Published in Virol J on December 17, 2009
Giant virus with a remarkable complement of genes infects marine zooplankton. Proc Natl Acad Sci U S A (2010) 2.34
Computational methods for Gene Orthology inference. Brief Bioinform (2011) 2.16
Chlorovirus ATCV-1 is part of the human oropharyngeal virome and is associated with changes in cognitive functions in humans and mice. Proc Natl Acad Sci U S A (2014) 1.60
Origin and evolution of eukaryotic large nucleo-cytoplasmic DNA viruses. Intervirology (2010) 1.54
Phylogenetic and phyletic studies of informational genes in genomes highlight existence of a 4 domain of life including giant viruses. PLoS One (2010) 1.53
DNA viruses: the really big ones (giruses). Annu Rev Microbiol (2010) 1.51
Viruses with more than 1,000 genes: Mamavirus, a new Acanthamoeba polyphaga mimivirus strain, and reannotation of Mimivirus genes. Genome Biol Evol (2011) 1.47
"Megavirales", a proposed new order for eukaryotic nucleocytoplasmic large DNA viruses. Arch Virol (2013) 1.41
Related giant viruses in distant locations and different habitats: Acanthamoeba polyphaga moumouvirus represents a third lineage of the Mimiviridae that is close to the megavirus lineage. Genome Biol Evol (2012) 1.40
Chloroviruses: not your everyday plant virus. Trends Plant Sci (2011) 1.37
Hidden evolutionary complexity of Nucleo-Cytoplasmic Large DNA viruses of eukaryotes. Virol J (2012) 1.32
Exploring nucleo-cytoplasmic large DNA viruses in Tara Oceans microbial metagenomes. ISME J (2013) 1.26
Virus world as an evolutionary network of viruses and capsidless selfish elements. Microbiol Mol Biol Rev (2014) 1.26
Faustovirus, an asfarvirus-related new lineage of giant viruses infecting amoebae. J Virol (2015) 1.22
Mimiviridae: clusters of orthologous genes, reconstruction of gene repertoire evolution and proposed expansion of the giant virus family. Virol J (2013) 1.20
Conservation of major and minor jelly-roll capsid proteins in Polinton (Maverick) transposons suggests that they are bona fide viruses. Biol Direct (2014) 1.10
Origin of giant viruses from smaller DNA viruses not from a fourth domain of cellular life. Virology (2014) 1.10
Evolution of DNA ligases of nucleo-cytoplasmic large DNA viruses of eukaryotes: a case of hidden complexity. Biol Direct (2009) 1.09
Zamilon, a novel virophage with Mimiviridae host specificity. PLoS One (2014) 1.09
Towards defining the chloroviruses: a genomic journey through a genus of large DNA viruses. BMC Genomics (2013) 1.08
The molecular biology of frog virus 3 and other iridoviruses infecting cold-blooded vertebrates. Viruses (2011) 1.08
Two new subfamilies of DNA mismatch repair proteins (MutS) specifically abundant in the marine environment. ISME J (2011) 1.07
The giant Cafeteria roenbergensis virus that infects a widespread marine phagocytic protist is a new member of the fourth domain of Life. PLoS One (2011) 1.05
Evolution of divergent life history strategies in marine alphaproteobacteria. MBio (2013) 1.04
Marine prasinovirus genomes show low evolutionary divergence and acquisition of protein metabolism genes by horizontal gene transfer. J Virol (2010) 1.03
What does virus evolution tell us about virus origins? J Virol (2011) 1.01
Identification of an L-rhamnose synthetic pathway in two nucleocytoplasmic large DNA viruses. J Virol (2010) 1.01
Marine viruses, a genetic reservoir revealed by targeted viromics. ISME J (2013) 1.01
Preview. The incredible expanding ancestor of eukaryotes. Cell (2010) 1.00
Orthopoxvirus genome evolution: the role of gene loss. Viruses (2010) 0.98
Lateral gene exchanges shape the genomes of amoeba-resisting microorganisms. Front Cell Infect Microbiol (2012) 0.94
Using signature genes as tools to assess environmental viral ecology and diversity. Appl Environ Microbiol (2014) 0.93
Plant genomes enclose footprints of past infections by giant virus relatives. Nat Commun (2014) 0.93
