SAFETY study: alanine aminotransferase cutoff values are set too high for reliable detection of pediatric chronic liver disease.

PubWeight™: 1.81‹?› | Rank: Top 3%

🔗 View Article (PMC 2846968)

Published in Gastroenterology on January 11, 2010

Authors

Jeffrey B Schwimmer1, Winston Dunn, Gregory J Norman, Perrie E Pardee, Michael S Middleton, Nanda Kerkar, Claude B Sirlin

Author Affiliations

1: Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics University of California, San Diego School of Medicine, San Diego, California 92103-8450, USA. jschwimmer@ucsd.edu

Articles citing this

Increasing prevalence of nonalcoholic fatty liver disease among United States adolescents, 1988-1994 to 2007-2010. J Pediatr (2012) 1.72

Ultrasonographic quantitative estimation of hepatic steatosis in children With NAFLD. J Pediatr Gastroenterol Nutr (2011) 1.59

Paediatric gastroenterology evaluation of overweight and obese children referred from primary care for suspected non-alcoholic fatty liver disease. Aliment Pharmacol Ther (2013) 1.44

Children's Hospital Association consensus statements for comorbidities of childhood obesity. Child Obes (2014) 1.40

Histological abnormalities in children with nonalcoholic fatty liver disease and normal or mildly elevated alanine aminotransferase levels. J Pediatr (2013) 1.35

Persistent hypertransaminasemia in asymptomatic children: a stepwise approach. World J Gastroenterol (2013) 1.06

Non-alcoholic fatty liver disease is associated with low bone mineral density in obese children. Aliment Pharmacol Ther (2011) 1.02

Alanine aminotransferase-old biomarker and new concept: a review. Int J Med Sci (2014) 1.01

The Prevalence of Non-Alcoholic Fatty Liver Disease in Children and Adolescents: A Systematic Review and Meta-Analysis. PLoS One (2015) 0.99

Association between insulin resistance and oxidative stress parameters in obese adolescents with non-alcoholic fatty liver disease. J Clin Res Pediatr Endocrinol (2013) 0.93

Suspected nonalcoholic Fatty liver disease is not associated with vitamin d status in adolescents after adjustment for obesity. J Obes (2011) 0.90

Upper limits of normal for serum alanine aminotransferase levels in Chinese Han population. PLoS One (2012) 0.90

Main characteristics and participation rate of European adolescents included in the HELENA study. Arch Public Health (2012) 0.88

Proton density fat-fraction is an accurate biomarker of hepatic steatosis in adolescent girls and young women. Eur Radiol (2015) 0.88

Independent and supra-additive effects of alcohol consumption, cigarette smoking, and metabolic syndrome on the elevation of serum liver enzyme levels. PLoS One (2013) 0.85

Normal liver enzymes are correlated with severity of metabolic syndrome in a large population based cohort. Sci Rep (2015) 0.82

High Prevalence of Nonalcoholic Fatty Liver Disease in Adolescents Undergoing Bariatric Surgery. Gastroenterology (2015) 0.81

Hepatic steatosis and thyroid function tests in overweight and obese children. Int J Endocrinol (2013) 0.81

Clinical advances in pediatric nonalcoholic fatty liver disease. Hepatology (2016) 0.81

Intensive lifestyle treatment for non-alcoholic fatty liver disease in children with severe obesity: inpatient versus ambulatory treatment. Int J Obes (Lond) (2015) 0.80

Predicting hepatic steatosis in a racially and ethnically diverse cohort of adolescent girls. J Pediatr (2014) 0.80

Accuracy of Liver Fat Quantification With Advanced CT, MRI, and Ultrasound Techniques: Prospective Comparison With MR Spectroscopy. AJR Am J Roentgenol (2016) 0.79

The etiology of hypertransaminasemia in Turkish children. Bosn J Basic Med Sci (2016) 0.79

Pediatric non-alcoholic fatty liver disease: Recent solutions, unresolved issues, and future research directions. World J Gastroenterol (2016) 0.78

Clinical features of pediatric nonalcoholic fatty liver disease: a need for increased awareness and a consensus for screening. Clin Pediatr (Phila) (2014) 0.78

Comparison of Controlled Attenuation Parameter and Liver Biopsy to Assess Hepatic Steatosis in Pediatric Patients. J Pediatr (2016) 0.78

Features of Severe Liver Disease With Portal Hypertension in Patients With Cystic Fibrosis. Clin Gastroenterol Hepatol (2016) 0.78

