Published in ALTEX on January 01, 2009
Rapid behavior-based identification of neuroactive small molecules in the zebrafish. Nat Chem Biol (2010) 2.87
Chemical regulators have overreached. Nature (2009) 1.63
Alternatives to animal testing: current status and future perspectives. Arch Toxicol (2011) 1.37
t4 workshop report: Pathways of Toxicity. ALTEX (2013) 1.06
Assessment and validation of the CAESAR predictive model for bioconcentration factor (BCF) in fish. Chem Cent J (2010) 0.97
Current perspectives on the use of alternative species in human health and ecological hazard assessments. Environ Health Perspect (2013) 0.92
Global analysis of publicly available safety data for 9,801 substances registered under REACH from 2008-2014. ALTEX (2016) 0.90
Analytical in vitro approach for studying cyto- and genotoxic effects of particulate airborne material. Anal Bioanal Chem (2011) 0.88
International STakeholder NETwork (ISTNET): creating a developmental neurotoxicity (DNT) testing road map for regulatory purposes. Arch Toxicol (2015) 0.87
The CULTEX RFS: a comprehensive technical approach for the in vitro exposure of airway epithelial cells to the particulate matter at the air-liquid interface. Biomed Res Int (2013) 0.87
Predicting the future: opportunities and challenges for the chemical industry to apply 21st-century toxicity testing. J Am Assoc Lab Anim Sci (2015) 0.83
Identifying and designing chemicals with minimal acute aquatic toxicity. Proc Natl Acad Sci U S A (2014) 0.81
Analysis of public oral toxicity data from REACH registrations 2008-2014. ALTEX (2016) 0.80
Probabilistic hazard assessment for skin sensitization potency by dose-response modeling using feature elimination instead of quantitative structure-activity relationships. J Appl Toxicol (2015) 0.80
Of reductionism and the pendulum swing: connecting toxicology and human health. Dose Response (2011) 0.79
Analysis of Draize eye irritation testing and its prediction by mining publicly available 2008-2014 REACH data. ALTEX (2016) 0.79
Testing Chemical Safety: What Is Needed to Ensure the Widespread Application of Non-animal Approaches? PLoS Biol (2015) 0.78
Comparison of toxicogenomic responses to phthalate ester exposure in an organotypic testis co-culture model and responses observed in vivo. Reprod Toxicol (2015) 0.78
Wind of change challenges toxicological regulators. Environ Health Perspect (2012) 0.76
Age matters: Developmental stage of Danio rerio larvae influences photomotor response thresholds to diazinion or diphenhydramine. Aquat Toxicol (2015) 0.76
Biology-inspired microphysiological system approaches to solve the prediction dilemma of substance testing. ALTEX (2016) 0.75
The presence of macrophages and inflammatory responses in an in vitro testicular co-culture model of male reproductive development enhance relevance to in vivo conditions. Toxicol In Vitro (2016) 0.75
Development of a Test Method for the Evaluation of DNA Damage in Mouse Spermatogonial Stem Cells. Toxicol Res (2017) 0.75
Green Toxicology: a strategy for sustainable chemical and material development. Environ Sci Eur (2017) 0.75
CD36 is a sensor of diacylglycerides. Nature (2005) 5.20
Toll-like receptor 2 suppresses immunity against Candida albicans through induction of IL-10 and regulatory T cells. J Immunol (2004) 3.13
Membrane sorting of toll-like receptor (TLR)-2/6 and TLR2/1 heterodimers at the cell surface determines heterotypic associations with CD36 and intracellular targeting. J Biol Chem (2006) 2.90
Enhanced antiinflammatory capacity of a Lactobacillus plantarum mutant synthesizing modified teichoic acids. Proc Natl Acad Sci U S A (2005) 2.82
Innate immunity in Arabidopsis thaliana: lipopolysaccharides activate nitric oxide synthase (NOS) and induce defense genes. Proc Natl Acad Sci U S A (2004) 2.40
Diagnosis of antiretroviral therapy failure in Malawi: poor performance of clinical and immunological WHO criteria. Trop Med Int Health (2009) 2.21
Synthetic lipoteichoic acid from Staphylococcus aureus is a potent stimulus of cytokine release. J Exp Med (2002) 1.93