Giant Viruses of Amoebas: An Update. Front Microbiol (2016) 0.92
The Double-Stranded DNA Virosphere as a Modular Hierarchical Network of Gene Sharing. MBio (2016) 0.90
Salmon Gill Poxvirus, the Deepest Representative of the Chordopoxvirinae. J Virol (2015) 0.90
Identification of hepatotropic viruses from plasma using deep sequencing: a next generation diagnostic tool. PLoS One (2013) 0.90
A Brazilian Marseillevirus Is the Founding Member of a Lineage in Family Marseilleviridae. Viruses (2016) 0.90
Pandoraviruses are highly derived phycodnaviruses. Biol Direct (2013) 0.89
Evolution of double-stranded DNA viruses of eukaryotes: from bacteriophages to transposons to giant viruses. Ann N Y Acad Sci (2015) 0.88
DNA-dependent RNA polymerase detects hidden giant viruses in published databanks. Genome Biol Evol (2014) 0.87
Mimivirus circulation among wild and domestic mammals, Amazon Region, Brazil. Emerg Infect Dis (2014) 0.86
Phylogenomics and evolutionary dynamics of the family Actinomycetaceae. Genome Biol Evol (2014) 0.86
MitoCOGs: clusters of orthologous genes from mitochondria and implications for the evolution of eukaryotes. BMC Evol Biol (2014) 0.85
Structure of a baculovirus sulfhydryl oxidase, a highly divergent member of the erv flavoenzyme family. J Virol (2011) 0.84
Four novel algal virus genomes discovered from Yellowstone Lake metagenomes. Sci Rep (2015) 0.82
Deep RNA sequencing reveals hidden features and dynamics of early gene transcription in Paramecium bursaria chlorella virus 1. PLoS One (2014) 0.82
The logic of DNA replication in double-stranded DNA viruses: insights from global analysis of viral genomes. Nucleic Acids Res (2016) 0.81
Faustoviruses: Comparative Genomics of New Megavirales Family Members. Front Microbiol (2016) 0.81
Niemeyer Virus: A New Mimivirus Group A Isolate Harboring a Set of Duplicated Aminoacyl-tRNA Synthetase Genes. Front Microbiol (2015) 0.81
Prokaryotic Virus Orthologous Groups (pVOGs): a resource for comparative genomics and protein family annotation. Nucleic Acids Res (2016) 0.81
Another really, really big virus. Viruses (2011) 0.80
Genomic comparison of closely related Giant Viruses supports an accordion-like model of evolution. Front Microbiol (2015) 0.80
Cedratvirus, a Double-Cork Structured Giant Virus, is a Distant Relative of Pithoviruses. Viruses (2016) 0.79
Welcome to pandoraviruses at the 'Fourth TRUC' club. Front Microbiol (2015) 0.79
Global analysis of Chlorella variabilis NC64A mRNA profiles during the early phase of Paramecium bursaria chlorella virus-1 infection. PLoS One (2014) 0.79
Mimiviridae, Marseilleviridae, and virophages as emerging human pathogens causing healthcare-associated infections. GMS Hyg Infect Control (2014) 0.79
Chlorovirus PBCV-1 encodes an active copper-zinc superoxide dismutase. J Virol (2014) 0.79
A functional calcium-transporting ATPase encoded by chlorella viruses. J Gen Virol (2010) 0.78
Pithovirus sibericum, a new bona fide member of the "Fourth TRUC" club. Front Microbiol (2015) 0.77
Punctuated evolution and transitional hybrid network in an ancestral cell cycle of fungi. Elife (2016) 0.77
MG-Digger: An Automated Pipeline to Search for Giant Virus-Related Sequences in Metagenomes. Front Microbiol (2016) 0.76
Two distinct SSB protein families in nucleo-cytoplasmic large DNA viruses. Bioinformatics (2012) 0.76
Development of Potent Antiviral Drugs Inspired by Viral Hexameric DNA-Packaging Motors with Revolving Mechanism. J Virol (2016) 0.76
Pacmanvirus, a new giant icosahedral virus at the crossroads between Asfarviridae and Faustoviruses. J Virol (2017) 0.76
A Student's Guide to Giant Viruses Infecting Small Eukaryotes: From Acanthamoeba to Zooxanthellae. Viruses (2017) 0.75
Marine Prasinoviruses and Their Tiny Plankton Hosts: A Review. Viruses (2017) 0.75
Mimivirus: leading the way in the discovery of giant viruses of amoebae. Nat Rev Microbiol (2017) 0.75
