Published in Gastroenterology on November 10, 2009
Molecular pathways involved in colorectal cancer: implications for disease behavior and prevention. Int J Mol Sci (2013) 2.00
APOBEC3G promotes liver metastasis in an orthotopic mouse model of colorectal cancer and predicts human hepatic metastasis. J Clin Invest (2011) 1.23
The oncogenic role of microRNA-130a/301a/454 in human colorectal cancer via targeting Smad4 expression. PLoS One (2013) 1.22
Hepatic stem cells and transforming growth factor β in hepatocellular carcinoma. Nat Rev Gastroenterol Hepatol (2012) 1.17
Genetic and epigenetic biomarkers for diagnosis, prognosis and treatment of colorectal cancer. World J Gastroenterol (2014) 1.13
Autophagy suppresses tumorigenesis of hepatitis B virus-associated hepatocellular carcinoma through degradation of microRNA-224. Hepatology (2013) 1.12
Perspectives of TGF-β inhibition in pancreatic and hepatocellular carcinomas. Oncotarget (2014) 1.08
Smoking induces epithelial-to-mesenchymal transition in non-small cell lung cancer through HDAC-mediated downregulation of E-cadherin. Mol Cancer Ther (2012) 1.06
Phosphatase PRL-3 is a direct regulatory target of TGFbeta in colon cancer metastasis. Cancer Res (2010) 1.06
The clinical and biological significance of MIR-224 expression in colorectal cancer metastasis. Gut (2015) 1.03
Loss of Smad4 in colorectal cancer induces resistance to 5-fluorouracil through activating Akt pathway. Br J Cancer (2014) 1.01
Effects of activin and TGFβ on p21 in colon cancer. PLoS One (2012) 1.01
A comparison of epithelial-to-mesenchymal transition and re-epithelialization. Semin Cancer Biol (2012) 1.00
Up-regulation of miR-224 promotes cancer cell proliferation and invasion and predicts relapse of colorectal cancer. Cancer Cell Int (2013) 0.97
TGF-beta induces serous borderline ovarian tumor cell invasion by activating EMT but triggers apoptosis in low-grade serous ovarian carcinoma cells. PLoS One (2012) 0.97
Hotspot mutation panel testing reveals clonal evolution in a study of 265 paired primary and metastatic tumors. Clin Cancer Res (2015) 0.94
Molecular targets and pathways involved in liver metastasis of colorectal cancer. Clin Exp Metastasis (2015) 0.90
Reduced expression of bone morphogenetic protein receptor IA in pancreatic cancer is associated with a poor prognosis. Br J Cancer (2013) 0.89
Alterations in the Smad pathway in human cancers. Front Biosci (Landmark Ed) (2012) 0.89
MicroRNA-224 suppresses colorectal cancer cell migration by targeting Cdc42. Dis Markers (2014) 0.89
SMAD4 exerts a tumor-promoting role in hepatocellular carcinoma. Oncogene (2014) 0.89
The dual role of Smad7 in the control of cancer growth and metastasis. Int J Mol Sci (2013) 0.88
TGF-Beta suppresses VEGFA-mediated angiogenesis in colon cancer metastasis. PLoS One (2013) 0.88
Fucosylated TGF-β receptors transduces a signal for epithelial-mesenchymal transition in colorectal cancer cells. Br J Cancer (2013) 0.86
Development and progression of colorectal neoplasia. Cancer Biomark (2010) 0.85
SMAD4--molecular gladiator of the TGF-beta signaling is trampled upon by mutational insufficiency in colorectal carcinoma of Kashmiri population: an analysis with relation to KRAS proto-oncogene. BMC Cancer (2010) 0.84
The impact of TGF-β1 on the mRNA expression of TβR I, TβR II, Smad4 and the invasiveness of the JEG-3 placental choriocarcinoma cell line. Oncol Lett (2012) 0.84
Restoration of transforming growth factor-beta receptor II expression in colon cancer cells with microsatellite instability increases metastatic potential in vivo. J Biol Chem (2011) 0.83
Cooperativity of E-cadherin and Smad4 loss to promote diffuse-type gastric adenocarcinoma and metastasis. Mol Cancer Res (2014) 0.83
Genomic profiling of rectal adenoma and carcinoma by array-based comparative genomic hybridization. BMC Med Genomics (2012) 0.83
KLF17 empowers TGF-β/Smad signaling by targeting Smad3-dependent pathway to suppress tumor growth and metastasis during cancer progression. Cell Death Dis (2015) 0.82
The density of macrophages in colorectal cancer is inversely correlated to TGF-β1 expression and patients' survival. J Mol Histol (2013) 0.81
The liver prometastatic reaction of cancer patients: implications for microenvironment-dependent colon cancer gene regulation. Cancer Microenviron (2011) 0.81