The Frequent Adiponutrin (PNPLA3) Variant p.Ile148Met Is Associated with Early Liver Injury: Analysis of a German Pediatric Cohort. Gastroenterol Res Pract (2015) 0.77

Liver disease among children in Hawai'i diagnosed with metabolic syndrome. Hawaii J Med Public Health (2013) 0.77

Predictive effect of serial serum alanine aminotransferase levels on spontaneous HBeAg seroconversion in chronic genotype B and C HBV-infected children. J Pediatr Gastroenterol Nutr (2012) 0.76

Screening for elevated risk of liver disease in preschool children (aged 2-5 years) being seen for obesity management. SAGE Open Med (2014) 0.76

Health-related Quality of Life in Pediatric Patients With Chronic Hepatitis B Living in the United States and Canada. J Pediatr Gastroenterol Nutr (2017) 0.75

Pediatric Nonalcoholic Fatty Liver Disease: A Report from the Expert Committee on Nonalcoholic Fatty Liver Disease (ECON). J Pediatr (2016) 0.75

Incidence and clinical significance of elevated liver function tests in cystic fibrosis clinical trials. Contemp Clin Trials (2012) 0.75

A novel system for predicting liver histopathology in patients with chronic hepatitis B. Medicine (Baltimore) (2017) 0.75

Association between serum alanine aminotransferase level and obesity indices in Korean adolescents. Korean J Pediatr (2015) 0.75

Comparison of the Phenotype and Approach to Pediatric vs Adult Patients With Nonalcoholic Fatty Liver Disease. Gastroenterology (2016) 0.75

Pediatric Non-Alcoholic Fatty Liver Disease. J Med Biochem (2014) 0.75

An ALTernate interpretation of serum transaminases. Dig Dis Sci (2014) 0.75

A clinically relevant method to screen for hepatic steatosis in overweight adolescents: a cross sectional study. BMC Pediatr (2015) 0.75

Prevalence and risk factors for non-alcoholic fatty liver in children and youth with obesity. BMC Pediatr (2017) 0.75

The effect of weight loss on pediatric nonalcoholic Fatty liver disease. ISRN Gastroenterol (2013) 0.75

Genetic and clinical markers of elevated liver fat content in overweight and obese Hispanic children. Obesity (Silver Spring) (2013) 0.75

Urinary Metabolomics in Pediatric Obesity and NAFLD Identifies Metabolic Pathways/Metabolites Related to Dietary Habits and Gut-Liver Axis Perturbations. Nutrients (2017) 0.75

Liver chemistry in new-onset Henoch-Schönlein syndrome. Ital J Pediatr (2017) 0.75

Screening for non-alcoholic fatty liver disease in children and adolescents with type 1 diabetes mellitus: a cross-sectional analysis. Eur J Pediatr (2017) 0.75

Upper Normal Alanine Aminotransferase Range and Insulin Resistance in Korean Adolescents: Korean National Health and Nutrition Examination Survey, 2009-2010. Dig Dis Sci (2015) 0.75

Cardio-metabolic risk factors in youth with classical 21-hydroxylase deficiency. Eur J Pediatr (2017) 0.75

Articles cited by this

Expert committee recommendations regarding the prevention, assessment, and treatment of child and adolescent overweight and obesity: summary report. Pediatrics (2007) 23.88

Chronic hepatitis B. Hepatology (2007) 13.75

Updated definitions of healthy ranges for serum alanine aminotransferase levels. Ann Intern Med (2002) 10.78

Drug-related hepatotoxicity. N Engl J Med (2006) 7.49

Simple proton spectroscopic imaging. Radiology (1984) 7.30

Prevalence of fatty liver in children and adolescents. Pediatrics (2006) 7.00

Normal serum aminotransferase concentration and risk of mortality from liver diseases: prospective cohort study. BMJ (2004) 4.22

Relaxation effects in the quantification of fat using gradient echo imaging. Magn Reson Imaging (2008) 4.13

Fat quantification with IDEAL gradient echo imaging: correction of bias from T(1) and noise. Magn Reson Med (2007) 3.88

Multiecho reconstruction for simultaneous water-fat decomposition and T2* estimation. J Magn Reson Imaging (2007) 3.79

Heritability of nonalcoholic fatty liver disease. Gastroenterology (2009) 3.17

Liver, muscle, and adipose tissue insulin action is directly related to intrahepatic triglyceride content in obese subjects. Gastroenterology (2008) 3.04

