Published in PLoS One on January 01, 2010
Crystal structure of the swine-origin A (H1N1)-2009 influenza A virus hemagglutinin (HA) reveals similar antigenicity to that of the 1918 pandemic virus. Protein Cell (2010) 1.74
Variations in the hemagglutinin of the 2009 H1N1 pandemic virus: potential for strains with altered virulence phenotype? PLoS Pathog (2010) 1.70
Immuno-epidemiologic correlates of pandemic H1N1 surveillance observations: higher antibody and lower cell-mediated immune responses with advanced age. J Infect Dis (2011) 1.61
Characterization of quasispecies of pandemic 2009 influenza A virus (A/H1N1/2009) by de novo sequencing using a next-generation DNA sequencer. PLoS One (2010) 1.56
Influenza virus drug resistance: a time-sampled population genetics perspective. PLoS Genet (2014) 1.32
Characterization in vitro and in vivo of a pandemic H1N1 influenza virus from a fatal case. PLoS One (2013) 1.30
Antigenic drift of the pandemic 2009 A(H1N1) influenza virus in A ferret model. PLoS Pathog (2013) 1.20
The first influenza pandemic of the new millennium. Influenza Other Respir Viruses (2011) 1.14
A single-amino-acid substitution in the HA protein changes the replication and pathogenicity of the 2009 pandemic A (H1N1) influenza viruses in vitro and in vivo. Virol J (2010) 1.09
Theoretical basis to measure the impact of short-lasting control of an infectious disease on the epidemic peak. Theor Biol Med Model (2011) 1.07
Free-energy simulations reveal that both hydrophobic and polar interactions are important for influenza hemagglutinin antibody binding. Biophys J (2012) 1.02
Molecular basis of the structure and function of H1 hemagglutinin of influenza virus. Proc Jpn Acad Ser B Phys Biol Sci (2012) 1.00
Nationwide molecular surveillance of pandemic H1N1 influenza A virus genomes: Canada, 2009. PLoS One (2011) 1.00
New variants and age shift to high fatality groups contribute to severe successive waves in the 2009 influenza pandemic in Taiwan. PLoS One (2011) 0.99
Glycosylations in the globular head of the hemagglutinin protein modulate the virulence and antigenic properties of the H1N1 influenza viruses. Sci Transl Med (2013) 0.99
Structural vaccinology: structure-based design of influenza A virus hemagglutinin subtype-specific subunit vaccines. Protein Cell (2012) 0.98
An influenza A/H1N1/2009 hemagglutinin vaccine produced in Escherichia coli. PLoS One (2010) 0.97
Emerged HA and NA mutants of the pandemic influenza H1N1 viruses with increasing epidemiological significance in Taipei and Kaohsiung, Taiwan, 2009-10. PLoS One (2012) 0.95
Predominance of HA-222D/G polymorphism in influenza A(H1N1)pdm09 viruses associated with fatal and severe outcomes recently circulating in Germany. PLoS One (2013) 0.95
Epidemiological and virological characteristics of influenza viruses circulating in Cambodia from 2009 to 2011. PLoS One (2014) 0.89
A (H1N1) pdm09 HA D222 variants associated with severity and mortality in patients during a second wave in Mexico. Virol J (2013) 0.89
Molecular characterization of the predominant influenza A(H1N1)pdm09 virus in Mexico, December 2011-February 2012. PLoS One (2012) 0.89
N-linked glycosylation of the hemagglutinin protein influences virulence and antigenicity of the 1918 pandemic and seasonal H1N1 influenza A viruses. J Virol (2013) 0.88
Prediction of directional changes of influenza A virus genome sequences with emphasis on pandemic H1N1/09 as a model case. DNA Res (2011) 0.87
Emerging antigenic variants at the antigenic site Sb in pandemic A(H1N1)2009 influenza virus in Japan detected by a human monoclonal antibody. PLoS One (2013) 0.86
