Published in Hum Mol Genet on December 03, 2009
FcgammaRIIB in autoimmunity and infection: evolutionary and therapeutic implications. Nat Rev Immunol (2010) 2.44
Major histocompatibility complex genomics and human disease. Annu Rev Genomics Hum Genet (2013) 1.75
Copy number variation leads to considerable diversity for B but not A haplotypes of the human KIR genes encoding NK cell receptors. Genome Res (2012) 1.60
Complete haplotype sequence of the human immunoglobulin heavy-chain variable, diversity, and joining genes and characterization of allelic and copy-number variation. Am J Hum Genet (2013) 1.29
Immunogenetics of HIV disease. Immunol Rev (2013) 1.25
Primate-specific regulation of natural killer cells. J Med Primatol (2010) 1.14
Exploring the role of copy number variants in human adaptation. Trends Genet (2012) 1.14
Variable NK cell receptors exemplified by human KIR3DL1/S1. J Immunol (2011) 1.12
Immunogenetics as a tool in anthropological studies. Immunology (2011) 1.11
Allele-level haplotype frequencies and pairwise linkage disequilibrium for 14 KIR loci in 506 European-American individuals. PLoS One (2012) 1.02
Allelic variation in KIR2DL3 generates a KIR2DL2-like receptor with increased binding to its HLA-C ligand. J Immunol (2013) 1.00
Recombinant structures expand and contract inter and intragenic diversification at the KIR locus. BMC Genomics (2013) 0.98
The role of KIR genes and their cognate HLA class I ligands in childhood acute lymphoblastic leukemia. Blood (2014) 0.92
Conserved KIR allele-level haplotypes are altered by microvariation in individuals with European ancestry. Genes Immun (2011) 0.91
Killer-cell Immunoglobulin-like Receptor gene linkage and copy number variation analysis by droplet digital PCR. Genome Med (2014) 0.88
Natural killer cells and their receptors in multiple sclerosis. Brain (2012) 0.87
Co-evolution of MHC class I and variable NK cell receptors in placental mammals. Immunol Rev (2015) 0.85
Copy number and nucleotide variation of the LILR family of myelomonocytic cell activating and inhibitory receptors. Immunogenetics (2013) 0.83
Role of KIR3DS1 in human diseases. Front Immunol (2012) 0.83
Sequence of a complete chicken BG haplotype shows dynamic expansion and contraction of two gene lineages with particular expression patterns. PLoS Genet (2014) 0.83
Immune mechanisms and the impact of the disrupted lung microbiome in chronic bacterial lung infection and bronchiectasis. Clin Exp Immunol (2013) 0.82
The role of KIR and HLA interactions in pregnancy complications. Immunogenetics (2017) 0.81
Immune selection during tumor checkpoint inhibition therapy paves way for NK-cell "missing self" recognition. Immunogenetics (2017) 0.80
Time to seroconversion in HIV-exposed subjects carrying protective versus non protective KIR3DS1/L1 and HLA-B genotypes. PLoS One (2014) 0.80
Extensive variation in gene copy number at the killer immunoglobulin-like receptor locus in humans. PLoS One (2013) 0.80
KIR2DL4 copy number variation is associated with CD4+ T-cell depletion and function of cytokine-producing NK cell subsets in SIV-infected Mamu-A*01-negative rhesus macaques. J Virol (2013) 0.80
Deciphering the KIR system at super-resolution for NK and T cell biology. Immunology (2016) 0.79
The characteristics of allelic polymorphism in killer-immunoglobulin-like receptor framework genes in African Americans. Immunogenetics (2011) 0.78
Skin Cancer Risk Is Modified by KIR/HLA Interactions That Influence the Activation of Natural Killer Immune Cells. Cancer Res (2016) 0.77
Two new cases of KIR3DP1, KIR2DL4-negative genotypes, one of which is also lacking KIR3DL2. Arch Immunol Ther Exp (Warsz) (2014) 0.77
Resurrecting KIR2DP1: A Key Intermediate in the Evolution of Human Inhibitory NK Cell Receptors That Recognize HLA-C. J Immunol (2017) 0.76
qKAT: a high-throughput qPCR method for KIR gene copy number and haplotype determination. Genome Med (2016) 0.75
KIR2DL2/2DL3-E(35) alleles are functionally stronger than -Q(35) alleles. Sci Rep (2016) 0.75
Novel insights in the genomic organization and hotspots of recombination in the human KIR locus through analysis of intergenic regions. Genes Immun (2014) 0.75
