Published in J Am Chem Soc on January 20, 2010
Number of solution states of bradykinin from ion mobility and mass spectrometry measurements. J Am Chem Soc (2011) 1.18
Ligand binding to distinct states diverts aggregation of an amyloid-forming protein. Nat Chem Biol (2011) 1.01
Z-Phe-Ala-diazomethylketone (PADK) disrupts and remodels early oligomer states of the Alzheimer disease Aβ42 protein. J Biol Chem (2012) 0.94
Advances in ion mobility spectrometry-mass spectrometry reveal key insights into amyloid assembly. Biochim Biophys Acta (2012) 0.94
Role of β-hairpin formation in aggregation: the self-assembly of the amyloid-β(25-35) peptide. Biophys J (2012) 0.91
Alzheimer's disease Aβ assemblies mediating rapid disruption of synaptic plasticity and memory. Mol Brain (2012) 0.90
Structural similarities and differences between amyloidogenic and non-amyloidogenic islet amyloid polypeptide (IAPP) sequences and implications for the dual physiological and pathological activities of these peptides. PLoS Comput Biol (2013) 0.86
Molecular insights into the reversible formation of tau protein fibrils. Chem Commun (Camb) (2013) 0.84
On the origins of the weak folding cooperativity of a designed ββα ultrafast protein FSD-1. PLoS Comput Biol (2010) 0.83
Ion mobility spectrometry: A personal view of its development at UCSB. Int J Mass Spectrom (2014) 0.81
Di-tyrosine cross-link decreases the collisional cross-section of aβ peptide dimers and trimers in the gas phase: an ion mobility study. PLoS One (2014) 0.77
Structural diversity and initial oligomerization of PrP106-126 studied by replica-exchange and conventional molecular dynamics simulations. PLoS One (2014) 0.76
β-hairpin-mediated formation of structurally distinct multimers of neurotoxic prion peptides. PLoS One (2014) 0.76
Effects of the Pathogenic Mutation A117V and the Protective Mutation H111S on the Folding and Aggregation of PrP106-126: Insights from Replica Exchange Molecular Dynamics Simulations. PLoS One (2015) 0.75
Regulation of the aggregation behavior of human islet amyloid polypeptide fragment by titanocene complexes. J Biol Inorg Chem (2017) 0.75
A point-charge force field for molecular mechanics simulations of proteins based on condensed-phase quantum mechanical calculations. J Comput Chem (2003) 15.88
Amyloid-β protein oligomerization and the importance of tetramers and dodecamers in the aetiology of Alzheimer's disease. Nat Chem (2009) 3.66
Amyloid beta-protein: monomer structure and early aggregation states of Abeta42 and its Pro19 alloform. J Am Chem Soc (2005) 2.19
Amyloid beta-protein monomer structure: a computational and experimental study. Protein Sci (2006) 1.99
Folding free-energy landscape of villin headpiece subdomain from molecular dynamics simulations. Proc Natl Acad Sci U S A (2007) 1.99
Elucidating amyloid beta-protein folding and assembly: A multidisciplinary approach. Acc Chem Res (2006) 1.80
Sirtuin 2, a mammalian homolog of yeast silent information regulator-2 longevity regulator, is an oligodendroglial protein that decelerates cell differentiation through deacetylating alpha-tubulin. J Neurosci (2007) 1.60
Ion mobility-mass spectrometry reveals a conformational conversion from random assembly to β-sheet in amyloid fibril formation. Nat Chem (2010) 1.53
Structure of the 21-30 fragment of amyloid beta-protein. Protein Sci (2006) 1.51
Human islet amyloid polypeptide monomers form ordered beta-hairpins: a possible direct amyloidogenic precursor. J Am Chem Soc (2009) 1.46
Inflammatory cytokine TSLP stimulates platelet secretion and potentiates platelet aggregation via a TSLPR-dependent PI3K/Akt signaling pathway. Cell Physiol Biochem (2015) 1.43
The structure of the Alzheimer amyloid beta 10-35 peptide probed through replica-exchange molecular dynamics simulations in explicit solvent. J Mol Biol (2006) 1.42
Role of water in mediating the assembly of Alzheimer amyloid-beta Abeta16-22 protofilaments. J Am Chem Soc (2008) 1.42
Convergence of replica exchange molecular dynamics. J Chem Phys (2005) 1.35
Amyloid beta protein: Abeta40 inhibits Abeta42 oligomerization. J Am Chem Soc (2009) 1.30
Characterization of phosphorylated peptides using traveling wave-based and drift cell ion mobility mass spectrometry. Anal Chem (2009) 1.29
