PubRank

Stefan Rose-John

Author PubWeight™ 220.85‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer. Cancer Cell 2009 11.52
2 The pro- and anti-inflammatory properties of the cytokine interleukin-6. Biochim Biophys Acta 2011 5.72
3 TGF-beta suppresses tumor progression in colon cancer by inhibition of IL-6 trans-signaling. Immunity 2004 4.48
4 Stat3/Socs3 activation by IL-6 transsignaling promotes progression of pancreatic intraepithelial neoplasia and development of pancreatic cancer. Cancer Cell 2011 4.12
5 The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion. Blood 2003 3.51
6 CNTF reverses obesity-induced insulin resistance by activating skeletal muscle AMPK. Nat Med 2006 3.11
7 The IL-6R alpha chain controls lung CD4+CD25+ Treg development and function during allergic airway inflammation in vivo. J Clin Invest 2005 2.91
8 Transcriptional profiling identifies Id2 function in dendritic cell development. Nat Immunol 2003 2.91
9 Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling. J Clin Invest 2011 2.83
10 Not interferon, but interleukin-6 controls early gene expression in hepatitis B virus infection. Hepatology 2009 2.48
11 ADAM17: a molecular switch to control inflammation and tissue regeneration. Trends Immunol 2011 2.19
12 The transmembrane CXC-chemokine ligand 16 is induced by IFN-gamma and TNF-alpha and shed by the activity of the disintegrin-like metalloproteinase ADAM10. J Immunol 2004 2.19
13 IL-6 transsignaling: the in vivo consequences. J Interferon Cytokine Res 2005 2.17
14 Fever-range thermal stress promotes lymphocyte trafficking across high endothelial venules via an interleukin 6 trans-signaling mechanism. Nat Immunol 2006 2.05
15 Cellular cholesterol depletion triggers shedding of the human interleukin-6 receptor by ADAM10 and ADAM17 (TACE). J Biol Chem 2003 2.05
16 Apoptosis is a natural stimulus of IL6R shedding and contributes to the proinflammatory trans-signaling function of neutrophils. Blood 2007 1.92
17 Selective blockade of interleukin-6 trans-signaling improves survival in a murine polymicrobial sepsis model. Crit Care Med 2011 1.87
18 Critical role of the disintegrin metalloprotease ADAM17 for intestinal inflammation and regeneration in mice. J Exp Med 2010 1.80
19 Cutting edge: trans-signaling via the soluble IL-6R abrogates the induction of FoxP3 in naive CD4+CD25 T cells. J Immunol 2007 1.78
20 Maintenance of pluripotency in human embryonic stem cells is STAT3 independent. Stem Cells 2004 1.73
21 Interplay between IFN-gamma and IL-6 signaling governs neutrophil trafficking and apoptosis during acute inflammation. J Clin Invest 2003 1.69
22 Soluble IL-6 receptor governs IL-6 activity in experimental arthritis: blockade of arthritis severity by soluble glycoprotein 130. J Immunol 2003 1.68
23 Interleukin-6 and its receptor: from bench to bedside. Med Microbiol Immunol 2006 1.65
24 G protein-coupled receptor 43 is essential for neutrophil recruitment during intestinal inflammation. J Immunol 2009 1.65
25 The IL-6-gp130-STAT3 pathway in hepatocytes triggers liver protection in T cell-mediated liver injury. J Clin Invest 2005 1.63
26 Essential roles of IL-6 trans-signaling in colonic epithelial cells, induced by the IL-6/soluble-IL-6 receptor derived from lamina propria macrophages, on the development of colitis-associated premalignant cancer in a murine model. J Immunol 2009 1.62
27 Differentially regulated GPVI ectodomain shedding by multiple platelet-expressed proteinases. Blood 2010 1.56
28 The role of soluble receptors in cytokine biology: the agonistic properties of the sIL-6R/IL-6 complex. Biochim Biophys Acta 2002 1.53
