Published in Channels (Austin) on January 20, 2010
Structure of a KirBac potassium channel with an open bundle crossing indicates a mechanism of channel gating. Nat Struct Mol Biol (2012) 1.18
Dual-mode phospholipid regulation of human inward rectifying potassium channels. Biophys J (2011) 1.14
Direct and specific activation of human inward rectifier K+ channels by membrane phosphatidylinositol 4,5-bisphosphate. J Biol Chem (2010) 1.09
Cholesterol sensitivity of KIR2.1 is controlled by a belt of residues around the cytosolic pore. Biophys J (2011) 0.97
Enantioselective protein-sterol interactions mediate regulation of both prokaryotic and eukaryotic inward rectifier K+ channels by cholesterol. PLoS One (2011) 0.96
Genetic defects in the hotspot of inwardly rectifying K(+) (Kir) channels and their metabolic consequences: a review. Mol Genet Metab (2011) 0.95
Functional complementation and genetic deletion studies of KirBac channels: activatory mutations highlight gating-sensitive domains. J Biol Chem (2010) 0.92
Cholesterol regulates prokaryotic Kir channel by direct binding to channel protein. Biochim Biophys Acta (2011) 0.87
Distant cytosolic residues mediate a two-way molecular switch that controls the modulation of inwardly rectifying potassium (Kir) channels by cholesterol and phosphatidylinositol 4,5-bisphosphate (PI(4,5)P(2)). J Biol Chem (2012) 0.83
Identification of novel cholesterol-binding regions in Kir2 channels. J Biol Chem (2013) 0.83
Hypercholesterolemia induces up-regulation of KACh cardiac currents via a mechanism independent of phosphatidylinositol 4,5-bisphosphate and Gβγ. J Biol Chem (2011) 0.79
Silencing of Kir2 channels by caveolin-1: cross-talk with cholesterol. J Physiol (2014) 0.79
Cholesterol sensitivity of KIR2.1 depends on functional inter-links between the N and C termini. Channels (Austin) (2013) 0.78
Lovastatin-Induced Phosphatidylinositol-4-Phosphate 5-Kinase Diffusion from Microvilli Stimulates ROMK Channels. J Am Soc Nephrol (2014) 0.77
Cholesterol depletion facilitates recovery from hypotonic cell swelling in CHO cells. Cell Physiol Biochem (2011) 0.77
Identification of a cholesterol-binding pocket in inward rectifier K(+) (Kir) channels. Biophys J (2014) 0.75
Cholesterol up-regulates neuronal G protein-gated inwardly rectifying potassium (GIRK) channel activity in the hippocampus. J Biol Chem (2017) 0.75
Interplay Between Lipid Modulators of Kir2 Channels: Cholesterol and PIP2. Comput Struct Biotechnol J (2014) 0.75
Atherosclerosis--an inflammatory disease. N Engl J Med (1999) 59.28
Truncation of Kir6.2 produces ATP-sensitive K+ channels in the absence of the sulphonylurea receptor. Nature (1997) 6.03
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Crystal structure of a Kir3.1-prokaryotic Kir channel chimera. EMBO J (2007) 3.31
Structural basis of inward rectification: cytoplasmic pore of the G protein-gated inward rectifier GIRK1 at 1.8 A resolution. Cell (2002) 3.26
Cytoplasmic domain structures of Kir2.1 and Kir3.1 show sites for modulating gating and rectification. Nat Neurosci (2005) 3.22
Atherogenesis in perspective: hypercholesterolemia and inflammation as partners in crime. Nat Med (2002) 2.82
Assembly of Trp1 in a signaling complex associated with caveolin-scaffolding lipid raft domains. J Biol Chem (2000) 2.43
Membrane stiffness and channel function. Biochemistry (1996) 2.19
Differential targeting of Shaker-like potassium channels to lipid rafts. J Biol Chem (2000) 2.02
Regulation of sodium channel function by bilayer elasticity: the importance of hydrophobic coupling. Effects of Micelle-forming amphiphiles and cholesterol. J Gen Physiol (2004) 1.83
