Published in Harefuah on December 01, 2009
Analysis of T cell function in autoimmune murine strains. Defects in production and responsiveness to interleukin 2. J Exp Med (1981) 3.27
Antigen analog-major histocompatibility complexes act as antagonists of the T cell receptor. Cell (1992) 3.24
T cell antigen receptor-mediated activation of phospholipase C requires tyrosine phosphorylation. Science (1990) 3.23
Rapid activation of the T-cell tyrosine protein kinase pp56lck by the CD45 phosphotyrosine phosphatase. Proc Natl Acad Sci U S A (1989) 2.70
Macrophage-activating factor produced by a T cell hybridoma: physiochemical and biosynthetic resemblance to gamma-interferon. J Immunol (1983) 2.61
Antigen-induced translocation of PKC-theta to membrane rafts is required for T cell activation. Nat Immunol (2001) 2.18
Neoadjuvant hormonal ablative therapy before radical prostatectomy: a review. Is it indicated? J Urol (2000) 2.16
NF-kappa B activation induced by T cell receptor/CD28 costimulation is mediated by protein kinase C-theta. Proc Natl Acad Sci U S A (2000) 2.13
Tyrosine kinase-stimulated guanine nucleotide exchange activity of Vav in T cell activation. Science (1993) 2.10
Molecular cloning and characterization of PKC theta, a novel member of the protein kinase C (PKC) gene family expressed predominantly in hematopoietic cells. J Biol Chem (1993) 1.98
Functional and physical interactions of Syk family kinases with the Vav proto-oncogene product. Immunity (1996) 1.95
Protein kinase C-theta isoenzyme selective stimulation of the transcription factor complex AP-1 in T lymphocytes. Mol Cell Biol (1996) 1.86
Identification of a T cell hybridoma that produces large quantities of macrophage-activating factor. J Exp Med (1982) 1.81
Macrophage activation: priming activity from a T-cell hybridoma is attributable to interferon-gamma. Proc Natl Acad Sci U S A (1983) 1.73
Vav1/Rac-dependent actin cytoskeleton reorganization is required for lipid raft clustering in T cells. J Cell Biol (2001) 1.70
A novel functional interaction between Vav and PKCtheta is required for TCR-induced T cell activation. Immunity (2000) 1.65
Chlorophyll catabolism in senescing plant tissues: In vivo breakdown intermediates suggest different degradative pathways for Citrus fruit and parsley leaves. Proc Natl Acad Sci U S A (1987) 1.61
Protein kinase C-theta phosphorylation of moesin in the actin-binding sequence. J Biol Chem (1998) 1.60
T-lymphocyte activation: the role of protein kinase C and the bifurcating inositol phospholipid signal transduction pathway. Immunol Rev (1987) 1.60
Effects of retinoic acid (RA) on the growth and phenotypic expression of several human neuroblastoma cell lines. Exp Cell Res (1983) 1.53
Dual Mechanisms in Polyamine-mediated Control of Ribonuclease Activity in Oat Leaf Protoplasts. Plant Physiol (1978) 1.48
Predominant expression and activation-induced tyrosine phosphorylation of phospholipase C-gamma 2 in B lymphocytes. Proc Natl Acad Sci U S A (1992) 1.48
Dephosphorylation and activation of the T cell tyrosine kinase pp56lck by the leukocyte common antigen (CD45). Oncogene (1990) 1.44
Suppression of T lymphocyte function by measles virus is due to cell cycle arrest in G1. J Immunol (1988) 1.38
Structure and expression of novel protein-tyrosine kinases, Emb and Emt, in hematopoietic cells. Biochem Biophys Res Commun (1993) 1.37
Inhibition of the c-Jun N-terminal kinase/AP-1 and NF-kappaB pathways by PICOT, a novel protein kinase C-interacting protein with a thioredoxin homology domain. J Biol Chem (2000) 1.37
Human T lymphocyte activation by tumor promoters: role of protein kinase C. J Immunol (1987) 1.35
Presence and identification of polyamines in xylem and Phloem exudates of plants. Plant Physiol (1986) 1.32
Hypertonicity regulates the function of human neutrophils by modulating chemoattractant receptor signaling and activating mitogen-activated protein kinase p38. J Clin Invest (1998) 1.31
Inhibition of phosphatidylinositol 3-kinase activity by association with 14-3-3 proteins in T cells. Proc Natl Acad Sci U S A (1995) 1.31
Direct stimulation of Vav guanine nucleotide exchange activity for Ras by phorbol esters and diglycerides. Mol Cell Biol (1994) 1.27
Protein kinase C mu is negatively regulated by 14-3-3 signal transduction proteins. J Biol Chem (1999) 1.26
Adaptor function for the Syk kinases-interacting protein 3BP2 in IL-2 gene activation. Immunity (1998) 1.25
