Published in Biochimie on January 22, 2010
Arginine 104 is a key catalytic residue in leukotriene C4 synthase. J Biol Chem (2010) 0.91
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Trichostatin A induces 5-lipoxygenase promoter activity and mRNA expression via inhibition of histone deacetylase 2 and 3. J Cell Mol Med (2012) 0.82
Protective role of 5-lipoxigenase during Leishmania infantum infection is associated with Th17 subset. Biomed Res Int (2014) 0.80
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Expression of 5-lipoxygenase and leukotriene A4 hydrolase in human atherosclerotic lesions correlates with symptoms of plaque instability. Proc Natl Acad Sci U S A (2006) 1.28
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Human CMV infection induces 5-lipoxygenase expression and leukotriene B4 production in vascular smooth muscle cells. J Exp Med (2008) 1.14
Structure-based dissection of the active site chemistry of leukotriene A4 hydrolase: implications for M1 aminopeptidases and inhibitor design. Chem Biol (2008) 1.12
Leukotriene A4 hydrolase/aminopeptidase. Glutamate 271 is a catalytic residue with specific roles in two distinct enzyme mechanisms. J Biol Chem (2001) 1.10
Leukotriene B4/antimicrobial peptide LL-37 proinflammatory circuits are mediated by BLT1 and FPR2/ALX and are counterregulated by lipoxin A4 and resolvin E1. FASEB J (2011) 1.07
The use of network analyses for elucidating mechanisms in cardiovascular disease. Mol Biosyst (2009) 1.06
The rat leukocyte-type 12-lipoxygenase exhibits an intrinsic hepoxilin A3 synthase activity. J Biol Chem (2004) 1.04
Engineering membrane protein overproduction in Escherichia coli. Protein Sci (2008) 1.03
Expression of enzymes and receptors of the leukotriene pathway in human neuroblastoma promotes tumor survival and provides a target for therapy. FASEB J (2008) 1.01
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Leukotriene A4 hydrolase: identification of a common carboxylate recognition site for the epoxide hydrolase and aminopeptidase substrates. J Biol Chem (2004) 0.98
Lipid mediator serum profiles in asthmatics significantly shift following dietary supplementation with omega-3 fatty acids. Mol Nutr Food Res (2013) 0.96
Increased expression of leukotriene C4 synthase and predominant formation of cysteinyl-leukotrienes in human abdominal aortic aneurysm. Proc Natl Acad Sci U S A (2010) 0.96
Mutation of a critical arginine in microsomal prostaglandin E synthase-1 shifts the isomerase activity to a reductase activity that converts prostaglandin H2 into prostaglandin F2alpha. J Biol Chem (2008) 0.96
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Differential induction of BLT receptor expression on human endothelial cells by lipopolysaccharide, cytokines, and leukotriene B4. Proc Natl Acad Sci U S A (2006) 0.92
Leukotriene B4 triggers release of the cathelicidin LL-37 from human neutrophils: novel lipid-peptide interactions in innate immune responses. FASEB J (2007) 0.92
Asthmatics exhibit altered oxylipin profiles compared to healthy individuals after subway air exposure. PLoS One (2011) 0.91
Arginine 104 is a key catalytic residue in leukotriene C4 synthase. J Biol Chem (2010) 0.91
Allergic asthmatics show divergent lipid mediator profiles from healthy controls both at baseline and following birch pollen provocation. PLoS One (2012) 0.91
Dominant expression of the CysLT2 receptor accounts for calcium signaling by cysteinyl leukotrienes in human umbilical vein endothelial cells. Arterioscler Thromb Vasc Biol (2003) 0.90
Novel inhibitory effect on 5-lipoxygenase activity by the anti-asthma drug montelukast. Biochem Biophys Res Commun (2004) 0.90
GeneRegionScan: a Bioconductor package for probe-level analysis of specific, small regions of the genome. Bioinformatics (2009) 0.89
Leukotriene B4-induced changes in vascular permeability are mediated by neutrophil release of heparin-binding protein (HBP/CAP37/azurocidin). FASEB J (2009) 0.88
Targeting leukotriene B4 in inflammation. Expert Opin Ther Targets (2013) 0.84
Cathelicidin LL-37 induces angiogenesis via PGE2-EP3 signaling in endothelial cells, in vivo inhibition by aspirin. Arterioscler Thromb Vasc Biol (2013) 0.84
