Immunomodulatory properties of pentoxifylline are mediated via adenosine-dependent pathways.

PubWeight™: 1.52‹?› | Rank: Top 4%

🔗 View Article (PMID 19997047)

Published in Shock on July 01, 2010

Authors

Simone Kreth1, Carola Ledderose, Benjamin Luchting, Florian Weis, Manfred Thiel

Author Affiliations

1: Department of Anaesthesiology, Ludwig Maximilians University, Munich, Germany.

Articles citing this

Ibudilast, a pharmacologic phosphodiesterase inhibitor, prevents human immunodeficiency virus-1 Tat-mediated activation of microglial cells. PLoS One (2011) 0.84

A review of the potential protective effects of pentoxifylline against drug-induced nephrotoxicity. Eur J Clin Pharmacol (2012) 0.82

Circulating adenosine increases during human experimental endotoxemia but blockade of its receptor does not influence the immune response and subsequent organ injury. Crit Care (2011) 0.81

Role of pentoxifylline in non-alcoholic fatty liver disease in high-fat diet-induced obesity in mice. World J Hepatol (2015) 0.77

Pentoxifylline modulates LPS-induced hyperinflammation in monocytes of preterm infants in vitro. Pediatr Res (2017) 0.77

Pulmonary Protection Strategies in Cardiac Surgery: Are We Making Any Progress? Oxid Med Cell Longev (2015) 0.76

Pentoxifylline for Anemia in Chronic Kidney Disease: A Systematic Review and Meta-Analysis. PLoS One (2015) 0.75

Adenosine production: a common path for mesenchymal stem-cell and regulatory T-cell-mediated immunosuppression. Purinergic Signal (2016) 0.75

Pentoxifylline Neuroprotective Effects Are Possibly Related to Its Anti-Inflammatory and TNF-Alpha Inhibitory Properties, in the 6-OHDA Model of Parkinson's Disease. Parkinsons Dis (2015) 0.75

Adenosine-mediated attenuation of the innate immune response for only those who need it? The tailored potential of pentoxifylline. Shock (2010) 0.75

Pentoxifylline inhibits pulmonary inflammation induced by infrarenal aorticcross-clamping dependent of adenosine receptor A2A. Am J Transl Res (2016) 0.75

Articles by these authors

Physiological control of immune response and inflammatory tissue damage by hypoxia-inducible factors and adenosine A2A receptors. Annu Rev Immunol (2004) 4.28

Perioperative use of levosimendan: best practice in operative settings. J Cardiothorac Vasc Anesth (2012) 2.15

Shedding of the endothelial glycocalyx in patients undergoing major vascular surgery with global and regional ischemia. Circulation (2007) 2.11

Corticosteroid resistance in sepsis is influenced by microRNA-124--induced downregulation of glucocorticoid receptor-α. Crit Care Med (2012) 1.91

Monitoring of the sublingual microcirculation in cardiac surgery using orthogonal polarization spectral imaging: preliminary results. Anesthesiology (2007) 1.72

O-methylguanine-DNA methyltransferase (MGMT) mRNA expression predicts outcome in malignant glioma independent of MGMT promoter methylation. PLoS One (2011) 1.32

Estimation of liver size for liver transplantation: the impact of age and gender. Liver Transpl (2004) 1.18

Real-time monitoring of propofol in expired air in humans undergoing total intravenous anesthesia. Anesthesiology (2007) 1.16

Polymorphonuclear leukocyte dysfunction syndrome in patients with increasing sepsis severity. Shock (2006) 1.08

Motion sickness, stress and the endocannabinoid system. PLoS One (2010) 1.02

Alpha-gluthathione S-transferase as an early marker of hepatic ischemia/reperfusion injury after liver resection. World J Surg (2005) 0.99

Beneficial effects of ischemic preconditioning in patients undergoing hepatectomy: the role of neutrophils. Arch Surg (2005) 0.98

An Algorithm for Systemic Inflammatory Response Syndrome Criteria-Based Prediction of Sepsis in a Polytrauma Cohort. Crit Care Med (2016) 0.98

Critical role of hypoxia and A2A adenosine receptors in liver tissue-protecting physiological anti-inflammatory pathway. Mol Med (2008) 0.96

Effects of adenosine on functions of polymorphonuclear leukocytes from patients with septic shock. Shock (2007) 0.96

Stress doses of hydrocortisone in septic shock: beneficial effects on opsonization-dependent neutrophil functions. Intensive Care Med (2007) 0.96