Protein kinase ctheta cooperates with calcineurin to induce Fas ligand expression during activation-induced T cell death. J Immunol (1999) 1.24
Hypertonic saline resuscitation: a tool to modulate immune function in trauma patients? Shock (1997) 1.24
Serine phosphorylation of Cbl induced by phorbol ester enhances its association with 14-3-3 proteins in T cells via a novel serine-rich 14-3-3-binding motif. J Biol Chem (1997) 1.22
Cell-free media of mixed lymphocyte cultures augmenting sensitization in vitro of mouse T lymphocytes against allogeneic fibroblasts. Eur J Immunol (1976) 1.22
Direct interaction between protein kinase C theta (PKC theta) and 14-3-3 tau in T cells: 14-3-3 overexpression results in inhibition of PKC theta translocation and function. Mol Cell Biol (1996) 1.20
p56lck-independent activation and tyrosine phosphorylation of p72syk by T-cell antigen receptor/CD3 stimulation. Proc Natl Acad Sci U S A (1994) 1.19
Regulation of protein kinase Ctheta function during T cell activation by Lck-mediated tyrosine phosphorylation. J Biol Chem (2000) 1.17
Differential effects of sucrose, abscisic Acid, and benzyladenine on shoot growth and callus formation in the abscission zone of excised citrus buds. Plant Physiol (1977) 1.15
Views on Vav. Immunol Today (1997) 1.15
Role of Ethylene in Abscisic Acid-induced Callus Formation in Citrus Bud Cultures. Plant Physiol (1979) 1.14
Monocyte deactivation by interleukin 10 via inhibition of tyrosine kinase activity and the Ras signaling pathway. Proc Natl Acad Sci U S A (1994) 1.14
A role for PKCtheta in outside-in alpha(IIb)beta3 signaling. J Thromb Haemost (2006) 1.13
Activation of Ras in vitro and in intact fibroblasts by the Vav guanine nucleotide exchange protein. Mol Cell Biol (1994) 1.12
Coordinated regulation of the tyrosine phosphorylation of Cbl by Fyn and Syk tyrosine kinases. J Biol Chem (1998) 1.12
Polyamines and root formation in mung bean hypocotyl cuttings : I. Effects of exogenous compounds and changes in endogenous polyamine content. Plant Physiol (1982) 1.11
Construction of T cell hybridomas secreting allogeneic effect factor. J Exp Med (1980) 1.11
T-cell receptor antagonists induce Vav phosphorylation by selective activation of Fyn kinase. Proc Natl Acad Sci U S A (2000) 1.10
Protein kinase Ctheta, a selective upstream regulator of JNK/SAPK and IL-2 promoter activation in Jurkat T cells. Eur J Immunol (1999) 1.09
Tumor promoters in conjunction with calcium ionophores mimic antigenic stimulation by reactivation of alloantigen-primed murine T lymphocytes. J Immunol (1985) 1.06
Differential T cell signaling induced by antagonist peptide-MHC complexes and the associated phenotypic responses. J Immunol (1997) 1.06
Activation-modulated association of 14-3-3 proteins with Cbl in T cells. J Biol Chem (1996) 1.05
Selective post-transcriptional down-regulation of protein kinase C isoenzymes in leukemic T cells chronically treated with phorbol ester. J Biol Chem (1990) 1.05
Expression and biochemical characterization of human protein kinase C-theta. Eur J Biochem (1994) 1.04
Molecular analysis of the beta-thalassemia phenotype associated with inheritance of hemoglobin E (alpha 2 beta2(26)Glu leads to Lys). J Clin Invest (1981) 1.04
Regulation of the p70zap tyrosine protein kinase in T cells by the CD45 phosphotyrosine phosphatase. Eur J Immunol (1995) 1.04
Activation of p56lck by p72syk through physical association and N-terminal tyrosine phosphorylation. Mol Cell Biol (1994) 1.04
Vav modulation of the Ras/MEK/ERK signaling pathway plays a role in NFAT activation and CD69 up-regulation. Eur J Immunol (2000) 1.03
Do CD4 and CD8 control T-cell activation via a specific tyrosine protein kinase? Immunol Today (1989) 1.03
Tyrosine phosphorylation and complex formation of Cbl-b upon T cell receptor stimulation. Oncogene (1999) 1.02
Cbl: complex formation and functional implications. Cell Signal (1998) 1.01
Vav-Rac1-mediated activation of the c-Jun N-terminal kinase/c-Jun/AP-1 pathway plays a major role in stimulation of the distal NFAT site in the interleukin-2 gene promoter. Mol Cell Biol (2001) 1.01
Improved specificity of RT-PCR amplifications using nested cDNA primers. Nucleic Acids Res (1993) 1.00
Specific high-affinity binding and biologic action of retinoic acid in human neuroblastoma cell lines. Proc Natl Acad Sci U S A (1983) 0.99
Inhibition of phorbol ester-induced T cell proliferation by bryostatin is associated with rapid degradation of protein kinase C. J Immunol (1993) 0.99
