Published in Angew Chem Int Ed Engl on February 08, 2010
Mechanistic evidence for a front-side, SNi-type reaction in a retaining glycosyltransferase. Nat Chem Biol (2011) 1.24
Characterization of the N-acetyl-α-D-glucosaminyl l-malate synthase and deacetylase functions for bacillithiol biosynthesis in Bacillus anthracis . Biochemistry (2010) 1.20
Structural snapshots of the reaction coordinate for O-GlcNAc transferase. Nat Chem Biol (2012) 1.20
Glycosyltransferase structural biology and its role in the design of catalysts for glycosylation. Curr Opin Biotechnol (2011) 1.07
The structure of sucrose synthase-1 from Arabidopsis thaliana and its functional implications. J Biol Chem (2011) 0.97
Pseudoglycosyltransferase catalyzes nonglycosidic C-N coupling in validamycin a biosynthesis. J Am Chem Soc (2011) 0.95
Structure of a novel O-linked N-acetyl-D-glucosamine (O-GlcNAc) transferase, GtfA, reveals insights into the glycosylation of pneumococcal serine-rich repeat adhesins. J Biol Chem (2014) 0.90
Acceptor substrate discrimination in phosphatidyl-myo-inositol mannoside synthesis: structural and mutational analysis of mannosyltransferase Corynebacterium glutamicum PimB'. J Biol Chem (2010) 0.86
Structural and functional analysis of validoxylamine A 7'-phosphate synthase ValL involved in validamycin A biosynthesis. PLoS One (2012) 0.83
Substrate and metal ion promiscuity in mannosylglycerate synthase. J Biol Chem (2011) 0.83
Mechanistic insights into validoxylamine A 7'-phosphate synthesis by VldE using the structure of the entire product complex. PLoS One (2012) 0.80
Structure and mechanism of Staphylococcus aureus TarM, the wall teichoic acid α-glycosyltransferase. Proc Natl Acad Sci U S A (2015) 0.79
Geometric attributes of retaining glycosyltransferase enzymes favor an orthogonal mechanism. PLoS One (2013) 0.79
Mechanistic insights into the retaining glucosyl-3-phosphoglycerate synthase from mycobacteria. J Biol Chem (2012) 0.78
A computational and experimental study of O-glycosylation. Catalysis by human UDP-GalNAc polypeptide:GalNAc transferase-T2. Org Biomol Chem (2014) 0.78
TPS1 drug design for rice blast disease in magnaporthe oryzae. Springerplus (2014) 0.78
Notch-modifying xylosyltransferase structures support an SNi-like retaining mechanism. Nat Chem Biol (2015) 0.78
Distinct Substrate Specificity and Catalytic Activity of the Pseudoglycosyltransferase VldE. Chem Biol (2015) 0.76
Synthesis of the C-glycoside of α-(D)-mannose-(1 → 6)-(D)-myo-inositol. Org Biomol Chem (2013) 0.75
Stepwise catalytic mechanism via short-lived intermediate inferred from combined QM/MM MERP and PES calculations on retaining glycosyltransferase ppGalNAcT2. PLoS Comput Biol (2015) 0.75
Structures of a human blood group glycosyltransferase in complex with a photo-activatable UDP-Gal derivative reveal two different binding conformations. Acta Crystallogr F Struct Biol Commun (2014) 0.75
Discovery of inhibitors of Leishmania β-1,2-mannosyltransferases using a click-chemistry-derived guanosine monophosphate library. PLoS One (2012) 0.75
Inhibitory properties of 1,4-dideoxy-1,4-imino-d-arabinitol (DAB) derivatives acting on glycogen metabolising enzymes. Org Biomol Chem (2016) 0.75
Carbohydrate-binding modules: fine-tuning polysaccharide recognition. Biochem J (2004) 8.19
An evolving hierarchical family classification for glycosyltransferases. J Mol Biol (2003) 6.48
Insights into the oxidative degradation of cellulose by a copper metalloenzyme that exploits biomass components. Proc Natl Acad Sci U S A (2011) 3.59
A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo. Nat Chem Biol (2008) 3.46
Expanding the diversity of chemical protein modification allows post-translational mimicry. Nature (2007) 2.45
Insights into trehalose synthesis provided by the structure of the retaining glucosyltransferase OtsA. Chem Biol (2002) 2.30