The Expanding Family of Virophages. Viruses (2016) 0.75
MimiLook: A Phylogenetic Workflow for Detection of Gene Acquisition in Major Orthologous Groups of Megavirales. Viruses (2017) 0.75
Changes in the composition of the RNA virome mark evolutionary transitions in green plants. BMC Biol (2016) 0.75
Evolution and Phylogeny of Large DNA Viruses, Mimiviridae and Phycodnaviridae Including Newly Characterized Heterosigma akashiwo Virus. Front Microbiol (2016) 0.75
A Glimpse of Nucleo-Cytoplasmic Large DNA Virus Biodiversity through the Eukaryotic Genomics Window. Viruses (2017) 0.75
Saudi Moumouvirus, the First Group B Mimivirus Isolated from Asia. Front Microbiol (2016) 0.75
Molecular network, pathway, and functional analysis of time-dependent gene changes associated with pancreatic cancer susceptibility to oncolytic vaccinia virotherapy. Mol Ther Oncolytics (2016) 0.75
Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res (1997) 665.31
MUSCLE: multiple sequence alignment with high accuracy and high throughput. Nucleic Acids Res (2004) 168.89
The COG database: an updated version includes eukaryotes. BMC Bioinformatics (2003) 60.98
A genomic perspective on protein families. Science (1997) 50.51
GeneMark.hmm: new solutions for gene finding. Nucleic Acids Res (1998) 25.21
Distinguishing homologous from analogous proteins. Syst Zool (1970) 25.10
A general empirical model of protein evolution derived from multiple protein families using a maximum-likelihood approach. Mol Biol Evol (2001) 16.83
CD-Search: protein domain annotations on the fly. Nucleic Acids Res (2004) 16.76
An approximately unbiased test of phylogenetic tree selection. Syst Biol (2002) 11.00
Retracted TREEFINDER: a powerful graphical analysis environment for molecular phylogenetics. BMC Evol Biol (2004) 8.78
Orthologs, paralogs, and evolutionary genomics. Annu Rev Genet (2005) 8.62
The 1.2-megabase genome sequence of Mimivirus. Science (2004) 8.37
Inferring phylogenies from protein sequences by parsimony, distance, and likelihood methods. Methods Enzymol (1996) 6.99
Evolutionary genomics of nucleo-cytoplasmic large DNA viruses. Virus Res (2006) 4.49
Common origin of four diverse families of large eukaryotic DNA viruses. J Virol (2001) 4.28
The virophage as a unique parasite of the giant mimivirus. Nature (2008) 4.09
Genome trees and the tree of life. Trends Genet (2002) 3.79
Comparative genomics, minimal gene-sets and the last universal common ancestor. Nat Rev Microbiol (2003) 3.59
Redefining viruses: lessons from Mimivirus. Nat Rev Microbiol (2008) 3.27
Non-orthologous gene displacement. Trends Genet (1996) 3.12
The ancient Virus World and evolution of cells. Biol Direct (2006) 3.06
The Big Bang of picorna-like virus evolution antedates the radiation of eukaryotic supergroups. Nat Rev Microbiol (2008) 2.74
Search for a 'Tree of Life' in the thicket of the phylogenetic forest. J Biol (2009) 2.66
The genome of molluscum contagiosum virus: analysis and comparison with other poxviruses. Virology (1997) 2.58
Clusters of orthologous genes for 41 archaeal genomes and implications for evolutionary genomics of archaea. Biol Direct (2007) 2.53
Giant Marseillevirus highlights the role of amoebae as a melting pot in emergence of chimeric microorganisms. Proc Natl Acad Sci U S A (2009) 2.52
New dimensions of the virus world discovered through metagenomics. Trends Microbiol (2009) 2.41
Unusual life style of giant chlorella viruses. Annu Rev Genet (2003) 2.22
The origin of viruses and their possible roles in major evolutionary transitions. Virus Res (2006) 2.21
A duplicated catalytic motif in a new superfamily of phosphohydrolases and phospholipid synthases that includes poxvirus envelope proteins. Trends Biochem Sci (1996) 2.16
Computing prokaryotic gene ubiquity: rescuing the core from extinction. Genome Res (2004) 2.14