Prevalence of Borrelia burgdorferi sensu lato genospecies in Ixodes ricinus ticks in Europe: a metaanalysis. Appl Environ Microbiol (2005) 1.71
L-ficolin specifically binds to lipoteichoic acid, a cell wall constituent of Gram-positive bacteria, and activates the lectin pathway of complement. J Immunol (2004) 1.70
High frequency of polymorphism Arg753Gln of the Toll-like receptor-2 gene detected by a novel allele-specific PCR. J Mol Med (Berl) (2003) 1.66
Cellular trafficking of lipoteichoic acid and Toll-like receptor 2 in relation to signaling: role of CD14 and CD36. J Leukoc Biol (2008) 1.61
"ToxRTool", a new tool to assess the reliability of toxicological data. Toxicol Lett (2009) 1.54
Heterozygous Arg753Gln polymorphism of human TLR-2 impairs immune activation by Borrelia burgdorferi and protects from late stage Lyme disease. J Immunol (2005) 1.49
mRNA expression is a relevant tool to identify developmental neurotoxicants using an in vitro approach. Toxicol Sci (2009) 1.49
Structural decomposition and heterogeneity of commercial lipoteichoic Acid preparations. Infect Immun (2002) 1.46
Anti-tumor necrosis factor antibody impairs the therapeutic effect of ceftriaxone in murine pneumococcal pneumonia. J Infect Dis (2003) 1.44
Lateral diffusion of Toll-like receptors reveals that they are transiently confined within lipid rafts on the plasma membrane. J Cell Sci (2004) 1.41
Lipopolysaccharide- and lipoteichoic acid-induced tolerance and cross-tolerance: distinct alterations in IL-1 receptor-associated kinase. J Immunol (2002) 1.39
Role of lipoteichoic acid in the phagocyte response to group B streptococcus. J Immunol (2005) 1.35
Differential effects of CpG-DNA in Toll-like receptor-2/-4/-9 tolerance and cross-tolerance. Immunology (2005) 1.34
Cytokine induction by purified lipoteichoic acids from various bacterial species--role of LBP, sCD14, CD14 and failure to induce IL-12 and subsequent IFN-gamma release. Eur J Immunol (2002) 1.34
Coronary microembolization: the role of TNF-alpha in contractile dysfunction. J Mol Cell Cardiol (2002) 1.32
Lipoteichoic acid and toll-like receptor 2 internalization and targeting to the Golgi are lipid raft-dependent. J Biol Chem (2004) 1.31
Highly purified lipoteichoic acid activates neutrophil granulocytes and delays their spontaneous apoptosis via CD14 and TLR2. J Leukoc Biol (2003) 1.29
Heterozygous toll-like receptor 4 polymorphism does not influence lipopolysaccharide-induced cytokine release in human whole blood. J Infect Dis (2003) 1.28
Guidance on good cell culture practice. a report of the second ECVAM task force on good cell culture practice. Altern Lab Anim (2005) 1.27
Lipopolysaccharide (LPS)-binding protein mediates LPS detoxification by chylomicrons. J Immunol (2003) 1.26
Workgroup report: incorporating in vitro alternative methods for developmental neurotoxicity into international hazard and risk assessment strategies. Environ Health Perspect (2007) 1.26
Distribution of clinically relevant Borrelia genospecies in ticks assessed by a novel, single-run, real-time PCR. J Clin Microbiol (2002) 1.24
Toll-like receptor 4 (TLR4)-deficient murine macrophage cell line as an in vitro assay system to show TLR4-independent signaling of Bacteroides fragilis lipopolysaccharide. Infect Immun (2002) 1.21
Consensus report on the future of animal-free systemic toxicity testing. ALTEX (2014) 1.20
Mitogen-activated protein kinase-activated protein kinase 2-deficient mice show increased susceptibility to Listeria monocytogenes infection. J Immunol (2002) 1.19
Perspectives on validation of high-throughput assays supporting 21st century toxicity testing. ALTEX (2013) 1.19
Comparison of lipoteichoic acid from different serotypes of Streptococcus pneumoniae. J Biol Chem (2006) 1.17
Cytokine induction by Gram-positive bacteria. Immunobiology (2008) 1.15
A roadmap for the development of alternative (non-animal) methods for systemic toxicity testing - t4 report*. ALTEX (2012) 1.15
Inflammatory findings on species extrapolations: humans are definitely no 70-kg mice. Arch Toxicol (2013) 1.14
Structure/function relationships of lipoteichoic acids. J Endotoxin Res (2005) 1.13
