A novel type of influenza vaccine: safety and immunogenicity of replication-deficient influenza virus created by deletion of the interferon antagonist NS1.

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Published in J Infect Dis on February 01, 2010

Authors

Volker Wacheck1, Andrej Egorov, Franz Groiss, Andrea Pfeiffer, Thorsten Fuereder, Doris Hoeflmayer, Michael Kundi, Therese Popow-Kraupp, Monika Redlberger-Fritz, Christian A Mueller, Jindrich Cinatl, Martin Michaelis, Janina Geiler, Michael Bergmann, Julia Romanova, Elisabeth Roethl, Alexander Morokutti, Markus Wolschek, Boris Ferko, Joachim Seipelt, Rosmarie Dick-Gudenus, Thomas Muster

Author Affiliations

1: Departments of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria.

Associated clinical trials:

Randomized, Double-blind, Placebo-controlled, Phase I Dose-escalation Study of Single Dose GHB01L1 in Healthy Volunteers (GHBCS-01) | NCT00724997

A Study to Evaluate Safety and Immunogenicity of DelNS1-nCoV-RBD LAIV for COVID-19 | NCT04809389

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