29 Classic interleukin-6 receptor signaling and interleukin-6 trans-signaling differentially control angiotensin II-dependent hypertension, cardiac signal transducer and activator of transcription-3 activation, and vascular hypertrophy in vivo. Am J Pathol 2007 1.49
30 IL-6/IL-6R axis plays a critical role in acute kidney injury. J Am Soc Nephrol 2008 1.48
31 L1 is sequentially processed by two differently activated metalloproteases and presenilin/gamma-secretase and regulates neural cell adhesion, cell migration, and neurite outgrowth. Mol Cell Biol 2005 1.47
32 IL-6 trans-signaling licenses mouse and human tumor microvascular gateways for trafficking of cytotoxic T cells. J Clin Invest 2011 1.46
33 VEGF receptor signaling links inflammation and tumorigenesis in colitis-associated cancer. J Exp Med 2010 1.45
34 A role for IL-27p28 as an antagonist of gp130-mediated signaling. Nat Immunol 2010 1.44
35 In vivo evidence suggesting reciprocal renal hypoxia-inducible factor-1 upregulation and signal transducer and activator of transcription 3 activation in response to hypoxic and non-hypoxic stimuli. Clin Exp Pharmacol Physiol 2013 1.41
36 IL-6 trans-signaling modulates TLR4-dependent inflammatory responses via STAT3. J Immunol 2010 1.39
37 Plasticity and cross-talk of interleukin 6-type cytokines. Cytokine Growth Factor Rev 2012 1.38
38 A key role for gp130 expressed on peripheral sensory nerves in pathological pain. J Neurosci 2009 1.37
39 Transgenic blockade of interleukin 6 transsignaling abrogates inflammation. Blood 2007 1.37
40 Loss of CD4+ T cell IL-6R expression during inflammation underlines a role for IL-6 trans signaling in the local maintenance of Th17 cells. J Immunol 2010 1.36
41 The soluble Interleukin 6 receptor: generation and role in inflammation and cancer. Eur J Cell Biol 2010 1.35
42 Therapeutic targeting of IL-6 trans signaling counteracts STAT3 control of experimental inflammatory arthritis. J Immunol 2009 1.35
43 IL-6 trans-signaling in formation and progression of malignant ascites in ovarian cancer. Cancer Res 2010 1.31
44 Species specificity of ADAM10 and ADAM17 proteins in interleukin-6 (IL-6) trans-signaling and novel role of ADAM10 in inducible IL-6 receptor shedding. J Biol Chem 2011 1.29
45 Transsignaling of interleukin-6 crucially contributes to atherosclerosis in mice. Arterioscler Thromb Vasc Biol 2011 1.29
46 Interleukin-6 trans-signaling in inflammatory bowel disease. Cytokine Growth Factor Rev 2006 1.29
47 Inhibition of classic signaling is a novel function of soluble glycoprotein 130 (sgp130), which is controlled by the ratio of interleukin 6 and soluble interleukin 6 receptor. J Biol Chem 2011 1.29
48 IL-6 trans-signaling promotes pancreatitis-associated lung injury and lethality. J Clin Invest 2013 1.28
49 Interleukin-31 and oncostatin-M mediate distinct signaling reactions and response patterns in lung epithelial cells. J Biol Chem 2006 1.27
50 Tumor development in murine ulcerative colitis depends on MyD88 signaling of colonic F4/80+CD11b(high)Gr1(low) macrophages. J Clin Invest 2011 1.25
51 The transcription factor IFN regulatory factor-4 controls experimental colitis in mice via T cell-derived IL-6. J Clin Invest 2008 1.24
52 Dynamics of the gp130 cytokine complex: a model for assembly on the cellular membrane. Protein Sci 2005 1.23
53 Antibodies against tumor necrosis factor (TNF) induce T-cell apoptosis in patients with inflammatory bowel diseases via TNF receptor 2 and intestinal CD14⁺ macrophages. Gastroenterology 2011 1.20
54 IL6/sIL6R complex contributes to emergency granulopoietic responses in G-CSF- and GM-CSF-deficient mice. Blood 2007 1.20
