|
1
|
Lethality to leukemia cell lines of DNA interstrand cross-links generated by Cloretazine derived alkylating species.
|
Leuk Res
|
2008
|
0.97
|
|
2
|
Reductive activation of the prodrug 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)-2-[[1-(4-nitrophenyl)ethoxy]carbonyl]hydrazine (KS119) selectively occurs in oxygen-deficient cells and overcomes O(6)-alkylguanine-DNA alkyltransferase mediated KS119 tumor cell resistance.
|
Biochem Pharmacol
|
2009
|
0.97
|
|
3
|
Preclinical evaluation of Laromustine for use in combination with radiation therapy in the treatment of solid tumors.
|
Int J Radiat Biol
|
2011
|
0.89
|
|
4
|
Regression of glomerulosclerosis in response to transient treatment with angiotensin II blockers is attenuated by blockade of matrix metalloproteinase-2.
|
Kidney Int
|
2010
|
0.85
|
|
5
|
KS900: A hypoxia-directed, reductively activated methylating antitumor prodrug that selectively ablates O(6)-alkylguanine-DNA alkyltransferase in neoplastic cells.
|
Biochem Pharmacol
|
2011
|
0.84
|
|
6
|
Influence of phosphate and phosphoesters on the decomposition pathway of 1,2-bis(methylsulfonyl)-1-(2-chloroethyhydrazine (90CE), the active anticancer moiety generated by Laromustine, KS119, and KS119W.
|
Chem Res Toxicol
|
2014
|
0.82
|
|
7
|
Absence of gelatinase (MMP-9) or collagenase (MMP-13) attenuates adriamycin-induced albuminuria and glomerulosclerosis.
|
Nephron Exp Nephrol
|
2010
|
0.82
|
|
8
|
Prevention and regression of hypertension: role of renal microvascular protection.
|
Hypertens Res
|
2009
|
0.80
|
|
9
|
Design of a hypoxia-activated prodrug inhibitor of O6-alkylguanine-DNA alkyltransferase.
|
Bioorg Med Chem Lett
|
2012
|
0.80
|
|
10
|
Influence of glutathione and glutathione S-transferases on DNA interstrand cross-link formation by 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)hydrazine, the active anticancer moiety generated by laromustine.
|
Chem Res Toxicol
|
2014
|
0.80
|
|
11
|
Identification of a splice variant of mouse caveolin-2 mRNA encoding an isoform lacking the C-terminal domain.
|
Arch Biochem Biophys
|
2002
|
0.79
|
|
12
|
Chloroethylating and methylating dual function antineoplastic agents display superior cytotoxicity against repair proficient tumor cells.
|
Bioorg Med Chem Lett
|
2013
|
0.77
|
|
13
|
1,2-Bis(methylsulfonyl)-1-(2-chloroethyl)-2-[[1-(4-nitrophenyl)ethoxy]carbonyl]hydrazine (KS119): a cytotoxic prodrug with two stable conformations differing in biological and physical properties.
|
Chem Biol Drug Des
|
2011
|
0.76
|
|
14
|
The short treatment with the angiotensin receptor blocker candesartan surveyed by telemedicine (STAR CAST) study: rationale and study design.
|
Hypertens Res
|
2008
|
0.76
|
|
15
|
Tumor-associated mutations in O⁶ -methylguanine DNA-methyltransferase (MGMT) reduce DNA repair functionality.
|
Mol Carcinog
|
2012
|
0.75
|
|
16
|
A strategy for selective O(6)-alkylguanine-DNA alkyltransferase depletion under hypoxic conditions.
|
Chem Biol Drug Des
|
2012
|
0.75
|