Targeting the ERK pathway reduces liver metastasis of Smad4-inactivated colorectal cancer. Cancer Biol Ther (2013) 0.80
Brain metastases from colorectal cancer: microenvironment and molecular mechanisms. Int J Mol Sci (2012) 0.80
A Meta-Analysis of SMAD4 Immunohistochemistry as a Prognostic Marker in Colorectal Cancer. Transl Oncol (2015) 0.79
Novel role of STRAP in progression and metastasis of colorectal cancer through Wnt/β-catenin signaling. Oncotarget (2016) 0.79
Epithelial-specific deletion of 11β-HSD2 hinders Apcmin/+ mouse tumorigenesis. Mol Cancer Res (2013) 0.79
An epigenetic auto-feedback loop regulates TGF-β type II receptor expression and function in NSCLC. Oncotarget (2015) 0.79
The CEA-/lo colorectal cancer cell population harbors cancer stem cells and metastatic cells. Oncotarget (2016) 0.79
MicroRNA-20a-5p promotes colorectal cancer invasion and metastasis by downregulating Smad4. Oncotarget (2016) 0.78
Genetic dissection of colorectal cancer progression by orthotopic transplantation of engineered cancer organoids. Proc Natl Acad Sci U S A (2017) 0.77
Matrix metalloproteinase-9 in the initial injury after hepatectomy in mice. World J Gastroenterol (2013) 0.77
SMAD4 protein expression and cell proliferation in colorectal adenocarcinomas. Virchows Arch (2011) 0.76
Deletion and down-regulation of SMAD4 gene in colorectal cancers in a Chinese population. Chin J Cancer Res (2014) 0.75
TGF-β signaling in liver and gastrointestinal cancers. Cancer Lett (2016) 0.75
miR-509-5p and miR-1243 increase the sensitivity to gemcitabine by inhibiting epithelial-mesenchymal transition in pancreatic cancer. Sci Rep (2017) 0.75
MiR-146b protects cardiomyocytes injury in myocardial ischemia/reperfusion by targeting Smad4. Am J Transl Res (2017) 0.75
TES inhibits colorectal cancer progression through activation of p38. Oncotarget (2016) 0.75
Role of human cytomegalovirus in the proliferation and invasion of extravillous cytotrophoblasts isolated from early placentae. Int J Clin Exp Med (2015) 0.75
Therapeutic Inhibition of miR-4260 Suppresses Colorectal Cancer via Targeting MCC and SMAD4. Theranostics (2017) 0.75
Prognostic value of loss of heterozygosity and sub-cellular localization of SMAD4 varies with tumor stage in colorectal cancer. Oncotarget (2017) 0.75
Transforming Growth Factor-beta: A Therapeutic Target for Cancer. Hum Vaccin Immunother (2017) 0.75
Smad-dependent and Smad-independent pathways in TGF-beta family signalling. Nature (2003) 20.48
TGFbeta in Cancer. Cell (2008) 17.44
Breast cancer bone metastasis mediated by the Smad tumor suppressor pathway. Proc Natl Acad Sci U S A (2005) 4.20
LY2109761, a novel transforming growth factor beta receptor type I and type II dual inhibitor, as a therapeutic approach to suppressing pancreatic cancer metastasis. Mol Cancer Ther (2008) 2.99
Effect of Smad7 expression on metastasis of mouse mammary carcinoma JygMC(A) cells. J Natl Cancer Inst (2005) 2.23
Higher frequency of Smad4 gene mutation in human colorectal cancer with distant metastasis. Oncogene (1999) 2.22
A specific inhibitor of TGF-beta receptor kinase, SB-431542, as a potent antitumor agent for human cancers. Neoplasia (2005) 2.16
Inhibition of growth and metastasis of mouse mammary carcinoma by selective inhibitor of transforming growth factor-beta type I receptor kinase in vivo. Clin Cancer Res (2006) 2.01
Stable overexpression of Smad7 in human melanoma cells impairs bone metastasis. Cancer Res (2007) 1.89
Cadherins and catenins: role in signal transduction and tumor progression. Cancer Metastasis Rev (1999) 1.83
Inhibition of pulmonary and skeletal metastasis by a transforming growth factor-beta type I receptor kinase inhibitor. Cancer Res (2006) 1.82
Blocking transforming growth factor-beta up-regulates E-cadherin and reduces migration and invasion of hepatocellular carcinoma cells. Hepatology (2008) 1.73
SMAD4 as a prognostic marker in colorectal cancer. Clin Cancer Res (2005) 1.50
Smad4/DPC4 silencing and hyperactive Ras jointly disrupt transforming growth factor-beta antiproliferative responses in colon cancer cells. J Biol Chem (1999) 1.42
Smad7 induces hepatic metastasis in colorectal cancer. Br J Cancer (2008) 1.12
Metastasis suppressor genes: from gene identification to protein function and regulation. Cancer Biol Ther (2005) 1.10
Loss of Smad4 expression predicts liver metastasis in human colorectal cancer. Oncol Rep (2007) 1.09