The cyanobacterial genome core and the origin of photosynthesis. Proc Natl Acad Sci U S A (2006) 2.11
Taxonomic distribution of large DNA viruses in the sea. Genome Biol (2008) 2.04
Mimivirus and the emerging concept of "giant" virus. Virus Res (2006) 1.98
Mimivirus and its virophage. Annu Rev Genet (2009) 1.93
Giant viruses, giant chimeras: the multiple evolutionary histories of Mimivirus genes. BMC Evol Biol (2008) 1.87
Marine mimivirus relatives are probably large algal viruses. Virol J (2008) 1.80
Mimivirus. Curr Top Microbiol Immunol (2009) 1.66
Genomic and evolutionary aspects of Mimivirus. Virus Res (2005) 1.56
Mimivirus relatives in the Sargasso sea. Virol J (2005) 1.55
Streamlining and large ancestral genomes in Archaea inferred with a phylogenetic birth-and-death model. Mol Biol Evol (2009) 1.54
Phylogenetic evidence for extensive lateral acquisition of cellular genes by Nucleocytoplasmic large DNA viruses. BMC Evol Biol (2008) 1.51
TOPD/FMTS: a new software to compare phylogenetic trees. Bioinformatics (2007) 1.49
I am what I eat and I eat what I am: acquisition of bacterial genes by giant viruses. Trends Genet (2006) 1.39
Mimivirus and Mimiviridae: giant viruses with an increasing number of potential hosts, including corals and sponges. J Invertebr Pathol (2009) 1.29
Similarities in the induction of post-Golgi vesicles by the vaccinia virus F13L protein and phospholipase D. J Virol (2002) 1.18
Virology: Gulliver among the Lilliputians. Curr Biol (2005) 1.10
Evolution of DNA ligases of nucleo-cytoplasmic large DNA viruses of eukaryotes: a case of hidden complexity. Biol Direct (2009) 1.09
Remarkable sequence similarity between the dinoflagellate-infecting marine girus and the terrestrial pathogen African swine fever virus. Virol J (2009) 1.05
The manifold phospholipases A of Legionella pneumophila - identification, export, regulation, and their link to bacterial virulence. Int J Med Microbiol (2008) 1.03
Lateral gene transfer, lineage-specific gene expansion and the evolution of Nucleo Cytoplasmic Large DNA viruses. J Invertebr Pathol (2009) 0.87
The COG database: an updated version includes eukaryotes. BMC Bioinformatics (2003) 60.98
Small CRISPR RNAs guide antiviral defense in prokaryotes. Science (2008) 17.79
Evolution and classification of the CRISPR-Cas systems. Nat Rev Microbiol (2011) 17.11
Ongoing revolution in bacteriology: routine identification of bacteria by matrix-assisted laser desorption ionization time-of-flight mass spectrometry. Clin Infect Dis (2009) 16.51
De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling. Nature (2004) 12.41
A putative RNA-interference-based immune system in prokaryotes: computational analysis of the predicted enzymatic machinery, functional analogies with eukaryotic RNAi, and hypothetical mechanisms of action. Biol Direct (2006) 11.31
Identification of rare pathogenic bacteria in a clinical microbiology laboratory: impact of matrix-assisted laser desorption ionization-time of flight mass spectrometry. J Clin Microbiol (2013) 11.31
Role of Rpn11 metalloprotease in deubiquitination and degradation by the 26S proteasome. Science (2002) 7.49
Malaria morbidity and pyrethroid resistance after the introduction of insecticide-treated bednets and artemisinin-based combination therapies: a longitudinal study. Lancet Infect Dis (2011) 7.42
Orthology, paralogy and proposed classification for paralog subtypes. Trends Genet (2002) 7.25
Tick-borne rickettsioses around the world: emerging diseases challenging old concepts. Clin Microbiol Rev (2005) 7.02
Classification and evolution of P-loop GTPases and related ATPases. J Mol Biol (2002) 6.85
The ecoresponsive genome of Daphnia pulex. Science (2011) 6.55
Comparative genomics of multidrug resistance in Acinetobacter baumannii. PLoS Genet (2006) 6.32
Essential genes are more evolutionarily conserved than are nonessential genes in bacteria. Genome Res (2002) 6.08