Obesity, insulin resistance, and other clinicopathological correlates of pediatric nonalcoholic fatty liver disease. J Pediatr (2003) 2.77

Cardiovascular risk factors and the metabolic syndrome in pediatric nonalcoholic fatty liver disease. Circulation (2008) 2.70

Hepatic fat fraction: MR imaging for quantitative measurement and display--early experience. Radiology (2005) 2.69

Prevention and treatment of pediatric obesity: an endocrine society clinical practice guideline based on expert opinion. J Clin Endocrinol Metab (2008) 2.52

Outcome and prognostic markers in severe drug-induced liver disease. Hepatology (2005) 2.36

Drug-induced liver injury: summary of a single topic clinical research conference. Hepatology (2006) 2.24

Serum leptin levels in patients with nonalcoholic steatohepatitis. Am J Gastroenterol (2000) 1.96

Synopsis of the 2006 Canadian clinical practice guidelines on the management and prevention of obesity in adults and children. CMAJ (2007) 1.48

Children with hepatitis C. Hepatology (2002) 1.47

Trends in the prevalence of chronic medication use in children: 2002-2005. Pediatrics (2008) 1.40

Influence of local reference populations on upper limits of normal for serum alanine aminotransferase levels. Arch Intern Med (2008) 1.25

Drug hepatotoxicity from a regulatory perspective. Clin Liver Dis (2007) 1.04

Review article: The use of potentially hepatotoxic drugs in patients with liver disease. Aliment Pharmacol Ther (2008) 0.90

Articles by these authors

A text message-based intervention for weight loss: randomized controlled trial. J Med Internet Res (2009) 6.06

Relaxation effects in the quantification of fat using gradient echo imaging. Magn Reson Imaging (2008) 4.13

Nonalcoholic fatty liver disease: diagnostic and fat-grading accuracy of low-flip-angle multiecho gradient-recalled-echo MR imaging at 1.5 T. Radiology (2009) 3.31

Heritability of nonalcoholic fatty liver disease. Gastroenterology (2009) 3.17

Decoding global gene expression programs in liver cancer by noninvasive imaging. Nat Biotechnol (2007) 3.17

Quantification of hepatic steatosis with T1-independent, T2-corrected MR imaging with spectral modeling of fat: blinded comparison with MR spectroscopy. Radiology (2011) 3.08

In vivo characterization of the liver fat ¹H MR spectrum. NMR Biomed (2010) 3.07

Quantitative assessment of liver fat with magnetic resonance imaging and spectroscopy. J Magn Reson Imaging (2011) 2.75

Cardiovascular risk factors and the metabolic syndrome in pediatric nonalcoholic fatty liver disease. Circulation (2008) 2.70

Where are youth active? Roles of proximity, active transport, and built environment. Med Sci Sports Exerc (2008) 2.70

Diet, physical activity, and sedentary behaviors as risk factors for overweight in adolescence. Arch Pediatr Adolesc Med (2004) 2.45

Randomized controlled trial of a primary care and home-based intervention for physical activity and nutrition behaviors: PACE+ for adolescents. Arch Pediatr Adolesc Med (2006) 2.44

Estimation of hepatic proton-density fat fraction by using MR imaging at 3.0 T. Radiology (2011) 2.42

CT and MR imaging of extrahepatic fatty masses of the abdomen and pelvis: techniques, diagnosis, differential diagnosis, and pitfalls. Radiographics (2005) 2.37

T(1) independent, T(2) (*) corrected chemical shift based fat-water separation with multi-peak fat spectral modeling is an accurate and precise measure of hepatic steatosis. J Magn Reson Imaging (2011) 2.27

Liver fibrosis: noninvasive diagnosis with double contrast material-enhanced MR imaging. Radiology (2006) 2.23

Fatty liver: imaging patterns and pitfalls. Radiographics (2006) 2.21

Effect of PRESS and STEAM sequences on magnetic resonance spectroscopic liver fat quantification. J Magn Reson Imaging (2009) 2.18

Automated registration of sequential breath-hold dynamic contrast-enhanced MR images: a comparison of three techniques. Magn Reson Imaging (2011) 2.15

Whole-body CT screening: spectrum of findings and recommendations in 1192 patients. Radiology (2005) 2.14