Production and isolation of helper and suppressor factors. J Immunol Methods (1980) 0.98
TCR antagonist peptides induce formation of APC-T cell conjugates and activate a Rac signaling pathway. Eur J Immunol (2000) 0.98
Antibodies of predetermined specificity against chemically synthesized peptides of human interleukin 2. Proc Natl Acad Sci U S A (1984) 0.98
Constitutive and mitogen-induced production of T cell growth factor by stable T cell hybridoma lines. J Immunol (1982) 0.97
Protein kinase C-theta mediates a selective T cell survival signal via phosphorylation of BAD. J Immunol (2001) 0.95
Lpr T cell hyporesponsiveness to mitogens linked to deficient receptor-stimulated phosphoinositide hydrolysis. J Biol Chem (1988) 0.94
Hypertonic saline activates protein tyrosine kinases and mitogen-activated protein kinase p38 in T-cells. J Trauma (1997) 0.94
The biology of monoclonal lymphokines secreted by T cell lines and hybridomas. Adv Immunol (1982) 0.93
Mapping of the human protein kinase C-theta (PRKCQ) gene locus to the short arm of chromosome 10 (10p15) by FISH. Genomics (1995) 0.93
Integrin-dependent tyrosine phosphorylation and growth regulation by Vav. Cell Adhes Commun (1999) 0.92
Tyrosine phosphorylation and activation of Vav GTP/GDP exchange activity in antigen receptor-triggered B cells. J Immunol (1994) 0.92
Identification of a protein, SPY75, with repetitive helix-turn-helix motifs and an SH3 domain as a major substrate for protein tyrosine kinase(s) activated by Fc epsilon RI cross-linking. J Immunol (1994) 0.92
Endocrine regulation of gonadotropin and growth hormone gene transcription in fish. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol (1998) 0.92
American Academy of Pediatrics Report of the Subcommittee on the Management of Pain Associated with Procedures in Children with Cancer. Pediatrics (1990) 0.91
A direct interaction between the adaptor protein Cbl-b and the kinase zap-70 induces a positive signal in T cells. Curr Biol (1999) 0.90
The tumor promoter teleocidin induces IL 2 receptor expression and IL 2-independent proliferation of human peripheral blood T cells. J Immunol (1985) 0.90
PICOT-HD: a highly conserved protein domain that is often associated with thioredoxin and glutaredoxin modules. Trends Biochem Sci (2000) 0.90
Membrane lipid microdomains and the role of PKCtheta in T cell activation. Semin Immunol (2001) 0.90
New perspectives on PKCtheta, a member of the novel subfamily of protein kinase C. Stem Cells (1998) 0.89
Ras-dependent, Ca2+-stimulated activation of nuclear factor of activated T cells by a constitutively active Cbl mutant in T cells. J Biol Chem (1997) 0.89
Teleocidin and phorbol ester tumor promoters exert similar mitogenic effects on human lymphocytes. Biochem Biophys Res Commun (1985) 0.89
Inhibition of phosphatidylinositol 3-kinase blocks T cell antigen receptor/CD3-induced activation of the mitogen-activated kinase Erk2. Eur J Biochem (1996) 0.89
Hypothalamic and thyroidal regulation of growth hormone in tilapia. Gen Comp Endocrinol (1995) 0.88
Immunogenic targeting of recombinant peptide vaccines to human antigen-presenting cells by chimeric anti-HLA-DR and anti-surface immunoglobulin D antibody Fab fragments in vitro. J Virol (1995) 0.88
Transcriptional activity of isolated maize chloroplasts. Arch Biochem Biophys (1984) 0.88
Superior vena cava syndrome - changing etiology in the third millennium. Lupus (2011) 0.88
Interleukin 2 mediates the inhibition of oligodendrocyte progenitor cell proliferation in vitro. Proc Natl Acad Sci U S A (1986) 0.88
Production of interleukin 2 (IL 2) by salivary gland lymphocytes in Sjögren's syndrome. Detection of reactive cells by using antibody directed to synthetic peptides of IL 2. J Immunol (1985) 0.88
Spatial dependence of the phase in localized bioelectrical impedance analysis. Phys Med Biol (2001) 0.87
Polyamines and Root Formation in Mung Bean Hypocotyl Cuttings : II. Incorporation of Precursors into Polyamines. Plant Physiol (1985) 0.86
Direct cloning of human neuroblastoma cells in soft agar culture. Cancer Res (1980) 0.86
Reconstitution of T cell antigen receptor-induced Erk2 kinase activation in Lck-negative JCaM1 cells by Syk. Eur J Biochem (1997) 0.86
Protein kinase C activation inhibits tyrosine phosphorylation of Cbl and its recruitment of Src homology 2 domain-containing proteins. J Immunol (1999) 0.85