Revealing complete complex KIR haplotypes phased by long-read sequencing technology. Genes Immun (2017) 0.75
Killer Immunoglobulin-Like Receptor Allele Determination Using Next-Generation Sequencing Technology. Front Immunol (2017) 0.75
The identification of additional zebrafish DICP genes reveals haplotype variation and linkage to MHC class I genes. Immunogenetics (2016) 0.75
Initial sequencing and analysis of the human genome. Nature (2001) 212.86
The sequence of the human genome. Science (2001) 101.55
Detection of large-scale variation in the human genome. Nat Genet (2004) 49.18
Mapping and sequencing of structural variation from eight human genomes. Nature (2008) 30.28
A fine-scale map of recombination rates and hotspots across the human genome. Science (2005) 26.82
Structural variation in the human genome. Nat Rev Genet (2006) 21.40
A common sequence motif associated with recombination hot spots and genome instability in humans. Nat Genet (2008) 8.64
MHC class I molecules and KIRs in human history, health and survival. Nat Rev Immunol (2005) 6.98
Innate partnership of HLA-B and KIR3DL1 subtypes against HIV-1. Nat Genet (2007) 6.83
An Alu transposition model for the origin and expansion of human segmental duplications. Am J Hum Genet (2003) 5.33
The fine-scale and complex architecture of human copy-number variation. Am J Hum Genet (2008) 5.08
Human diversity in killer cell inhibitory receptor genes. Immunity (1997) 4.82
The DNA sequence and analysis of human chromosome 6. Nature (2003) 4.75
Germline rates of de novo meiotic deletions and duplications causing several genomic disorders. Nat Genet (2007) 4.59
Mechanisms for human genomic rearrangements. Pathogenetics (2008) 4.54
Implications of human genome architecture for rearrangement-based disorders: the genomic basis of disease. Hum Mol Genet (2004) 4.47
Three-dimensional maps of all chromosomes in human male fibroblast nuclei and prometaphase rosettes. PLoS Biol (2005) 4.33
The average number of generations until extinction of an individual mutant gene in a finite population. Genetics (1969) 3.49
Human genomic deletions mediated by recombination between Alu elements. Am J Hum Genet (2006) 3.15
Plasticity in the organization and sequences of human KIR/ILT gene families. Proc Natl Acad Sci U S A (2000) 3.09
Genetic analysis of completely sequenced disease-associated MHC haplotypes identifies shuffling of segments in recent human history. PLoS Genet (2006) 2.80
The killer immunoglobulin-like receptor gene cluster: tuning the genome for defense. Annu Rev Genomics Hum Genet (2006) 2.43
Killer Ig-like receptor haplotype analysis by gene content: evidence for genomic diversity with a minimum of six basic framework haplotypes, each with multiple subsets. J Immunol (2002) 2.38
Murine major histocompatibility complex class-I mutants: molecular analysis and structure-function implications. Annu Rev Immunol (1986) 2.29
Natural selection drives recurrent formation of activating killer cell immunoglobulin-like receptor and Ly49 from inhibitory homologues. J Exp Med (2005) 2.23
The killer cell immunoglobulin-like receptor (KIR) genomic region: gene-order, haplotypes and allelic polymorphism. Immunol Rev (2002) 2.21
Copy number of FCGR3B, which is associated with systemic lupus erythematosus, correlates with protein expression and immune complex uptake. J Exp Med (2008) 2.13
KIR and disease: a model system or system of models? Immunol Rev (2006) 2.07
Identification of a new, abundant superfamily of mammalian LTR-transposons. Nucleic Acids Res (1993) 2.04
Cutting edge: susceptibility to psoriatic arthritis: influence of activating killer Ig-like receptor genes in the absence of specific HLA-C alleles. J Immunol (2002) 1.95
L1 recombination-associated deletions generate human genomic variation. Proc Natl Acad Sci U S A (2008) 1.79
Allelic polymorphism synergizes with variable gene content to individualize human KIR genotype. J Immunol (2002) 1.79
Relative rates of gene fusion and fission in multi-domain proteins. Trends Genet (2005) 1.75
Genetic control of variegated KIR gene expression: polymorphisms of the bi-directional KIR3DL1 promoter are associated with distinct frequencies of gene expression. PLoS Genet (2008) 1.60
