PubRank

D A Agard

Author PubWeight™ 176.67‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen. Cell 1998 9.96
2 Interphase chromosomes undergo constrained diffusional motion in living cells. Curr Biol 1997 5.00
3 I5M: 3D widefield light microscopy with better than 100 nm axial resolution. J Microsc 1999 4.84
4 Perturbation of nuclear architecture by long-distance chromosome interactions. Cell 1996 4.73
5 Microtubule nucleation by gamma-tubulin-containing rings in the centrosome. Nature 1995 4.24
6 Estrogen receptor pathways to AP-1. J Steroid Biochem Mol Biol 2000 3.96
7 Three-dimensional architecture of a polytene nucleus. Nature 1983 3.82
8 Optical sectioning microscopy: cellular architecture in three dimensions. Annu Rev Biophys Bioeng 1984 3.73
9 Determination of three-dimensional imaging properties of a light microscope system. Partial confocal behavior in epifluorescence microscopy. Biophys J 1990 3.44
10 Three-dimensional structure of the LDL receptor-binding domain of human apolipoprotein E. Science 1991 3.42
11 Structure of the gamma-tubulin ring complex: a template for microtubule nucleation. Nat Cell Biol 2000 2.84
12 A protein-folding reaction under kinetic control. Nature 1992 2.82
13 Large-scale chromatin structural domains within mitotic and interphase chromosomes in vivo and in vitro. Chromosoma 1989 2.66
14 The use of a charge-coupled device for quantitative optical microscopy of biological structures. Science 1987 2.64
15 Three-dimensional multiple-wavelength fluorescence microscopy for the structural analysis of biological phenomena. Semin Cell Biol 1991 2.43
16 Three-dimensional structural characterization of centrosomes from early Drosophila embryos. J Cell Biol 1995 2.41
17 Meiotic chromosome pairing in maize is associated with a novel chromatin organization. Cell 1994 2.34
18 Specific interactions of chromatin with the nuclear envelope: positional determination within the nucleus in Drosophila melanogaster. Mol Biol Cell 1996 2.32
19 Interphase nuclear envelope lamins form a discontinuous network that interacts with only a fraction of the chromatin in the nuclear periphery. Cell 1990 2.32
20 The onset of homologous chromosome pairing during Drosophila melanogaster embryogenesis. J Cell Biol 1993 2.26
21 A three-dimensional approach to mitotic chromosome structure: evidence for a complex hierarchical organization. J Cell Biol 1987 2.26
22 Subdiffraction-resolution fluorescence microscopy reveals a domain of the centrosome critical for pericentriolar material organization. Nat Cell Biol 2012 2.23
23 Activation of a retroviral membrane fusion protein: soluble receptor-induced liposome binding of the ALSV envelope glycoprotein. J Cell Biol 1997 2.21
24 Structural studies of a membrane-bound acetylcholine receptor from Torpedo californica. J Mol Biol 1977 2.17
25 Telomeres cluster de novo before the initiation of synapsis: a three-dimensional spatial analysis of telomere positions before and during meiotic prophase. J Cell Biol 1997 2.17
26 Homologous chromosome pairing in Drosophila melanogaster proceeds through multiple independent initiations. J Cell Biol 1998 2.16
27 IVE (Image Visualization Environment): a software platform for all three-dimensional microscopy applications. J Struct Biol 1996 2.12
28 Human apolipoprotein E. Role of arginine 61 in mediating the lipoprotein preferences of the E3 and E4 isoforms. J Biol Chem 1994 2.04
29 Linking regions between helices in bacteriorhodopsin revealed. Biophys J 1982 2.03
30 Phase-retrieved pupil functions in wide-field fluorescence microscopy. J Microsc 2004 1.96
31 Computational adaptive optics for live three-dimensional biological imaging. Proc Natl Acad Sci U S A 2001 1.91
32 The alpha-lytic protease pro-region does not require a physical linkage to activate the protease domain in vivo. Nature 1989 1.91
33 Dispersion, aberration and deconvolution in multi-wavelength fluorescence images. J Microsc 1996 1.89
34 Multiple chromosomal populations of topoisomerase II detected in vivo by time-lapse, three-dimensional wide-field microscopy. Cell 1993 1.87
35 Uniqueness and the ab initio phase problem in macromolecular crystallography. Acta Crystallogr D Biol Crystallogr 1993 1.84
36 The three-dimensional architecture of chromatin in situ: electron tomography reveals fibers composed of a continuously variable zig-zag nucleosomal ribbon. J Cell Biol 1994 1.84
