Published in Immunity on December 18, 2009
Host genotype-specific therapies can optimize the inflammatory response to mycobacterial infections. Cell (2012) 3.54
HIV and tuberculosis: a deadly human syndemic. Clin Microbiol Rev (2011) 3.28
Revisiting the role of the granuloma in tuberculosis. Nat Rev Immunol (2012) 2.86
Dysbiosis of the gut microbiota is associated with HIV disease progression and tryptophan catabolism. Sci Transl Med (2013) 2.47
Indoleamine 2,3 dioxygenase and metabolic control of immune responses. Trends Immunol (2012) 2.37
The immunological life cycle of tuberculosis. Nat Rev Immunol (2012) 2.25
Regulation of neutrophils by interferon-γ limits lung inflammation during tuberculosis infection. J Exp Med (2011) 2.22
Autophagy protects against active tuberculosis by suppressing bacterial burden and inflammation. Proc Natl Acad Sci U S A (2012) 2.10
Pathological role of interleukin 17 in mice subjected to repeated BCG vaccination after infection with Mycobacterium tuberculosis. J Exp Med (2010) 2.10
Tryptophan biosynthesis protects mycobacteria from CD4 T-cell-mediated killing. Cell (2013) 1.96
Neutrophils exert protection in the early tuberculous granuloma by oxidative killing of mycobacteria phagocytosed from infected macrophages. Cell Host Microbe (2012) 1.94
Opposing biological functions of tryptophan catabolizing enzymes during intracellular infection. J Infect Dis (2011) 1.86
IL-17 and Th17 cells in tuberculosis. Cytokine Growth Factor Rev (2010) 1.86
Initiation and regulation of T-cell responses in tuberculosis. Mucosal Immunol (2011) 1.77
LprG-mediated surface expression of lipoarabinomannan is essential for virulence of Mycobacterium tuberculosis. PLoS Pathog (2014) 1.57
Dynamic roles of type I and type II IFNs in early infection with Mycobacterium tuberculosis. J Immunol (2012) 1.43
In search of a new paradigm for protective immunity to TB. Nat Rev Microbiol (2014) 1.39
Hypervirulent Mycobacterium tuberculosis strain triggers necrotic lung pathology associated with enhanced recruitment of neutrophils in resistant C57BL/6 mice. PLoS One (2017) 1.39
CXCL5-secreting pulmonary epithelial cells drive destructive neutrophilic inflammation in tuberculosis. J Clin Invest (2014) 1.24
S100A8/A9 proteins mediate neutrophilic inflammation and lung pathology during tuberculosis. Am J Respir Crit Care Med (2013) 1.23
Antagonistic crosstalk between type I and II interferons and increased host susceptibility to bacterial infections. Virulence (2010) 1.21
Tuberculosis immunopathology: the neglected role of extracellular matrix destruction. Sci Transl Med (2011) 1.19
Amino acid catabolism: a pivotal regulator of innate and adaptive immunity. Immunol Rev (2012) 1.16
B cells regulate neutrophilia during Mycobacterium tuberculosis infection and BCG vaccination by modulating the interleukin-17 response. PLoS Pathog (2013) 1.14
Psychological stress-induced, IDO1-dependent tryptophan catabolism: implications on immunosuppression in mice and humans. PLoS One (2010) 1.13
Cellular response to mycobacteria: balancing protection and pathology. Trends Immunol (2011) 1.10
Induced sputum MMP-1, -3 & -8 concentrations during treatment of tuberculosis. PLoS One (2013) 1.07
Highlights of 10 years of immunology in Nature Reviews Immunology. Nat Rev Immunol (2011) 1.06
Compensatory T cell responses in IRG-deficient mice prevent sustained Chlamydia trachomatis infections. PLoS Pathog (2011) 1.04
CD4+ T cell-dependent IFN-γ production by CD8+ effector T cells in Mycobacterium tuberculosis infection. J Immunol (2012) 1.03
Cytokines in the balance of protection and pathology during mycobacterial infections. Adv Exp Med Biol (2013) 0.97