55 Inhibition of T cell apoptosis in the aqueous humor of patients with uveitis by IL-6/soluble IL-6 receptor trans-signaling. J Immunol 2004 1.17
56 Opposing roles of gp130-mediated STAT-3 and ERK-1/ 2 signaling in liver progenitor cell migration and proliferation. Hepatology 2007 1.15
57 Interleukin-6 in sepsis and capillary leakage syndrome. J Interferon Cytokine Res 2011 1.14
58 HHV-8-encoded viral IL-6 collaborates with mouse IL-6 in the development of multicentric Castleman disease in mice. Blood 2012 1.14
59 Unraveling viral interleukin-6 binding to gp130 and activation of STAT-signaling pathways independently of the interleukin-6 receptor. J Virol 2009 1.14
60 Delivery of hyper-interleukin-6 to the injured spinal cord increases neutrophil and macrophage infiltration and inhibits axonal growth. J Comp Neurol 2002 1.11
61 Trans-signaling is a dominant mechanism for the pathogenic actions of interleukin-6 in the brain. J Neurosci 2014 1.10
62 Hitting a complex target: an update on interleukin-6 trans-signalling. Expert Opin Ther Targets 2012 1.10
63 The transcription factor NFATc2 controls IL-6-dependent T cell activation in experimental colitis. J Exp Med 2008 1.10
64 Ligand/receptor signaling threshold (LIST) model accounts for gp130-mediated embryonic stem cell self-renewal responses to LIF and HIL-6. Stem Cells 2002 1.09
65 Elastin-like polypeptides revolutionize recombinant protein expression and their biomedical application. Trends Biotechnol 2009 1.08
66 Activation of interleukin-6-induced glycoprotein 130/signal transducer and activator of transcription 3 pathway in mesenchymal stem cells enhances hepatic differentiation, proliferation, and liver regeneration. Liver Transpl 2010 1.08
67 Functional characterization of a soluble gp130 isoform and its therapeutic capacity in an experimental model of inflammatory arthritis. Arthritis Rheum 2006 1.07
68 ADAM17-mediated shedding of the IL6R induces cleavage of the membrane stub by gamma-secretase. Biochim Biophys Acta 2009 1.07
69 Genetic partitioning of interleukin-6 signalling in mice dissociates Stat3 from Smad3-mediated lung fibrosis. EMBO Mol Med 2012 1.07
70 The substrate degradome of meprin metalloproteases reveals an unexpected proteolytic link between meprin β and ADAM10. Cell Mol Life Sci 2012 1.05
71 Role of interleukin-6 for LV remodeling and survival after experimental myocardial infarction. FASEB J 2003 1.05
72 Signaling of human ciliary neurotrophic factor (CNTF) revisited. The interleukin-6 receptor can serve as an alpha-receptor for CTNF. J Biol Chem 2003 1.04
73 Sleep enhances IL-6 trans-signaling in humans. FASEB J 2006 1.03
74 TLR ligand-induced podosome disassembly in dendritic cells is ADAM17 dependent. J Cell Biol 2008 1.02
75 The interleukin-6 cytokine system regulates epidermal permeability barrier homeostasis. J Invest Dermatol 2004 1.01
76 Genetic manipulations utilizing albumin and alpha-fetoprotein promoter/enhancers affect both hepatocytes and oval cells. Hepatology 2004 1.01
77 Interleukin-6 and neural stem cells: more than gliogenesis. Mol Biol Cell 2008 1.01
78 An interleukin-6 receptor-dependent molecular switch mediates signal transduction of the IL-27 cytokine subunit p28 (IL-30) via a gp130 protein receptor homodimer. J Biol Chem 2012 1.01
79 Retracted Natural soluble interleukin-15Ralpha is generated by cleavage that involves the tumor necrosis factor-alpha-converting enzyme (TACE/ADAM17). J Biol Chem 2004 1.01
80 Ataxin-10, the spinocerebellar ataxia type 10 neurodegenerative disorder protein, is essential for survival of cerebellar neurons. J Biol Chem 2004 1.00
81 Forced dimerization of gp130 leads to constitutive STAT3 activation, cytokine-independent growth, and blockade of differentiation of embryonic stem cells. Mol Biol Cell 2006 1.00