Alu recombination-mediated structural deletions in the chimpanzee genome. PLoS Genet (2007) 1.59
NK cells in innate immunity. Curr Opin Immunol (2005) 1.49
The impact of variation at the KIR gene cluster on human disease. Curr Top Microbiol Immunol (2006) 1.46
Cutting edge: expansion of the KIR locus by unequal crossing over. J Immunol (2003) 1.46
Copy number variation of CCL3-like genes affects rate of progression to simian-AIDS in Rhesus Macaques (Macaca mulatta). PLoS Genet (2009) 1.43
Meiotic recombination generates rich diversity in NK cell receptor genes, alleles, and haplotypes. Genome Res (2009) 1.42
Definition of gene content for nine common group B haplotypes of the Caucasoid population: KIR haplotypes contain between seven and eleven KIR genes. Immunogenetics (2002) 1.37
The current excitement about copy-number variation: how it relates to gene duplications and protein families. Curr Opin Struct Biol (2008) 1.36
The genomic organization and evolution of the natural killer immunoglobulin-like receptor (KIR) gene cluster. Immunogenetics (2000) 1.29
Detection of KIR3DS1 on the cell surface of peripheral blood NK cells facilitates identification of a novel null allele and assessment of KIR3DS1 expression during HIV-1 infection. J Immunol (2007) 1.29
Some human KIR haplotypes contain two KIR2DL5 genes: KIR2DL5A and KIR2DL5B. Immunogenetics (2002) 1.22
KIR haplotype content at the allele level in 77 Northern Irish families. Immunogenetics (2007) 1.19
High KIR diversity in Amerindians is maintained using few gene-content haplotypes. Immunogenetics (2006) 1.17
SNP haplotypes and allele frequencies show evidence for disruptive and balancing selection in the human leukocyte receptor complex. Immunogenetics (2004) 1.15
KIR genes. Transpl Immunol (2005) 1.13
KIR haplotypes defined by segregation analysis in 59 Centre d'Etude Polymorphisme Humain (CEPH) families. Immunogenetics (2008) 1.10
IRIS: a database surveying known human immune system genes. Genomics (2005) 1.03
KIR2DL5, a novel killer-cell receptor with a D0-D2 configuration of Ig-like domains. J Immunol (2000) 0.97
A high-resolution HLA and SNP haplotype map for disease association studies in the extended human MHC. Nat Genet (2006) 15.63
Genetic variation in IL28B and spontaneous clearance of hepatitis C virus. Nature (2009) 13.99
Complete MHC haplotype sequencing for common disease gene mapping. Genome Res (2004) 12.09
Classification criteria for psoriatic arthritis: development of new criteria from a large international study. Arthritis Rheum (2006) 10.39
The major genetic determinants of HIV-1 control affect HLA class I peptide presentation. Science (2010) 9.61
Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways. Nat Genet (2009) 9.45
HLA and NK cell inhibitory receptor genes in resolving hepatitis C virus infection. Science (2004) 8.22
Epistatic interaction between KIR3DS1 and HLA-B delays the progression to AIDS. Nat Genet (2002) 7.58
Derivation and validation of the Systemic Lupus International Collaborating Clinics classification criteria for systemic lupus erythematosus. Arthritis Rheum (2012) 6.85
Innate partnership of HLA-B and KIR3DL1 subtypes against HIV-1. Nat Genet (2007) 6.83
Human NK cell education by inhibitory receptors for MHC class I. Immunity (2006) 6.73
Gene map of the extended human MHC. Nat Rev Genet (2004) 6.01
Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility. Nat Genet (2011) 5.56
Allele frequency net: a database and online repository for immune gene frequencies in worldwide populations. Nucleic Acids Res (2010) 4.62
The high-frequency major histocompatibility complex class I allele Mamu-B*17 is associated with control of simian immunodeficiency virus SIVmac239 replication. J Virol (2006) 4.26
Variation analysis and gene annotation of eight MHC haplotypes: the MHC Haplotype Project. Immunogenetics (2008) 4.25
Pegylated Interferon alfa-2a monotherapy results in suppression of HIV type 1 replication and decreased cell-associated HIV DNA integration. J Infect Dis (2012) 4.24
Sex differences in the Toll-like receptor-mediated response of plasmacytoid dendritic cells to HIV-1. Nat Med (2009) 4.22
HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8(+) T Cell Response against HIV-1. PLoS Med (2006) 4.19
Differential natural killer cell-mediated inhibition of HIV-1 replication based on distinct KIR/HLA subtypes. J Exp Med (2007) 4.14
HLA-A*3101 and carbamazepine-induced hypersensitivity reactions in Europeans. N Engl J Med (2011) 3.93
Combinations of maternal KIR and fetal HLA-C genes influence the risk of preeclampsia and reproductive success. J Exp Med (2004) 3.87
Common genetic variation and the control of HIV-1 in humans. PLoS Genet (2009) 3.68
Mamu-B*08-positive macaques control simian immunodeficiency virus replication. J Virol (2007) 3.61
Effects of thymic selection of the T-cell repertoire on HLA class I-associated control of HIV infection. Nature (2010) 3.57
Influence of HLA-C expression level on HIV control. Science (2013) 3.27
Control of human immunodeficiency virus replication by cytotoxic T lymphocytes targeting subdominant epitopes. Nat Immunol (2005) 3.23
Genetic control of MHC class II expression. Cell (2002) 3.11
HLA-C cell surface expression and control of HIV/AIDS correlate with a variant upstream of HLA-C. Nat Genet (2009) 3.03
AIDS restriction HLA allotypes target distinct intervals of HIV-1 pathogenesis. Nat Med (2005) 2.97
Constitutive and induced expression of DC-SIGN on dendritic cell and macrophage subpopulations in situ and in vitro. J Leukoc Biol (2002) 2.93
Host determinants of HIV-1 control in African Americans. J Infect Dis (2010) 2.90
Genetic analysis of completely sequenced disease-associated MHC haplotypes identifies shuffling of segments in recent human history. PLoS Genet (2006) 2.80
The Yin and Yang of HLA and KIR in human disease. Semin Immunol (2008) 2.72
High-resolution patterns of meiotic recombination across the human major histocompatibility complex. Am J Hum Genet (2002) 2.71
The shaping of modern human immune systems by multiregional admixture with archaic humans. Science (2011) 2.63
HIV-1 adaptation to NK-cell-mediated immune pressure. Nature (2011) 2.59
Human immunodeficiency virus type 1-specific CD8+ T-cell responses during primary infection are major determinants of the viral set point and loss of CD4+ T cells. J Virol (2009) 2.51
Golimumab, a new human tumor necrosis factor alpha antibody, administered every four weeks as a subcutaneous injection in psoriatic arthritis: Twenty-four-week efficacy and safety results of a randomized, placebo-controlled study. Arthritis Rheum (2009) 2.49
Structural basis for PRYSPRY-mediated tripartite motif (TRIM) protein function. Proc Natl Acad Sci U S A (2007) 2.49
Association of variants at 1q32 and STAT3 with ankylosing spondylitis suggests genetic overlap with Crohn's disease. PLoS Genet (2010) 2.44
The killer immunoglobulin-like receptor gene cluster: tuning the genome for defense. Annu Rev Genomics Hum Genet (2006) 2.43
Global diversity and evidence for coevolution of KIR and HLA. Nat Genet (2007) 2.40
Coordinate linkage of HIV evolution reveals regions of immunological vulnerability. Proc Natl Acad Sci U S A (2011) 2.37
Differential microRNA regulation of HLA-C expression and its association with HIV control. Nature (2011) 2.36
Sustained benefits of infliximab therapy for dermatologic and articular manifestations of psoriatic arthritis: results from the infliximab multinational psoriatic arthritis controlled trial (IMPACT). Arthritis Rheum (2005) 2.32
Comparative genomics of major histocompatibility complexes. Immunogenetics (2004) 2.31
Canadian Rheumatology Association Consensus on the use of anti-tumor necrosis factor-alpha directed therapies in the treatment of spondyloarthritis. J Rheumatol (2003) 2.30
An integrated haplotype map of the human major histocompatibility complex. Am J Hum Genet (2003) 2.29
Cutting Edge: Allele-specific and peptide-dependent interactions between KIR3DL1 and HLA-A and HLA-B. J Immunol (2007) 2.28
Promiscuity and the single receptor: NKG2D. Nat Rev Immunol (2007) 2.27
National Psoriasis Foundation clinical consensus on psoriasis comorbidities and recommendations for screening. J Am Acad Dermatol (2008) 2.19