Structural stability from solution to the gas phase: native solution structure of ubiquitin survives analysis in a solvent-free ion mobility-mass spectrometry environment. J Phys Chem B (2011) 1.29
Effects of surface tethering on protein folding mechanisms. Proc Natl Acad Sci U S A (2006) 1.27
Strike a balance: optimization of backbone torsion parameters of AMBER polarizable force field for simulations of proteins and peptides. J Comput Chem (2006) 1.26
G-quadruplex DNA assemblies: loop length, cation identity, and multimer formation. J Am Chem Soc (2008) 1.26
Effects of familial Alzheimer's disease mutations on the folding nucleation of the amyloid beta-protein. J Mol Biol (2008) 1.24
Folding landscapes of the Alzheimer amyloid-beta(12-28) peptide. J Mol Biol (2006) 1.24
The binding of thioflavin T and its neutral analog BTA-1 to protofibrils of the Alzheimer's disease Abeta(16-22) peptide probed by molecular dynamics simulations. J Mol Biol (2008) 1.22
The amyloid formation mechanism in human IAPP: dimers have β-strand monomer-monomer interfaces. J Am Chem Soc (2011) 1.22
The structure of Abeta42 C-terminal fragments probed by a combined experimental and theoretical study. J Mol Biol (2009) 1.19
Duplex formation and the onset of helicity in poly d(CG)n oligonucleotides in a solvent-free environment. J Am Chem Soc (2004) 1.19
Characterization, kinetics, and crystal structures of fructose-1,6-bisphosphate aldolase from the human parasite, Giardia lamblia. J Biol Chem (2006) 1.19
Reconstruction of the src-SH3 protein domain transition state ensemble using multiscale molecular dynamics simulations. J Mol Biol (2005) 1.18
Breaking non-native hydrophobic clusters is the rate-limiting step in the folding of an alanine-based peptide. Biopolymers (2003) 1.18
Alpha-synuclein: stable compact and extended monomeric structures and pH dependence of dimer formation. J Am Soc Mass Spectrom (2004) 1.17
Stabilization and structure of telomeric and c-myc region intramolecular G-quadruplexes: the role of central cations and small planar ligands. J Am Chem Soc (2007) 1.16
Intermolecular interactions in biomolecular systems examined by mass spectrometry. Annu Rev Phys Chem (2007) 1.11
A fast and simple method to fabricate circular microchannels in polydimethylsiloxane (PDMS). Lab Chip (2010) 1.08
Coarse-grained models for protein aggregation. Curr Opin Struct Biol (2011) 1.08
Rational design of a structural framework with potential use to develop chemical reagents that target and modulate multiple facets of Alzheimer's disease. J Am Chem Soc (2013) 1.07
Role of the familial Dutch mutation E22Q in the folding and aggregation of the 15-28 fragment of the Alzheimer amyloid-beta protein. Proc Natl Acad Sci U S A (2008) 1.06
Familial Alzheimer's disease mutations differentially alter amyloid β-protein oligomerization. ACS Chem Neurosci (2012) 1.05
Ion mobility analysis of molecular dynamics. Annu Rev Phys Chem (2013) 1.05
Effects of solvent on the structure of the Alzheimer amyloid-beta(25-35) peptide. Biophys J (2006) 1.04
Binding modes of thioflavin-T to the single-layer beta-sheet of the peptide self-assembly mimics. J Mol Biol (2009) 1.03
Posttransition state desolvation of the hydrophobic core of the src-SH3 protein domain. Biophys J (2003) 1.03
New insights into the mechanism of Alzheimer amyloid-beta fibrillogenesis inhibition by N-methylated peptides. Biophys J (2007) 1.02
Reconciling theories of chaperonin accelerated folding with experimental evidence. Cell Mol Life Sci (2009) 1.02
Aβ(39-42) modulates Aβ oligomerization but not fibril formation. Biochemistry (2011) 1.01
Coronaviral hypothetical and structural proteins were found in the intestinal surface enterocytes and pneumocytes of severe acute respiratory syndrome (SARS). Mod Pathol (2005) 1.01
Structural diversity of dimers of the Alzheimer amyloid-beta(25-35) peptide and polymorphism of the resulting fibrils. Phys Chem Chem Phys (2010) 1.01
Sequence periodicity and secondary structure propensity in model proteins. Protein Sci (2010) 1.00
Effect of beta-sheet propensity on peptide aggregation. J Chem Phys (2009) 1.00