Isoform-specific localization of voltage-gated K+ channels to distinct lipid raft populations. Targeting of Kv1.5 to caveolae. J Biol Chem (2000) 1.82
Probing the G-protein regulation of GIRK1 and GIRK4, the two subunits of the KACh channel, using functional homomeric mutants. J Biol Chem (1997) 1.73
Membrane cholesterol content modulates activation of volume-regulated anion current in bovine endothelial cells. J Gen Physiol (2000) 1.59
Cholesterol sensitivity and lipid raft targeting of Kir2.1 channels. Biophys J (2004) 1.56
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Modulation of membrane function by cholesterol. Biochimie (1991) 1.53
Modulation of endothelial inward-rectifier K+ current by optical isomers of cholesterol. Biophys J (2002) 1.53
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Variations of membrane cholesterol alter the kinetics of Ca2(+)-dependent K+ channels and membrane fluidity in vascular smooth muscle cells. Pflugers Arch (1989) 1.46
Caveolin-1 expression and membrane cholesterol content modulate N-type calcium channel activity in NG108-15 cells. Biophys J (2005) 1.29
Identification of a C-terminus domain critical for the sensitivity of Kir2.1 to cholesterol. Proc Natl Acad Sci U S A (2009) 1.22
Structural diversity in the cytoplasmic region of G protein-gated inward rectifier K+ channels. Channels (Austin) (2007) 1.20
Hypercholesterolemia inhibits L-type calcium current in coronary macro-, not microcirculation. J Appl Physiol (1985) (2004) 1.18
Hypercholesterolemia abolishes voltage-dependent K+ channel contribution to adenosine-mediated relaxation in porcine coronary arterioles. Am J Physiol Heart Circ Physiol (2004) 1.14
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K(ATP) channel opening is an endogenous mechanism of protection against the no-reflow phenomenon but its function is compromised by hypercholesterolemia. J Am Coll Cardiol (2002) 1.07
Distinct detergent-resistant membrane microdomains (lipid rafts) respectively harvest K(+) and water transport systems in brain astroglia. Eur J Neurosci (2007) 0.98
Sensitivity of volume-regulated anion current to cholesterol structural analogues. J Gen Physiol (2004) 0.98
The effect of hypercholesterolemia on the sodium inward currents in cardiac myocyte. J Mol Cell Cardiol (1995) 0.97
The neural cell adhesion molecule regulates cell-surface delivery of G-protein-activated inwardly rectifying potassium channels via lipid rafts. J Neurosci (2002) 0.96
Cholesterol and Kir channels. IUBMB Life (2009) 0.94
Cellular domains that contribute to Ca2+ entry events. Sci STKE (2004) 0.94
Epithelial sodium channel activity in detergent-resistant membrane microdomains. Am J Physiol Renal Physiol (2002) 0.88
Altered effects of potassium channel modulation in the coronary circulation in experimental hypercholesterolemia. Atherosclerosis (2001) 0.83
PIP(2) activates KCNQ channels, and its hydrolysis underlies receptor-mediated inhibition of M currents. Neuron (2003) 4.46
PI(4,5)P2 regulates the activation and desensitization of TRPM8 channels through the TRP domain. Nat Neurosci (2005) 4.00
Use of cyclodextrins to manipulate plasma membrane cholesterol content: evidence, misconceptions and control strategies. Biochim Biophys Acta (2007) 3.83
Alterations in conserved Kir channel-PIP2 interactions underlie channelopathies. Neuron (2002) 3.37
Decoding the signaling of a GPCR heteromeric complex reveals a unifying mechanism of action of antipsychotic drugs. Cell (2011) 2.55