37 Temporal and spatial coordination of chromosome movement, spindle formation, and nuclear envelope breakdown during prometaphase in Drosophila melanogaster embryos. J Cell Biol 1990 1.80
38 Unfolded conformations of alpha-lytic protease are more stable than its native state. Nature 1998 1.75
39 Structure determination of asymmetric membrane profiles using an iterative Fourier method. Biophys J 1979 1.75
40 Kinetics versus thermodynamics in protein folding. Biochemistry 1994 1.71
41 Automated microscopy for electron tomography. Ultramicroscopy 1992 1.56
42 Gamma-tubulin complexes and microtubule nucleation. Curr Opin Struct Biol 2001 1.53
43 A novel 3D wavelet-based filter for visualizing features in noisy biological data. J Microsc 2005 1.50
44 Focal points for chromosome condensation and decondensation revealed by three-dimensional in vivo time-lapse microscopy. Nature 1989 1.48
45 The role of pro regions in protein folding. Curr Opin Cell Biol 1993 1.47
46 Analysis of prepro-alpha-lytic protease expression in Escherichia coli reveals that the pro region is required for activity. J Bacteriol 1989 1.45
47 Direct cell lineage analysis in Drosophila melanogaster by time-lapse, three-dimensional optical microscopy of living embryos. J Cell Biol 1989 1.45
48 Structural plasticity broadens the specificity of an engineered protease. Nature 1989 1.44
49 Spatial organization of the Drosophila nucleus: a three-dimensional cytogenetic study. J Cell Sci Suppl 1984 1.44
50 A least-squares method for determining structure factors in three-dimensional tilted-view reconstructions. J Mol Biol 1983 1.43
51 Evidence for the coincident initiation of homolog pairing and synapsis during the telomere-clustering (bouquet) stage of meiotic prophase. J Cell Sci 2000 1.39
52 Chromosome elasticity and mitotic polar ejection force measured in living Drosophila embryos by four-dimensional microscopy-based motion analysis. Curr Biol 2001 1.38
53 Protease pro region required for folding is a potent inhibitor of the mature enzyme. Proteins 1992 1.36
54 Serine protease mechanism: structure of an inhibitory complex of alpha-lytic protease and a tightly bound peptide boronic acid. Biochemistry 1987 1.30
55 Kinetic stability as a mechanism for protease longevity. Proc Natl Acad Sci U S A 1999 1.28
56 Structure of alpha-lytic protease complexed with its pro region. Nat Struct Biol 1998 1.26
57 Computational method for the design of enzymes with altered substrate specificity. J Mol Biol 1991 1.24
58 Cryo automated electron tomography: towards high-resolution reconstructions of plastic-embedded structures. J Microsc 1994 1.23
59 Precise determination of the molecular limits of a polytene chromosome band: regulatory sequences for the Notch gene are in the interband. Cell 1988 1.19
60 Tilted view reconstruction in optical microscopy. Three-dimensional reconstruction of Drosophila melanogaster embryo nuclei. Biophys J 1989 1.19
61 Modeling side-chain conformation for homologous proteins using an energy-based rotamer search. J Mol Biol 1993 1.19
62 Molecular analysis of the gene encoding alpha-lytic protease: evidence for a preproenzyme. Gene 1988 1.18
63 Turnover of regulatory subunit of cyclic AMP-dependent protein kinase in S49 mouse lymphoma cells. Regulation by catalytic subunit and analogs of cyclic AMP. J Biol Chem 1981 1.15
64 Drosophila gastrulation: analysis of cell shape changes in living embryos by three-dimensional fluorescence microscopy. Development 1991 1.14
65 PRISM: topologically constrained phased refinement for macromolecular crystallography. Acta Crystallogr D Biol Crystallogr 1993 1.14
66 Quantitative analysis of electrophoretograms: a mathematical approach to super-resolution. Anal Biochem 1981 1.13
67 Conformational substates in enzyme mechanism: the 120 K structure of alpha-lytic protease at 1.5 A resolution. Protein Sci 1997 1.13
68 Influenza hemagglutinin: kinetic control of protein function. Structure 1994 1.12
69 Time-resolved, in vivo studies of mitotic spindle formation and nuclear lamina breakdown in Drosophila early embryos. J Cell Sci 1996 1.11
70 Enzyme specificity under dynamic control: a normal mode analysis of alpha-lytic protease. J Mol Biol 1999 1.10
71 Kinetic properties of the binding of alpha-lytic protease to peptide boronic acids. Biochemistry 1988 1.09
72 Structural basis for broad specificity in alpha-lytic protease mutants. Biochemistry 1991 1.06
73 A three-dimensional structural dissection of Drosophila polytene chromosomes. J Cell Biol 1995 1.06