Phylodynamics of H1N1/2009 influenza reveals the transition from host adaptation to immune-driven selection. Nat Commun (2015) 0.85
Soluble host defense lectins in innate immunity to influenza virus. J Biomed Biotechnol (2012) 0.85
Amino acids transitioning of 2009 H1N1pdm in Taiwan from 2009 to 2011. PLoS One (2012) 0.84
The Genomic Contributions of Avian H1N1 Influenza A Viruses to the Evolution of Mammalian Strains. PLoS One (2015) 0.84
Molecular evolution of the hemagglutinin and neuraminidase genes of pandemic (H1N1) 2009 influenza viruses in Sendai, Japan, during 2009-2011. Virus Genes (2013) 0.82
Hemagglutinin 222D/G polymorphism facilitates fast intra-host evolution of pandemic (H1N1) 2009 influenza A viruses. PLoS One (2014) 0.82
Survival analysis of infected mice reveals pathogenic variations in the genome of avian H1N1 viruses. Sci Rep (2014) 0.79
The DE and FG loops of the HPV major capsid protein contribute to the epitopes of vaccine-induced cross-neutralising antibodies. Sci Rep (2016) 0.77
Subsisting H1N1 influenza memory responses are insufficient to protect from pandemic H1N1 influenza challenge in C57BL/6 mice. J Gen Virol (2013) 0.77
Molecular dynamics analysis of antibody recognition and escape by human H1N1 influenza hemagglutinin. Biophys J (2015) 0.76
Extreme evolutionary conservation of functionally important regions in H1N1 influenza proteome. PLoS One (2013) 0.76
Amino acid substitutions in hemagglutinin of the 2009 pandemic influenza A(H1N1) viruses that might affect the viral antigenicity. BMC Res Notes (2014) 0.75
Genetic Characterization of Circulating 2015 A(H1N1)pdm09 Influenza Viruses from Eastern India. PLoS One (2016) 0.75
Predicting the Mutating Distribution at Antigenic Sites of the Influenza Virus. Sci Rep (2016) 0.75
Investigating the effect of AS03 adjuvant on the plasma cell repertoire following pH1N1 influenza vaccination. Sci Rep (2016) 0.75
Genomic reassortants of pandemic A (H1N1) 2009 virus and endemic porcine H1 and H3 viruses in swine in Japan. J Vet Med Sci (2014) 0.75
A Combinatorial approach: To design inhibitory molecules on Hemagglutinin protein of H1N1 virus (Swine Flu). Bioinformation (2013) 0.75
The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools. Nucleic Acids Res (1997) 175.36
Emergence of a novel swine-origin influenza A (H1N1) virus in humans. N Engl J Med (2009) 42.75
Antigenic and genetic characteristics of swine-origin 2009 A(H1N1) influenza viruses circulating in humans. Science (2009) 25.61
In vitro and in vivo characterization of new swine-origin H1N1 influenza viruses. Nature (2009) 14.59
The antigenic structure of the influenza virus A/PR/8/34 hemagglutinin (H1 subtype). Cell (1982) 12.44
Initial genetic characterization of the 1918 "Spanish" influenza virus. Science (1997) 10.17
Serum cross-reactive antibody response to a novel influenza A (H1N1) virus after vaccination with seasonal influenza vaccine. MMWR Morb Mortal Wkly Rep (2009) 9.94
Statistical potential for assessment and prediction of protein structures. Protein Sci (2006) 8.98
Origin and evolution of the 1918 "Spanish" influenza virus hemagglutinin gene. Proc Natl Acad Sci U S A (1999) 8.40
VERIFY3D: assessment of protein models with three-dimensional profiles. Methods Enzymol (1997) 6.71
Antigenic structure of influenza virus haemagglutinin defined by hybridoma antibodies. Nature (1981) 5.00
Theory and applications of the generalized Born solvation model in macromolecular simulations. Biopolymers (2001) 4.68
Tools for comparative protein structure modeling and analysis. Nucleic Acids Res (2003) 3.68
The origin of the 1918 pandemic influenza virus: a continuing enigma. J Gen Virol (2003) 2.98