82 ELPylated anti-human TNF therapeutic single-domain antibodies for prevention of lethal septic shock. Plant Biotechnol J 2011 0.98
83 No inhibition of IL-27 signaling by soluble gp130. Biochem Biophys Res Commun 2005 0.98
84 Increased inflammation and lethality of Dusp1-/- mice in polymicrobial peritonitis models. Immunology 2010 0.98
85 Impact of interleukin-6 classic- and trans-signaling on liver damage and regeneration. J Autoimmun 2009 0.98
86 N-linked glycosylation is essential for the stability but not the signaling function of the interleukin-6 signal transducer glycoprotein 130. J Biol Chem 2009 0.98
87 gp130 dimerization in the absence of ligand: preformed cytokine receptor complexes. Biochem Biophys Res Commun 2006 0.97
88 Role of IL-6 trans-signaling in CCl₄induced liver damage. Biochim Biophys Acta 2010 0.97
89 Soluble tumor necrosis factor (TNF) receptor-1 induces apoptosis via reverse TNF signaling and autocrine transforming growth factor-beta1. FASEB J 2004 0.97
90 Transcription factor NFATc2 controls the emergence of colon cancer associated with IL-6-dependent colitis. Cancer Res 2012 0.97
91 IL-6 controls the innate immune response against Listeria monocytogenes via classical IL-6 signaling. J Immunol 2012 0.96
92 Local blockade of IL-6R signaling induces lung CD4+ T cell apoptosis in a murine model of asthma via regulatory T cells. Int Immunol 2007 0.96
93 IL-6 transsignalling modulates the early effector phase of EAE and targets the blood-brain barrier. J Neuroimmunol 2008 0.93
94 Forced homo- and heterodimerization of all gp130-type receptor complexes leads to constitutive ligand-independent signaling and cytokine-independent growth. Mol Biol Cell 2010 0.93
95 Interleukin-6: a villain in the drama of pancreatic cancer development and progression. Hepatobiliary Pancreat Dis Int 2014 0.93
96 Differential expression of CD126 and CD130 mediates different STAT-3 phosphorylation in CD4+CD25- and CD25high regulatory T cells. Int Immunol 2006 0.92
97 "Activated" STAT proteins: a paradoxical consequence of inhibited JAK-STAT signaling in cytomegalovirus-infected cells. J Immunol 2013 0.92
98 Constitutively active mutant gp130 receptor protein from inflammatory hepatocellular adenoma is inhibited by an anti-gp130 antibody that specifically neutralizes interleukin 11 signaling. J Biol Chem 2012 0.91
99 Novel regulatory mechanisms for generation of the soluble leptin receptor: implications for leptin action. PLoS One 2012 0.91
100 Viral Interleukin-6: Structure, pathophysiology and strategies of neutralization. Eur J Cell Biol 2010 0.91
101 Structure-guided optimization of the interleukin-6 trans-signaling antagonist sgp130. J Biol Chem 2008 0.91
102 An analysis of the function and expression of D6 on lymphatic endothelial cells. Blood 2013 0.90
103 Enhancing influence of intranasal interleukin-6 on slow-wave activity and memory consolidation during sleep. FASEB J 2009 0.89
104 The membrane-proximal domain of A Disintegrin and Metalloprotease 17 (ADAM17) is responsible for recognition of the interleukin-6 receptor and interleukin-1 receptor II. FEBS Lett 2012 0.89
105 Human herpesvirus 8-derived viral IL-6 induces PTX3 expression in Kaposi's sarcoma cells. AIDS 2002 0.89
106 Identification of canonical tyrosine-dependent and non-canonical tyrosine-independent STAT3 activation sites in the intracellular domain of the interleukin 23 receptor. J Biol Chem 2013 0.89
107 Abrogation of viral interleukin-6 (vIL-6)-induced signaling by intracellular retention and neutralization of vIL-6 with an anti-vIL-6 single-chain antibody selected by phage display. J Virol 2006 0.88
