Published in Exp Physiol on November 27, 2009
Glutathione oxidation unmasks proarrhythmic vulnerability of chronically hyperglycemic guinea pigs. Am J Physiol Heart Circ Physiol (2013) 0.84
Streptozotocin-induced diabetes prolongs twitch duration without affecting the energetics of isolated ventricular trabeculae. Cardiovasc Diabetol (2014) 0.80
Electrophysiological properties of myocytes isolated from the mouse atrioventricular node: L-type ICa, IKr, If, and Na-Ca exchange. Physiol Rep (2015) 0.79
Different Profile of mRNA Expression in Sinoatrial Node from Streptozotocin-Induced Diabetic Rat. PLoS One (2016) 0.75
Characterization of L-type calcium channel activity in atrioventricular nodal myocytes from rats with streptozotocin-induced Diabetes mellitus. Physiol Rep (2015) 0.75
Pharmacogenomics of cardiovascular complications in diabetes and obesity. Recent Pat Biotechnol (2014) 0.75
Experimental conversion of liver to pancreas. Curr Biol (2003) 2.24
Erythropoietin mediates hepcidin expression in hepatocytes through EPOR signaling and regulation of C/EBPalpha. Blood (2008) 1.88
Sex, drugs and arrhythmia: are gender differences in risk of torsades de pointes simply a matter of testosterone? Cardiovasc Res (2003) 1.62
A novel, voltage-dependent nonselective cation current activated by insulin in guinea pig isolated ventricular myocytes. Circ Res (2003) 1.59
Beta cells occur naturally in extrahepatic bile ducts of mice. J Cell Sci (2006) 1.58
The Lambeth Conventions (II): guidelines for the study of animal and human ventricular and supraventricular arrhythmias. Pharmacol Ther (2013) 1.50
Isolation and culture of adult mouse hepatocytes. Methods Mol Biol (2010) 1.43
Inhibitory actions of the selective serotonin re-uptake inhibitor citalopram on HERG and ventricular L-type calcium currents. FEBS Lett (2002) 1.41
Blockade of HERG potassium currents by fluvoxamine: incomplete attenuation by S6 mutations at F656 or Y652. Br J Pharmacol (2003) 1.41
Recent advances in understanding sex differences in cardiac repolarization. Prog Biophys Mol Biol (2005) 1.38
Conversion of columnar to stratified squamous epithelium in the developing mouse oesophagus. Dev Biol (2005) 1.36
Psychotropic drugs, cardiac arrhythmia, and sudden death. J Clin Psychopharmacol (2003) 1.36
A novel chemically directed route for the generation of definitive endoderm from human embryonic stem cells based on inhibition of GSK-3. J Cell Sci (2011) 1.30
Application of micro-computed tomography with iodine staining to cardiac imaging, segmentation, and computational model development. IEEE Trans Med Imaging (2012) 1.29
Liver zonation occurs through a beta-catenin-dependent, c-Myc-independent mechanism. Gastroenterology (2009) 1.25
In vitro transdifferentiation of hepatoma cells into functional pancreatic cells. Mech Dev (2005) 1.23
Mechanistic links between Na+ channel (SCN5A) mutations and impaired cardiac pacemaking in sick sinus syndrome. Circ Res (2010) 1.18
Pro-arrhythmogenic effects of atrial fibrillation-induced electrical remodelling: insights from the three-dimensional virtual human atria. J Physiol (2013) 1.18
The low-potency, voltage-dependent HERG blocker propafenone--molecular determinants and drug trapping. Mol Pharmacol (2004) 1.17
Genetic dissection of differential signaling threshold requirements for the Wnt/beta-catenin pathway in vivo. PLoS Genet (2010) 1.16
Role of voltage-gated sodium, potassium and calcium channels in the development of cocaine-associated cardiac arrhythmias. Br J Clin Pharmacol (2010) 1.16
Constitutively active Akt1 expression in mouse pancreas requires S6 kinase 1 for insulinoma formation. J Clin Invest (2008) 1.11
Computer three-dimensional reconstruction of the atrioventricular node. Circ Res (2008) 1.11
A TRPC-like non-selective cation current activated by alpha 1-adrenoceptors in rat mesenteric artery smooth muscle cells. Cell Calcium (2006) 1.11
Ionic mechanisms for electrical heterogeneity between rabbit Purkinje fiber and ventricular cells. Biophys J (2010) 1.11
The N588K-HERG K+ channel mutation in the 'short QT syndrome': mechanism of gain-in-function determined at 37 degrees C. Biochem Biophys Res Commun (2005) 1.08
Troubleshooting problems with in vitro screening of drugs for QT interval prolongation using HERG K+ channels expressed in mammalian cell lines and Xenopus oocytes. J Pharmacol Toxicol Methods (2003) 1.07
Mechanism of hERG K+ channel blockade by the fluoroquinolone antibiotic moxifloxacin. Br J Pharmacol (2006) 1.07