The PDBFINDER database: a summary of PDB, DSSP and HSSP information with added value. Comput Appl Biosci (1996) 2.46
Evaluation of hemagglutinin subtype 1 swine influenza viruses from the United States. Vet Microbiol (2006) 2.45
The predicted antigenicity of the haemagglutinin of the 1918 Spanish influenza pandemic suggests an avian origin. Philos Trans R Soc Lond B Biol Sci (2001) 2.29
Plasmid-only rescue of influenza A virus vaccine candidates. Philos Trans R Soc Lond B Biol Sci (2001) 2.28
Antigenic conservation of H1N1 swine influenza viruses. J Gen Virol (1989) 1.98
Mapping the sequence mutations of the 2009 H1N1 influenza A virus neuraminidase relative to drug and antibody binding sites. Biol Direct (2009) 1.70
Hemagglutinin mutations related to antigenic variation in H1 swine influenza viruses. J Virol (1992) 1.66
Molecular evolution of hemagglutinin genes of H1N1 swine and human influenza A viruses. J Mol Evol (1991) 1.63
Addition of carbohydrate side chains at novel sites on influenza virus hemagglutinin can modulate the folding, transport, and activity of the molecule. J Cell Biol (1988) 1.50
Genetically destined potentials for N-linked glycosylation of influenza virus hemagglutinin. Virology (2008) 1.23
Cross-reactive H1N1 antibody responses to a live attenuated influenza vaccine in children: implication for selection of vaccine strains. J Infect Dis (2003) 0.95
In vitro and in vivo characterization of new swine-origin H1N1 influenza viruses. Nature (2009) 14.59
Avian flu: isolation of drug-resistant H5N1 virus. Nature (2005) 6.66
Enhanced virulence of influenza A viruses with the haemagglutinin of the 1918 pandemic virus. Nature (2004) 6.11
Architecture of ribonucleoprotein complexes in influenza A virus particles. Nature (2006) 4.52
Characterization of H7N9 influenza A viruses isolated from humans. Nature (2013) 3.71
Ebola virus VP40 drives the formation of virus-like filamentous particles along with GP. J Virol (2002) 3.62
Hierarchy among viral RNA (vRNA) segments in their role in vRNA incorporation into influenza A virions. J Virol (2006) 2.70
Contributions of two nuclear localization signals of influenza A virus nucleoprotein to viral replication. J Virol (2006) 2.60
Importance of both the coding and the segment-specific noncoding regions of the influenza A virus NS segment for its efficient incorporation into virions. J Virol (2005) 2.45
Molecular determinants of Ebola virus virulence in mice. PLoS Pathog (2006) 2.44
Cross-protective potential of a novel monoclonal antibody directed against antigenic site B of the hemagglutinin of influenza A viruses. PLoS Pathog (2009) 2.29
Tyro3 family-mediated cell entry of Ebola and Marburg viruses. J Virol (2006) 2.24
Polymorphisms and the differential antiviral activity of the chicken Mx gene. Genome Res (2002) 2.18
Characterization of a human H5N1 influenza A virus isolated in 2003. J Virol (2005) 2.09
Production of novel ebola virus-like particles from cDNAs: an alternative to ebola virus generation by reverse genetics. J Virol (2004) 2.09
Ebola virus VP40 late domains are not essential for viral replication in cell culture. J Virol (2005) 1.97
Immune parameters correlate with protection against ebola virus infection in rodents and nonhuman primates. Sci Transl Med (2012) 1.83
Intranasal immunization with formalin-inactivated virus vaccine induces a broad spectrum of heterosubtypic immunity against influenza A virus infection in mice. Vaccine (2003) 1.78
Concern Serological evidence of Ebola virus infection in Indonesian orangutans. PLoS One (2012) 1.75
Replication and transmission of influenza viruses in Japanese quail. Virology (2003) 1.64
Assembly and budding of Ebolavirus. PLoS Pathog (2006) 1.62