108 A disintegrin and metalloprotease (ADAM) 10 and ADAM17 are major sheddases of T cell immunoglobulin and mucin domain 3 (Tim-3). J Biol Chem 2013 0.88
109 The stress-induced cytokine interleukin-6 decreases the inhibition/excitation ratio in the rat temporal cortex via trans-signaling. Biol Psychiatry 2011 0.88
110 Interaction of vascular smooth muscle cells and monocytes by soluble factors synergistically enhances IL-6 and MCP-1 production. Am J Physiol Heart Circ Physiol 2009 0.88
111 Interleukin-6 receptor specific RNA aptamers for cargo delivery into target cells. RNA Biol 2012 0.87
112 Recombinant IL-6 treatment protects mice from organ specific autoimmune disease by IL-6 classical signalling-dependent IL-1ra induction. J Autoimmun 2012 0.87
113 Accurate variant detection across non-amplified and whole genome amplified DNA using targeted next generation sequencing. BMC Genomics 2012 0.87
114 Impaired hippocampus-dependent and -independent learning in IL-6 deficient mice. Behav Brain Res 2009 0.87
115 A designer hyper interleukin 11 (H11) is a biologically active cytokine. BMC Biotechnol 2012 0.87
116 Cytokines as therapeutic drugs. J Interferon Cytokine Res 2002 0.87
117 The human interleukin-6 (IL-6) receptor exists as a preformed dimer in the plasma membrane. FEBS Lett 2003 0.87
118 Trp53 deficiency protects against acute intestinal inflammation. J Immunol 2013 0.86
119 GP130 activation induces myeloma and collaborates with MYC. J Clin Invest 2014 0.86
120 Contribution of vascular cell-derived cytokines to innate and inflammatory pathways in atherogenesis. J Cell Mol Med 2011 0.86
121 Viral IL-6 blocks neutrophil infiltration during acute inflammation. J Immunol 2005 0.86
122 Inhibition of protein kinase II (CK2) prevents induced signal transducer and activator of transcription (STAT) 1/3 and constitutive STAT3 activation. Oncotarget 2014 0.85
123 Statins potently reduce the cytokine-mediated IL-6 release in SMC/MNC cocultures. J Cell Mol Med 2011 0.85
124 Altered pulmonary interleukin-6 signaling in preterm infants developing bronchopulmonary dysplasia. Exp Lung Res 2008 0.85
125 Increased inflammation and impaired resistance to Chlamydophila pneumoniae infection in Dusp1(-/-) mice: critical role of IL-6. J Leukoc Biol 2010 0.85
126 mTNF reverse signalling induced by TNFα antagonists involves a GDF-1 dependent pathway: implications for Crohn's disease. Gut 2012 0.85
127 Long-term survival of high-risk melanoma patients immunized with a Hyper-IL-6-modified allogeneic whole-cell vaccine after complete resection. Expert Opin Investig Drugs 2012 0.84
128 Cellular senescence or EGFR signaling induces Interleukin 6 (IL-6) receptor expression controlled by mammalian target of rapamycin (mTOR). Cell Cycle 2013 0.84
129 Interleukin-6 trans-signaling and colonic cancer associated with inflammatory bowel disease. Dig Dis 2012 0.84
130 Dendritic cell lineage commitment is instructed by distinct cytokine signals. Eur J Cell Biol 2011 0.84
131 ADAM10 inhibition of human CD30 shedding increases specificity of targeted immunotherapy in vitro. Cancer Res 2007 0.83
132 Early hepatocyte DNA synthetic response posthepatectomy is modulated by IL-6 trans-signaling and PI3K/AKT activation. J Hepatol 2010 0.83
133 A novel bispecific single-chain antibody for ADAM17 and CD3 induces T-cell-mediated lysis of prostate cancer cells. Biochem J 2012 0.83
134 Interleukin-6 trans-signaling exacerbates inflammation and renal pathology in lupus-prone mice. Arthritis Rheum 2013 0.83
135 The role of IL-6 trans-signaling in vascular leakage: implications for ovarian hyperstimulation syndrome in a murine model. J Clin Endocrinol Metab 2013 0.83