T cells from Programmed Death-1 deficient mice respond poorly to Mycobacterium tuberculosis infection. PLoS One (2011) 0.97
M. tuberculosis induces potent activation of IDO-1, but this is not essential for the immunological control of infection. PLoS One (2012) 0.96
Neutrophil-Derived MMP-8 Drives AMPK-Dependent Matrix Destruction in Human Pulmonary Tuberculosis. PLoS Pathog (2015) 0.96
Induction and role of indoleamine 2,3 dioxygenase in mouse models of influenza a virus infection. PLoS One (2013) 0.94
CD40 induces anti-Toxoplasma gondii activity in nonhematopoietic cells dependent on autophagy proteins. Infect Immun (2013) 0.94
Beyond macrophages: the diversity of mononuclear cells in tuberculosis. Immunol Rev (2014) 0.93
Protection versus pathology in tuberculosis: recent insights. Curr Opin Immunol (2012) 0.92
New Insights into IDO Biology in Bacterial and Viral Infections. Front Immunol (2014) 0.92
Characterization of innate responses to influenza virus infection in a novel lung type I epithelial cell model. J Gen Virol (2013) 0.91
Non-hematopoietic cells contribute to protective tolerance to Aspergillus fumigatus via a TRIF pathway converging on IDO. Cell Mol Immunol (2010) 0.91
MR1-restricted mucosal associated invariant T (MAIT) cells in the immune response to Mycobacterium tuberculosis. Immunol Rev (2015) 0.89
GCN2-dependent metabolic stress is essential for endotoxemic cytokine induction and pathology. Mol Cell Biol (2013) 0.89
IL-23 in infections, inflammation, autoimmunity and cancer: possible role in HIV-1 and AIDS. J Neuroimmune Pharmacol (2011) 0.88
Gut-Resident Lactobacillus Abundance Associates with IDO1 Inhibition and Th17 Dynamics in SIV-Infected Macaques. Cell Rep (2015) 0.87
Adventures within the speckled band: heterogeneity, angiogenesis, and balanced inflammation in the tuberculous granuloma. Immunol Rev (2015) 0.86
Immunity and tolerance to fungi in hematopoietic transplantation: principles and perspectives. Front Immunol (2012) 0.86
Critical and independent role for SOCS3 in either myeloid or T cells in resistance to Mycobacterium tuberculosis. PLoS Pathog (2013) 0.86
Interleukin 22 inhibits intracellular growth of Mycobacterium tuberculosis by enhancing calgranulin A expression. J Infect Dis (2013) 0.86
Lymphatic endothelial cells are a replicative niche for Mycobacterium tuberculosis. J Clin Invest (2016) 0.85
Lessons of leprosy: the emergence of TH17 cytokines during type II reactions (ENL) is teaching us about T-cell plasticity. J Drugs Dermatol (2012) 0.84
Immunometabolism within the tuberculosis granuloma: amino acids, hypoxia, and cellular respiration. Semin Immunopathol (2015) 0.84
Impaired M. tuberculosis Antigen-Specific IFN-γ Response without IL-17 Enhancement in Patients with Severe Cavitary Pulmonary Tuberculosis. PLoS One (2015) 0.83
CD4 T Cell-Derived IFN-γ Plays a Minimal Role in Control of Pulmonary Mycobacterium tuberculosis Infection and Must Be Actively Repressed by PD-1 to Prevent Lethal Disease. PLoS Pathog (2016) 0.83
Interferon γ and Tumor Necrosis Factor Are Not Essential Parameters of CD4+ T-Cell Responses for Vaccine Control of Tuberculosis. J Infect Dis (2015) 0.81
Variation of Mycobacterium tuberculosis antigen-specific IFN-γ and IL-17 responses in healthy tuberculin skin test (TST)-positive human subjects. PLoS One (2012) 0.81
Early control of Mycobacterium tuberculosis infection requires il12rb1 expression by rag1-dependent lineages. Infect Immun (2012) 0.80
Indoleamine 2,3-dioxygenase and metabolites protect murine lung allografts and impair the calcium mobilization of T cells. Am J Respir Cell Mol Biol (2012) 0.79
Mycobacterium tuberculosis infection of the 'non-classical immune cell'. Immunol Cell Biol (2015) 0.79