Enzyme-linked immunosorbent assay for detection of filovirus species-specific antibodies. Clin Vaccine Immunol (2010) 1.59
Tetraspanin CD151 protects against pulmonary fibrosis by maintaining epithelial integrity. Am J Respir Crit Care Med (2012) 1.55
Protective efficacy of neutralizing monoclonal antibodies in a nonhuman primate model of Ebola hemorrhagic fever. PLoS One (2012) 1.54
Characterization of H5N1 highly pathogenic avian influenza virus strains isolated from migratory waterfowl in Mongolia on the way back from the southern Asia to their northern territory. Virology (2010) 1.48
Neurotropism of the 1997 Hong Kong H5N1 influenza virus in mice. Vet Microbiol (2003) 1.47
Pathologic findings of initial biopsies reflect the outcomes of membranous nephropathy. Kidney Int (2004) 1.46
Influenza A virus polymerase inhibits type I interferon induction by binding to interferon beta promoter stimulator 1. J Biol Chem (2010) 1.43
The development and characterization of H5 influenza virus vaccines derived from a 2003 human isolate. Vaccine (2005) 1.42
Resistance to influenza A virus infection in transformed cell lines expressing an anti-PB2 monoclonal antibody. Vet J (2013) 1.39
Generation of velogenic Newcastle disease viruses from a nonpathogenic waterfowl isolate by passaging in chickens. Virology (2002) 1.37
The quail and chicken intestine have sialyl-galactose sugar chains responsible for the binding of influenza A viruses to human type receptors. Glycobiology (2007) 1.37
PB2 protein of a highly pathogenic avian influenza virus strain A/chicken/Yamaguchi/7/2004 (H5N1) determines its replication potential in pigs. J Virol (2008) 1.36
Rapid and simple detection of Ebola virus by reverse transcription-loop-mediated isothermal amplification. J Virol Methods (2006) 1.35
Efficacy and safety of intravenous peramivir for treatment of seasonal influenza virus infection. Antimicrob Agents Chemother (2010) 1.33
Immunogenicity and protective efficacy of replication-incompetent influenza virus-like particles. J Virol (2002) 1.30
Interregional transmission of the internal protein genes of H2 influenza virus in migratory ducks from North America to Eurasia. Virus Genes (2004) 1.28
Discussions and decisions of the 2012–2014 International Committee on Taxonomy of Viruses (ICTV) Filoviridae Study Group, January 2012–June 2013. Arch Virol (2014) 1.27
Molecular characterization of the hemagglutinin and neuraminidase genes of H5N1 influenza A viruses isolated from poultry in Vietnam from 2004 to 2005. J Vet Med Sci (2006) 1.23
Genetically destined potentials for N-linked glycosylation of influenza virus hemagglutinin. Virology (2008) 1.23
Early [18F]fluorodeoxyglucose positron emission tomography at two days of gefitinib treatment predicts clinical outcome in patients with adenocarcinoma of the lung. Clin Cancer Res (2011) 1.22
Heterosubtypic antibody recognition of the influenza virus hemagglutinin receptor binding site enhanced by avidity. Proc Natl Acad Sci U S A (2012) 1.22
Serological evidence of transmission of human influenza A and B viruses to Caspian seals (Phoca caspica). Microbiol Immunol (2002) 1.21
A p38 MAPK inhibitor, FR-167653, ameliorates murine bleomycin-induced pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol (2002) 1.20
Involvement of extracellular signal-regulated kinase and p38 in human diabetic nephropathy. Am J Kidney Dis (2005) 1.19
H9N2 influenza viruses prevalent in poultry in China are phylogenetically distinct from A/quail/Hong Kong/G1/97 presumed to be the donor of the internal protein genes of the H5N1 Hong Kong/97 virus. Avian Pathol (2003) 1.19
Development of vaccine strains of H5 and H7 influenza viruses. Jpn J Vet Res (2008) 1.18