74 Studies on the phosphorylation and synthesis of type I regulatory subunit of cyclic AMP-dependent protein kinase in intact S49 mouse lymphoma cells. J Biol Chem 1981 1.05
75 The solution structure of the viral binding domain of Tva, the cellular receptor for subgroup A avian leukosis and sarcoma virus. FEBS Lett 2001 1.02
76 Pro region C-terminus:protease active site interactions are critical in catalyzing the folding of alpha-lytic protease. Biochemistry 1998 1.01
77 Solid-state imagers for microscopy. Methods Cell Biol 1989 0.99
78 High-resolution wide-field microscopy with adaptive optics for spherical aberration correction and motionless focusing. J Microsc 2010 0.98
79 Inhibition of alpha-lytic protease by pro region C-terminal steric occlusion of the active site. Biochemistry 1997 0.98
80 Salt bridge relay triggers defective LDL receptor binding by a mutant apolipoprotein. Structure 1994 0.96
81 Kinetic and structural characterization of mutations of glycine 216 in alpha-lytic protease: a new target for engineering substrate specificity. J Mol Biol 1995 0.95
82 Functional linkage between the active site of alpha-lytic protease and distant regions of structure: scanning alanine mutagenesis of a surface loop affects activity and substrate specificity. J Mol Biol 1995 0.95
83 Structural analysis of specificity: alpha-lytic protease complexes with analogues of reaction intermediates. Biochemistry 1989 0.94
84 Enzyme specificity under dynamic control II: Principal component analysis of alpha-lytic protease using global and local solvent boundary conditions. Protein Sci 2001 0.93
85 Crystal structures of alpha-lytic protease complexes with irreversibly bound phosphonate esters. Biochemistry 1991 0.93
86 Quantitative analysis of nucleic acids, proteins, and viruses by Raman band deconvolution. Biophys J 1984 0.92
87 Toward fully automated high-resolution electron tomography. J Struct Biol 1996 0.91
88 alpha-lytic protease precursor: characterization of a structured folding intermediate. Biochemistry 1999 0.90
89 Correct folding of alpha-lytic protease is required for its extracellular secretion from Escherichia coli. J Cell Biol 1992 0.89
90 Chromosome structure inside the nucleus. Curr Opin Cell Biol 1993 0.88
91 Automated data collection for electron microscopic tomography. Methods Enzymol 2010 0.86
92 Relationship between enzyme specificity and the backbone dynamics of free and inhibited alpha-lytic protease. Biochemistry 1998 0.85
93 Mutational remodeling of enzyme specificity. Methods Enzymol 1991 0.84
94 Two energetically disparate folding pathways of alpha-lytic protease share a single transition state. Nat Struct Biol 2000 0.84
95 Practical image restoration of thick biological specimens using multiple focus levels in transmission electron microscopy. J Struct Biol 1997 0.82
96 Binding mode prediction for a flexible ligand in a flexible pocket using multi-conformation simulated annealing pseudo crystallographic refinement. J Mol Biol 2001 0.81
97 Optimal strategies for imaging thick biological specimens: exit wavefront reconstruction and energy-filtered imaging. J Microsc 1996 0.81
98 PRISM: application to the solution of two protein structures. Acta Crystallogr D Biol Crystallogr 1993 0.80
99 Alterations in chemical shifts and exchange broadening upon peptide boronic acid inhibitor binding to alpha-lytic protease. J Biomol NMR 1997 0.79
100 Mechanism of image formation for thick biological specimens: exit wavefront reconstruction and electron energy-loss spectroscopic imaging. J Microsc 1995 0.79
101 Free energy calculations on binding and catalysis by alpha-lytic protease: the role of substrate size in the P1 pocket. Proteins 1991 0.78
102 Reconstitution of centrosome microtubule nucleation in Drosophila. Methods Cell Biol 2001 0.77
103 Interferometer-based structured-illumination microscopy utilizing complementary phase relationship through constructive and destructive image detection by two cameras. J Microsc 2012 0.75
104 Crystallization and preliminary X-ray diffraction studies on the amino-terminal (receptor-binding) domain of human apolipoprotein E3 from serum very low density lipoproteins. J Mol Biol 1988 0.75
105 Direct measurement of interfacial curvature distributions in a bicontinuous block copolymer morphology. Phys Rev Lett 2000 0.75
106 An extended view of nuclear lamin structure, function, and dynamics. Semin Cell Biol 1992 0.75