Published in Fly (Austin) on April 10, 2010
The Hedgehog signal transduction network. Sci Signal (2012) 1.80
The influence of Hispanic ethnicity on nonsmall cell lung cancer histology and patient survival: an analysis of the Survival, Epidemiology, and End Results database. Cancer (2012) 3.12
G protein Galphai functions immediately downstream of Smoothened in Hedgehog signalling. Nature (2008) 1.88
Optimization of transrenal DNA analysis: detection of fetal DNA in maternal urine. Clin Chem (2009) 1.69
An Inv(16)(p13.3q24.3)-encoded CBFA2T3-GLIS2 fusion protein defines an aggressive subtype of pediatric acute megakaryoblastic leukemia. Cancer Cell (2012) 1.61
Transgenic cyclin E triggers dysplasia and multiple pulmonary adenocarcinomas. Proc Natl Acad Sci U S A (2007) 1.61
Characterization of a high-molecular-weight Notch complex in the nucleus of Notch(ic)-transformed RKE cells and in a human T-cell leukemia cell line. Mol Cell Biol (2002) 1.59
TGFbeta2 mediates the effects of hedgehog on hypertrophic differentiation and PTHrP expression. Development (2002) 1.37
A highly conserved amino-terminal region of sonic hedgehog is required for the formation of its freely diffusible multimeric form. J Biol Chem (2005) 1.37
A direct intersection between p53 and transforming growth factor beta pathways targets chromatin modification and transcription repression of the alpha-fetoprotein gene. Mol Cell Biol (2005) 1.22
Identification of a functional interaction between the transmembrane protein Smoothened and the kinesin-related protein Costal2. Curr Biol (2003) 1.21
Activation of Hedgehog signaling by the environmental toxicant arsenic may contribute to the etiology of arsenic-induced tumors. Cancer Res (2010) 1.15
A novel role of the hedgehog pathway in lens regeneration. Dev Biol (2004) 1.12
The carboxyl-terminal domain of the protein kinase fused can function as a dominant inhibitor of hedgehog signaling. Mol Cell Biol (2002) 1.06
p63 overexpression induces the expression of Sonic Hedgehog. Mol Cancer Res (2006) 1.06
Hedgehog-producing cancer cells respond to and require autocrine Hedgehog activity. Cancer Res (2011) 1.05
Association between In Utero arsenic exposure, placental gene expression, and infant birth weight: a US birth cohort study. Environ Health (2013) 1.04
Regulation of Hedgehog signaling: a complex story. Biochem Pharmacol (2004) 1.02
The extracellular loops of Smoothened play a regulatory role in control of Hedgehog pathway activation. Development (2012) 1.01
Costal2 functions as a kinesin-like protein in the hedgehog signal transduction pathway. Curr Biol (2008) 1.00
The Kinesin-related protein Costal2 associates with membranes in a Hedgehog-sensitive, Smoothened-independent manner. J Biol Chem (2003) 1.00
Hedgehog-stimulated phosphorylation of the kinesin-related protein Costal2 is mediated by the serine/threonine kinase fused. J Biol Chem (2002) 1.00
Hedgehog signaling regulates bladder cancer growth and tumorigenicity. Cancer Res (2012) 0.97
Sonic Hedgehog as a mediator of long-range signaling. Bioessays (2002) 0.97
Smoothened regulates activator and repressor functions of Hedgehog signaling via two distinct mechanisms. J Biol Chem (2006) 0.96
The full-length unprocessed hedgehog protein is an active signaling molecule. J Biol Chem (2009) 0.95
The adventures of sonic hedgehog in development and repair. III. Hedgehog processing and biological activity. Am J Physiol Gastrointest Liver Physiol (2008) 0.95
Sonic hedgehog mutations identified in holoprosencephaly patients can act in a dominant negative manner. Hum Genet (2008) 0.91
Epigenome-Wide Assessment of DNA Methylation in the Placenta and Arsenic Exposure in the New Hampshire Birth Cohort Study (USA). Environ Health Perspect (2016) 0.90
Hedgehog signaling regulates E-cadherin expression for the maintenance of the actin cytoskeleton and tight junctions. Am J Physiol Gastrointest Liver Physiol (2010) 0.89
An intramolecular association between two domains of the protein kinase Fused is necessary for Hedgehog signaling. Mol Cell Biol (2004) 0.88
Assembly of a Notch transcriptional activation complex requires multimerization. Mol Cell Biol (2011) 0.87
Unfolded protein response (UPR) signaling regulates arsenic trioxide-mediated macrophage innate immune function disruption. Toxicol Appl Pharmacol (2013) 0.87
Shh signaling in limb bud ectoderm: potential role in teratogen-induced postaxial ectrodactyly. Dev Dyn (2005) 0.86
The unfolded protein response selectively targets active smoothened mutants. Mol Cell Biol (2013) 0.86
A screen for modifiers of hedgehog signaling in Drosophila melanogaster identifies swm and mts. Genetics (2008) 0.86
A biochemical screen for identification of small-molecule regulators of the Wnt pathway using Xenopus egg extracts. J Biomol Screen (2011) 0.82
Replicated anterior zeugopod (raz): a polydactylous mouse mutant with lowered Shh signaling in the limb bud. Development (2003) 0.82
Response to inhibition of smoothened in diverse epithelial cancer cells that lack smoothened or patched 1 mutations. Int J Oncol (2012) 0.80
A quantification of pathway components supports a novel model of Hedgehog signal transduction. J Biol Chem (2009) 0.79
Screening for small molecule inhibitors of embryonic pathways: sometimes you gotta crack a few eggs. Bioorg Med Chem (2011) 0.77
Epigenetic pathways and glioblastoma treatment: insights from signaling cascades. J Cell Biochem (2015) 0.75
Repurposing an old anti-fungal drug as a Hedgehog inhibitor. Protein Cell (2010) 0.75
Quantitative Immunoblotting of Endogenous Hedgehog Pathway Components. Methods Mol Biol (2015) 0.75