Published in Angew Chem Int Ed Engl on February 22, 2010
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Complete genome sequence of the myxobacterium Sorangium cellulosum. Nat Biotechnol (2007) 2.43
Argyrin a reveals a critical role for the tumor suppressor protein p27(kip1) in mediating antitumor activities in response to proteasome inhibition. Cancer Cell (2008) 2.12
The total synthesis of chlorotonil A. Angew Chem Int Ed Engl (2008) 1.31
Rescue of progranulin deficiency associated with frontotemporal lobar degeneration by alkalizing reagents and inhibition of vacuolar ATPase. J Neurosci (2011) 1.26
Hepatitis C virus complete life cycle screen for identification of small molecules with pro- or antiviral activity. Antiviral Res (2010) 1.12
Bioactive metabolites from the Caribbean sponge Aka coralliphagum. J Nat Prod (2007) 1.09
The human cytomegalovirus UL51 protein is essential for viral genome cleavage-packaging and interacts with the terminase subunits pUL56 and pUL89. J Virol (2012) 1.08
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Disorazol A1, a highly effective antimitotic agent acting on tubulin polymerization and inducing apoptosis in mammalian cells. Biochem Pharmacol (2004) 1.02
Isolation, crystal and solution structure determination, and biosynthesis of tubulysins--powerful inhibitors of tubulin polymerization from myxobacteria. Angew Chem Int Ed Engl (2004) 1.02
The total synthesis of (+)-tedanolide. J Am Chem Soc (2006) 0.99
Mechanism of action of tubulysin, an antimitotic peptide from myxobacteria. Chembiochem (2006) 0.96
Total synthesis and biological evaluation of (-)-9-deoxy-englerin A. Org Lett (2011) 0.96
Evidence for the mode of action of the highly cytotoxic Streptomyces polyketide kendomycin. Chembiochem (2007) 0.95
TAR-RNA recognition by a novel cyclic aminoglycoside analogue. Nucleic Acids Res (2006) 0.93
Oxazaborolidinone-promoted vinylogous Mukaiyama aldol reactions. Org Lett (2007) 0.93
Identification and analysis of the core biosynthetic machinery of tubulysin, a potent cytotoxin with potential anticancer activity. Chem Biol (2004) 0.93
New, highly active nonbenzoquinone geldanamycin derivatives by using mutasynthesis. Chembiochem (2009) 0.92
Biological activity of volatiles from marine and terrestrial bacteria. Mar Drugs (2010) 0.92
Interaction between importin 13 and myopodin suggests a nuclear import pathway for myopodin. Mol Cell Biochem (2007) 0.91
The absolute configuration of rhizopodin and its inhibition of actin polymerization by dimerization. Angew Chem Int Ed Engl (2009) 0.91
Aetheramides A and B, potent HIV-inhibitory depsipeptides from a myxobacterium of the new genus "Aetherobacter". Org Lett (2012) 0.91
Introducing lasso peptides as molecular scaffolds for drug design: engineering of an integrin antagonist. Angew Chem Int Ed Engl (2011) 0.90
Gephyronic acid, a missing link between polyketide inhibitors of eukaryotic protein synthesis (part I): Structural revision and stereochemical assignment of gephyronic acid. Angew Chem Int Ed Engl (2010) 0.90
Chondramide C: synthesis, configurational assignment, and structure-activity relationship studies. Angew Chem Int Ed Engl (2008) 0.89
Synthesis and biological evaluation of cruentaren A analogues. Chemistry (2008) 0.88
Total synthesis and biological activity of neopeltolide and analogues. Chemistry (2008) 0.88
Synthesis and pharmacology of proteasome inhibitors. Angew Chem Int Ed Engl (2013) 0.88
Synthesis of a pladienolide B analogue with the fully functionalized core structure. Org Lett (2011) 0.88
The total synthesis of (+)-tedanolide--A macrocyclic polyketide from marine sponge Tedania ignis. Chemistry (2008) 0.87
