R Mark Wightman

Author PubWeight™ 151.54‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Subsecond dopamine release promotes cocaine seeking. Nature 2003 6.53
2 Associative learning mediates dynamic shifts in dopamine signaling in the nucleus accumbens. Nat Neurosci 2007 4.97
3 Dopamine operates as a subsecond modulator of food seeking. J Neurosci 2004 3.79
4 Real-time measurement of dopamine fluctuations after cocaine in the brain of behaving rats. Proc Natl Acad Sci U S A 2005 3.49
5 Resolving neurotransmitters detected by fast-scan cyclic voltammetry. Anal Chem 2004 3.18
6 Overoxidation of carbon-fiber microelectrodes enhances dopamine adsorption and increases sensitivity. Analyst 2003 3.04
7 Real-time chemical responses in the nucleus accumbens differentiate rewarding and aversive stimuli. Nat Neurosci 2008 2.76
8 Detecting subsecond dopamine release with fast-scan cyclic voltammetry in vivo. Clin Chem 2003 2.58
9 Monitoring rapid chemical communication in the brain. Chem Rev 2008 2.48
10 Regional specificity in the real-time development of phasic dopamine transmission patterns during acquisition of a cue-cocaine association in rats. Eur J Neurosci 2009 2.22
11 Synaptic overflow of dopamine in the nucleus accumbens arises from neuronal activity in the ventral tegmental area. J Neurosci 2009 2.16
12 Rapid dopamine signaling in the nucleus accumbens during contingent and noncontingent cocaine administration. Neuropsychopharmacology 2005 2.14
13 Cannabinoids enhance subsecond dopamine release in the nucleus accumbens of awake rats. J Neurosci 2004 2.10
14 Preferential enhancement of dopamine transmission within the nucleus accumbens shell by cocaine is attributable to a direct increase in phasic dopamine release events. J Neurosci 2008 1.97
15 Phasic nucleus accumbens dopamine encodes risk-based decision-making behavior. Biol Psychiatry 2011 1.96
16 Real-time decoding of dopamine concentration changes in the caudate-putamen during tonic and phasic firing. J Neurochem 2003 1.95
17 Phasic dopamine release evoked by abused substances requires cannabinoid receptor activation. J Neurosci 2007 1.95
18 Mesocortical dopamine neurons operate in distinct temporal domains using multimodal signaling. J Neurosci 2005 1.94
19 Extinction of cocaine self-administration reveals functionally and temporally distinct dopaminergic signals in the nucleus accumbens. Neuron 2005 1.90
20 Correlation of local changes in extracellular oxygen and pH that accompany dopaminergic terminal activity in the rat caudate-putamen. J Neurochem 2003 1.89
21 Cocaine increases dopamine release by mobilization of a synapsin-dependent reserve pool. J Neurosci 2006 1.88
22 Dynamic gain control of dopamine delivery in freely moving animals. J Neurosci 2004 1.86
23 Coordinated accumbal dopamine release and neural activity drive goal-directed behavior. Neuron 2007 1.84
24 In vivo comparison of norepinephrine and dopamine release in rat brain by simultaneous measurements with fast-scan cyclic voltammetry. J Neurochem 2011 1.81
25 Dynamic changes in accumbens dopamine correlate with learning during intracranial self-stimulation. Proc Natl Acad Sci U S A 2008 1.77
26 Phasic nucleus accumbens dopamine release encodes effort- and delay-related costs. Biol Psychiatry 2010 1.68
27 Dopamine detection with fast-scan cyclic voltammetry used with analog background subtraction. Anal Chem 2008 1.66
28 Carbon microelectrodes with a renewable surface. Anal Chem 2010 1.56
29 Neural encoding of cocaine-seeking behavior is coincident with phasic dopamine release in the accumbens core and shell. Eur J Neurosci 2009 1.56
30 Functional microcircuitry in the accumbens underlying drug addiction: insights from real-time signaling during behavior. Curr Opin Neurobiol 2004 1.55
31 Real-time measurements of phasic changes in extracellular dopamine concentration in freely moving rats by fast-scan cyclic voltammetry. Methods Mol Med 2003 1.53
32 Increased amphetamine-induced hyperactivity and reward in mice overexpressing the dopamine transporter. Proc Natl Acad Sci U S A 2008 1.52
33 Response times of carbon fiber microelectrodes to dynamic changes in catecholamine concentration. Anal Chem 2002 1.52
34 Multivariate concentration determination using principal component regression with residual analysis. Trends Analyt Chem 2009 1.52
35 Frequency of dopamine concentration transients increases in dorsal and ventral striatum of male rats during introduction of conspecifics. J Neurosci 2002 1.47
36 Simultaneous dopamine and single-unit recordings reveal accumbens GABAergic responses: implications for intracranial self-stimulation. Proc Natl Acad Sci U S A 2005 1.44