Specificity of activation by phosphoinositides determines lipid regulation of Kir channels. Proc Natl Acad Sci U S A (2003) 2.04
Characteristic interactions with phosphatidylinositol 4,5-bisphosphate determine regulation of kir channels by diverse modulators. J Biol Chem (2004) 1.89
Hypercholesterolemia suppresses inwardly rectifying K+ channels in aortic endothelium in vitro and in vivo. Circ Res (2006) 1.85
The (beta)gamma subunits of G proteins gate a K(+) channel by pivoted bending of a transmembrane segment. Mol Cell (2002) 1.74
Cholesterol depletion increases membrane stiffness of aortic endothelial cells. Biophys J (2004) 1.71
N-terminal transmembrane domain of the SUR controls trafficking and gating of Kir6 channel subunits. EMBO J (2003) 1.68
Phosphatidylinositol-4,5-bisphosphate regulates NMDA receptor activity through alpha-actinin. J Neurosci (2007) 1.67
The effect of cellular cholesterol on membrane-cytoskeleton adhesion. J Cell Sci (2007) 1.64
Cholesterol sensitivity and lipid raft targeting of Kir2.1 channels. Biophys J (2004) 1.56
Modulation of endothelial inward-rectifier K+ current by optical isomers of cholesterol. Biophys J (2002) 1.53
PIP2 hydrolysis underlies agonist-induced inhibition and regulates voltage gating of two-pore domain K+ channels. J Physiol (2005) 1.33
Endothelial actin and cell stiffness is modulated by substrate stiffness in 2D and 3D. J Biomech (2009) 1.31
CXCR4 modulates contractility in adult cardiac myocytes. J Mol Cell Cardiol (2006) 1.31
Identification of critical residues controlling G protein-gated inwardly rectifying K(+) channel activity through interactions with the beta gamma subunits of G proteins. J Biol Chem (2001) 1.31
New mechanisms of pulmonary arterial hypertension: role of Ca²⁺ signaling. Am J Physiol Heart Circ Physiol (2012) 1.24
Identification of a C-terminus domain critical for the sensitivity of Kir2.1 to cholesterol. Proc Natl Acad Sci U S A (2009) 1.22
Molecular characteristics of phosphoinositide binding. Pflugers Arch (2007) 1.22
Assaying phosphatidylinositol bisphosphate regulation of potassium channels. Methods Enzymol (2002) 1.21
OxLDL increases endothelial stiffness, force generation, and network formation. J Lipid Res (2006) 1.20
Functional expression of Kir2.x in human aortic endothelial cells: the dominant role of Kir2.2. Am J Physiol Cell Physiol (2005) 1.16
Shear stress increases expression of a KATP channel in rat and bovine pulmonary vascular endothelial cells. Am J Physiol Cell Physiol (2003) 1.15
PIP2 controls voltage-sensor movement and pore opening of Kv channels through the S4-S5 linker. Proc Natl Acad Sci U S A (2012) 1.13
A molecular dynamics investigation of lipid bilayer perturbation by PIP2. Biophys J (2010) 1.12
The molecular mechanism by which PIP(2) opens the intracellular G-loop gate of a Kir3.1 channel. Biophys J (2012) 1.10
Direct regulation of prokaryotic Kir channel by cholesterol. J Biol Chem (2009) 1.09
A sodium-mediated structural switch that controls the sensitivity of Kir channels to PtdIns(4,5)P(2). Nat Chem Biol (2008) 1.07
PIP(2) regulates the ionic current of P2X receptors and P2X(7) receptor-mediated cell death. Channels (Austin) (2007) 1.05
Relationship between Kir2.1/Kir2.3 activity and their distributions between cholesterol-rich and cholesterol-poor membrane domains. Am J Physiol Cell Physiol (2007) 1.05
Phosphatidylinositol-4,5-bisphosphate regulates epidermal growth factor receptor activation. Pflugers Arch (2010) 1.04
The RCK2 domain uses a coordination site present in Kir channels to confer sodium sensitivity to Slo2.2 channels. J Neurosci (2010) 1.03