The first cyclic monomeric 3-alkylpyridinium alkaloid from natural sources: identification, synthesis, and biological activity. Org Biomol Chem (2008) 0.87
Design, synthesis, and biological properties of highly potent tubulysin D analogues. Chemistry (2007) 0.85
Highly active ansamitocin derivatives: mutasynthesis using an AHBA-blocked mutant. Chembiochem (2008) 0.85
Isolation, biological activity evaluation, structure elucidation, and total synthesis of eliamid: a novel complex I inhibitor. Chemistry (2012) 0.83
Myxobacteria: natural pharmaceutical factories. Microb Cell Fact (2012) 0.83
Metal complexes of natural melophlins and their cytotoxic and antibiotic activities. J Inorg Biochem (2008) 0.83
Chemoenzymatic approaches toward dechloroansamitocin P-3. Org Lett (2007) 0.82
Mutational biosynthesis of ansamitocin antibiotics: a diversity-oriented approach to exploit biosynthetic flexibility. Chembiochem (2011) 0.82
A Kiyooka aldol approach for the synthesis of the C(14)-C(23) segment of the diastereomeric analog of tedanolide C. Org Lett (2011) 0.82
Doubly prenylated tryptamines: cytotoxicity, antimicrobial activity and cyclisation to the marine natural product flustramine A. Org Biomol Chem (2013) 0.82
Synthesis of penicillenol C1 and of a bis-azide analogue for photoaffinity labeling. J Org Chem (2013) 0.81
Design, synthesis, and biological evaluation of novel analogues of archazolid: a highly potent simplified V-ATPase inhibitor. Bioorg Med Chem Lett (2006) 0.81
Combined muta- and semisynthesis: a powerful synthetic hybrid approach to access target specific antitumor agents based on ansamitocin P3. Chemistry (2011) 0.81
Total synthesis of chivosazole F. J Am Chem Soc (2010) 0.81
Cruentaren A, a highly cytotoxic benzolactone from Myxobacteria is a novel selective inhibitor of mitochondrial F1-ATPases. FEBS Lett (2007) 0.81
Broad substrate specificity of the amide synthase in S. hygroscopicus--new 20-membered macrolactones derived from geldanamycin. J Am Chem Soc (2012) 0.81
Gephyronic acid, a missing link between polyketide inhibitors of eukaryotic protein synthesis (part II): Total synthesis of gephyronic acid. Angew Chem Int Ed Engl (2010) 0.81
The total synthesis of corallopyronin A and myxopyronin B. Angew Chem Int Ed Engl (2012) 0.80
Asymmetric vinylogous Mukaiyama aldol reaction of aldehyde-derived dienolates. Org Lett (2011) 0.80
Semisynthesis and antiplasmodial activity of the quinoline alkaloid aurachin E. J Nat Prod (2008) 0.80
Design, synthesis, and biological evaluation of simplified side chain hybrids of the potent actin binding polyketides rhizopodin and bistramide. ChemMedChem (2015) 0.80
Elucidation of the structure and intermolecular interactions of a reversible cyclic-peptide inhibitor of the proteasome by NMR spectroscopy and molecular modeling. Angew Chem Int Ed Engl (2010) 0.80
Cyclization of synthetic seco-proansamitocins to ansamitocin macrolactams by Actinosynnema pretiosum as biocatalyst. Chembiochem (2010) 0.80
The structure elucidation and total synthesis of β-lipomycin. Angew Chem Int Ed Engl (2014) 0.80
Archazolid A-15-O-β-D-glucopyranoside and iso-archazolid B: potent V-ATPase inhibitory polyketides from the myxobacteria Cystobacter violaceus and Archangium gephyra. J Nat Prod (2011) 0.80
Gold(I) biscarbene complexes derived from vascular-disrupting combretastatin A-4 address different targets and show antimetastatic potential. ChemMedChem (2014) 0.79
The oxygen-independent coproporphyrinogen III oxidase HemN utilizes harderoporphyrinogen as a reaction intermediate during conversion of coproporphyrinogen III to protoporphyrinogen IX. Biol Chem (2010) 0.79