Stress doses of hydrocortisone reduce severe systemic inflammatory response syndrome and improve early outcome in a risk group of patients after cardiac surgery. Crit Care Med (2003) 0.95

Mediastinal pheochromocytoma with single coronary blood supply: a case report. Heart Surg Forum (2007) 0.95

Relationship of a common polymorphism of the glucocorticoid receptor gene to traumatic memories and posttraumatic stress disorder in patients after intensive care therapy. Crit Care Med (2011) 0.93

Lymphocyte subsets and the role of TH1/TH2 balance in stressed chronic pain patients. Neuroimmunomodulation (2008) 0.91

Pannexin 1 channels link chemoattractant receptor signaling to local excitation and global inhibition responses at the front and back of polarized neutrophils. J Biol Chem (2013) 0.91

In vivo hypoxic preconditioning protects from warm liver ischemia-reperfusion injury through the adenosine A2B receptor. Transplantation (2012) 0.90

Intrathoracic blood volume index measured by thermodilution for preload monitoring after cardiac surgery. J Cardiothorac Vasc Anesth (2002) 0.90

Anandamide and neutrophil function in patients with fibromyalgia. Psychoneuroendocrinology (2008) 0.90

Traumatic memories, post-traumatic stress disorder and serum cortisol levels in long-term survivors of the acute respiratory distress syndrome. Brain Res (2009) 0.88

Differential expression of 5'-UTR splice variants of the adenosine A2A receptor gene in human granulocytes: identification, characterization, and functional impact on activation. FASEB J (2008) 0.88

Psychoneuroendocrine stress response may impair neutrophil function in complex regional pain syndrome. Clin Immunol (2007) 0.86

Altered myocardial expression of ghrelin and its receptor (GHSR-1a) in patients with severe heart failure. Peptides (2010) 0.86

Extracorporeal support in a patient with cardiogenic shock due to Aerococcus urinae endocarditis. J Heart Valve Dis (2009) 0.86

Strenuous physical exercise inhibits granulocyte activation induced by high altitude. J Appl Physiol (1985) (2004) 0.86

Adenosine A2A receptor upregulation in human PMNs is controlled by miRNA-214, miRNA-15, and miRNA-16. Shock (2012) 0.86

P-selectin mediates platelet-endothelial cell interactions and reperfusion injury in the mouse liver in vivo. Shock (2002) 0.85

Medical suppression of hypercortisolemia in Cushing's syndrome with particular consideration of etomidate. Pituitary (2012) 0.85

Use of methylene blue in the treatment of refractory vasodilatory shock after cardiac assist device implantation: report of four consecutive cases. J Clin Med Res (2012) 0.84

N-octanoyl-dopamine is an agonist at the capsaicin receptor TRPV1 and mitigates ischemia-induced [corrected] acute kidney injury in rat. PLoS One (2012) 0.84

Daptomycin: a novel lipopeptide antibiotic against Gram-positive pathogens. Infect Drug Resist (2010) 0.84

Comparison of Fenestra VC Contrast-enhanced computed tomography imaging with gadopentetate dimeglumine and ferucarbotran magnetic resonance imaging for the in vivo evaluation of murine liver damage after ischemia and reperfusion. Invest Radiol (2008) 0.83

Effects of general anesthesia on anandamide blood levels in humans. Anesthesiology (2006) 0.83

Postoperative hyperoxia (60%) worsens hepatic injury in mice. Anesthesiology (2014) 0.83

Oxygent as a top load to colloid and hyperoxia is more effective in resuscitation from hemorrhagic shock than colloid and hyperoxia alone. Shock (2005) 0.82

Local expression of myocardial galectin-3 does not correlate with its serum levels in patients undergoing heart transplantation. Ann Transplant (2013) 0.82

MicroRNA-146a controls Th1-cell differentiation of human CD4+ T lymphocytes by targeting PRKCε. Eur J Immunol (2014) 0.82

Noninvasive mechanical ventilation in patients with acute respiratory failure after cardiac surgery. Heart Surg Forum (2010) 0.82

Glucocorticoid-endocannabinoid interaction in cardiac surgical patients: relationship to early cognitive dysfunction and late depression. Rev Neurosci (2012) 0.81

Protective effects of pentoxifylline in pulmonary inflammation are adenosine receptor A2A dependent. FASEB J (2013) 0.81

