Published in Cell Cycle on February 01, 2010
Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging. Aging (Albany NY) (2011) 2.72
p53 Research: the past thirty years and the next thirty years. Cold Spring Harb Perspect Biol (2010) 2.34
Conservation of all three p53 family members and Mdm2 and Mdm4 in the cartilaginous fish. Cell Cycle (2011) 2.25
The origins and evolution of the p53 family of genes. Cold Spring Harb Perspect Biol (2009) 1.90
p53-based cancer therapy. Cold Spring Harb Perspect Biol (2010) 1.62
The evolution of MDM2 family genes. Gene (2011) 1.03
Loss of tumor suppressor RPL5/RPL11 does not induce cell cycle arrest but impedes proliferation due to reduced ribosome content and translation capacity. Mol Cell Biol (2013) 1.00
Pathological unfoldomics of uncontrolled chaos: intrinsically disordered proteins and human diseases. Chem Rev (2014) 0.98
Intrinsically disordered regions of p53 family are highly diversified in evolution. Biochim Biophys Acta (2013) 0.96
The structure of the FYR domain of transforming growth factor beta regulator 1. Protein Sci (2010) 0.95
Mutant TP53 posttranslational modifications: challenges and opportunities. Hum Mutat (2014) 0.91
Cooperative effects of Akt-1 and Raf-1 on the induction of cellular senescence in doxorubicin or tamoxifen treated breast cancer cells. Oncotarget (2011) 0.89
Mdm2 in evolution. Genes Cancer (2012) 0.84
Tracing the protectors path from the germ line to the genome. Proc Natl Acad Sci U S A (2010) 0.84
Tracing the evolution of the p53 tetramerization domain. Structure (2014) 0.79
Structure and stability insights into tumour suppressor p53 evolutionary related proteins. PLoS One (2013) 0.78
Tumor-specific signaling to p53 is mimicked by Mdm2 inactivation in zebrafish: insights from mdm2 and mdm4 mutant zebrafish. Oncogene (2015) 0.78
Impact of the K24N mutation on the transactivation domain of p53 and its binding to murine double-minute clone 2. Proteins (2013) 0.78
Functional Diversification after Gene Duplication: Paralog Specific Regions of Structural Disorder and Phosphorylation in p53, p63, and p73. PLoS One (2016) 0.78
Identification of 526 conserved metazoan genetic innovations exposes a new role for cofactor E-like in neuronal microtubule homeostasis. PLoS Genet (2013) 0.77
p53 and Mdm2: an auld alliance. Cell Cycle (2010) 0.77
Inhibitors of the p53-Mdm2 interaction increase programmed cell death and produce abnormal phenotypes in the placozoon Trichoplax adhaerens (F.E. Schulze). Dev Genes Evol (2014) 0.77
Significant Prognostic Features and Patterns of Somatic TP53 Mutations in Human Cancers. Cancer Inform (2017) 0.75
Avoiding drug resistance through extended drug target interfaces: a case for stapled peptides. Oncotarget (2016) 0.75
The cnidarian origin of the proto-oncogenes NF-κB/STAT and WNT-like oncogenic pathway drives the ctenophores (Review). Int J Oncol (2015) 0.75
Functional characterization of p53 pathway components in the ancient metazoan Trichoplax adhaerens. Sci Rep (2016) 0.75
Evolution of the p53-MDM2 pathway. BMC Evol Biol (2017) 0.75
Rapid growth of a hepatocellular carcinoma and the driving mutations revealed by cell-population genetic analysis of whole-genome data. Proc Natl Acad Sci U S A (2011) 3.80
Epidemiologic and clinical characteristics of children with newly diagnosed inflammatory bowel disease in Wisconsin: a statewide population-based study. J Pediatr (2003) 3.49
Proinflammatory cytokine expression profile in degenerated and herniated human intervertebral disc tissues. Arthritis Rheum (2010) 3.45
Rational strain selection and engineering creates a broad-spectrum, systemically effective oncolytic poxvirus, JX-963. J Clin Invest (2007) 2.36
Conservation of all three p53 family members and Mdm2 and Mdm4 in the cartilaginous fish. Cell Cycle (2011) 2.25