136 Hepatocytes contribute to immune regulation in the liver by activation of the Notch signaling pathway in T cells. J Immunol 2013 0.83
137 Therapeutic targeting of interleukin-6 trans-signaling does not affect the outcome of experimental tuberculosis. Immunobiology 2012 0.83
138 The interleukin 6 pathway and atherosclerosis. Lancet 2012 0.83
139 Inactivation of IL-6 and soluble IL-6 receptor by neutrophil derived serine proteases in cystic fibrosis. Biochim Biophys Acta 2010 0.83
140 Short-term TNFα shedding is independent of cytoplasmic phosphorylation or furin cleavage of ADAM17. Biochim Biophys Acta 2013 0.82
141 Functional expression of a biologically active fragment of soluble gp130 as an ELP-fusion protein in transgenic plants: purification via inverse transition cycling. Biochem J 2006 0.82
142 Towards determining the differentiation program of antigen-presenting dendritic cells by transcriptional profiling. Eur J Cell Biol 2003 0.82
143 Polo-like kinase 2, a novel ADAM17 signaling component, regulates tumor necrosis factor α ectodomain shedding. J Biol Chem 2013 0.82
144 IL-6 regulates MCP-1, ICAM-1 and IL-6 expression in human myoblasts. J Neuroimmunol 2008 0.82
145 The regenerative activity of interleukin-6. Methods Mol Biol 2013 0.82
146 IL-10-induced gp130 expression in mouse mast cells permits IL-6 trans-signaling. J Leukoc Biol 2011 0.81
147 Mouse neutrophils express the decoy type 2 interleukin-1 receptor (IL-1R2) constitutively and in acute inflammatory conditions. J Leukoc Biol 2013 0.81
148 d(GGGT) 4 and r(GGGU) 4 are both HIV-1 inhibitors and interleukin-6 receptor aptamers. RNA Biol 2012 0.81
149 Oncogenic deletion mutants of gp130 signal from intracellular compartments. J Cell Sci 2013 0.81
150 Essential role of neutrophil mobilization in concanavalin A-induced hepatitis is based on classic IL-6 signaling but not on IL-6 trans-signaling. Biochim Biophys Acta 2010 0.80
151 Differential response of neuronal cells to a fusion protein of ciliary neurotrophic factor/soluble CNTF-receptor and leukemia inhibitory factor. Eur J Biochem 2002 0.80
152 A non-conservative polymorphism in the IL-6 signal transducer (IL6ST)/gp130 is associated with myocardial infarction in a hypertensive population. Regul Pept 2007 0.80
153 Polycomb group protein Bmi1 promotes hematopoietic cell development from embryonic stem cells. Stem Cells Dev 2011 0.80
154 The upper cytokine-binding module and the Ig-like domain of the leukaemia inhibitory factor (LIF) receptor are sufficient for a functional LIF receptor complex. J Mol Biol 2002 0.80
155 Virokines in the pathogenesis of cancer: focus on human herpesvirus 8. Ann N Y Acad Sci 2004 0.80
156 gp130 activation is regulated by D2-D3 interdomain connectivity. Biochem J 2013 0.79
157 The effect of gp130 stimulation on glutamate-induced excitotoxicity in primary hippocampal neurons. Biochem Biophys Res Commun 2002 0.79
158 Progressive and controlled development of mouse dendritic cells from Flt3+CD11b+ progenitors in vitro. J Immunol 2005 0.79
159 Conservation of IL-6 trans-signaling mechanisms controlling L-selectin adhesion by fever-range thermal stress. Eur J Immunol 2007 0.79
160 Transglutaminase-catalyzed covalent multimerization of Camelidae anti-human TNF single domain antibodies improves neutralizing activity. J Biotechnol 2009 0.79
161 Interleukin 27 induces differentiation of neural C6-precursor cells into astrocytes. Biochem Biophys Res Commun 2007 0.79
162 Semisynthesis of biologically active glycoforms of the human cytokine interleukin 6. Angew Chem Int Ed Engl 2014 0.79
