Published in PLoS Genet on December 24, 2009
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TSC1 stabilizes TSC2 by inhibiting the interaction between TSC2 and the HERC1 ubiquitin ligase. J Biol Chem (2006) 1.85
Mouse PRDM9 DNA-binding specificity determines sites of histone H3 lysine 4 trimethylation for initiation of meiotic recombination. PLoS Biol (2011) 1.73
Cblb is a major susceptibility gene for rat type 1 diabetes mellitus. Nat Genet (2002) 1.63
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The slit receptor Rig-1/Robo3 controls midline crossing by hindbrain precerebellar neurons and axons. Neuron (2004) 1.54
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Mutations in the gene encoding pejvakin, a newly identified protein of the afferent auditory pathway, cause DFNB59 auditory neuropathy. Nat Genet (2006) 1.51
A deletion in the gene encoding sphingomyelin phosphodiesterase 3 (Smpd3) results in osteogenesis and dentinogenesis imperfecta in the mouse. Nat Genet (2005) 1.50
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Keratin 17 null mice exhibit age- and strain-dependent alopecia. Genes Dev (2002) 1.47
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The radiation-induced nackt (nkt) allele is a loss-of-function mutation of the mouse cathepsin L gene. J Immunol (2006) 1.40
The 2',5'-oligoadenylate synthetase 1b is a potent inhibitor of West Nile virus replication inside infected cells. J Biol Chem (2005) 1.37
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The mitochondrial protease AFG3L2 is essential for axonal development. J Neurosci (2008) 1.29
A missense mutation in Tbce causes progressive motor neuronopathy in mice. Nat Genet (2002) 1.22
The RCC1 superfamily: from genes, to function, to disease. Biochim Biophys Acta (2008) 1.20
An ENU-induced mutant archive for gene targeting in rats. Nat Genet (2008) 1.19
Mutations in the gene encoding the low-density lipoprotein receptor LRP4 cause abnormal limb development in the mouse. Genomics (2006) 1.16
BMP-2 decreases Mash1 stability by increasing Id1 expression. EMBO J (2004) 1.16
Purkinje cell death: differences between developmental cell death and neurodegenerative death in mutant mice. Cerebellum (2006) 1.10
Plexin-B2 controls the development of cerebellar granule cells. J Neurosci (2007) 1.09
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Restoration of aspartoacylase activity in CNS neurons does not ameliorate motor deficits and demyelination in a model of Canavan disease. Mol Ther (2005) 1.08
Long-term changes in the molecular composition of the glial scar and progressive increase of serotoninergic fibre sprouting after hemisection of the mouse spinal cord. Eur J Neurosci (2004) 1.05
A set of highly informative rat simple sequence length polymorphism (SSLP) markers and genetically defined rat strains. BMC Genet (2006) 1.05
Cmv4, a new locus linked to the NK cell gene complex, controls innate resistance to cytomegalovirus in wild-derived mice. J Immunol (2006) 1.04
Generation and characterization of severe combined immunodeficiency rats. Cell Rep (2012) 1.04
The archetypal R90C CADASIL-NOTCH3 mutation retains NOTCH3 function in vivo. Hum Mol Genet (2007) 1.04
Two quantitative trait loci affecting progressive hearing loss in 101/H mice. Mamm Genome (2006) 1.03
ENU mutagenesis reveals a highly mutable locus on mouse Chromosome 4 that affects ear morphogenesis. Mamm Genome (2002) 1.03
Lanosterol synthase mutations cause cholesterol deficiency-associated cataracts in the Shumiya cataract rat. J Clin Invest (2006) 1.03
Enhanced colitis-associated colon carcinogenesis in a novel Apc mutant rat. Cancer Sci (2009) 1.02
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Mutation of HERC2 causes developmental delay with Angelman-like features. J Med Genet (2012) 0.98
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A mutation in the gene encoding mitochondrial Mg²+ channel MRS2 results in demyelination in the rat. PLoS Genet (2011) 0.94
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The developmental loss of the ability of Purkinje cells to regenerate their axons occurs in the absence of myelin: an in vitro model to prevent myelination. J Neurosci (2003) 0.93
Progressive motor neuronopathy: a critical role of the tubulin chaperone TBCE in axonal tubulin routing from the Golgi apparatus. J Neurosci (2007) 0.93