Chikungunya outbreaks--the globalization of vectorborne diseases. N Engl J Med (2007) 6.05
Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD. Science (2004) 5.88
Selection in the evolution of gene duplications. Genome Biol (2002) 5.58
A giant virus in amoebae. Science (2003) 5.07
Role of predicted metalloprotease motif of Jab1/Csn5 in cleavage of Nedd8 from Cul1. Science (2002) 4.95
A comprehensive evolutionary classification of proteins encoded in complete eukaryotic genomes. Genome Biol (2004) 4.94
Genomics of bacteria and archaea: the emerging dynamic view of the prokaryotic world. Nucleic Acids Res (2008) 4.78
Positron emission tomography/computed tomography for diagnosis of prosthetic valve endocarditis: increased valvular 18F-fluorodeoxyglucose uptake as a novel major criterion. J Am Coll Cardiol (2013) 4.72
Algorithms for computing parsimonious evolutionary scenarios for genome evolution, the last universal common ancestor and dominance of horizontal gene transfer in the evolution of prokaryotes. BMC Evol Biol (2003) 4.70
Evolutionary history and higher order classification of AAA+ ATPases. J Struct Biol (2004) 4.68
Evolutionary genomics of nucleo-cytoplasmic large DNA viruses. Virus Res (2006) 4.49
The structure of the protein universe and genome evolution. Nature (2002) 4.47
Whipple's disease. N Engl J Med (2007) 4.46
A DNA repair system specific for thermophilic Archaea and bacteria predicted by genomic context analysis. Nucleic Acids Res (2002) 4.39
Origin of a substantial fraction of human regulatory sequences from transposable elements. Trends Genet (2003) 4.39
Amoebal coculture of "Mycobacterium massiliense" sp. nov. from the sputum of a patient with hemoptoic pneumonia. J Clin Microbiol (2004) 4.32
The role of lineage-specific gene family expansion in the evolution of eukaryotes. Genome Res (2002) 4.28
Microorganisms resistant to free-living amoebae. Clin Microbiol Rev (2004) 4.22
rpoB gene sequence-based characterization of emerging non-tuberculous mycobacteria with descriptions of Mycobacterium bolletii sp. nov., Mycobacterium phocaicum sp. nov. and Mycobacterium aubagnense sp. nov. Int J Syst Evol Microbiol (2006) 4.22
The virophage as a unique parasite of the giant mimivirus. Nature (2008) 4.09
Selection for short introns in highly expressed genes. Nat Genet (2002) 4.04
Comparative genomics and evolution of proteins involved in RNA metabolism. Nucleic Acids Res (2002) 4.00
Comparative analysis of Acinetobacters: three genomes for three lifestyles. PLoS One (2008) 3.94
Unification of Cas protein families and a simple scenario for the origin and evolution of CRISPR-Cas systems. Biol Direct (2011) 3.92
Gene loss, protein sequence divergence, gene dispensability, expression level, and interactivity are correlated in eukaryotic evolution. Genome Res (2003) 3.90
Molecular quantification of Gardnerella vaginalis and Atopobium vaginae loads to predict bacterial vaginosis. Clin Infect Dis (2008) 3.90
Rickettsial infections and fever, Vientiane, Laos. Emerg Infect Dis (2006) 3.87
Long-term outcome of Q fever endocarditis: a 26-year personal survey. Lancet Infect Dis (2010) 3.84
Comprehensive diagnostic strategy for blood culture-negative endocarditis: a prospective study of 819 new cases. Clin Infect Dis (2010) 3.84
Genome trees and the tree of life. Trends Genet (2002) 3.79
The complete genome of hyperthermophile Methanopyrus kandleri AV19 and monophyly of archaeal methanogens. Proc Natl Acad Sci U S A (2002) 3.72
Remarkable interkingdom conservation of intron positions and massive, lineage-specific intron loss and gain in eukaryotic evolution. Curr Biol (2003) 3.72
Gene sequence-based criteria for identification of new rickettsia isolates and description of Rickettsia heilongjiangensis sp. nov. J Clin Microbiol (2003) 3.59
Understanding the cholera epidemic, Haiti. Emerg Infect Dis (2011) 3.57