Local protease signaling contributes to neural tube closure in the mouse embryo. Dev Cell (2010) 2.19
Outcomes following HSCT using fludarabine, busulfan, and thymoglobulin: a matched comparison to allogeneic transplants conditioned with busulfan and cyclophosphamide. Biol Blood Marrow Transplant (2008) 1.67
p53-based cancer therapy. Cold Spring Harb Perspect Biol (2010) 1.62
Life-threatening hemolytic anemia due to an autoanti-Pr cold agglutinin: evidence that glycophorin A antibodies may induce lipid bilayer exposure and cation permeability independent of agglutination. Transfusion (2009) 1.53
Design of a novel MDM2 binding peptide based on the p53 family. Cell Cycle (2009) 1.52
High busulfan exposure is associated with worse outcomes in a daily i.v. busulfan and fludarabine allogeneic transplant regimen. Biol Blood Marrow Transplant (2008) 1.46
Identification of minimal enhancer elements sufficient for Pax3 expression in neural crest and implication of Tead2 as a regulator of Pax3. Development (2004) 1.46
Multiple self-healing squamous epithelioma is caused by a disease-specific spectrum of mutations in TGFBR1. Nat Genet (2011) 1.39
The Mdm2 and p53 genes are conserved in the Arachnids. Cell Cycle (2010) 1.36
Defensins knowledgebase: a manually curated database and information source focused on the defensins family of antimicrobial peptides. Nucleic Acids Res (2006) 1.28
Adult recipients of matched related donor blood cell transplants given myeloablative regimens including pretransplant antithymocyte globulin have lower mortality related to graft-versus-host disease: a matched pair analysis. Biol Blood Marrow Transplant (2007) 1.26
Impact of surgical approach on complications and resource utilization of cervical spine fusion: a nationwide perspective to the surgical treatment of diffuse cervical spondylosis. Spine J (2008) 1.24
The crystal structure of the AAA domain of the ATP-dependent protease FtsH of Escherichia coli at 1.5 A resolution. Structure (2002) 1.22
Hydrogen peroxide stimulates activity and alters behavior in Drosophila melanogaster. PLoS One (2009) 1.15
Comparative study of overlapping genes in bacteria, with special reference to Rickettsia prowazekii and Rickettsia conorii. Int J Syst Evol Microbiol (2005) 1.14
Structural and functional analysis of phosphothreonine-dependent FHA domain interactions. Structure (2010) 1.13
Microtubule-associated protein tau is essential for long-term depression in the hippocampus. Philos Trans R Soc Lond B Biol Sci (2013) 1.10
Conformational flexibility of Mycobacterium tuberculosis thioredoxin reductase: crystal structure and normal-mode analysis. Acta Crystallogr D Biol Crystallogr (2005) 1.09
Differential binding of p53 and nutlin to MDM2 and MDMX: computational studies. Cell Cycle (2010) 1.09
Cranial neural crest ablation of Jagged1 recapitulates the craniofacial phenotype of Alagille syndrome patients. Hum Mol Genet (2011) 1.04
Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion. EMBO Rep (2012) 1.03
Impact of preoperative neurological status on perioperative morbidity associated with anterior and posterior cervical fusion. J Neurosurg Spine (2008) 1.03
The XPF-ERCC1 endonuclease and homologous recombination contribute to the repair of minor groove DNA interstrand crosslinks in mammalian cells produced by the pyrrolo[2,1-c][1,4]benzodiazepine dimer SJG-136. Nucleic Acids Res (2005) 1.02
Impact of body habitus on perioperative morbidity associated with fusion of the thoracolumbar and lumbar spine. Neurosurgery (2009) 1.01
Insight into the assembly properties and functional organisation of the magnetotactic bacterial actin-like homolog, MamK. PLoS One (2012) 1.00
Tbx1 is necessary for palatal elongation and elevation. Mech Dev (2010) 0.99
Aneurysmal bone cysts recur at juxtaphyseal locations in skeletally immature patients. Clin Orthop Relat Res (2008) 0.98