37 Sources contributing to the average extracellular concentration of dopamine in the nucleus accumbens. J Neurochem 2012 1.37
38 Basolateral amygdala modulates terminal dopamine release in the nucleus accumbens and conditioned responding. Biol Psychiatry 2009 1.36
39 In vivo voltammetric monitoring of norepinephrine release in the rat ventral bed nucleus of the stria terminalis and anteroventral thalamic nucleus. Eur J Neurosci 2009 1.35
40 Cocaine cues drive opposing context-dependent shifts in reward processing and emotional state. Biol Psychiatry 2011 1.34
41 Dopamine release is severely compromised in the R6/2 mouse model of Huntington's disease. J Neurochem 2006 1.29
42 Higher sensitivity dopamine measurements with faster-scan cyclic voltammetry. Anal Chem 2011 1.29
43 Characterization of local pH changes in brain using fast-scan cyclic voltammetry with carbon microelectrodes. Anal Chem 2010 1.27
44 Functional selectivity of dopamine receptor agonists. I. Selective activation of postsynaptic dopamine D2 receptors linked to adenylate cyclase. J Pharmacol Exp Ther 2002 1.25
45 Simultaneous decoupled detection of dopamine and oxygen using pyrolyzed carbon microarrays and fast-scan cyclic voltammetry. Anal Chem 2009 1.23
46 Disparity between tonic and phasic ethanol-induced dopamine increases in the nucleus accumbens of rats. Alcohol Clin Exp Res 2009 1.22
47 Amperometry and cyclic voltammetry with carbon fiber microelectrodes at single cells. Curr Protoc Neurosci 2002 1.19
48 Electroosmotic flow and its contribution to iontophoretic delivery. Anal Chem 2008 1.18
49 PAP and NT5E inhibit nociceptive neurotransmission by rapidly hydrolyzing nucleotides to adenosine. Mol Pain 2011 1.18
50 Nomifensine amplifies subsecond dopamine signals in the ventral striatum of freely-moving rats. J Neurochem 2004 1.16
51 Neurochemistry and electroanalytical probes. Curr Opin Chem Biol 2002 1.14
52 Paradoxical modulation of short-term facilitation of dopamine release by dopamine autoreceptors. J Neurochem 2007 1.14
53 Fluorinated xerogel-derived microelectrodes for amperometric nitric oxide sensing. Anal Chem 2008 1.14
54 Microfabricated FSCV-compatible microelectrode array for real-time monitoring of heterogeneous dopamine release. Analyst 2010 1.13
55 Microelectrodes for studying neurobiology. Curr Opin Chem Biol 2008 1.12
56 Electrochemical Dopamine Detection: Comparing Gold and Carbon Fiber Microelectrodes using Background Subtracted Fast Scan Cyclic Voltammetry. J Electroanal Chem (Lausanne) 2008 1.12
57 Simultaneous monitoring of dopamine concentration at spatially different brain locations in vivo. Biosens Bioelectron 2009 1.12
58 Flexible software platform for fast-scan cyclic voltammetry data acquisition and analysis. Anal Chem 2013 1.11
59 Carbon-fiber microelectrodes modified with 4-sulfobenzene have increased sensitivity and selectivity for catecholamines. Langmuir 2006 1.09
60 Synaptic vesicles really do kiss and run. Nat Neurosci 2004 1.08
61 Conical tungsten tips as substrates for the preparation of ultramicroelectrodes. Langmuir 2006 1.08
62 Synapsins differentially control dopamine and serotonin release. J Neurosci 2010 1.07
63 Rapid dopamine signaling differentially modulates distinct microcircuits within the nucleus accumbens during sucrose-directed behavior. J Neurosci 2011 1.07
64 Rank estimation and the multivariate analysis of in vivo fast-scan cyclic voltammetric data. Anal Chem 2010 1.05
65 Sensitization of rapid dopamine signaling in the nucleus accumbens core and shell after repeated cocaine in rats. J Neurophysiol 2010 1.04
66 Assessing principal component regression prediction of neurochemicals detected with fast-scan cyclic voltammetry. ACS Chem Neurosci 2011 1.04
67 Pharmacologically induced, subsecond dopamine transients in the caudate-putamen of the anesthetized rat. Synapse 2007 1.03
68 Catecholamines in the bed nucleus of the stria terminalis reciprocally respond to reward and aversion. Biol Psychiatry 2011 1.03
69 Differential dopamine release dynamics in the nucleus accumbens core and shell track distinct aspects of goal-directed behavior for sucrose. Neuropharmacology 2012 1.02
70 Electrochemical Analysis of Neurotransmitters. Annu Rev Anal Chem (Palo Alto Calif) 2015 1.01
71 Brain dopamine and serotonin differ in regulation and its consequences. Proc Natl Acad Sci U S A 2012 1.00
72 Probing presynaptic regulation of extracellular dopamine with iontophoresis. ACS Chem Neurosci 2010 1.00
73 Wireless transmission of fast-scan cyclic voltammetry at a carbon-fiber microelectrode: proof of principle. J Neurosci Methods 2004 1.00