High levels of Nm23 gene expression in advanced stage of thyroid carcinomas. Br J Cancer (1993) 0.94
nm23 protein expression in colorectal carcinoma metastasis in regional lymph nodes and the liver. Eur J Surg Oncol (2001) 0.93
Nuclear localization and intensity of staining of nm23 protein is useful marker for breast cancer progression. Cancer Cell Int (2008) 0.88
A specific inhibitor of TGF-beta receptor kinase, SB-431542, as a potent antitumor agent for human cancers. Neoplasia (2005) 2.16
Role of beta-arrestin 1 in the metastatic progression of colorectal cancer. Proc Natl Acad Sci U S A (2006) 1.97
Effective treatment of biliary cystadenoma. Ann Surg (2005) 1.83
Selective visualization of cyclooxygenase-2 in inflammation and cancer by targeted fluorescent imaging agents. Cancer Res (2010) 1.66
Targeting the transforming growth factor-beta signaling pathway in human cancer. Expert Opin Investig Drugs (2010) 1.57
Role of STRAP in regulating GSK3β function and Notch3 stabilization. Cell Cycle (2011) 1.54
Use of short tandem repeats for DNA fingerprinting to rapidly diagnose graft-versus-host disease in solid organ transplant patients. Transplantation (2006) 1.54
Smad7 induces tumorigenicity by blocking TGF-beta-induced growth inhibition and apoptosis. Exp Cell Res (2005) 1.53
Matrix metalloproteinase-9 from bone marrow-derived cells contributes to survival but not growth of tumor cells in the lung microenvironment. Cancer Res (2006) 1.50
Long-term detrimental effect of bile duct injury on health-related quality of life. Arch Surg (2004) 1.49
Serum sickness following rabbit antithymocyte-globulin induction in a liver transplant recipient: case report and literature review. Liver Transpl (2007) 1.43
Smad4 regulates claudin-1 expression in a transforming growth factor-beta-independent manner in colon cancer cells. Cancer Res (2007) 1.19
Oncogenic function of a novel WD-domain protein, STRAP, in human carcinogenesis. Cancer Res (2006) 1.16
Vitamin D inhibits proliferation of human uterine leiomyoma cells via catechol-O-methyltransferase. Fertil Steril (2010) 1.15
Warm hepatic ischemia-reperfusion promotes growth of colorectal carcinoma micrometastases in mouse liver via matrix metalloproteinase-9 induction. Cancer Res (2007) 1.11
Stability of the Sp3-DNA complex is promoter-specific: Sp3 efficiently competes with Sp1 for binding to promoters containing multiple Sp-sites. Nucleic Acids Res (2003) 1.09
Targeting transforming growth factor-beta signaling in liver metastasis of colon cancer. Cancer Lett (2009) 1.07
Smoking induces epithelial-to-mesenchymal transition in non-small cell lung cancer through HDAC-mediated downregulation of E-cadherin. Mol Cancer Ther (2012) 1.06
Transforming growth factor β induces expression of connective tissue growth factor in hepatic progenitor cells through Smad independent signaling. Cell Signal (2013) 1.05
CYFIP2, a direct p53 target, is leptomycin-B sensitive. Cell Cycle (2007) 1.01
Smad4-dependent regulation of urokinase plasminogen activator secretion and RNA stability associated with invasiveness by autocrine and paracrine transforming growth factor-beta. J Biol Chem (2006) 1.01
Serum vitamin D3 level inversely correlates with uterine fibroid volume in different ethnic groups: a cross-sectional observational study. Int J Womens Health (2013) 1.00
Impact of donor, technical, and recipient risk factors on survival and quality of life after liver transplantation. Arch Surg (2005) 0.99
The diagnostic criteria for right colonic diverticulitis: prospective evaluation of 100 patients. Int J Colorectal Dis (2008) 0.98
Survival after pediatric liver transplantation: why does living donation offer an advantage? Arch Surg (2005) 0.98
Oncogenic serine-threonine kinase receptor-associated protein modulates the function of Ewing sarcoma protein through a novel mechanism. Cancer Res (2006) 0.98
Diagnostic and therapeutic challenges in hepatic epithelioid hemangioendothelioma. J Gastrointest Cancer (2012) 0.96
Smad3 has a critical role in TGF-beta-mediated growth inhibition and apoptosis in colonic epithelial cells. J Surg Res (2004) 0.95
Role of Smad proteins in the regulation of NF-kappaB by TGF-beta in colon cancer cells. Cell Signal (2005) 0.94
Previously unreported high-grade complications of adrenalectomy. Surg Endosc (2008) 0.93