Structure-dependent charge density as a determinant of antimicrobial activity of peptide analogues of defensin. Biochemistry (2009) 0.97
Structural origins of the functional divergence of human insulin-like growth factor-I and insulin. Biochemistry (2002) 0.97
Why an A-loop phospho-mimetic fails to activate PAK1: understanding an inaccessible kinase state by molecular dynamics simulations. Structure (2010) 0.94
The p53 inducing drug dosage may determine quiescence or senescence. Aging (Albany NY) (2010) 0.94
Clustered clinical findings for diagnosis of cervical spine myelopathy. J Man Manip Ther (2010) 0.94
Incidence, clinical characteristics, and natural history of pediatric IBD in Wisconsin: a population-based epidemiological study. Inflamm Bowel Dis (2013) 0.91
Rapid bactericidal action of alpha-mangostin against MRSA as an outcome of membrane targeting. Biochim Biophys Acta (2012) 0.90
Directed evolution of p53 variants with altered DNA-binding specificities by in vitro compartmentalization. J Mol Biol (2007) 0.90
Linear analogues of human beta-defensin 3: concepts for design of antimicrobial peptides with reduced cytotoxicity to mammalian cells. Chembiochem (2008) 0.89
HIV and other lentiviral infections cause defects in neutrophil chemotaxis, recruitment, and cell structure: immunorestorative effects of granulocyte-macrophage colony-stimulating factor. J Immunol (2006) 0.89
Primary and 3-D modelled structures of two cyclotides from Viola odorata. Phytochemistry (2003) 0.88
In vitro selection of mutant HDM2 resistant to Nutlin inhibition. PLoS One (2013) 0.87
Stability of the core domain of p53: insights from computer simulations. BMC Bioinformatics (2008) 0.87
The development of a clinical decision making algorithm for detection of osteoporotic vertebral compression fracture or wedge deformity. J Man Manip Ther (2010) 0.86
New insights into p53 based therapy. Discov Med (2011) 0.86
The clinical value of a cluster of patient history and observational findings as a diagnostic support tool for lumbar spine stenosis. Physiother Res Int (2010) 0.86
Molecular rotors as conditionally fluorescent labels for rapid detection of biomolecular interactions. J Am Chem Soc (2014) 0.86
Compartmentalized linkage of genes encoding interacting protein pairs. Proteomics (2011) 0.86
Inhibition of nutlin-resistant HDM2 mutants by stapled peptides. PLoS One (2013) 0.85
Botulinum toxin injection site localization for the tibialis posterior muscle. J Pediatr Orthop B (2006) 0.84
Sequence signatures of allosteric proteins towards rational design. Syst Synth Biol (2011) 0.84
Mdm2 in evolution. Genes Cancer (2012) 0.84
Herpes zoster--varicella complicating anterior thoracic surgery: 2 case reports. J Spinal Disord Tech (2006) 0.84
Differences in the transactivation domains of p53 family members: a computational study. BMC Genomics (2010) 0.83
Selection of bacteriophage lambda integrases with altered recombination specificity by in vitro compartmentalization. Nucleic Acids Res (2009) 0.83
Investigating peptide sequence variations for 'double-click' stapled p53 peptides. Org Biomol Chem (2014) 0.83
Arabidopsis thaliana calcium-dependent lipid-binding protein (AtCLB): a novel repressor of abiotic stress response. J Exp Bot (2011) 0.83
The very C-terminus of protein kinase Cepsilon is critical for the full catalytic competence but its hydrophobic motif is dispensable for the interaction with 3-phosphoinositide-dependent kinase-1. Cell Signal (2005) 0.83
The last 10 amino acid residues beyond the hydrophobic motif are critical for the catalytic competence and function of protein kinase Calpha. J Biol Chem (2006) 0.82
The yeast ATP-binding cassette (ABC) transporter Ycf1p enhances the recruitment of the soluble SNARE Vam7p to vacuoles for efficient membrane fusion. J Biol Chem (2013) 0.82