Extracellular gelsolin binds lipoteichoic acid and modulates cellular response to proinflammatory bacterial wall components. J Immunol (2008) 1.12
Definition of structural prerequisites for lipoteichoic acid-inducible cytokine induction by synthetic derivatives. J Immunol (2003) 1.10
Borrelia burgdorferi-induced tolerance as a model of persistence via immunosuppression. Infect Immun (2003) 1.10
Cellular recognition of trimyristoylated peptide or enterobacterial lipopolysaccharide via both TLR2 and TLR4. J Biol Chem (2007) 1.09
t4 workshop report: Pathways of Toxicity. ALTEX (2013) 1.06
Inflammatory neurodegeneration induced by lipoteichoic acid from Staphylococcus aureus is mediated by glia activation, nitrosative and oxidative stress, and caspase activation. J Neurochem (2005) 1.06
Induction of cytokine production in human T cells and monocytes by highly purified lipoteichoic acid: involvement of Toll-like receptors and CD14. Med Sci Monit (2002) 1.06
The dawning of a new age of toxicology. ALTEX (2008) 1.06
Induction and regulation of endogenous granulocyte colony-stimulating factor formation. Biol Chem (2002) 1.05
A proposed eye irritation testing strategy to reduce and replace in vivo studies using Bottom-Up and Top-Down approaches. Toxicol In Vitro (2009) 1.04
Review: toxicometabolomics. J Appl Toxicol (2013) 1.03
Profound differences in leukocyte-endothelial cell responses to lipopolysaccharide versus lipoteichoic acid. J Immunol (2002) 1.03
D-alanyl ester depletion of teichoic acids in Lactobacillus plantarum results in a major modification of lipoteichoic acid composition and cell wall perforations at the septum mediated by the Acm2 autolysin. J Bacteriol (2006) 1.02
A European perspective on alternatives to animal testing for environmental hazard identification and risk assessment. Regul Toxicol Pharmacol (2013) 1.02
Molecular interaction between lipoteichoic acids and Lactobacillus delbrueckii phages depends on D-alanyl and alpha-glucose substitution of poly(glycerophosphate) backbones. J Bacteriol (2007) 1.02
Diagnosis: toxic!--trying to apply approaches of clinical diagnostics and prevalence in toxicology considerations. Toxicol Sci (2005) 1.01
MDP and other muropeptides--direct and synergistic effects on the immune system. J Endotoxin Res (2006) 1.01
Activation of neutrophils and inhibition of the proinflammatory cytokine response by endogenous granulocyte colony-stimulating factor in murine pneumococcal pneumonia. J Infect Dis (2004) 1.00
International validation of novel pyrogen tests based on human monocytoid cells. J Immunol Methods (2005) 0.99
The Center for Alternatives to Animal Testing - Europe (CAAT-EU): a transatlantic bridge for the paradigm shift in toxicology. ALTEX (2010) 0.99
Can the initial success of the Malawi ART scale-up programme be sustained? The example of Queen Elizabeth Central Hospital, Blantyre. AIDS Care (2007) 0.99
Lipoteichoic acid from Staphylococcus aureus is a potent stimulus for neutrophil recruitment. Immunobiology (2003) 0.98
Meeting report: Validation of toxicogenomics-based test systems: ECVAM-ICCVAM/NICEATM considerations for regulatory use. Environ Health Perspect (2006) 0.98
The principles of weight of evidence validation of test methods and testing strategies. The report and recommendations of ECVAM workshop 58. Altern Lab Anim (2006) 0.97
Heterozygous toll-like receptor 2 polymorphism does not affect lipoteichoic acid-induced chemokine and inflammatory responses. Infect Immun (2004) 0.97
Comparison of eleven commercial tests for Chlamydia pneumoniae-specific immunoglobulin G in asymptomatic healthy individuals. J Clin Microbiol (2002) 0.97
Structural requirements of synthetic muropeptides to synergize with lipopolysaccharide in cytokine induction. J Biol Chem (2003) 0.97
The practical application of three validated in vitro embryotoxicity tests. The report and recommendations of an ECVAM/ZEBET workshop (ECVAM workshop 57). Altern Lab Anim (2006) 0.96
CTEP: a novel, potent, long-acting, and orally bioavailable metabotropic glutamate receptor 5 inhibitor. J Pharmacol Exp Ther (2011) 0.96