Diversity of kinetic pathways in amyloid fibril formation. J Chem Phys (2009) 0.99
Ion mobility spectrometry reveals the mechanism of amyloid formation of Aβ(25-35) and its modulation by inhibitors at the molecular level: epigallocatechin gallate and scyllo-inositol. J Am Chem Soc (2013) 0.97
The effect of the initial water of hydration on the energetics, structures, and H/D exchange mechanism of a family of pentapeptides: an experimental and theoretical study. J Am Chem Soc (2003) 0.96
Gas-phase conformations of deprotonated trinucleotides (dGTT-, dTGT-, and dTTG-): the question of zwitterion formation. J Am Soc Mass Spectrom (2003) 0.95
Peptide self-assembly at the nanoscale: a challenging target for computational and experimental biotechnology. Trends Biotechnol (2007) 0.95
Folding processes of the B domain of protein A to the native state observed in all-atom ab initio folding simulations. J Chem Phys (2008) 0.95
Z-Phe-Ala-diazomethylketone (PADK) disrupts and remodels early oligomer states of the Alzheimer disease Aβ42 protein. J Biol Chem (2012) 0.94
A small molecule directly inhibits the p53 transactivation domain from binding to replication protein A. Nucleic Acids Res (2012) 0.94
The influence of different treatments of electrostatic interactions on the thermodynamics of folding of peptides. J Phys Chem B (2005) 0.94
Landing of size-selected Agn+ clusters on single crystal TiO2 (110)-(1x1) surfaces at room temperature. J Chem Phys (2005) 0.93
Spermine binding to Parkinson's protein alpha-synuclein and its disease-related A30P and A53T mutants. J Phys Chem B (2008) 0.93
Molecular dynamics simulations and free energy analyses on the dimer formation of an amyloidogenic heptapeptide from human beta2-microglobulin: implication for the protofibril structure. J Mol Biol (2005) 0.93
Probing the structural hierarchy and energy landscape of an RNA T-loop hairpin. Nucleic Acids Res (2007) 0.93
Interactions of the hormone oxytocin with divalent metal ions. J Am Chem Soc (2008) 0.92
Cyclo[n]pyrroles: size and site-specific binding to G-quadruplexes. J Am Chem Soc (2006) 0.92
Folding of the 25 residue Abeta(12-36) peptide in TFE/water: temperature-dependent transition from a funneled free-energy landscape to a rugged one. J Phys Chem B (2007) 0.92
Conformational evolution of ubiquitin ions in electrospray mass spectrometry: molecular dynamics simulations at gradually increasing temperatures. Phys Chem Chem Phys (2008) 0.92
Amyloid beta-protein: experiment and theory on the 21-30 fragment. J Phys Chem B (2009) 0.91
Role of β-hairpin formation in aggregation: the self-assembly of the amyloid-β(25-35) peptide. Biophys J (2012) 0.91
Reaction coordinates, one-dimensional Smoluchowski equations, and a test for dynamical self-consistency. J Chem Phys (2013) 0.91
Structural characterization of G-quadruplexes in deoxyguanosine clusters using ion mobility mass spectrometry. J Am Soc Mass Spectrom (2005) 0.91
Non-pathogenic protein aggregates in skeletal muscle in MLF1 transgenic mice. J Neurol Sci (2007) 0.90
Self-assembly of beta-sheet forming peptides into chiral fibrillar aggregates. J Chem Phys (2007) 0.90
The linker between the dimerization and catalytic domains of the CheA histidine kinase propagates changes in structure and dynamics that are important for enzymatic activity. Biochemistry (2014) 0.90
Structural analysis of prion proteins by means of drift cell and traveling wave ion mobility mass spectrometry. J Am Soc Mass Spectrom (2010) 0.90
Self-assembly of peptides into a beta-barrel motif. J Chem Phys (2004) 0.89
Stability of a protein tethered to a surface. J Chem Phys (2007) 0.89
What determines the structure and stability of KFFE monomers, dimers, and protofibrils? Biophys J (2009) 0.89
Swiveling domain mechanism in pyruvate phosphate dikinase. Biochemistry (2007) 0.89
Factors contributing to the collision cross section of polyatomic ions in the kilodalton to gigadalton range: application to ion mobility measurements. Anal Chem (2013) 0.88
Binding of Congo red to amyloid protofibrils of the Alzheimer Aβ(9-40) peptide probed by molecular dynamics simulations. Biophys J (2012) 0.88
B-DNA helix stability in a solvent-free environment. J Am Soc Mass Spectrom (2007) 0.88