Management of hepatocellular adenoma: comparison of resection, embolization and observation. HPB (Oxford) (2012) 0.93
Elucidating the mechanism of regulation of transforming growth factor β Type II receptor expression in human lung cancer cell lines. Neoplasia (2011) 0.91
Alterations in the Smad pathway in human cancers. Front Biosci (Landmark Ed) (2012) 0.89
Is there racial disparity in outcomes after solid organ transplantation? Am J Surg (2004) 0.89
Lipopolysaccharide-dependent interaction between PU.1 and c-Jun determines production of lipocalin-type prostaglandin D synthase and prostaglandin D2 in macrophages. Am J Physiol Lung Cell Mol Physiol (2009) 0.88
Phosphorylation of PNKP by ATM prevents its proteasomal degradation and enhances resistance to oxidative stress. Nucleic Acids Res (2012) 0.88
Rapid extravasation and establishment of breast cancer micrometastases in the liver microenvironment. Mol Cancer Res (2010) 0.88
Reduced expression of transcriptional intermediary factor 1 gamma promotes metastasis and indicates poor prognosis of hepatocellular carcinoma. Hepatology (2014) 0.88
Smoking attenuates transforming growth factor-β-mediated tumor suppression function through downregulation of Smad3 in lung cancer. Cancer Prev Res (Phila) (2012) 0.87
Functional colonography of Min mice using dark lumen dynamic contrast-enhanced MRI. Magn Reson Med (2008) 0.86
TGF-beta-dependent and -independent roles of STRAP in cancer. Front Biosci (Landmark Ed) (2011) 0.85
Selective laparoscopic management of adhesive small bowel obstruction using CT guidance. Am Surg (2009) 0.85
TIS11D is a candidate pro-apoptotic p53 target gene. Cell Cycle (2006) 0.84
Serine threonine receptor-associated protein (STRAP) plays a role in the maintenance of mesenchymal morphology. Cell Signal (2009) 0.83
A clinical comparative analysis of crush/clamp, stapler, and dissecting sealer hepatic transection methods. HPB (Oxford) (2008) 0.82
1,25-dihydroxyvitamin D3 regulates expression of sex steroid receptors in human uterine fibroid cells. J Clin Endocrinol Metab (2015) 0.82
Laparoscopic and open surgery for right colonic diverticulitis. Am Surg (2010) 0.82
Intraoperative blood loss predicts hemorrhage-related reoperation after orthotopic liver transplantation. Am Surg (2010) 0.82
Continuous versus interrupted suture for end-to-end biliary anastomosis during liver transplantation gives equal results. Liver Transpl (2007) 0.81
Oncogenic STRAP functions as a novel negative regulator of E-cadherin and p21(Cip1) by modulating the transcription factor Sp1. Cell Cycle (2014) 0.81
Targeting the ERK pathway reduces liver metastasis of Smad4-inactivated colorectal cancer. Cancer Biol Ther (2013) 0.80
Prognostic value of CEA and CA 19-9 tumor markers combined with cytology from peritoneal fluid in colorectal cancer. Ann Surg Oncol (2009) 0.80
Long-term smoking mediated down-regulation of Smad3 induces resistance to carboplatin in non-small cell lung cancer. Neoplasia (2012) 0.80
Smad6 suppresses the growth and self-renewal of hepatic progenitor cells. J Cell Physiol (2014) 0.80
Survival and quality of life after organ transplantation in veterans and nonveterans. Am J Surg (2003) 0.79
Role of TGF-β signaling in curcumin-mediated inhibition of tumorigenicity of human lung cancer cells. J Cancer Res Clin Oncol (2012) 0.78
Increased metastases are associated with inflammation and matrix metalloproteinase-9 activity at incision sites in a murine model of peritoneal dissemination of colorectal cancer. J Surg Res (2012) 0.76
Management of portal vein thrombosis after liver transplantation with a combined open and endovascular approach. Liver Transpl (2015) 0.75
STRAP regulates c-Jun ubiquitin-mediated proteolysis and cellular proliferation. Biochem Biophys Res Commun (2011) 0.75
Contralateral portal vein embolization for hepatectomy in the setting of hepatic steatosis. Am Surg (2004) 0.75
Biliary reconstruction using non-penetrating, tissue everting clips versus conventional sewn biliary anastomosis in liver transplantation. HPB (Oxford) (2006) 0.75
Automation of fluorescent differential display with digital readout. Methods Mol Biol (2006) 0.75
Identification of p53 target genes by fluorescent differential display. Methods Mol Biol (2003) 0.75
Liver transplantation for hepatocellular carcinoma: current role and future opportunities. Curr Pharm Des (2007) 0.75