Granulomas and Inflammation: Host-Directed Therapies for Tuberculosis. Front Immunol (2016) 0.79
STIM1 controls T cell-mediated immune regulation and inflammation in chronic infection. J Clin Invest (2015) 0.78
IL-17RA in Non-Hematopoietic Cells Controls CXCL-1 and 5 Critical to Recruit Neutrophils to the Lung of Mycobacteria-Infected Mice during the Adaptive Immune Response. PLoS One (2016) 0.78
Evolution to a chronic disease niche correlates with increased sensitivity to tryptophan availability for the obligate intracellular bacterium Chlamydia pneumoniae. J Bacteriol (2014) 0.77
Broad adaptive immune responses to M. tuberculosis antigens precede TST conversion in tuberculosis exposed household contacts in a TB-endemic setting. PLoS One (2014) 0.76
Host-Directed Therapies for Tuberculosis. Cold Spring Harb Perspect Med (2015) 0.76
Infection rate and tissue localization of murine IL-12p40-producing monocyte-derived CD103(+) lung dendritic cells during pulmonary tuberculosis. PLoS One (2013) 0.76
Investigation of the kynurenine pathway in Indoleamine 2, 3 dioxygenase deficient mice with inflammatory arthritis. Transgenic Res (2013) 0.76
Postprimary Tuberculosis and Macrophage Necrosis: Is There a Big ConNECtion? MBio (2016) 0.76
Indoleamine 2,3-dioxygenase, tryptophan catabolism, and Mycobacterium avium subsp. paratuberculosis: a model for chronic mycobacterial infections. Infect Immun (2011) 0.76
Mouse model of tuberculosis. Cold Spring Harb Perspect Med (2014) 0.76
Divergent Functions of TLR2 on Hematopoietic and Nonhematopoietic Cells during Chronic Mycobacterium tuberculosis Infection. J Immunol (2016) 0.75
S100A12 is up-regulated in pulmonary tuberculosis and predicts the extent of alveolar infiltration on chest radiography: an observational study. Sci Rep (2016) 0.75
Cytokines and Chemokines in Mycobacterium tuberculosis Infection. Microbiol Spectr (2016) 0.75
Expression and regulation of immune-modulatory enzyme indoleamine 2,3-dioxygenase (IDO) by human airway epithelial cells and its effect on T cell activation. Oncotarget (2016) 0.75
One Episode of Self-Resolving Plasmodium yoelii Infection Transiently Exacerbates Chronic Mycobacterium tuberculosis Infection. Front Microbiol (2016) 0.75
Programmed death-1(+) T cells inhibit effector T cells at the pathological site of miliary tuberculosis. Clin Exp Immunol (2016) 0.75
Serum indoleamine 2,3-dioxygenase activity is associated with reduced immunogenicity following vaccination with MVA85A. BMC Infect Dis (2014) 0.75
Striking the right immunological balance prevents progression of tuberculosis. Inflamm Res (2017) 0.75
Nitric Oxide Modulates Macrophage Responses to Mycobacterium tuberculosis Infection through Activation of HIF-1α and Repression of NF-κB. J Immunol (2017) 0.75
Inhibition of acute lethal pulmonary inflammation by the IDO-AhR pathway. Proc Natl Acad Sci U S A (2017) 0.75
An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection. J Exp Med (1993) 18.56
Disseminated tuberculosis in interferon gamma gene-disrupted mice. J Exp Med (1993) 17.01
Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages. Cell (2004) 12.71
Interferon-gamma: an overview of signals, mechanisms and functions. J Leukoc Biol (2003) 12.34
T(H)-17 cells in the circle of immunity and autoimmunity. Nat Immunol (2007) 12.20
IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge. Nat Immunol (2007) 10.71
IDO expression by dendritic cells: tolerance and tryptophan catabolism. Nat Rev Immunol (2004) 10.08
Identification of nitric oxide synthase as a protective locus against tuberculosis. Proc Natl Acad Sci U S A (1997) 7.90