Chemical modification of proteins at cysteine: opportunities in chemistry and biology. Chem Asian J (2009) 2.10
Glycoprotein synthesis: an update. Chem Rev (2009) 2.04
Structure of a flavonoid glucosyltransferase reveals the basis for plant natural product modification. EMBO J (2006) 1.98
Cellulosome assembly revealed by the crystal structure of the cohesin-dockerin complex. Proc Natl Acad Sci U S A (2003) 1.92
Mechanistic insights into glycosidase chemistry. Curr Opin Chem Biol (2008) 1.85
Cellvibrio japonicus alpha-L-arabinanase 43A has a novel five-blade beta-propeller fold. Nat Struct Biol (2002) 1.82
Structural and biochemical evidence for a boat-like transition state in beta-mannosidases. Nat Chem Biol (2008) 1.75
Selective electrochemical glycosylation by reactivity tuning. Org Biomol Chem (2004) 1.70
Structure of an O-GlcNAc transferase homolog provides insight into intracellular glycosylation. Nat Struct Mol Biol (2008) 1.66
Structural and thermodynamic dissection of specific mannan recognition by a carbohydrate binding module, TmCBM27. Structure (2003) 1.63
Functional divergence in the glutathione transferase superfamily in plants. Identification of two classes with putative functions in redox homeostasis in Arabidopsis thaliana. J Biol Chem (2002) 1.60
The active site of a carbohydrate esterase displays divergent catalytic and noncatalytic binding functions. PLoS Biol (2009) 1.57
Characterization and engineering of the bifunctional N- and O-glucosyltransferase involved in xenobiotic metabolism in plants. Proc Natl Acad Sci U S A (2007) 1.55
High-purity discrete PEG-oligomer crystals allow structural insight. Angew Chem Int Ed Engl (2009) 1.55
A carbohydrate-antioxidant hybrid polymer reduces oxidative damage in spermatozoa and enhances fertility. Nat Chem Biol (2005) 1.52
Structure and mechanism of a bacterial beta-glucosaminidase having O-GlcNAcase activity. Nat Struct Mol Biol (2006) 1.52
Recent insights into copper-containing lytic polysaccharide mono-oxygenases. Curr Opin Struct Biol (2013) 1.50
Sugar synthesis in a protocellular model leads to a cell signalling response in bacteria. Nat Chem (2009) 1.46
Analysis of PUGNAc and NAG-thiazoline as transition state analogues for human O-GlcNAcase: mechanistic and structural insights into inhibitor selectivity and transition state poise. J Am Chem Soc (2007) 1.46
Genome analyses highlight the different biological roles of cellulases. Nat Rev Microbiol (2012) 1.46
Filled and glycosylated carbon nanotubes for in vivo radioemitter localization and imaging. Nat Mater (2010) 1.45
The donor subsite of trehalose-6-phosphate synthase: binary complexes with UDP-glucose and UDP-2-deoxy-2-fluoro-glucose at 2 A resolution. J Biol Chem (2003) 1.43
Facile conversion of cysteine and alkyl cysteines to dehydroalanine on protein surfaces: versatile and switchable access to functionalized proteins. J Am Chem Soc (2008) 1.42
A "tag-and-modify" approach to site-selective protein modification. Acc Chem Res (2011) 1.39
Evidence that family 35 carbohydrate binding modules display conserved specificity but divergent function. Proc Natl Acad Sci U S A (2009) 1.38
Lectins: tools for the molecular understanding of the glycocode. Org Biomol Chem (2005) 1.38
Allyl sulfides are privileged substrates in aqueous cross-metathesis: application to site-selective protein modification. J Am Chem Soc (2008) 1.36
Evidence for a dual binding mode of dockerin modules to cohesins. Proc Natl Acad Sci U S A (2007) 1.36
Differential oligosaccharide recognition by evolutionarily-related beta-1,4 and beta-1,3 glucan-binding modules. J Mol Biol (2002) 1.36
Family 6 carbohydrate binding modules in beta-agarases display exquisite selectivity for the non-reducing termini of agarose chains. J Biol Chem (2006) 1.35
Tps1 regulates the pentose phosphate pathway, nitrogen metabolism and fungal virulence. EMBO J (2007) 1.35