VEGF-mediated elevated intracellular calcium and angiogenesis in human microvascular endothelial cells in vitro are inhibited by dominant negative TRPC6. Microcirculation (2008) 1.05
Evolution and pharmacological modulation of the arrhythmogenic wave dynamics in canine pulmonary vein model. Europace (2014) 1.05
High affinity HERG K(+) channel blockade by the antiarrhythmic agent dronedarone: resistance to mutations of the S6 residues Y652 and F656. Biochem Biophys Res Commun (2004) 1.04
Disopyramide is an effective inhibitor of mutant HERG K+ channels involved in variant 1 short QT syndrome. J Mol Cell Cardiol (2006) 1.03
Effects of cell swelling on intracellular calcium and membrane currents in bovine articular chondrocytes. J Cell Biochem (2002) 1.02
Transdifferentiation, metaplasia and tissue regeneration. Organogenesis (2004) 1.02
The molecular basis of transdifferentiation. J Cell Mol Med (2005) 1.01
KCNE5 (KCNE1L) variants are novel modulators of Brugada syndrome and idiopathic ventricular fibrillation. Circ Arrhythm Electrophysiol (2011) 1.01
Regulation of cardiac Na+-Ca2+ exchanger activity by protein kinase phosphorylation--still a paradox? Cell Calcium (2008) 1.01
Transdifferentiation in developmental biology, disease, and in therapy. Dev Dyn (2007) 1.00
Transdifferentiation of pancreas to liver. Mech Dev (2003) 0.98
Inhibition of the current of heterologously expressed HERG potassium channels by flecainide and comparison with quinidine, propafenone and lignocaine. Br J Pharmacol (2002) 0.98
How does inflammation cause Barrett's metaplasia? Curr Opin Pharmacol (2009) 0.96
Acidosis inhibits spontaneous activity and membrane currents in myocytes isolated from the rabbit atrioventricular node. J Mol Cell Cardiol (2008) 0.95
Increased susceptibility to atrial tachyarrhythmia in spontaneously hypertensive rat hearts. Hypertension (2007) 0.95
Glucocorticoids suppress beta-cell development and induce hepatic metaplasia in embryonic pancreas. Biochem J (2003) 0.95
Investigating dynamic protocol-dependence of hERG potassium channel inhibition at 37 degrees C: Cisapride versus dofetilide. J Pharmacol Toxicol Methods (2010) 0.95
Atrial proarrhythmia due to increased inward rectifier current (I(K1)) arising from KCNJ2 mutation--a simulation study. Prog Biophys Mol Biol (2008) 0.95
Atrial remodeling and the substrate for atrial fibrillation in rat hearts with elevated afterload. Circ Arrhythm Electrophysiol (2011) 0.94
Preferential closed channel blockade of HERG potassium currents by chemically synthesised BeKm-1 scorpion toxin. FEBS Lett (2003) 0.94
Hepatic differentiation of murine embryonic stem cells. Exp Cell Res (2002) 0.94
Induction and regulation of acute phase proteins in transdifferentiated hepatocytes. Exp Cell Res (2004) 0.93
Topical antiangiogenic SRPK1 inhibitors reduce choroidal neovascularization in rodent models of exudative AMD. Invest Ophthalmol Vis Sci (2013) 0.92
In silico investigation of the short QT syndrome, using human ventricle models incorporating electromechanical coupling. Front Physiol (2013) 0.91
In vitro culture of embryonic mouse intestinal epithelium: cell differentiation and introduction of reporter genes. BMC Dev Biol (2006) 0.91
Inhibition of spontaneous activity of rabbit atrioventricular node cells by KB-R7943 and inhibitors of sarcoplasmic reticulum Ca(2+) ATPase. Cell Calcium (2010) 0.91
Methadone, QTc interval prolongation and torsade de pointes: Case reports offer the best understanding of this problem. Ther Adv Psychopharmacol (2013) 0.90
Proarrhythmia in KCNJ2-linked short QT syndrome: insights from modelling. Cardiovasc Res (2012) 0.90
Characterisation of recombinant HERG K+ channel blockade by the Class Ia antiarrhythmic drug procainamide. Biochem Biophys Res Commun (2003) 0.90
Risperidone, QTc interval prolongation, and torsade de pointes: a systematic review of case reports. Psychopharmacology (Berl) (2013) 0.90
Is timing everything? Therapeutic potential of modulators of cardiac Na(+) transporters. Expert Opin Investig Drugs (2003) 0.89
Characteristics of single cells isolated from the atrioventricular node of the adult guinea-pig heart. Pflugers Arch (2002) 0.89
Keratinocyte serum-free medium maintains long-term liver gene expression and function in cultured rat hepatocytes by preventing the loss of liver-enriched transcription factors. Int J Biochem Cell Biol (2006) 0.89
Lidoflazine is a high affinity blocker of the HERG K(+)channel. J Mol Cell Cardiol (2004) 0.89
Gender-related differences in ventricular myocyte repolarization in the guinea pig. Basic Res Cardiol (2003) 0.88