Intravenous peramivir for treatment of influenza A and B virus infection in high-risk patients. Antimicrob Agents Chemother (2011) 1.16
Virus nomenclature below the species level: a standardized nomenclature for laboratory animal-adapted strains and variants of viruses assigned to the family Filoviridae. Arch Virol (2013) 1.16
Isolation and characterization of potentially pathogenic H5N2 influenza virus from a chicken in Taiwan in 2008. Avian Dis (2010) 1.13
Reintroduction of H5N1 highly pathogenic avian influenza virus by migratory water birds, causing poultry outbreaks in the 2010-2011 winter season in Japan. J Gen Virol (2011) 1.13
Phase III randomized, double-blind study comparing single-dose intravenous peramivir with oral oseltamivir in patients with seasonal influenza virus infection. Antimicrob Agents Chemother (2011) 1.12
Virus nomenclature below the species level: a standardized nomenclature for filovirus strains and variants rescued from cDNA. Arch Virol (2013) 1.10
Seroepidemiological evidence of avian H4, H5, and H9 influenza A virus transmission to pigs in southeastern China. Vet Microbiol (2002) 1.09
Subcutaneous hematoma due to frequent insulin injections in a single site. Intern Med (2004) 1.08
Nucleocapsid-like structures of Ebola virus reconstructed using electron tomography. J Vet Med Sci (2005) 1.06
Novel arenavirus, Zambia. Emerg Infect Dis (2011) 1.06
Sustained interleukin-6 signalling leads to the development of lymphoid organ-like structures in the lung. J Pathol (2003) 1.05
A novel Ebola virus expressing luciferase allows for rapid and quantitative testing of antivirals. Antiviral Res (2013) 1.04
Single immunization with a monovalent vesicular stomatitis virus-based vaccine protects nonhuman primates against heterologous challenge with Bundibugyo ebolavirus. J Infect Dis (2011) 1.03
Involvement of endothelial apoptosis underlying chronic obstructive pulmonary disease-like phenotype in adiponectin-null mice: implications for therapy. Am J Respir Crit Care Med (2011) 1.02
Antibody-dependent enhancement of Marburg virus infection. J Infect Dis (2011) 1.02
Computational discovery of DNA motifs associated with cell type-specific gene expression in Ciona. Dev Biol (2004) 1.02
Detection of all known filovirus species by reverse transcription-polymerase chain reaction using a primer set specific for the viral nucleoprotein gene. J Virol Methods (2010) 1.01
Pathogenicity of H5N1 influenza A viruses isolated in Vietnam between late 2003 and 2005. J Vet Med Sci (2006) 1.01
Tobacco calmodulin-like protein provides secondary defense by binding to and directing degradation of virus RNA silencing suppressors. Proc Natl Acad Sci U S A (2012) 1.00
Inhibition of Marburg virus budding by nonneutralizing antibodies to the envelope glycoprotein. J Virol (2012) 1.00
H2N5 influenza virus isolates from terns in Australia: genetic reassortants between those of the Eurasian and American lineages. Virus Genes (2008) 0.99
Inhibitory roles of signal transducer and activator of transcription 3 in antitumor immunity during carcinogen-induced lung tumorigenesis. Cancer Res (2012) 0.99
Antigenic, genetic, and pathogenic characterization of H5N1 highly pathogenic avian influenza viruses isolated from dead whooper swans (Cygnus cygnus) found in northern Japan in 2008. Virus Genes (2010) 0.99
Detection of cell-cell fusion mediated by Ebola virus glycoproteins. J Virol (2006) 0.98
Different potential of C-type lectin-mediated entry between Marburg virus strains. J Virol (2010) 0.98
Safe and successful treatment with erlotinib after gefitinib-induced hepatotoxicity: difference in metabolism as a possible mechanism. J Clin Oncol (2011) 0.98