163 ADAM17-overexpressing breast cancer cells selectively targeted by antibody-toxin conjugates. Cancer Immunol Immunother 2012 0.78
164 Analysis of the leukemia inhibitory factor receptor functional domains by chimeric receptors and cytokines. Biochemistry 2003 0.78
165 Development of a monoclonal antibody-based enzyme-linked immunoabsorbent assay for the binding of gp130 to the IL-6/IL-6R complex and its competitive inhibition. J Immunol Methods 2004 0.78
166 Erratum: STAT3 regulated ARF expression suppresses prostate cancer metastasis. Nat Commun 2015 0.78
167 Multilevel regulation of IL-6R by IL-6-sIL-6R fusion protein according to the primitiveness of peripheral blood-derived CD133+ cells. Stem Cells 2005 0.78
168 TNFα cleavage beyond TACE/ADAM17: matrix metalloproteinase 13 is a potential therapeutic target in sepsis and colitis. EMBO Mol Med 2013 0.78
169 Whole Cell Therapeutic Vaccine Modified With Hyper-IL6 for Combinational Treatment of Nonresected Advanced Melanoma. Medicine (Baltimore) 2015 0.78
170 Analysis of IL-6/gp130 family receptor expression reveals that in contrast to astroglia, microglia lack the oncostatin M receptor and functional responses to oncostatin M. Glia 2014 0.78
171 Interleukin 6/Wnt interactions in rheumatoid arthritis: interleukin 6 inhibits Wnt signaling in synovial fibroblasts and osteoblasts. Croat Med J 2016 0.78
172 Dendritic cell development requires histone deacetylase activity. Eur J Immunol 2014 0.77
173 Cytokines come of age. Biochim Biophys Acta 2002 0.77
174 Synthetic mimetics of the gp130 binding site for viral interleukin-6 as inhibitors of the vIL-6-gp130 interaction. Chem Biol Drug Des 2008 0.77
175 Interleukin-6 trans-signaling regulates glycogen consumption after D-galactosamine-induced liver damage. J Interferon Cytokine Res 2009 0.76
176 IL-6-trans-signalling increases rapid-eye-movement sleep in rats. Eur J Pharmacol 2009 0.76
177 Mycobacterium simiae infection in two unrelated patients with different forms of inherited IFN-γR2 deficiency. J Clin Immunol 2014 0.75
178 Effects of blockade of peripheral interleukin-6 trans-signaling on hippocampus-dependent and independent memory in mice. J Interferon Cytokine Res 2012 0.75
179 Designing cytokine variants by phage-display. Comb Chem High Throughput Screen 2005 0.75
180 T-cell immunoglobulin and mucin domain 2 (TIM-2) is a target of ADAM10-mediated ectodomain shedding. FEBS J 2013 0.75
181 Pharmaceutical relevant cytokine receptors: lessons from the first drafts of the human proteome. J Proteome Res 2014 0.75
182 Activation of the anti-inflammatory reflex blocks lipopolysaccharide-induced decrease in synaptic inhibition in the temporal cortex of the rat. J Neurosci Res 2015 0.75
183 The solution structure of the membrane-proximal cytokine receptor domain of the human interleukin-6 receptor. Biol Chem 2006 0.75
184 Direct determination of the interleukin-6 binding epitope of the interleukin-6 receptor by NMR spectroscopy. J Biol Chem 2003 0.75
185 Corrigendum: Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic TH17 cells. Nat Immunol 2017 0.75
186 The transcription factor repertoire of Flt3+ hematopoietic stem cells. Cells Tissues Organs 2008 0.75
187 The structure of the unliganded extracellular domain of the interleukin-6 signal transducer gp130 in solution. Eur J Cell Biol 2010 0.75
188 1H, 15N and 13C backbone assignment of the carboxyl terminal domain of the cytokine binding module of the interleukin-6 receptor. J Biomol NMR 2004 0.75
189 Novel Potent Proline-Based Metalloproteinase Inhibitors: Design, (Radio)Synthesis, and First in Vivo Evaluation as Radiotracers for Positron Emission Tomography. J Med Chem 2016 0.75