The crystal structure of two macrolide glycosyltransferases provides a blueprint for host cell antibiotic immunity. Proc Natl Acad Sci U S A (2007) 1.34
Tailored catalysts for plant cell-wall degradation: redesigning the exo/endo preference of Cellvibrio japonicus arabinanase 43A. Proc Natl Acad Sci U S A (2005) 1.30
Characterization and three-dimensional structures of two distinct bacterial xyloglucanases from families GH5 and GH12. J Biol Chem (2007) 1.30
Conversion of cysteine into dehydroalanine enables access to synthetic histones bearing diverse post-translational modifications. Angew Chem Int Ed Engl (2012) 1.30
Elevation of global O-GlcNAc levels in 3T3-L1 adipocytes by selective inhibition of O-GlcNAcase does not induce insulin resistance. J Biol Chem (2008) 1.28
Structural and biochemical analysis of Cellvibrio japonicus xylanase 10C: how variation in substrate-binding cleft influences the catalytic profile of family GH-10 xylanases. J Biol Chem (2003) 1.27
Understanding how diverse beta-mannanases recognize heterogeneous substrates. Biochemistry (2009) 1.27
Insights into the synthesis of lipopolysaccharide and antibiotics through the structures of two retaining glycosyltransferases from family GT4. Chem Biol (2006) 1.26
The mechanisms by which family 10 glycoside hydrolases bind decorated substrates. J Biol Chem (2003) 1.26
Glyconanoparticles allow pre-symptomatic in vivo imaging of brain disease. Proc Natl Acad Sci U S A (2008) 1.26
Glycosidase mechanisms. Curr Opin Chem Biol (2002) 1.26
Mechanistic evidence for a front-side, SNi-type reaction in a retaining glycosyltransferase. Nat Chem Biol (2011) 1.24
The copper active site of CBM33 polysaccharide oxygenases. J Am Chem Soc (2013) 1.23
A convenient catalyst for aqueous and protein Suzuki-Miyaura cross-coupling. J Am Chem Soc (2009) 1.23
Uptake of unnatural trehalose analogs as a reporter for Mycobacterium tuberculosis. Nat Chem Biol (2011) 1.23
Structural basis for ligand binding and processivity in cellobiohydrolase Cel6A from Humicola insolens. Structure (2003) 1.21
Systemic inflammatory response reactivates immune-mediated lesions in rat brain. J Neurosci (2009) 1.21
Promiscuity in ligand-binding: The three-dimensional structure of a Piromyces carbohydrate-binding module, CBM29-2, in complex with cello- and mannohexaose. Proc Natl Acad Sci U S A (2002) 1.21
An NADPH-dependent genetic switch regulates plant infection by the rice blast fungus. Proc Natl Acad Sci U S A (2010) 1.19
QuaNCAT: quantitating proteome dynamics in primary cells. Nat Methods (2013) 1.18
Structural dissection and high-throughput screening of mannosylglycerate synthase. Nat Struct Mol Biol (2005) 1.16
Probing the breadth of macrolide glycosyltransferases: in vitro remodeling of a polyketide antibiotic creates active bacterial uptake and enhances potency. J Am Chem Soc (2005) 1.16
Ab initio structure determination and functional characterization of CBM36; a new family of calcium-dependent carbohydrate binding modules. Structure (2004) 1.15
Crystal structure of a family GT4 glycosyltransferase from Bacillus anthracis ORF BA1558. Proteins (2008) 1.15
The imitation game--a computational chemical approach to recognizing life. Nat Biotechnol (2006) 1.14
Glycosidase inhibition: assessing mimicry of the transition state. Org Biomol Chem (2009) 1.14
Substrate distortion by a beta-mannanase: snapshots of the Michaelis and covalent-intermediate complexes suggest a B(2,5) conformation for the transition state. Angew Chem Int Ed Engl (2002) 1.14
How nature can exploit nonspecific catalytic and carbohydrate binding modules to create enzymatic specificity. Proc Natl Acad Sci U S A (2012) 1.14
Mechanistic insights into a Ca2+-dependent family of alpha-mannosidases in a human gut symbiont. Nat Chem Biol (2009) 1.14
The Cellvibrio japonicus mannanase CjMan26C displays a unique exo-mode of action that is conferred by subtle changes to the distal region of the active site. J Biol Chem (2008) 1.13