Reactive oxygen and nitrogen intermediates in the relationship between mammalian hosts and microbial pathogens. Proc Natl Acad Sci U S A (2000) 7.39
The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17-producing effector T helper cells in vivo. Nat Immunol (2009) 6.74
Interferon gamma blocks the growth of Toxoplasma gondii in human fibroblasts by inducing the host cells to degrade tryptophan. Proc Natl Acad Sci U S A (1984) 5.96
Immune control of tuberculosis by IFN-gamma-inducible LRG-47. Science (2003) 5.50
Indoleamine 2,3-dioxygenase and tumor-induced tolerance. J Clin Invest (2007) 5.05
The role of the granuloma in expansion and dissemination of early tuberculous infection. Cell (2009) 4.79
Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease. Nature (2008) 4.28
Reprogramming of the macrophage transcriptome in response to interferon-gamma and Mycobacterium tuberculosis: signaling roles of nitric oxide synthase-2 and phagocyte oxidase. J Exp Med (2001) 3.75
Mycobacterium tuberculosis infects dendritic cells with high frequency and impairs their function in vivo. J Immunol (2007) 3.73
Initiation of the adaptive immune response to Mycobacterium tuberculosis depends on antigen production in the local lymph node, not the lungs. J Exp Med (2007) 3.67
Inborn errors of IL-12/23- and IFN-gamma-mediated immunity: molecular, cellular, and clinical features. Semin Immunol (2006) 3.41
Cytokine activation leads to acidification and increases maturation of Mycobacterium avium-containing phagosomes in murine macrophages. J Immunol (1998) 3.36
Mycobacterium tuberculosis invades and replicates within type II alveolar cells. Infect Immun (1996) 3.11
The T cell-specific CXC chemokines IP-10, Mig, and I-TAC are expressed by activated human bronchial epithelial cells. J Immunol (1999) 2.99
Partial interferon-gamma receptor 1 deficiency in a child with tuberculoid bacillus Calmette-Guérin infection and a sibling with clinical tuberculosis. J Clin Invest (1997) 2.76
Cutting edge: IFN-gamma regulates the induction and expansion of IL-17-producing CD4 T cells during mycobacterial infection. J Immunol (2006) 2.64
A replication clock for Mycobacterium tuberculosis. Nat Med (2009) 2.49
Indoleamine 2,3-dioxygenase in T-cell tolerance and tumoral immune escape. Immunol Rev (2008) 2.47
Mycobacterium tuberculosis inhibits IFN-gamma transcriptional responses without inhibiting activation of STAT1. J Immunol (1999) 2.37
IL-23 and IL-17 in tuberculosis. Cytokine (2008) 2.35
Failure of bone marrow to reconstitute lung epithelium. Am J Respir Cell Mol Biol (2005) 2.26
Dynamics of macrophage cell populations during murine pulmonary tuberculosis. J Immunol (2003) 2.25
Low penetrance, broad resistance, and favorable outcome of interleukin 12 receptor beta1 deficiency: medical and immunological implications. J Exp Med (2003) 2.19
Role of Nox family NADPH oxidases in host defense. Antioxid Redox Signal (2006) 1.98
Neutrophils, interleukin-17A and lung disease. Eur Respir J (2005) 1.86
Innate inhibition of adaptive immunity: Mycobacterium tuberculosis-induced IL-6 inhibits macrophage responses to IFN-gamma. J Immunol (2003) 1.78
Pulmonary interleukin-23 gene delivery increases local T-cell immunity and controls growth of Mycobacterium tuberculosis in the lungs. Infect Immun (2005) 1.65
Chemokine production by a human alveolar epithelial cell line in response to Mycobacterium tuberculosis. Infect Immun (1998) 1.58
Characterization of an indoleamine 2,3-dioxygenase induced by gamma-interferon in cultured human fibroblasts. J Interferon Res (1986) 1.58
Potent inhibition of macrophage responses to IFN-gamma by live virulent Mycobacterium tuberculosis is independent of mature mycobacterial lipoproteins but dependent on TLR2. J Immunol (2006) 1.57