In vitro developmental neurotoxicity (DNT) testing: relevant models and endpoints. Neurotoxicology (2009) 0.96
Phyllanthus amarus has anti-inflammatory potential by inhibition of iNOS, COX-2, and cytokines via the NF-kappaB pathway. J Hepatol (2003) 0.96
Garlic (Allium sativum L.) modulates cytokine expression in lipopolysaccharide-activated human blood thereby inhibiting NF-kappaB activity. J Nutr (2003) 0.96
From "weight of evidence" to quantitative data integration using multicriteria decision analysis and Bayesian methods. ALTEX (2015) 0.95
Internalization and coreceptor expression are critical for TLR2-mediated recognition of lipoteichoic acid in human peripheral blood. J Immunol (2010) 0.95
Food for thought... on cell culture. ALTEX (2007) 0.95
Read-across approaches--misconceptions, promises and challenges ahead. ALTEX (2014) 0.95
Evidence-based toxicology for the 21st century: opportunities and challenges. ALTEX (2013) 0.94
Induction of blood-brain barrier properties in cultured brain capillary endothelial cells: comparison between primary glial cells and C6 cell line. Glia (2005) 0.94
Protecting more than animals. Sci Am (2006) 0.94
Food for thought... on the economics of animal testing. ALTEX (2009) 0.94
Highly purified lipoteichoic acid induced pro-inflammatory signalling in primary culture of rat microglia through Toll-like receptor 2: selective potentiation of nitric oxide production by muramyl dipeptide. J Neurochem (2006) 0.94
State-of-the-art of 3D cultures (organs-on-a-chip) in safety testing and pathophysiology. ALTEX (2014) 0.94
Metabolomics in toxicology and preclinical research. ALTEX (2013) 0.93
Increased D-alanylation of lipoteichoic acid and a thickened septum are main determinants in the nisin resistance mechanism of Lactococcus lactis. Microbiology (2008) 0.92
Gene expression as a sensitive endpoint to evaluate cell differentiation and maturation of the developing central nervous system in primary cultures of rat cerebellar granule cells (CGCs) exposed to pesticides. Toxicol Appl Pharmacol (2008) 0.92
Metabolism: a bottleneck in in vitro toxicological test development. The report and recommendations of ECVAM workshop 54. Altern Lab Anim (2006) 0.91
First steps in establishing a developmental toxicity test method based on human embryonic stem cells. Toxicol In Vitro (2007) 0.91
Critical evaluation of urine-based PCR assay for diagnosis of Lyme borreliosis. Clin Diagn Lab Immunol (2005) 0.91
Electrophysiological recording of re-aggregating brain cell cultures on multi-electrode arrays to detect acute neurotoxic effects. Neurotoxicology (2007) 0.90
Assessment of pyrogenic contaminations with validated human whole-blood assay. Nat Protoc (2009) 0.90
Cell activation by ligands of the toll-like receptor and interleukin-1 receptor family depends on the function of the large-conductance potassium channel MaxiK in human macrophages. Infect Immun (2006) 0.90
Endotoxin evaluation of eleven lipopolysaccharides by whole blood assay does not always correlate with Limulus amebocyte lysate assay. J Endotoxin Res (2006) 0.90
Use of synthetic derivatives to determine the minimal active structure of cytokine-inducing lipoteichoic acid. Clin Vaccine Immunol (2007) 0.90
Inhibition of microglial inflammation by the MLK inhibitor CEP-1347. J Neurochem (2005) 0.90
International validation of pyrogen tests based on cryopreserved human primary blood cells. J Immunol Methods (2006) 0.90
Substrate specific metabolism by polymorphic cytochrome P450 2D6 alleles. Toxicol In Vitro (2005) 0.90
Estimation of acute oral toxicity using the No Observed Adverse Effect Level (NOAEL) from the 28 day repeated dose toxicity studies in rats. Regul Toxicol Pharmacol (2008) 0.90
Arsenic induces telomerase expression and maintains telomere length in human cord blood cells. Toxicology (2009) 0.89
Integrated Testing Strategies (ITS) for safety assessment. ALTEX (2014) 0.89
Endogenous cortisol determines the circadian rhythm of lipopolysaccharide-- but not lipoteichoic acid--inducible cytokine release. Eur J Immunol (2006) 0.89