Mechanistic and structural analysis of a family 31 alpha-glycosidase and its glycosyl-enzyme intermediate. J Biol Chem (2004) 1.13
How family 26 glycoside hydrolases orchestrate catalysis on different polysaccharides: structure and activity of a Clostridium thermocellum lichenase, CtLic26A. J Biol Chem (2005) 1.13
The structural basis for catalysis and specificity of the Pseudomonas cellulosa alpha-glucuronidase, GlcA67A. Structure (2002) 1.12
Crystal structures of Clostridium thermocellum xyloglucanase, XGH74A, reveal the structural basis for xyloglucan recognition and degradation. J Biol Chem (2006) 1.12
Iminosugar glycosidase inhibitors: structural and thermodynamic dissection of the binding of isofagomine and 1-deoxynojirimycin to beta-glucosidases. J Am Chem Soc (2003) 1.11
The three-dimensional structure of the N-acetylglucosamine-6-phosphate deacetylase, NagA, from Bacillus subtilis: a member of the urease superfamily. J Biol Chem (2003) 1.11
Novel catalytic mechanism of glycoside hydrolysis based on the structure of an NAD+/Mn2+ -dependent phospho-alpha-glucosidase from Bacillus subtilis. Structure (2004) 1.11
A nonself sugar mimic of the HIV glycan shield shows enhanced antigenicity. Proc Natl Acad Sci U S A (2010) 1.10
Thiyl glycosylation of olefinic proteins: S-linked glycoconjugate synthesis. Angew Chem Int Ed Engl (2009) 1.08
Olefin cross-metathesis on proteins: investigation of allylic chalcogen effects and guiding principles in metathesis partner selection. J Am Chem Soc (2010) 1.07
The Clostridium cellulolyticum dockerin displays a dual binding mode for its cohesin partner. J Biol Chem (2008) 1.06
Inhibition of SnRK1 by metabolites: tissue-dependent effects and cooperative inhibition by glucose 1-phosphate in combination with trehalose 6-phosphate. Plant Physiol Biochem (2012) 1.05
Structure and kinetics of a monomeric glucosamine 6-phosphate deaminase: missing link of the NagB superfamily? J Biol Chem (2005) 1.05
Convergent evolution sheds light on the anti-beta -elimination mechanism common to family 1 and 10 polysaccharide lyases. Proc Natl Acad Sci U S A (2002) 1.05
Crystal structure of levansucrase from the Gram-negative bacterium Gluconacetobacter diazotrophicus. Biochem J (2005) 1.05
Structure of a group A streptococcal phage-encoded virulence factor reveals a catalytically active triple-stranded beta-helix. Proc Natl Acad Sci U S A (2005) 1.04
Structure and activity of two metal ion-dependent acetylxylan esterases involved in plant cell wall degradation reveals a close similarity to peptidoglycan deacetylases. J Biol Chem (2006) 1.04
An endoglycosidase with alternative glycan specificity allows broadened glycoprotein remodelling. J Am Chem Soc (2012) 1.03
Mannose foraging by Bacteroides thetaiotaomicron: structure and specificity of the beta-mannosidase, BtMan2A. J Biol Chem (2007) 1.02
Insights into the molecular determinants of substrate specificity in glycoside hydrolase family 5 revealed by the crystal structure and kinetics of Cellvibrio mixtus mannosidase 5A. J Biol Chem (2004) 1.02
An unusual mechanism of glycoside hydrolysis involving redox and elimination steps by a family 4 beta-glycosidase from Thermotoga maritima. J Am Chem Soc (2004) 1.01
Palladium-mediated cell-surface labeling. J Am Chem Soc (2011) 1.01
Insights into the structural determinants of cohesin-dockerin specificity revealed by the crystal structure of the type II cohesin from Clostridium thermocellum SdbA. J Mol Biol (2005) 1.01
Signature active site architectures illuminate the molecular basis for ligand specificity in family 35 carbohydrate binding module. Biochemistry (2010) 1.01
Structural and enzymatic characterization of a glycoside hydrolase family 31 α-xylosidase from Cellvibrio japonicus involved in xyloglucan saccharification. Biochem J (2011) 1.00
Biosynthesis of the tunicamycin antibiotics proceeds via unique exo-glycal intermediates. Nat Chem (2012) 0.99