oxLDL-induced decrease in lipid order of membrane domains is inversely correlated with endothelial stiffness and network formation. Am J Physiol Cell Physiol (2010) 1.01
Protein kinase A modulates PLC-dependent regulation and PIP2-sensitivity of K+ channels. Channels (Austin) (2007) 1.01
Gating of a G protein-sensitive mammalian Kir3.1 prokaryotic Kir channel chimera in planar lipid bilayers. J Biol Chem (2010) 1.00
An inactivation gate in the selectivity filter of KCNQ1 potassium channels. Biophys J (2007) 0.98
Sensitivity of volume-regulated anion current to cholesterol structural analogues. J Gen Physiol (2004) 0.98
New roles for a key glycine and its neighboring residue in potassium channel gating. Biophys J (2006) 0.98
G beta gamma and KACh: old story, new insights. Sci STKE (2003) 0.98
Novel role of p66Shc in ROS-dependent VEGF signaling and angiogenesis in endothelial cells. Am J Physiol Heart Circ Physiol (2011) 0.97
Cholesterol sensitivity of KIR2.1 is controlled by a belt of residues around the cytosolic pore. Biophys J (2011) 0.97
Modification of Cellular Cholesterol Content Affects Traction Force, Adhesion and Cell Spreading. Cell Mol Bioeng (2010) 0.96
Mechanism of PLC-mediated Kir3 current inhibition. Channels (Austin) (2007) 0.94
Direct modulation of P2X1 receptor-channels by the lipid phosphatidylinositol 4,5-bisphosphate. Mol Pharmacol (2008) 0.92
Plasma membrane surface increases with tonic stretch of alveolar epithelial cells. Am J Respir Cell Mol Biol (2004) 0.92
Dynamic changes in phosphoinositide levels control ion channel activity. Pflugers Arch (2007) 0.91
Dual Regulation of Voltage-Sensitive Ion Channels by PIP(2). Front Pharmacol (2012) 0.91
Uric acid transport. Curr Opin Nephrol Hypertens (2003) 0.91
Gbeta residues that do not interact with Galpha underlie agonist-independent activity of K+ channels. J Biol Chem (2001) 0.91
oxLDL facilitates flow-induced realignment of aortic endothelial cells. Am J Physiol Cell Physiol (2008) 0.90
Galectin 9 is the sugar-regulated urate transporter/channel UAT. Glycoconj J (2004) 0.90
OxLDL and substrate stiffness promote neutrophil transmigration by enhanced endothelial cell contractility and ICAM-1. J Biomech (2012) 0.89
Cytosolic malate dehydrogenase confers selectivity of the nucleic acid-conducting channel. Proc Natl Acad Sci U S A (2002) 0.89
Potassium channel gating in the absence of the highly conserved glycine of the inner transmembrane helix. Channels (Austin) (2007) 0.89
Molecular determinants responsible for differential cellular distribution of G protein-gated inwardly rectifying K+ channels. J Biol Chem (2003) 0.89
Specificity of Gbetagamma signaling to Kir3 channels depends on the helical domain of pertussis toxin-sensitive Galpha subunits. J Biol Chem (2007) 0.88
Hypercholesterolemia suppresses Kir channels in porcine bone marrow progenitor cells in vivo. Biochem Biophys Res Commun (2007) 0.88
Distinct sites on G protein beta gamma subunits regulate different effector functions. J Biol Chem (2002) 0.88
Regulation of ion channels by membrane lipids. Compr Physiol (2012) 0.87
The cytosolic GH loop regulates the phosphatidylinositol 4,5-bisphosphate-induced gating kinetics of Kir2 channels. J Biol Chem (2012) 0.87
Cholesterol regulates prokaryotic Kir channel by direct binding to channel protein. Biochim Biophys Acta (2011) 0.87
The role of oxysterols in control of endothelial stiffness. J Lipid Res (2012) 0.87
Regulation of ATP-gated P2X receptors by phosphoinositides. Pflugers Arch (2007) 0.87