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Identification and distribution of aspartoacylase in the postnatal rat brain. Neuroreport (2003) 0.92
Molecular mechanisms controlling midline crossing by precerebellar neurons. J Neurosci (2008) 0.92
Hyporesponsiveness of SPRET/Ei mice to lethal shock induced by tumor necrosis factor and implications for a TNF-based antitumor therapy. Proc Natl Acad Sci U S A (2002) 0.91
Interspecific recombinant congenic strains between C57BL/6 and mice of the Mus spretus species: a powerful tool to dissect genetic control of complex traits. Genetics (2007) 0.91
The ataxic groggy rat has a missense mutation in the P/Q-type voltage-gated Ca2+ channel alpha1A subunit gene and exhibits absence seizures. Brain Res (2006) 0.91
Deletion of a conserved regulatory element required for Hmx1 expression in craniofacial mesenchyme in the dumbo rat: a newly identified cause of congenital ear malformation. Dis Model Mech (2012) 0.91
Myelin lipid abnormalities in the aspartoacylase-deficient tremor rat. Neurochem Res (2008) 0.91
Evaluation of LEXF/FXLE rat recombinant inbred strains for genetic dissection of complex traits. Physiol Genomics (2007) 0.91
Impaired hair follicle morphogenesis and cycling with abnormal epidermal differentiation in nackt mice, a cathepsin L-deficient mutation. Am J Pathol (2002) 0.90
Transient maternal hypothyroxinemia at onset of corticogenesis alters tangential migration of medial ganglionic eminence-derived neurons. Eur J Neurosci (2005) 0.90
A 5-bp insertion in Mip causes recessive congenital cataract in KFRS4/Kyo rats. PLoS One (2012) 0.90
Cryopreservation of spermatozoa from closed colonies, and inbred, spontaneous mutant, and transgenic strains of rats. Comp Med (2003) 0.89
Separation of antiepileptogenic and antiseizure effects of levetiracetam in the spontaneously epileptic rat (SER). Epilepsia (2005) 0.89
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Genetic analyses of fancy rat-derived mutations. Exp Anim (2010) 0.88
Two hypomorphic alleles of mouse Ass1 as a new animal model of citrullinemia type I and other hyperammonemic syndromes. Am J Pathol (2010) 0.87
Heterogeneity of NG2-expressing cells in the newborn mouse cerebellum. Dev Biol (2005) 0.87
A new locus for resistance to gamma-radiation-induced thymic lymphoma identified using inter-specific consomic and inter-specific recombinant congenic strains of mice. Oncogene (2002) 0.87
Progestins activate 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3) in breast cancer cells. Biochem J (2012) 0.87
Inhibition of protein kinase C prevents Purkinje cell death but does not affect axonal regeneration. J Neurosci (2002) 0.87
A missense mutation of the gene encoding voltage-dependent sodium channel (Nav1.1) confers susceptibility to febrile seizures in rats. J Neurosci (2010) 0.87
Rat resources in biomedical research. Curr Pharm Biotechnol (2009) 0.87
Long-lasting antiepileptic effects of levetiracetam against epileptic seizures in the spontaneously epileptic rat (SER): differentiation of levetiracetam from conventional antiepileptic drugs. Epilepsia (2005) 0.87
Mature Purkinje cells require the retinoic acid-related orphan receptor-α (RORα) to maintain climbing fiber mono-innervation and other adult characteristics. J Neurosci (2013) 0.87
The Israeli strain IS-98-ST1 of West Nile virus as viral model for West Nile encephalitis in the Old World. Virol J (2004) 0.87
Identification of the rat Rex mutation as a 7-bp deletion at splicing acceptor site of the Krt71 gene. J Vet Med Sci (2010) 0.86
Hague (Hag). A new mouse hair mutation with an unstable semidominant allele. Genetics (2002) 0.86
Quantitative effects produced by modifications of neuronal activity on the size of GABAA receptor clusters in hippocampal slice cultures. Eur J Neurosci (2004) 0.86
A mouse model provides evidence that genetic background modulates anemia and liver injury in erythropoietic protoporphyria. Am J Physiol Gastrointest Liver Physiol (2005) 0.86
Rat neurological mutations cerebellar vermis defect and hobble are caused by mutations in the netrin-1 receptor gene Unc5h3. Brain Res Mol Brain Res (2004) 0.86
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Akt-dependent activation of the heart 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB2) isoenzyme by amino acids. J Biol Chem (2013) 0.85
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A rat model of hypohidrotic ectodermal dysplasia carries a missense mutation in the Edaradd gene. BMC Genet (2011) 0.85