Functional relevance of dynamic properties of Dimeric NADP-dependent Isocitrate Dehydrogenases. BMC Bioinformatics (2012) 0.82
The fluorescent two-hybrid assay to screen for protein-protein interaction inhibitors in live cells: targeting the interaction of p53 with Mdm2 and Mdm4. J Biomol Screen (2014) 0.82
Effect of structural parameters of peptides on dimer formation and highly oxidized side products in the oxidation of thiols of linear analogues of human beta-defensin 3 by DMSO. J Pept Sci (2009) 0.81
Identification of a second Nutlin-3 responsive interaction site in the N-terminal domain of MDM2 using hydrogen/deuterium exchange mass spectrometry. Proteomics (2013) 0.80
Molecular simulations suggest how a branched antimicrobial peptide perturbs a bacterial membrane and enhances permeability. Biochim Biophys Acta (2012) 0.80
Design and synthesis of amphiphilic xanthone-based, membrane-targeting antimicrobials with improved membrane selectivity. J Med Chem (2013) 0.80
The very C-terminus of PRK1/PKN is essential for its activation by RhoA and downstream signaling. Cell Signal (2006) 0.80
Rational design and biophysical characterization of thioredoxin-based aptamers: insights into peptide grafting. J Mol Biol (2009) 0.80
A comparison of the dynamics of pantothenate synthetase from M. tuberculosis and E. coli: computational studies. Proteins (2011) 0.80
Growth inhibition of pathogenic bacteria by sulfonylurea herbicides. Antimicrob Agents Chemother (2012) 0.80
Biological effects of cobalt-chromium nanoparticles and ions on dural fibroblasts and dural epithelial cells. Biomaterials (2013) 0.80
A new technique of "midline anchoring" in spinal cord stimulation dramatically reduces lead migration. Neuromodulation (2004) 0.79
The use of chlorobenzene as a probe molecule in molecular dynamics simulations. J Chem Inf Model (2014) 0.79
Placebo analgesia: cognitive influences on therapeutic outcome. Arthritis Res Ther (2012) 0.79
Trends in the evolution of the prodynorphin gene in teleosts: cloning of eel and tilapia prodynorphin cDNAs. Peptides (2005) 0.79
Progressive structuring of a branched antimicrobial peptide on the path to the inner membrane target. J Biol Chem (2012) 0.79
Modelling study of dimerization in mammalian defensins. BMC Bioinformatics (2006) 0.79
The C-terminus of PRK2/PKNgamma is required for optimal activation by RhoA in a GTP-dependent manner. Arch Biochem Biophys (2008) 0.79
A novel p53 phosphorylation site within the MDM2 ubiquitination signal: II. a model in which phosphorylation at SER269 induces a mutant conformation to p53. J Biol Chem (2010) 0.79
Amino acid modified xanthone derivatives: novel, highly promising membrane-active antimicrobials for multidrug-resistant Gram-positive bacterial infections. J Med Chem (2014) 0.78
Binding of Translationally Controlled Tumour Protein to the N-terminal domain of HDM2 is inhibited by nutlin-3. PLoS One (2012) 0.78
Attitudes, knowledge and practice of CRC screening among GPs in Queensland. Aust Fam Physician (2006) 0.78
Protecting normal cells from the cytotoxicity of chemotherapy. Cell Cycle (2012) 0.78
Molecular dynamics simulations of a new branched antimicrobial peptide: a comparison of force fields. J Chem Phys (2012) 0.78
Differences in comorbidities on low back pain and low back related leg pain. Pain Pract (2011) 0.77
The risk of risk-adjustment measures for perioperative spine infection after spinal surgery. Spine (Phila Pa 1976) (2011) 0.77
Reducing morphological variability of the cervical carotid artery in serial magnetic resonance imaging using a head and neck immobilization device. J Magn Reson Imaging (2008) 0.77
A generic scaffold for conversion of peptide ligands into homogenous biosensors. Biosens Bioelectron (2013) 0.77