74 Acute ethanol decreases dopamine transporter velocity in rat striatum: in vivo and in vitro electrochemical measurements. Alcohol Clin Exp Res 2005 0.98
75 Optimizing the Temporal Resolution of Fast-Scan Cyclic Voltammetry. ACS Chem Neurosci 2012 0.98
76 Pathway-specific dopaminergic deficits in a mouse model of Angelman syndrome. J Clin Invest 2012 0.97
77 Presynaptic dopaminergic function is largely unaltered in mesolimbic and mesostriatal terminals of adult rats that were prenatally exposed to cocaine. Brain Res 2003 0.97
78 Cannabinoid modulation of electrically evoked pH and oxygen transients in the nucleus accumbens of awake rats. J Neurochem 2006 0.96
79 Construction of Training Sets for Valid Calibration of in Vivo Cyclic Voltammetric Data by Principal Component Analysis. Anal Chem 2015 0.95
80 Instrumentation for fast-scan cyclic voltammetry combined with electrophysiology for behavioral experiments in freely moving animals. Rev Sci Instrum 2011 0.95
81 Tissue-nonspecific alkaline phosphatase acts redundantly with PAP and NT5E to generate adenosine in the dorsal spinal cord. J Neurosci 2013 0.94
82 Monitoring extracellular pH, oxygen, and dopamine during reward delivery in the striatum of primates. Front Behav Neurosci 2012 0.93
83 Controlled iontophoresis coupled with fast-scan cyclic voltammetry/electrophysiology in awake, freely moving animals. ACS Chem Neurosci 2013 0.93
84 Temperature-dependent differences between readily releasable and reserve pool vesicles in chromaffin cells. Biochim Biophys Acta 2007 0.92
85 Temporal separation of vesicle release from vesicle fusion during exocytosis. J Biol Chem 2002 0.90
86 Catecholamine exocytosis is diminished in R6/2 Huntington's disease model mice. J Neurochem 2007 0.90
87 In vivo voltammetry monitoring of electrically evoked extracellular norepinephrine in subregions of the bed nucleus of the stria terminalis. J Neurophysiol 2011 0.89
88 Neuropeptide Release is Impaired in a Mouse Model of Fragile X Mental Retardation Syndrome. ACS Chem Neurosci 2010 0.89
89 Noradrenergic synaptic function in the bed nucleus of the stria terminalis varies in animal models of anxiety and addiction. Neuropsychopharmacology 2013 0.88
90 Real-time monitoring of chemical transmission in slices of the murine adrenal gland. Endocrinology 2010 0.87
91 Vesicular Ca(2+) -induced secretion promoted by intracellular pH-gradient disruption. Biophys Chem 2006 0.84
92 Release and uptake of catecholamines in the bed nucleus of the stria terminalis measured in the mouse brain slice. Synapse 2002 0.84
93 Synapsin II negatively regulates catecholamine release. Brain Cell Biol 2007 0.84
94 In vivo measurement of somatodendritic release of dopamine in the ventral tegmental area. Synapse 2009 0.83
95 Characterization of solute distribution following iontophoresis from a micropipet. Anal Chem 2014 0.82
96 Opposing catecholamine changes in the bed nucleus of the stria terminalis during intracranial self-stimulation and its extinction. Biol Psychiatry 2012 0.82
97 Monitoring serotonin signaling on a subsecond time scale. Front Integr Neurosci 2013 0.81
98 "To learn, you must pay attention." Molecular insights into teachers' wisdom. Proc Natl Acad Sci U S A 2009 0.81
99 Norepinephrine and dopamine transmission in 2 limbic regions differentially respond to acute noxious stimulation. Pain 2015 0.81
100 Chronically Implanted, Nafion-Coated Ag/AgCl Reference Electrodes for Neurochemical Applications. ACS Chem Neurosci 2011 0.81
101 Dopamine transport into a single cell in a picoliter vial. Anal Chem 2002 0.80
102 Extrasynaptic dopamine and phasic neuronal activity. Nat Neurosci 2004 0.80
103 Facilitation of quantal release induced by a D1-like receptor on bovine chromaffin cells. Biochemistry 2007 0.78
104 Probing electric fields inside microfluidic channels during electroosmotic flow with fast-scan cyclic voltammetry. Anal Chem 2004 0.77
105 Distinguishing splanchnic nerve and chromaffin cell stimulation in mouse adrenal slices with fast-scan cyclic voltammetry. Am J Physiol Cell Physiol 2010 0.77
106 Voltammetric detection of metal nanoparticles separated by liquid chromatography. Anal Chem 2004 0.76
107 Paying attention with the latest technology. Neuron 2007 0.75
108 Electrogenerated chemiluminescence detection in reversed-phase liquid chromatography. Anal Chem 2002 0.75
109 Comparison of Spreading Depolarizations in the Motor Cortex and Nucleus Accumbens: Similar Patterns of Oxygen Responses and the Role of Dopamine. ACS Chem Neurosci 2017 0.75
110 Tuning emissive states in electrogenerated chemiluminescence. J Am Chem Soc 2004 0.75
111 Separating vesicle fusion and exocytosis in hypertonic conditions. Ann N Y Acad Sci 2002 0.75