem (2015) 0.80
Synthesis and in vitro antimicrobial studies of medicinally important novel N-alkyl and N-sulfonyl derivatives of 1-[bis(4-fluorophenyl)-methyl]piperazine. Bioorg Med Chem (2006) 0.80
Synthesis and in vitro antiproliferative activity against human cancer cell lines of novel 5-(4-methyl-benzylidene)-thiazolidine-2,4-diones. Invest New Drugs (2008) 0.80
Anti-tumor and anti-angiogenic activity of novel hydantoin derivatives: Inhibition of VEGF secretion in liver metastatic osteosarcoma cells. Bioorg Med Chem (2009) 0.79
Novel rhodanine derivatives induce growth inhibition followed by apoptosis. Bioorg Med Chem Lett (2010) 0.79
Differential reaction kinetics, cleavage complex formation, and nonamer binding domain dependence dictate the structure-specific and sequence-specific nuclease activity of RAGs. J Mol Biol (2011) 0.79
Roles of glycosaminoglycans and glycanmimetics in tumor progression and metastasis. Glycoconj J (2014) 0.79
Synthesis and in vitro cytotoxic evaluation of novel diazaspiro bicyclo hydantoin derivatives in human leukemia cells: a SAR study. Invest New Drugs (2008) 0.78
A non-B DNA can replace heptamer of V(D)J recombination when present along with a nonamer: implications in chromosomal translocations and cancer. Biochem J (2012) 0.78
Simple and an efficient method for the synthesis of 1-[2-dimethylamino-1-(4-methoxy-phenyl)-ethyl]-cyclohexanol hydrochloride: (+/-) venlafaxine racemic mixtures. Bioorg Med Chem Lett (2004) 0.78
5-Isopropylidene-3-ethyl rhodanine induce growth inhibition followed by apoptosis in leukemia cells. Eur J Med Chem (2010) 0.78
Differential regulation of MRN (Mre11-Rad50-Nbs1) complex subunits and telomerase activity in cancer cells. Biochem Biophys Res Commun (2010) 0.78
Evaluation of in vivo wound-healing potential of 2-[4-(2,4-dimethoxy-benzoyl)-phenoxy]-1-[4-(3-piperidin-4-yl-propyl)-piperidin-1-yl]-ethanone derivatives. Eur J Med Chem (2009) 0.78
Synthesis, characterization and in-vitro antiproliferative effects of novel 5-amino pyrazole derivatives against breast cancer cell lines. Recent Pat Anticancer Drug Discov (2011) 0.77
Synthesis and efficacy of 1-[bis(4-fluorophenyl)-methyl]piperazine derivatives for acetylcholinesterase inhibition, as a stimulant of central cholinergic neurotransmission in Alzheimer's disease. Bioorg Med Chem Lett (2006) 0.77
Synthesis of novel 6-fluoro-3-(4-piperidinyl)-1,2-benzisoxazole derivatives as antiproliferative agents: a structure-activity relationship study. Invest New Drugs (2008) 0.77
Structure-specific nuclease activity of RAGs is modulated by sequence, length and phase position of flanking double-stranded DNA. FEBS J (2014) 0.77
Sequence and structural basis for chromosomal fragility during translocations in cancer. Future Oncol (2012) 0.77
Synthesis and antiproliferative activity of substituted diazaspiro hydantoins: a structure-activity relationship study. Invest New Drugs (2008) 0.77
Facile synthesis of antimalarial 1,2-disubstituted 4-quinolones from 1,3-bisaryl-monothio-1,3-diketones. Org Biomol Chem (2014) 0.77
Intercalative pyrimido[4',5':4,5]thieno(2,3-b)quinolines induce apoptosis in leukemic cells: a comparative study of methoxy and morpholino substitution. Invest New Drugs (2010) 0.76
Methyl angolensate from callus of Indian redwood induces cytotoxicity in human breast cancer cells. Int J Biomed Sci (2010) 0.76
Synthesis of Novel 3-Aryl-N-Methyl-1,2,5,6-Tetrahydropyridine Derivatives by Suzuki coupling: As Acetyl Cholinesterase Inhibitors. Open Med Chem J (2007) 0.76
Pluronic copolymer encapsulated SCR7 as a potential anticancer agent. Faraday Discuss (2015) 0.76
Active site directed docking studies: synthesis and pharmacological evaluation of cis-2,6-dimethyl piperidine sulfonamides as inhibitors of acetylcholinesterase. Eur J Med Chem (2009) 0.76
Correction: Novel Synthetic Oxazines Target NF-κB in Colon Cancer In Vitro and Inflammatory Bowel Disease In Vivo. PLoS One (2017) 0.75
Synthesis and pharmacological evaluation of novel N-alkyl/aryl substituted thiazolidinone arecoline analogues as muscarinic receptor 1 agonist in Alzheimer's dementia models. Eur J Med Chem (2009) 0.75
Effect of novel N-aryl sulfonamide substituted 3-morpholino arecoline derivatives as muscarinic receptor 1 agonists in Alzheimer's dementia models. Bioorg Med Chem (2008) 0.75
Synthesis and identification of a new class of antileukemic agents containing 2-(arylcarboxamide)-(S)-6-amino-4,5,6,7-tetrahydrobenzo[d]thiazole. Eur J Med Chem (2010) 0.75
Quality of life among dentists in teaching hospitals in South Canara, India. Indian J Dent Res (2011) 0.75
Synthesis of 1-(4-methoxybenzyl)-3-cyclopropyl-1H-pyrazol-5-amine derivatives as antimicrobial agents. J Enzyme Inhib Med Chem (2010) 0.75
Amplification of chromosomal translocation junctions from paraffin-embedded tissues of follicular lymphoma patients. Biomed Mater (2008) 0.75
Synthesis and antileukemic activity of novel 4-(3-(piperidin-4-yl) propyl)piperidine derivatives. Chem Biol Drug Des (2011) 0.75
Synthesis and anti-inflammatory activity of novel (4-hydroxyphenyl)(2,4-dimethoxyphenyl) methanone derivatives. Arch Pharm (Weinheim) (2009) 0.75
Synthesis and antimicrobial activity of 1-benzhydryl-sulfonyl-4-(3-(piperidin-4-yl) propyl)piperidine derivatives against pathogens of Lycopersicon esculentum: a structure-activity evaluation study. Arch Pharm Res (2009) 0.75
Synthesis and identification of a new class of (S)-2,6-diamino-4,5,6,7-tetrahydrobenzo[d]thiazole derivatives as potent antileukemic agents. Invest New Drugs (2009) 0.75