PubRank

Michel Chrétien

Author PubWeight™ 50.45‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 NARC-1/PCSK9 and its natural mutants: zymogen cleavage and effects on the low density lipoprotein (LDL) receptor and LDL cholesterol. J Biol Chem 2004 4.37
2 Proprotein convertases: lessons from knockouts. FASEB J 2006 1.92
3 PCSK9: a key modulator of cardiovascular health. Circ Res 2014 1.71
4 Plasma PCSK9 levels are significantly modified by statins and fibrates in humans. Lipids Health Dis 2008 1.56
5 The secretory proprotein convertases furin, PC5, and PC7 activate VEGF-C to induce tumorigenesis. J Clin Invest 2003 1.51
6 Proprotein convertases in tumor progression and malignancy: novel targets in cancer therapy. Am J Pathol 2002 1.46
7 Plasma PCSK9 levels correlate with cholesterol in men but not in women. Biochem Biophys Res Commun 2007 1.27
8 The multifaceted proprotein convertases: their unique, redundant, complementary, and opposite functions. J Biol Chem 2013 1.27
9 Deletion of the gene encoding proprotein convertase 5/6 causes early embryonic lethality in the mouse. Mol Cell Biol 2006 1.23
10 Involvement of matrix metalloproteinases in the adipose conversion of 3T3-L1 preadipocytes. Biochem J 2002 1.18
11 Inhibition of Chikungunya virus infection in cultured human muscle cells by furin inhibitors: impairment of the maturation of the E2 surface glycoprotein. J Biol Chem 2008 1.14
12 Novel loss-of-function PCSK9 variant is associated with low plasma LDL cholesterol in a French-Canadian family and with impaired processing and secretion in cell culture. Clin Chem 2011 1.14
13 The proteolytic processing of pro-platelet-derived growth factor-A at RRKR(86) by members of the proprotein convertase family is functionally correlated to platelet-derived growth factor-A-induced functions and tumorigenicity. Cancer Res 2003 1.12
14 A rapid fluorometric assay for the proteolytic activity of SKI-1/S1P based on the surface glycoprotein of the hemorrhagic fever Lassa virus. FEBS Lett 2002 1.08
15 Implication of proprotein convertases in the processing and spread of severe acute respiratory syndrome coronavirus. Biochem Biophys Res Commun 2005 1.08
16 Regulation of matrix metalloproteinase MT1-MMP/MMP-2 in cardiac fibroblasts by TGF-beta1 involves furin-convertase. Cardiovasc Res 2004 1.05
17 Loss- and gain-of-function PCSK9 variants: cleavage specificity, dominant negative effects, and low density lipoprotein receptor (LDLR) degradation. J Biol Chem 2012 1.00
18 PCSK9 is phosphorylated by a Golgi casein kinase-like kinase ex vivo and circulates as a phosphoprotein in humans. FEBS J 2008 0.99
19 Structure-function analysis of the prosegment of the proprotein convertase PC5A. J Biol Chem 2002 0.97
20 Furin-like proprotein convertases are central regulators of the membrane type matrix metalloproteinase-pro-matrix metalloproteinase-2 proteolytic cascade in atherosclerosis. Circulation 2005 0.95
21 In vitro elucidation of substrate specificity and bioassay of proprotein convertase 4 using intramolecularly quenched fluorogenic peptides. Biochem J 2004 0.92
22 Abnormal expression and processing of the proprotein convertases PC1 and PC2 in human colorectal liver metastases. BMC Cancer 2005 0.92
23 Effects of rs6234/rs6235 and rs6232/rs6234/rs6235 PCSK1 single-nucleotide polymorphism clusters on proprotein convertase 1/3 biosynthesis and activity. Mol Genet Metab 2011 0.89
24 Proprotein convertases are important mediators of the adipocyte differentiation of mouse 3T3-L1 cells. J Cell Sci 2002 0.88
25 Differential effects of PCSK9 loss of function variants on serum lipid and PCSK9 levels in Caucasian and African Canadian populations. Lipids Health Dis 2013 0.87
26 Evidence for proprotein convertase activity in the endoplasmic reticulum/early Golgi. FEBS Lett 2005 0.86