Advances in pediatric nonalcoholic fatty liver disease. Hepatology (2009) 2.03

High sustained virologic response rates in children with chronic hepatitis C receiving peginterferon alfa-2b plus ribavirin. J Hepatol (2010) 2.01

Abdominal wall hernias: imaging features, complications, and diagnostic pitfalls at multi-detector row CT. Radiographics (2005) 1.98

Classification accuracies of physical activities using smartphone motion sensors. J Med Internet Res (2012) 1.91

Proton density fat-fraction: a standardized MR-based biomarker of tissue fat concentration. J Magn Reson Imaging (2012) 1.90

Improved adherence and outcomes for pediatric liver transplant recipients by using text messaging. Pediatrics (2009) 1.85

Independent evaluation of the California Tobacco Control Program: relationships between program exposure and outcomes, 1996-1998. Am J Public Health (2002) 1.81

Extrahepatic anomalies in infants with biliary atresia: results of a large prospective North American multicenter study. Hepatology (2013) 1.80

Intravenous N-acetylcysteine in pediatric patients with nonacetaminophen acute liver failure: a placebo-controlled clinical trial. Hepatology (2013) 1.78

Neighborhood Environment Walkability Scale for Youth (NEWS-Y): reliability and relationship with physical activity. Prev Med (2009) 1.78

Nonalcoholic fatty liver disease: MR imaging of liver proton density fat fraction to assess hepatic steatosis. Radiology (2013) 1.77

Gadoxetate disodium-enhanced MRI of the liver: part 1, protocol optimization and lesion appearance in the noncirrhotic liver. AJR Am J Roentgenol (2010) 1.70

Combination of complex-based and magnitude-based multiecho water-fat separation for accurate quantification of fat-fraction. Magn Reson Med (2011) 1.67

Reproducibility of MRI-determined proton density fat fraction across two different MR scanner platforms. J Magn Reson Imaging (2011) 1.66

MR imaging of liver fibrosis: current state of the art. Radiographics (2009) 1.62

Patterns and correlates of physical activity and nutrition behaviors in adolescents. Am J Prev Med (2006) 1.58

Outcomes of a 12-month web-based intervention for overweight and obese men. Ann Behav Med (2011) 1.58

Disproportionate fat stranding: a helpful CT sign in patients with acute abdominal pain. Radiographics (2004) 1.54

Quantification of liver fat with magnetic resonance imaging. Magn Reson Imaging Clin N Am (2010) 1.51

Evaluating a brief self-report measure of neighborhood environments for physical activity research and surveillance: Physical Activity Neighborhood Environment Scale (PANES). J Phys Act Health (2010) 1.50

Parents and clinicians underestimate distress and depression in children who had a transplant. Pediatr Transplant (2005) 1.50

Validation of the Neighborhood Environment Walkability Scale (NEWS) items using geographic information systems. J Phys Act Health (2009) 1.49

Optimal phased-array combination for spectroscopy. Magn Reson Imaging (2008) 1.48

Reliability and validity of the Sedentary Behavior Questionnaire (SBQ) for adults. J Phys Act Health (2010) 1.48

Double-contrast MRI for accurate staging of hepatocellular carcinoma in patients with cirrhosis. AJR Am J Roentgenol (2008) 1.47

Fatty liver disease: MR imaging techniques for the detection and quantification of liver steatosis. Radiographics (2009) 1.46

Medication adherence in pediatric and adolescent liver transplant recipients. Pediatrics (2004) 1.44

Radiogenomic analysis to identify imaging phenotypes associated with drug response gene expression programs in hepatocellular carcinoma. J Vasc Interv Radiol (2007) 1.42

Liver transplantation for children with biliary atresia in the pediatric end-stage liver disease era: the role of insurance status. Liver Transpl (2013) 1.42

Characteristics of diabetes after pediatric liver transplant. Pediatr Transplant (2012) 1.39

Cross-sectional imaging of extranodal involvement in abdominopelvic lymphoproliferative malignancies. Radiographics (2007) 1.38

Health-related quality of life in pediatric patients with irritable bowel syndrome: a comparative analysis. J Dev Behav Pediatr (2006) 1.38

T-cell PTLD presenting as acalculous cholecystitis. Pediatr Transplant (2008) 1.37

Noninvasive assessment of hepatic steatosis. Clin Gastroenterol Hepatol (2008) 1.36

Television viewing and hypertension in obese children. Am J Prev Med (2007) 1.35

Gadoxetate disodium-enhanced MRI of the liver: part 2, protocol optimization and lesion appearance in the cirrhotic liver. AJR Am J Roentgenol (2010) 1.33

