PubRank

Stephen J Haggarty

Author PubWeight™ 106.78‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease. Science 2006 25.99
2 HDAC2 negatively regulates memory formation and synaptic plasticity. Nature 2009 6.96
3 Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signaling. Cell 2009 5.34
4 Histone deacetylase 5 epigenetically controls behavioral adaptations to chronic emotional stimuli. Neuron 2007 4.96
5 Chemical phylogenetics of histone deacetylases. Nat Chem Biol 2010 4.36
6 Essential role of the histone methyltransferase G9a in cocaine-induced plasticity. Science 2010 3.97
7 Inhibitors of class 1 histone deacetylases reverse contextual memory deficits in a mouse model of Alzheimer's disease. Neuropsychopharmacology 2009 3.64
8 Zebrafish behavioral profiling links drugs to biological targets and rest/wake regulation. Science 2010 3.60
9 Antidepressant actions of histone deacetylase inhibitors. J Neurosci 2009 3.17
10 Deregulation of HDAC1 by p25/Cdk5 in neurotoxicity. Neuron 2008 2.88
11 Rapid behavior-based identification of neuroactive small molecules in the zebrafish. Nat Chem Biol 2010 2.87
12 An epigenetic blockade of cognitive functions in the neurodegenerating brain. Nature 2012 2.67
13 An aldol-based build/couple/pair strategy for the synthesis of medium- and large-sized rings: discovery of macrocyclic histone deacetylase inhibitors. J Am Chem Soc 2010 2.30
14 Revealing complex traits with small molecules and naturally recombinant yeast strains. Chem Biol 2006 1.87
15 Finding new components of the target of rapamycin (TOR) signaling network through chemical genetics and proteome chips. Proc Natl Acad Sci U S A 2004 1.75
16 Epigenetic characterization of the FMR1 gene and aberrant neurodevelopment in human induced pluripotent stem cell models of fragile X syndrome. PLoS One 2011 1.75
17 Chemical genetic strategy identifies histone deacetylase 1 (HDAC1) and HDAC2 as therapeutic targets in sickle cell disease. Proc Natl Acad Sci U S A 2010 1.72
18 Chemical genetic modifier screens: small molecule trichostatin suppressors as probes of intracellular histone and tubulin acetylation. Chem Biol 2003 1.46
19 Large-scale in vivo femtosecond laser neurosurgery screen reveals small-molecule enhancer of regeneration. Proc Natl Acad Sci U S A 2010 1.37
20 Class I HDAC inhibition blocks cocaine-induced plasticity by targeted changes in histone methylation. Nat Neurosci 2013 1.35
21 Molecular signatures of human induced pluripotent stem cells highlight sex differences and cancer genes. Cell Stem Cell 2012 1.23
22 Synapse microarray identification of small molecules that enhance synaptogenesis. Nat Commun 2011 1.19
23 Crebinostat: a novel cognitive enhancer that inhibits histone deacetylase activity and modulates chromatin-mediated neuroplasticity. Neuropharmacology 2012 1.18
24 Effect of Inhibiting Histone Deacetylase with Short-Chain Carboxylic Acids and Their Hydroxamic Acid Analogs on Vertebrate Development and Neuronal Chromatin. ACS Med Chem Lett 2010 1.11
25 A selective HDAC 1/2 inhibitor modulates chromatin and gene expression in brain and alters mouse behavior in two mood-related tests. PLoS One 2013 1.10
26 Bruton's tyrosine kinase revealed as a negative regulator of Wnt-beta-catenin signaling. Sci Signal 2009 1.10
27 AKT kinase activity is required for lithium to modulate mood-related behaviors in mice. Neuropsychopharmacology 2011 1.08
28 Disruption of a large intergenic noncoding RNA in subjects with neurodevelopmental disabilities. Am J Hum Genet 2012 1.07
29 Chemical-genetic screen identifies riluzole as an enhancer of Wnt/β-catenin signaling in melanoma. Chem Biol 2010 1.05
30 Brain-penetrant LSD1 inhibitors can block memory consolidation. ACS Chem Neurosci 2011 1.04
31 A high-throughput screen for Wnt/β-catenin signaling pathway modulators in human iPSC-derived neural progenitors. J Biomol Screen 2012 1.03
32 The DNA damage mark pH2AX differentiates the cytotoxic effects of small molecule HDAC inhibitors in ovarian cancer cells. Cancer Biol Ther 2011 1.01
33 Human iPSC models of neuronal ceroid lipofuscinosis capture distinct effects of TPP1 and CLN3 mutations on the endocytic pathway. Hum Mol Genet 2013 0.96
34 SpectralNET--an application for spectral graph analysis and visualization. BMC Bioinformatics 2005 0.94
35 Class I HDAC imaging using [ (3)H]CI-994 autoradiography. Epigenetics 2013 0.92
36 Striatal neurons expressing full-length mutant huntingtin exhibit decreased N-cadherin and altered neuritogenesis. Hum Mol Genet 2011 0.89
37 In vivo imaging of histone deacetylases (HDACs) in the central nervous system and major peripheral organs. J Med Chem 2014 0.86
38 Advancing drug discovery for schizophrenia. Ann N Y Acad Sci 2011 0.86
39 Image-guided synthesis reveals potent blood-brain barrier permeable histone deacetylase inhibitors. ACS Chem Neurosci 2014 0.83
40 AAK1 identified as an inhibitor of neuregulin-1/ErbB4-dependent neurotrophic factor signaling using integrative chemical genomics and proteomics. Chem Biol 2011 0.82
41 PDGFRβ expression and function in fibroblasts derived from pluripotent cells is linked to DNA demethylation. J Cell Sci 2012 0.81
42 FDG-PET imaging reveals local brain glucose utilization is altered by class I histone deacetylase inhibitors. Neurosci Lett 2013 0.80
43 Detecting binding interactions using microarrays of natural product extracts. J Am Chem Soc 2007 0.79
44 Emerging roles of epigenetic mechanisms in Parkinson's disease. Funct Integr Genomics 2011 0.78
45 Chemical genomics: probing protein function using small molecules. Am J Pharmacogenomics 2004 0.77
46 Regulation of primitive hematopoiesis by class I histone deacetylases. Dev Dyn 2013 0.77
47 Chemical genetics identifies small-molecule modulators of neuritogenesis involving neuregulin-1/ErbB4 signaling. ACS Chem Neurosci 2010 0.77