Inflammatory reactions and hydrocortisone in the setting of cardiac surgery: an overview. Cardiovasc Hematol Agents Med Chem (2011) 0.81

Routine use of corticosteroids to prevent inflammation response in cardiac surgery. Recent Pat Cardiovasc Drug Discov (2012) 0.81

The protective effects of levosimendan on ischemia/reperfusion injury and apoptosis. Recent Pat Cardiovasc Drug Discov (2011) 0.81

Giant left atrial thrombus with mechanical compromise of the mitral valve. J Thorac Cardiovasc Surg (2008) 0.80

Experimental miRNA target validation. Methods Mol Biol (2013) 0.80

Breath isoprene concentrations in persons undergoing general anesthesia and in healthy volunteers. J Breath Res (2012) 0.79

Perioperative fluid retention and clinical outcome in elective, high-risk colorectal surgery. Int J Colorectal Dis (2009) 0.79

Reduced ligand affinity leads to an impaired function of the adenosine A2A receptor of human granulocytes in sepsis. J Cell Mol Med (2009) 0.78

Tubuloglomerular feedback and renal function in mice with targeted deletion of the type 1 equilibrative nucleoside transporter. Am J Physiol Renal Physiol (2012) 0.77

Primary graft failure after heart transplantation: urgent need for a consensus guideline. Transplantation (2011) 0.77

MicroRNAs as potential therapeutic agents in the treatment of myocardial infarction. Curr Vasc Pharmacol (2011) 0.77

Impact of intraischemic temperature on oxidative stress during hepatic reperfusion. Free Radic Biol Med (2003) 0.77

Influence of gender on postoperative outcome after intra-aortic balloon counter-pulsation and cardiac surgery. Thorac Cardiovasc Surg (2013) 0.76

Antiviral therapy for recurrent hepatitis C after liver transplantation: sustained virologic response is related to genotype 2/3 and response at week 12. Eur J Gastroenterol Hepatol (2008) 0.76

Buccal absorption of propofol when dosed in 1-perfluorobutylpentane to anaesthetised and conscious Wistar rats and Göttingen mini-pigs. Eur J Pharm Biopharm (2013) 0.76

Inhibition of Neutrophils by Hypertonic Saline Involves Pannexin-1, CD39, CD73, and Other Ectonucleotidases. Shock (2015) 0.75

Ghrelin resistance in heart failure or why failing cardiomyocytes do not produce ghrelin: the same problem? Eur J Heart Fail (2009) 0.75

Use of drug-eluting balloon coronary intervention prior to living donor kidney transplantation. BMC Cardiovasc Disord (2014) 0.75

Perioperative intra-aortic balloon counterpulsation in a patient with myocardium at risk undergoing urgent noncardiac surgery. Ann Card Anaesth (2015) 0.75

Ruptured splenic artery aneurysm masquerading as a gastric hemorrhage. J Vasc Surg (2012) 0.75

Effect of high altitude and exercise on microvascular parameters in acclimatized subjects. Clin Sci (Lond) (2006) 0.75

Heparin-induced thrombosis without thrombocytopenia causing fulminant pulmonary embolism after off-pump coronary artery bypass grafting. Heart Surg Forum (2009) 0.75

Chronic granulomatous disease in an adult recognized by an invasive aspergillosis. Am J Med Sci (2012) 0.75

Donor transmitted left atrial myxoma 13 years after heart transplantation. Ann Transplant (2012) 0.75

Decrease in adhesion molecules on polymorphonuclear leukocytes of patients with fibromyalgia. Rheumatol Int (2008) 0.75

Adenosine A2(A) receptor modulates the oxidative stress response of primed polymorphonuclear leukocytes after parabolic flight. Hum Immunol (2011) 0.75

Hirudin for management of heparin-induced thrombocytopenia type II in a patient with biventricular assist device support. Heart Surg Forum (2009) 0.75

Systemic Adenosine Triphosphate Impairs Neutrophil Chemotaxis and Host Defense in Sepsis. Crit Care Med (2017) 0.75

Early adaption to the antarctic environment at dome C: consequences on stress-sensitive innate immune functions. High Alt Med Biol (2014) 0.75

Current use of daptomycin in cardiac surgery and postoperative intensive care. Expert Rev Anti Infect Ther (2013) 0.75

The role of micafungin and anidulafungin in the treatment of systemic fungal infections: applications and patents for two novel echinocandins. Recent Pat Antiinfect Drug Discov (2012) 0.75