Leukotriene A4 hydrolase, insights into the molecular evolution by homology modeling and mutational analysis of enzyme from Saccharomyces cerevisiae. J Biol Chem (2005) 0.84
Synthesis of glutamic acid analogs as potent inhibitors of leukotriene A4 hydrolase. Bioorg Med Chem (2008) 0.84
Thromboxane synthase expression and thromboxane A2 production in the atherosclerotic lesion. J Mol Med (Berl) (2010) 0.84
Annexin A5 inhibits atherogenic and pro-inflammatory effects of lysophosphatidylcholine. Prostaglandins Other Lipid Mediat (2013) 0.83
Leukotriene B4 is an indirectly acting vasoconstrictor in guinea pig aorta via an inducible type of BLT receptor. Am J Physiol Heart Circ Physiol (2004) 0.83
Lipid mediator metabolic profiling demonstrates differences in eicosanoid patterns in two phenotypically distinct mast cell populations. J Lipid Res (2012) 0.83
Zymosan suppresses leukotriene C₄ synthase activity in differentiating monocytes: antagonism by aspirin and protein kinase inhibitors. FASEB J (2011) 0.82
Pre-steady-state kinetic characterization of thiolate anion formation in human leukotriene C₄ synthase. Biochemistry (2012) 0.82
Binding of Pro-Gly-Pro at the active site of leukotriene A4 hydrolase/aminopeptidase and development of an epoxide hydrolase selective inhibitor. Proc Natl Acad Sci U S A (2014) 0.82
Endothelium-dependent vascular responses induced by leukotriene B4. Prostaglandins Other Lipid Mediat (2007) 0.81
Cysteinyl leukotriene signaling aggravates myocardial hypoxia in experimental atherosclerotic heart disease. PLoS One (2012) 0.81
15-deoxy-Delta12,14-prostaglandin J2 inhibits the expression of microsomal prostaglandin E synthase type 2 in colon cancer cells. J Lipid Res (2006) 0.81
Human mast cells express two leukotriene C(4) synthase isoenzymes and the CysLT(1) receptor. Biochim Biophys Acta (2002) 0.81
Catalytic characterization of human microsomal glutathione S-transferase 2: identification of rate-limiting steps. Biochemistry (2013) 0.81
HPLC/MS/MS-based approaches for detection and quantification of eicosanoids. Methods Mol Biol (2009) 0.81
Targeted knock-down of a structurally atypical zebrafish 12S-lipoxygenase leads to severe impairment of embryonic development. Proc Natl Acad Sci U S A (2011) 0.81
Commonly used leukotriene B4 receptor antagonists possess intrinsic activity as agonists in human endothelial cells: Effects on calcium transients, adhesive events and mediator release. Prostaglandins Leukot Essent Fatty Acids (2010) 0.80
Molecular and catalytic properties of three rat leukotriene C(4) synthase homologs. Biochem Biophys Res Commun (2003) 0.80
A leukotriene A4 hydrolase-related aminopeptidase from yeast undergoes induced fit upon inhibitor binding. J Mol Biol (2010) 0.80
Cold adaptation of enzymes: structural, kinetic and microcalorimetric characterizations of an aminopeptidase from the Arctic psychrophile Colwellia psychrerythraea and of human leukotriene A(4) hydrolase. Biochim Biophys Acta (2008) 0.79
Residues from transmembrane helices 3 and 5 participate in leukotriene B4 binding to BLT1. Biochemistry (2006) 0.79
Crystal structures of leukotriene C4 synthase in complex with product analogs: implications for the enzyme mechanism. J Biol Chem (2013) 0.79
Fluorescent leukotriene B4: potential applications. J Lipid Res (2005) 0.78
Non-specific effects of leukotriene synthesis inhibitors on HeLa cell physiology. Prostaglandins Leukot Essent Fatty Acids (2005) 0.78
Subcellular localization of leukotriene receptors in human endothelial cells. Exp Cell Res (2010) 0.77
Crystal structure of leukotriene A4 hydrolase in complex with kelatorphan, implications for design of zinc metallopeptidase inhibitors. FEBS Lett (2010) 0.76
Crystallization and X-ray diffraction data analysis of leukotriene A4 hydrolase from Saccharomyces cerevisiae. Acta Crystallogr D Biol Crystallogr (2003) 0.76
A remarkable activity of human leukotriene A4 hydrolase (LTA4H) toward unnatural amino acids. Amino Acids (2014) 0.75
Assay for rapid analysis of the tri-peptidase activity of LTA4 hydrolase. Proteins (2007) 0.75
High-level expression, purification, and crystallization of recombinant rat leukotriene C(4) synthase from the yeast Pichia pastoris. Protein Expr Purif (2008) 0.75