CT and MR imaging diagnosis and staging of hepatocellular carcinoma: part II. Extracellular agents, hepatobiliary agents, and ancillary imaging features. Radiology (2014) 1.33

LI-RADS (Liver Imaging Reporting and Data System): summary, discussion, and consensus of the LI-RADS Management Working Group and future directions. Hepatology (2014) 1.31

Assessment of liver fat quantification in the presence of iron. Magn Reson Imaging (2010) 1.30

Adolescent screen time and rules to limit screen time in the home. J Adolesc Health (2010) 1.29

Psychosocial correlates of fruit, vegetable, and dietary fat intake among adolescent boys and girls. J Am Diet Assoc (2006) 1.27

Community food environment, home food environment, and fruit and vegetable intake of children and adolescents. J Nutr Educ Behav (2011) 1.23

Dietary fiber and nutrient density are inversely associated with the metabolic syndrome in US adolescents. J Am Diet Assoc (2011) 1.22

CT appearance of the normal appendix in adults. Eur Radiol (2005) 1.21

Patterns of sedentary behavior among adolescents. Health Psychol (2007) 1.19

Ezetimibe for the treatment of nonalcoholic steatohepatitis: assessment by novel magnetic resonance imaging and magnetic resonance elastography in a randomized trial (MOZART trial). Hepatology (2015) 1.18

Brief scales to assess physical activity and sedentary equipment in the home. Int J Behav Nutr Phys Act (2010) 1.15

Do neighborhood environments moderate the effect of physical activity lifestyle interventions in adults? Health Place (2010) 1.14

Perceived neighborhood environment and physical activity in 11 countries: do associations differ by country? Int J Behav Nutr Phys Act (2013) 1.13

Examining the role of perceived susceptibility on colorectal cancer screening intention and behavior. Ann Behav Med (2010) 1.12

Cisterna chyli at routine abdominal MR imaging: a normal anatomic structure in the retrocrural space. Radiographics (2004) 1.11

Hepatic fat quantification: a prospective comparison of magnetic resonance spectroscopy and analysis methods for chemical-shift gradient echo magnetic resonance imaging with histologic assessment as the reference standard. Invest Radiol (2012) 1.11

Cirrhosis-associated hepatocellular nodules: correlation of histopathologic and MR imaging features. Radiographics (2008) 1.10

Reliability and validity of destination-specific barriers to walking and cycling for youth. Prev Med (2007) 1.10

Musculoskeletal pain in obese children and adolescents. Acta Paediatr (2008) 1.09

Pediatric nonalcoholic fatty liver disease: a comprehensive review. Adv Pediatr (2010) 1.08

Imaging-based diagnostic systems for hepatocellular carcinoma. AJR Am J Roentgenol (2013) 1.08

Patterns and correlates of multiple risk behaviors in overweight women. Prev Med (2007) 1.08

Construct validity of the stages of change of exercise adoption for different intensities of physical activity in four samples of differing age groups. Am J Health Promot (2002) 1.08

Pediatric inflammatory myofibroblastic tumor with late metastasis to the lung: case report and review of the literature. Pediatr Dev Pathol (2005) 1.07

Reproducibility of hepatic fat fraction measurement by magnetic resonance imaging. J Magn Reson Imaging (2012) 1.06

Relation of school environment and policy to adolescent physical activity. J Sch Health (2009) 1.06

MR imaging of extracapsular silicone from breast implants: diagnostic pitfalls. AJR Am J Roentgenol (2002) 1.04

Assessment of physical activity in middle-aged and older adults with schizophrenia. Schizophr Res (2008) 1.04

Attrition and adherence rates of sustained vs. intermittent exercise interventions. Ann Behav Med (2011) 1.04

MR contrast agents for liver imaging: what, when, how. Radiographics (2006) 1.03

Accuracy of MR imaging-estimated proton density fat fraction for classification of dichotomized histologic steatosis grades in nonalcoholic fatty liver disease. Radiology (2014) 1.02

Covariation of adolescent physical activity and dietary behaviors over 12 months. J Adolesc Health (2007) 1.02

Body image and self-esteem among adolescents undergoing an intervention targeting dietary and physical activity behaviors. J Adolesc Health (2007) 1.02

Promoting walking among older adults living in retirement communities. J Aging Phys Act (2011) 1.02