|
1
|
Impaired B and T cell antigen receptor signaling in p110delta PI 3-kinase mutant mice.
|
Science
|
2002
|
6.01
|
|
2
|
Exploring the specificity of the PI3K family inhibitor LY294002.
|
Biochem J
|
2007
|
2.66
|
|
3
|
A selective PIKfyve inhibitor blocks PtdIns(3,5)P(2) production and disrupts endomembrane transport and retroviral budding.
|
EMBO Rep
|
2008
|
2.09
|
|
4
|
Evaluation of two-dimensional differential gel electrophoresis for proteomic expression analysis of a model breast cancer cell system.
|
Mol Cell Proteomics
|
2002
|
1.60
|
|
5
|
Synthesis and biological evaluation of pyrido[3',2':4,5]furo[3,2-d]pyrimidine derivatives as novel PI3 kinase p110alpha inhibitors.
|
Bioorg Med Chem Lett
|
2007
|
1.33
|
|
6
|
Cluster analysis of an extensive human breast cancer cell line protein expression map database.
|
Proteomics
|
2002
|
1.22
|
|
7
|
Synthesis and biological evaluation of imidazo[1,2-a]pyridine derivatives as novel PI3 kinase p110alpha inhibitors.
|
Bioorg Med Chem
|
2006
|
1.15
|
|
8
|
Proteomic analysis of redox- and ErbB2-dependent changes in mammary luminal epithelial cells using cysteine- and lysine-labelling two-dimensional difference gel electrophoresis.
|
Proteomics
|
2005
|
1.14
|
|
9
|
Synthesis and biological evaluation of sulfonylhydrazone-substituted imidazo[1,2-a]pyridines as novel PI3 kinase p110alpha inhibitors.
|
Bioorg Med Chem
|
2007
|
1.10
|
|
10
|
Phosphoinositide 3-Kinase C2beta regulates cytoskeletal organization and cell migration via Rac-dependent mechanisms.
|
Mol Biol Cell
|
2006
|
1.07
|
|
11
|
Effects of ErbB-2 overexpression on mitogenic signalling and cell cycle progression in human breast luminal epithelial cells.
|
Oncogene
|
2002
|
1.07
|
|
12
|
Dynamic cofilin phosphorylation in the control of lamellipodial actin homeostasis.
|
J Cell Sci
|
2007
|
1.06
|
|
13
|
Two distinct phosphoinositide 3-kinases mediate polypeptide growth factor-stimulated PKB activation.
|
EMBO J
|
2002
|
1.06
|
|
14
|
Structural and membrane binding analysis of the Phox homology domain of phosphoinositide 3-kinase-C2alpha.
|
J Biol Chem
|
2006
|
1.05
|
|
15
|
A parallel proteomic and metabolomic analysis of the hydrogen peroxide- and Sty1p-dependent stress response in Schizosaccharomyces pombe.
|
Proteomics
|
2006
|
1.04
|
|
16
|
Major role of epidermal growth factor receptor and Src kinases in promoting oxidative stress-dependent loss of adhesion and apoptosis in epithelial cells.
|
J Biol Chem
|
2009
|
0.97
|
|
17
|
Gene targeting: attention to detail.
|
Cell
|
2004
|
0.95
|
|
18
|
Proteomic analysis of UVC irradiation-induced damage of plasma proteins: Serum amyloid P component as a major target of photolysis.
|
FEBS Lett
|
2006
|
0.92
|
|
19
|
Differential proteome analysis of replicative senescence in rat embryo fibroblasts.
|
Mol Cell Proteomics
|
2002
|
0.91
|
|
20
|
Targeting PI3KC2β impairs proliferation and survival in acute leukemia, brain tumours and neuroendocrine tumours.
|
Anticancer Res
|
2012
|
0.89
|
|
21
|
Identification of novel candidates for replicative senescence by functional proteomics.
|
Oncogene
|
2002
|
0.85
|
|
22
|
Targeted expression of the class II phosphoinositide 3-kinase in Drosophila melanogaster reveals lipid kinase-dependent effects on patterning and interactions with receptor signaling pathways.
|
Mol Cell Biol
|
2004
|
0.84
|
|
23
|
Structural analysis of PI3-kinase isoforms: identification of residues enabling selective inhibition by small molecule ATP-competitive inhibitors.
|
Arch Biochem Biophys
|
2008
|
0.82
|
|
24
|
Stress-induced changes in the Schizosaccharomyces pombe proteome using two-dimensional difference gel electrophoresis, mass spectrometry and a novel integrated robotics platform.
|
Proteomics
|
2005
|
0.78
|