Maternal activating KIRs protect against human reproductive failure mediated by fetal HLA-C2. J Clin Invest (2010) 2.19
Abatacept in the treatment of patients with psoriatic arthritis: results of a six-month, multicenter, randomized, double-blind, placebo-controlled, phase II trial. Arthritis Rheum (2011) 2.11
KIR and disease: a model system or system of models? Immunol Rev (2006) 2.07
KIR/HLA pleiotropism: protection against both HIV and opportunistic infections. PLoS Pathog (2006) 2.06
NK cell responses to cytomegalovirus infection lead to stable imprints in the human KIR repertoire and involve activating KIRs. Blood (2013) 2.04
DEC-205 receptor on dendritic cells mediates presentation of HIV gag protein to CD8+ T cells in a spectrum of human MHC I haplotypes. Proc Natl Acad Sci U S A (2007) 2.04
HLA class I subtype-dependent expansion of KIR3DS1+ and KIR3DL1+ NK cells during acute human immunodeficiency virus type 1 infection. J Virol (2009) 2.03
Raji B cells, misidentified as THP-1 cells, stimulate DC-SIGN-mediated HIV transmission. Virology (2004) 2.00
The silent KIR3DP1 gene (CD158c) is transcribed and might encode a secreted receptor in a minority of humans, in whom the KIR3DP1, KIR2DL4 and KIR3DL1/KIR3DS1 genes are duplicated. Eur J Immunol (2005) 2.00
A second major histocompatibility complex susceptibility locus for multiple sclerosis. Ann Neurol (2007) 1.99
Next-generation sequencing for HLA typing of class I loci. BMC Genomics (2011) 1.99
Cutting edge: susceptibility to psoriatic arthritis: influence of activating killer Ig-like receptor genes in the absence of specific HLA-C alleles. J Immunol (2002) 1.95
Functional polymorphism of the KIR3DL1/S1 receptor on human NK cells. J Immunol (2007) 1.94
Balanced polymorphism selected by genetic versus infectious human disease. Annu Rev Genomics Hum Genet (2002) 1.93
Rare and common variants in CARD14, encoding an epidermal regulator of NF-kappaB, in psoriasis. Am J Hum Genet (2012) 1.88
Comparative genomics of natural killer cell receptor gene clusters. PLoS Genet (2005) 1.85
Effects of belimumab, a B lymphocyte stimulator-specific inhibitor, on disease activity across multiple organ domains in patients with systemic lupus erythematosus: combined results from two phase III trials. Ann Rheum Dis (2012) 1.85
Cutting edge: heterozygote advantage in autoimmune disease: hierarchy of protection/susceptibility conferred by HLA and killer Ig-like receptor combinations in psoriatic arthritis. J Immunol (2004) 1.83
HLA-Cw*04 and hepatitis C virus persistence. J Virol (2002) 1.83
Genome-wide association study of spontaneous resolution of hepatitis C virus infection: data from multiple cohorts. Ann Intern Med (2013) 1.82
Adjunctive passive immunotherapy in human immunodeficiency virus type 1-infected individuals treated with antiviral therapy during acute and early infection. J Virol (2007) 1.81
High HLA-DP Expression and Graft-versus-Host Disease. N Engl J Med (2015) 1.74
CCL3L1 and HIV/AIDS susceptibility. Nat Med (2009) 1.73
Peptide antagonism as a mechanism for NK cell activation. Proc Natl Acad Sci U S A (2010) 1.72
DNA methylation maintains allele-specific KIR gene expression in human natural killer cells. J Exp Med (2003) 1.70
You say ITAM and I say ITIM, let's call the whole thing off: the ambiguity of immunoreceptor signalling. Eur J Immunol (2006) 1.70
Relationship between SPRY and B30.2 protein domains. Evolution of a component of immune defence? Immunology (2005) 1.68
Reciprocal regulation of human natural killer cells and macrophages associated with distinct immune synapses. Blood (2007) 1.66
HLA/KIR restraint of HIV: surviving the fittest. Annu Rev Immunol (2011) 1.66
Repeat-region polymorphisms in the gene for the dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin-related molecule: effects on HIV-1 susceptibility. J Infect Dis (2006) 1.62
Copy number variation leads to considerable diversity for B but not A haplotypes of the human KIR genes encoding NK cell receptors. Genome Res (2012) 1.60
Genetic control of variegated KIR gene expression: polymorphisms of the bi-directional KIR3DL1 promoter are associated with distinct frequencies of gene expression. PLoS Genet (2008) 1.60