27 Allelic clustering and ancestry-dependent frequencies of rs6232, rs6234, and rs6235 PCSK1 SNPs in a Northern Ontario population sample. J Community Genet 2012 0.85
28 Differences of pancreatic expression of 7B2 between C57BL/6J and C3H/HeJ mice and genetic polymorphisms at its locus (Sgne1). Diabetes 2006 0.85
29 Endoproteolytic activation of alpha(v) integrin by proprotein convertase PC5 is required for vascular smooth muscle cell adhesion to vitronectin and integrin-dependent signaling. Circulation 2004 0.85
30 A fluorogenic peptide containing the processing site of human SARS corona virus S-protein: kinetic evaluation and NMR structure elucidation. Chembiochem 2007 0.84
31 A targeted deletion/insertion in the mouse Pcsk1 locus is associated with homozygous embryo preimplantation lethality, mutant allele preferential transmission and heterozygous female susceptibility to dietary fat. Dev Biol 2007 0.83
32 Proprotein convertases subtilisin/kexin type 9, an enzyme turned escort protein: hepatic and extra hepatic functions. J Diabetes 2013 0.82
33 Aminoethyl benzenesulfonyl fluoride and its hexapeptide (Ac-VFRSLK) conjugate are both in vitro inhibitors of subtilisin kexin isozyme-1. FEBS Lett 2004 0.82
34 Increased stress-induced analgesia in mice lacking the proneuropeptide convertase PC2. Neurosci Lett 2006 0.82
35 Expression of PCSK1 (PC1/3), PCSK2 (PC2) and PCSK3 (furin) in mouse small intestine. Regul Pept 2008 0.81
36 Proprotein convertase PC5 regulation by PDGF-BB involves PI3-kinase/p70(s6)-kinase activation in vascular smooth muscle cells. Hypertension 2002 0.81
37 Quantitative proteomic analysis of PCSK9 gain of function in human hepatic HuH7 cells. J Proteome Res 2011 0.81
38 PCSK2-null mice exhibit delayed intestinal motility, reduced refeeding response and altered plasma levels of several regulatory peptides. Life Sci 2010 0.80
39 Of PCSK9, cholesterol homeostasis and parasitic infections: possible survival benefits of loss-of-function PCSK9 genetic polymorphisms. Med Hypotheses 2007 0.80
40 The metabolism of beta-amyloid converting enzyme and beta-amyloid precursor protein processing. Biochem Biophys Res Commun 2004 0.79
41 Variable effects of gender and Western diet on lipid and glucose homeostasis in aged PCSK9-deficient C57BL/6 mice CSK9PC57BL/6. J Diabetes 2014 0.79
42 Expression and transient nuclear translocation of proprotein convertase 1 (PC1) during mouse preimplantation embryonic development. Mol Reprod Dev 2005 0.79
43 Proprotein convertases regulate insulin-like growth factor 1-induced membrane-type 1 matrix metalloproteinase in VSMCs via endoproteolytic activation of the insulin-like growth factor-1 receptor. Biochem Biophys Res Commun 2004 0.78
44 Coordinated regulation and colocalization of alphav integrin and its activating enzyme proprotein convertase PC5 in vivo. Histochem Cell Biol 2003 0.77
45 Characterization of a repressor element in the promoter region of proprotein convertase 2 (PC2) gene. Brain Res Mol Brain Res 2002 0.76
46 Targeted production of proprotein convertase PC1 enhances mammary development and tumorigenesis in transgenic mice. Can J Physiol Pharmacol 2009 0.76
47 Immunohistochemical localization of subtilisin/kexin-like proprotein convertases in human atherosclerosis. Virchows Arch 2005 0.76
48 Mechanisms required to ensure research integrity. CMAJ 2011 0.75
49 Structural and biochemical investigation of heptad repeat derived peptides of human SARS corona virus (hSARS-CoV) spike protein. Protein Pept Lett 2008 0.75
50 Endoproteolysis in health and diseases--implications of proprotein convertases (PCs). J Mol Med (Berl) 2005 0.75
51 Proteomic analysis of neuroendocrine peptidergic system disruption using the AtT20 pituitary cell line as a model. Methods Mol Biol 2008 0.75
52 Genetic mapping of the gene for SKI-1/S1P protease (locus symbol Mbtps1) to mouse chromosome 8. DNA Seq 2002 0.75