The common aromatic amino acid biosynthesis pathway is essential in Mycobacterium tuberculosis. Microbiology (2002) 1.57
The M cell as a portal of entry to the lung for the bacterial pathogen Mycobacterium tuberculosis. Immunity (1999) 1.50
Indoleamine 2,3-dioxygenase in infection: the paradox of an evasive strategy that benefits the host. Microbes Infect (2008) 1.39
Stimulated innate resistance of lung epithelium protects mice broadly against bacteria and fungi. Am J Respir Cell Mol Biol (2009) 1.36
Microarray analysis of primary endothelial cells challenged with different inflammatory and immune cytokines. Cytokine (2005) 1.33
Interferons and indoleamine 2,3-dioxygenase: role in antimicrobial and antitumor effects. Experientia (1989) 1.33
Tuberculosis triggers a tissue-dependent program of differentiation and acquisition of effector functions by circulating monocytes. J Immunol (2008) 1.32
Primary type II alveolar epithelial cells present microbial antigens to antigen-specific CD4+ T cells. Am J Physiol Lung Cell Mol Physiol (2005) 1.29
Antioxidant activities of some tryptophan metabolites: possible implication for inflammatory diseases. Proc Natl Acad Sci U S A (1990) 1.25
Lack of IL-10 alters inflammatory and immune responses during pulmonary Mycobacterium tuberculosis infection. Tuberculosis (Edinb) (2009) 1.20
Inducible nitric oxide synthase is increased in murine lung epithelial cells by cytokine stimulation. Biochem Biophys Res Commun (1994) 1.17
Effect of interferon on a primary conjunctival epithelial cell model of trachoma. Invest Ophthalmol Vis Sci (1991) 1.11
The potential role of lung epithelial cells and beta-defensins in experimental latent tuberculosis. Scand J Immunol (2008) 1.10
Residual lung damage after completion of treatment for multidrug-resistant tuberculosis. Int J Tuberc Lung Dis (2004) 1.06
Antimicrobial and immunoregulatory effects mediated by human lung cells: role of IFN-gamma-induced tryptophan degradation. FEMS Immunol Med Microbiol (2008) 1.00
Entry and intracellular replication of Mycobacterium tuberculosis in cultured human microvascular endothelial cells. Microb Pathog (2006) 1.00
Clinical relevance of indoleamine 2,3-dioxygenase for alloimmunity and transplantation. Curr Opin Organ Transplant (2008) 0.93
Anti-infectious activity of tryptophan metabolites in the L-tryptophan-L-kynurenine pathway. Biol Pharm Bull (2009) 0.90
Indoleamine-2,3-dioxygenase modulation of allergic immune responses. Curr Allergy Asthma Rep (2006) 0.86
Human T cell epitopes of Mycobacterium tuberculosis are evolutionarily hyperconserved. Nat Genet (2010) 4.94
Mycobacterium tuberculosis infects dendritic cells with high frequency and impairs their function in vivo. J Immunol (2007) 3.73
Initiation of the adaptive immune response to Mycobacterium tuberculosis depends on antigen production in the local lymph node, not the lungs. J Exp Med (2007) 3.67
HIV and tuberculosis: a deadly human syndemic. Clin Microbiol Rev (2011) 3.28
Mycobacterium tuberculosis inhibits macrophage responses to IFN-gamma through myeloid differentiation factor 88-dependent and -independent mechanisms. J Immunol (2004) 2.08
Tuberculosis pathogenesis and immunity. Annu Rev Pathol (2011) 1.92
Innate inhibition of adaptive immunity: Mycobacterium tuberculosis-induced IL-6 inhibits macrophage responses to IFN-gamma. J Immunol (2003) 1.78
CCR2-dependent trafficking of F4/80dim macrophages and CD11cdim/intermediate dendritic cells is crucial for T cell recruitment to lungs infected with Mycobacterium tuberculosis. J Immunol (2004) 1.67