Assessing hERG pore models as templates for drug docking using published experimental constraints: the inactivated state in the context of drug block. J Chem Inf Model (2014) 0.88
Action potential clamp and chloroquine sensitivity of mutant Kir2.1 channels responsible for variant 3 short QT syndrome. J Mol Cell Cardiol (2009) 0.88
In silico study of action potential and QT interval shortening due to loss of inactivation of the cardiac rapid delayed rectifier potassium current. Biochem Biophys Res Commun (2004) 0.88
Stem cells in the adult pancreas and liver. Biochem J (2007) 0.88
Torsades de pointes following clarithromycin treatment. Expert Rev Cardiovasc Ther (2013) 0.88
Molecular determinants of hERG potassium channel inhibition by disopyramide. J Mol Cell Cardiol (2011) 0.88
Erythromycin block of the HERG K+ channel: accessibility to F656 and Y652. Biochem Biophys Res Commun (2006) 0.88
Increased vulnerability of human ventricle to re-entrant excitation in hERG-linked variant 1 short QT syndrome. PLoS Comput Biol (2011) 0.87
The Wnt/beta-catenin pathway: master regulator of liver zonation? Bioessays (2006) 0.87
Inhibition of the HERG K+ channel by the antifungal drug ketoconazole depends on channel gating and involves the S6 residue F656. FEBS Lett (2006) 0.87
Dexamethasone treatment induces the reprogramming of pancreatic acinar cells to hepatocytes and ductal cells. PLoS One (2010) 0.87
Repolarisation and vulnerability to re-entry in the human heart with short QT syndrome arising from KCNQ1 mutation--a simulation study. Prog Biophys Mol Biol (2007) 0.86
Human cardiac tissue induces transdifferentiation of adult stem cells towards cardiomyocytes. Cytotherapy (2010) 0.86
Pro-arrhythmogenic effects of the S140G KCNQ1 mutation in human atrial fibrillation - insights from modelling. J Physiol (2012) 0.86
Characterization of liver function in transdifferentiated hepatocytes. J Cell Physiol (2006) 0.86
Modeling the chronotropic effect of isoprenaline on rabbit sinoatrial node. Front Physiol (2012) 0.86
Therapeutic potential of transdifferentiated cells. Clin Sci (Lond) (2005) 0.85
hERG K+ channel blockade by the antipsychotic drug thioridazine: An obligatory role for the S6 helix residue F656. Biochem Biophys Res Commun (2006) 0.85
Acidosis impairs the protective role of hERG K(+) channels against premature stimulation. J Cardiovasc Electrophysiol (2010) 0.85
Interactions between voltage sensor and pore domains in a hERG K+ channel model from molecular simulations and the effects of a voltage sensor mutation. J Chem Inf Model (2013) 0.85
The hERG K(+) channel S4 domain L532P mutation: characterization at 37°C. Biochim Biophys Acta (2011) 0.85
N- and C-terminal KCNE1 mutations cause distinct phenotypes of long QT syndrome. Heart Rhythm (2006) 0.85
Differentiation of pancreatic acinar cells to hepatocytes requires an intermediate cell type. Gastroenterology (2010) 0.85
Isolation and culture of embryonic pancreas and liver. Methods Mol Biol (2010) 0.84
Clemastine, a conventional antihistamine, is a high potency inhibitor of the HERG K+ channel. J Mol Cell Cardiol (2005) 0.84
All-trans retinoic acid suppresses exocrine differentiation and branching morphogenesis in the embryonic pancreas. Differentiation (2007) 0.83
The sodium channel Nav1.5a is the predominant isoform expressed in adult mouse dorsal root ganglia and exhibits distinct inactivation properties from the full-length Nav1.5 channel. Mol Cell Neurosci (2007) 0.83
Cdx genes, inflammation and the pathogenesis of Barrett's metaplasia. Trends Mol Med (2009) 0.83
Cardiac safety concerns for domperidone, an antiemetic and prokinetic, and galactogogue medicine. Expert Opin Drug Saf (2013) 0.82
Activation of glibenclamide-sensitive ATP-sensitive K+ channels during β-adrenergically induced metabolic stress produces a substrate for atrial tachyarrhythmia. Circ Arrhythm Electrophysiol (2012) 0.82
Characterization of recombinant hERG K(+) channel inhibition by the active metabolite of amiodarone desethyl-amiodarone. J Electrocardiol (2010) 0.82
C/EBPalpha and C/EBPbeta are markers of early liver development. Int J Dev Biol (2006) 0.82
Xanthine oxidoreductase is present in bile ducts of normal and cirrhotic liver. Free Radic Biol Med (2004) 0.82
Liver specification: a new role for Wnts in liver development. Curr Biol (2006) 0.82
Quetiapine and the need for a thorough QT/QTc study. J Clin Psychopharmacol (2014) 0.81
Molecular aspects of esophageal development. Ann N Y Acad Sci (2011) 0.81
Hepatic progenitor cells. Cell Tissue Res (2010) 0.81