Phosphatidylinositol 4,5-bisphosphate activates Slo3 currents and its hydrolysis underlies the epidermal growth factor-induced current inhibition. J Biol Chem (2010) 0.84
A computational model predicts that Gβγ acts at a cleft between channel subunits to activate GIRK1 channels. Sci Signal (2013) 0.84
Critical determinants of the G protein gamma subunits in the Gbetagamma stimulation of G protein-activated inwardly rectifying potassium (GIRK) channel activity. J Biol Chem (2003) 0.84
How cholesterol regulates endothelial biomechanics. Front Physiol (2012) 0.84
Stoichiometry of Kir channels with phosphatidylinositol bisphosphate. Channels (Austin) (2008) 0.83
Micropipette aspiration of substrate-attached cells to estimate cell stiffness. J Vis Exp (2012) 0.83
Identification of novel cholesterol-binding regions in Kir2 channels. J Biol Chem (2013) 0.83
Distant cytosolic residues mediate a two-way molecular switch that controls the modulation of inwardly rectifying potassium (Kir) channels by cholesterol and phosphatidylinositol 4,5-bisphosphate (PI(4,5)P(2)). J Biol Chem (2012) 0.83
Anthrax lethal factor activates K(+) channels to induce IL-1β secretion in macrophages. J Immunol (2011) 0.81
Hydrogen-bonding dynamics between adjacent blades in G-protein beta-subunit regulates GIRK channel activation. Biophys J (2006) 0.80
G protein {beta}{gamma} gating confers volatile anesthetic inhibition to Kir3 channels. J Biol Chem (2010) 0.80
Hypercholesterolemia induces up-regulation of KACh cardiac currents via a mechanism independent of phosphatidylinositol 4,5-bisphosphate and Gβγ. J Biol Chem (2011) 0.79
Influence of membrane cholesterol and substrate elasticity on endothelial cell spreading behavior. J Biomed Mater Res A (2012) 0.78
SLO-2 isoforms with unique Ca(2+) - and voltage-dependence characteristics confer sensitivity to hypoxia in C. elegans. Channels (Austin) (2013) 0.78
Mass spectrometric analysis reveals a functionally important PKA phosphorylation site in a Kir3 channel subunit. Pflugers Arch (2009) 0.78
Cholesterol sensitivity of KIR2.1 depends on functional inter-links between the N and C termini. Channels (Austin) (2013) 0.78
A unique alkaline pH-regulated and fatty acid-activated tandem pore domain potassium channel (K₂P) from a marine sponge. J Exp Biol (2012) 0.77
Cholesterol depletion facilitates recovery from hypotonic cell swelling in CHO cells. Cell Physiol Biochem (2011) 0.77
Oxidized low-density lipoprotein alters the effect of matrix stiffness on the formation of endothelial networks and capillary lumens. Pulm Circ (2013) 0.77
Specificity of Gbetagamma signaling depends on Galpha subunit coupling with G-protein-sensitive K(+) channels. Pharmacology (2009) 0.77
Localization of the nucleic acid channel regulatory subunit, cytosolic malate dehydrogenase. J Membr Biol (2008) 0.77
GIRK channel trafficking: different paths for different family members. Mol Interv (2002) 0.76
The where and how of PIP regulation of cone photoreceptor CNG channels. J Gen Physiol (2013) 0.76
Wicking: a rapid method for manually inserting ion channels into planar lipid bilayers. PLoS One (2013) 0.76
Dual effect of fluid shear stress on volume-regulated anion current in bovine aortic endothelial cells. Am J Physiol Cell Physiol (2002) 0.76
Side-chain interactions in the regulatory domain of human glutamate dehydrogenase determine basal activity and regulation. J Neurochem (2015) 0.75
Exploring the Nanotoxicology of MoS2: A Study on the Interaction of MoS2 Nanoflake and K+ Channels. ACS Nano (2017) 0.75
Preface. Curr Top Membr (2017) 0.75