Potent inhibition of macrophage responses to IFN-gamma by live virulent Mycobacterium tuberculosis is independent of mature mycobacterial lipoproteins but dependent on TLR2. J Immunol (2006) 1.57
Lung neutrophils facilitate activation of naive antigen-specific CD4+ T cells during Mycobacterium tuberculosis infection. J Immunol (2011) 1.56
An analysis of the epitope knowledge related to Mycobacteria. Immunome Res (2007) 1.53
Mycobacterium tuberculosis exerts gene-selective inhibition of transcriptional responses to IFN-gamma without inhibiting STAT1 function. J Immunol (2003) 1.52
Dynamic roles of type I and type II IFNs in early infection with Mycobacterium tuberculosis. J Immunol (2012) 1.43
Suboptimal activation of antigen-specific CD4+ effector cells enables persistence of M. tuberculosis in vivo. PLoS Pathog (2011) 1.40
Mycobacterium tuberculosis inhibits neutrophil apoptosis, leading to delayed activation of naive CD4 T cells. Cell Host Microbe (2012) 1.37
Mechanisms of cell recruitment in the immune response to Mycobacterium tuberculosis. Microbes Infect (2003) 1.26
Codominance of TLR2-dependent and TLR2-independent modulation of MHC class II in Mycobacterium tuberculosis infection in vivo. J Immunol (2007) 1.12
Who benefits from granulomas, mycobacteria or host? Cell (2009) 1.09
Lipoprotein processing is essential for resistance of Mycobacterium tuberculosis to malachite green. Antimicrob Agents Chemother (2009) 1.06
CD4+ T cell-dependent IFN-γ production by CD8+ effector T cells in Mycobacterium tuberculosis infection. J Immunol (2012) 1.03
Cutting edge: Direct recognition of infected cells by CD4 T cells is required for control of intracellular Mycobacterium tuberculosis in vivo. J Immunol (2013) 1.02
Sequence diversity in the pe_pgrs genes of Mycobacterium tuberculosis is independent of human T cell recognition. MBio (2014) 1.00
RP105 facilitates macrophage activation by Mycobacterium tuberculosis lipoproteins. Cell Host Microbe (2009) 1.00
Ectopic activation of Mycobacterium tuberculosis-specific CD4+ T cells in lungs of CCR7-/- mice. J Immunol (2009) 0.97
M. tuberculosis T Cell Epitope Analysis Reveals Paucity of Antigenic Variation and Identifies Rare Variable TB Antigens. Cell Host Microbe (2015) 0.96
Anti-TNF immunotherapy and tuberculosis reactivation: another mechanism revealed. J Clin Invest (2009) 0.95
Beyond macrophages: the diversity of mononuclear cells in tuberculosis. Immunol Rev (2014) 0.93
Impaired fitness of Mycobacterium africanum despite secretion of ESAT-6. J Infect Dis (2012) 0.92
GTP-dependent secretion from neutrophils is regulated by Cdk5. J Biol Chem (2004) 0.90
TLR2-dependent inhibition of macrophage responses to IFN-gamma is mediated by distinct, gene-specific mechanisms. PLoS One (2009) 0.89
Illuminating the black box of TNF action in tuberculous granulomas. Immunity (2008) 0.89
CO-opting the host HO-1 pathway in tuberculosis and malaria. Cell Host Microbe (2008) 0.81
Variation of Mycobacterium tuberculosis antigen-specific IFN-γ and IL-17 responses in healthy tuberculin skin test (TST)-positive human subjects. PLoS One (2012) 0.81
LspA-independent action of globomycin on Mycobacterium tuberculosis. J Antimicrob Chemother (2007) 0.80
STIM1 controls T cell-mediated immune regulation and inflammation in chronic infection. J Clin Invest (2015) 0.78
Equivalent T cell epitope promiscuity in ecologically diverse human pathogens. PLoS One (2013) 0.76
Directly observing therapy: a new view of drug tolerance in tuberculosis. Cell (2011) 0.76
Correction: LprG-Mediated Surface Expression of Lipoarabinomannan Is Essential for Virulence of Mycobacterium tuberculosis. PLoS Pathog (2015) 0.75
Taking sides: interferons in leprosy. Cell Host Microbe (2013) 0.75