Genome sequence of the cyanobacterium Prochlorococcus marinus SS120, a nearly minimal oxyphototrophic genome. Proc Natl Acad Sci U S A (2003) 3.55
'Conserved hypothetical' proteins: prioritization of targets for experimental study. Nucleic Acids Res (2004) 3.50
Q Fever. Vet Microbiol (2009) 3.49
Novel chikungunya virus variant in travelers returning from Indian Ocean islands. Emerg Infect Dis (2006) 3.43
Gene-sequence-based criteria for species definition in bacteriology: the Bartonella paradigm. Trends Microbiol (2003) 3.40
Characterization of the naturally occurring oxacillinase of Acinetobacter baumannii. Antimicrob Agents Chemother (2005) 3.25
rpoB gene sequencing for identification of Corynebacterium species. J Clin Microbiol (2004) 3.24
Direct identification of bacteria in positive blood culture bottles by matrix-assisted laser desorption ionisation time-of-flight mass spectrometry. PLoS One (2009) 3.23
Cause of Black Death. Lancet Infect Dis (2002) 3.20
Long intervals of stasis punctuated by bursts of positive selection in the seasonal evolution of influenza A virus. Biol Direct (2006) 3.18
Monitoring bacterial community of human gut microbiota reveals an increase in Lactobacillus in obese patients and Methanogens in anorexic patients. PLoS One (2009) 3.18
Comprehensive comparative-genomic analysis of type 2 toxin-antitoxin systems and related mobile stress response systems in prokaryotes. Biol Direct (2009) 3.17
Introns and the origin of nucleus-cytosol compartmentalization. Nature (2006) 3.16
One-component systems dominate signal transduction in prokaryotes. Trends Microbiol (2005) 3.09
No simple dependence between protein evolution rate and the number of protein-protein interactions: only the most prolific interactors tend to evolve slowly. BMC Evol Biol (2003) 3.07
Pig liver sausage as a source of hepatitis E virus transmission to humans. J Infect Dis (2010) 3.00
A novel family of sequence-specific endoribonucleases associated with the clustered regularly interspaced short palindromic repeats. J Biol Chem (2008) 3.00
Molecular detection of Bartonella quintana, B. koehlerae, B. henselae, B. clarridgeiae, Rickettsia felis, and Wolbachia pipientis in cat fleas, France. Emerg Infect Dis (2003) 2.99
Update on tick-borne rickettsioses around the world: a geographic approach. Clin Microbiol Rev (2013) 2.97
Emerging rickettsioses of the Thai-Myanmar border. Emerg Infect Dis (2003) 2.91
The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite. PLoS Biol (2005) 2.88
Reductive genome evolution from the mother of Rickettsia. PLoS Genet (2007) 2.87
Comparative meta-analysis of the effect of Lactobacillus species on weight gain in humans and animals. Microb Pathog (2012) 2.85
A universal trend of amino acid gain and loss in protein evolution. Nature (2005) 2.81
MALDI-TOF-mass spectrometry applications in clinical microbiology. Future Microbiol (2010) 2.79
Marseillevirus-like virus recovered from blood donated by asymptomatic humans. J Infect Dis (2013) 2.79
Whipple's disease: new aspects of pathogenesis and treatment. Lancet Infect Dis (2008) 2.78
Blood culture-negative endocarditis in a reference center: etiologic diagnosis of 348 cases. Medicine (Baltimore) (2005) 2.78
Conservation and coevolution in the scale-free human gene coexpression network. Mol Biol Evol (2004) 2.78
Genome sequences of the human body louse and its primary endosymbiont provide insights into the permanent parasitic lifestyle. Proc Natl Acad Sci U S A (2010) 2.76
Genotyping, Orientalis-like Yersinia pestis, and plague pandemics. Emerg Infect Dis (2004) 2.76
The Big Bang of picorna-like virus evolution antedates the radiation of eukaryotic supergroups. Nat Rev Microbiol (2008) 2.74
Point-of-care syndrome-based, rapid diagnosis of infections on commercial ships. J Travel Med (2013) 2.71
A dual function of the CRISPR-Cas system in bacterial antivirus immunity and DNA repair. Mol Microbiol (2010) 2.70