Synthesis of the C10-C32 core structure of spirangien A. Org Lett (2008) 0.79
Chivosazole A--elucidation of the absolute and relative configuration. Angew Chem Int Ed Engl (2007) 0.79
Antimicrobial phenalenone derivatives from the marine-derived fungus Coniothyrium cereale. Org Biomol Chem (2010) 0.79
Identification of myxobacteria-derived HIV inhibitors by a high-throughput two-step infectivity assay. Microb Cell Fact (2013) 0.78
Syntheses of the tedanolides. Nat Prod Rep (2008) 0.78
Multicomponent reactions for the synthesis of multifunctional agents with activity against cancer cells. Chem Commun (Camb) (2009) 0.78
Structure-activity relationships of precursors and analogs of natural 3-enoyl-tetramic acids. Chem Biodivers (2010) 0.78
Tandem intramolecular Michael-aldol reaction as a tool for the construction of the C-ring of hexacyclinic acid. Org Lett (2006) 0.78
Exploring synthetic avenues for the effective synthesis of selenium- and tellurium-containing multifunctional redox agents. Org Biomol Chem (2009) 0.78
Synthesis of deguelin-biotin conjugates and investigation into deguelin's interactions. Bioorg Med Chem (2011) 0.78
Cytotoxic and antivascular 1-methyl-4-(3-fluoro-4-methoxyphenyl)-5-(halophenyl)-imidazoles. Bioorg Med Chem Lett (2011) 0.78
Synthesis and biological characterization of argyrin F. ChemMedChem (2010) 0.77
Unprecedented deoxygenation at C-7 of the ansamitocin core during mutasynthetic biotransformations. Beilstein J Org Chem (2012) 0.77
Bioreduction of aryl azides during mutasynthesis of new ansamitocins. Org Lett (2013) 0.77
Intramolecular stereoselective protonation of aldehyde-derived enolates. Angew Chem Int Ed Engl (2010) 0.77
The myxobacterial metabolite ratjadone A inhibits HIV infection by blocking the Rev/CRM1-mediated nuclear export pathway. Microb Cell Fact (2014) 0.77
Prismatomerin, a new iridoid from Prismatomeris tetrandra. Structure elucidation, determination of absolute configuration, and cytotoxicity. J Nat Prod (2007) 0.77
Total synthesis and biological evaluation of jerantinine E. Angew Chem Int Ed Engl (2013) 0.77
A selective 3-acylation of tetramic acids and the first synthesis of ravenic acid. Chemistry (2010) 0.77
The first hydroxylated archazolid from the myxobacterium Cystobacter violaceus: isolation, structural elucidation and V-ATPase inhibition. J Antibiot (Tokyo) (2007) 0.77
Baceridin, a cyclic hexapeptide from an epiphytic bacillus strain, inhibits the proteasome. Chembiochem (2014) 0.77
The interplay between mutasynthesis and semisynthesis: generation and evaluation of an ansamitocin library. Angew Chem Int Ed Engl (2011) 0.77
The myxobacterial compounds spirangien a and spirangien M522 are potent inhibitors of IL-8 expression. Chembiochem (2012) 0.77
Identification of StiR, the first regulator of secondary metabolite formation in the myxobacterium Cystobacter fuscus Cb f17.1. J Biotechnol (2005) 0.76
Novel peptidomimetic compounds containing redox active chalcogens and quinones as potential anticancer agents. Eur J Med Chem (2012) 0.76
Fluorescent analogs of the marine natural product psammaplin A: synthesis and biological activity. Org Biomol Chem (2012) 0.76
Configurational assignment of secondary hydroxyl groups and methyl branches in polyketide natural products through bioinformatic analysis of the ketoreductase domain. Chembiochem (2013) 0.76
Synthesis of chondramide A analogues with modified β-tyrosine and their biological evaluation. Chemistry (2011) 0.76
HLE-inhibitory alkaloids with a polyketide skeleton from the marine-derived fungus Coniothyrium cereale. J Nat Prod (2011) 0.76
The tubulin-bound structure of the antimitotic drug tubulysin. Angew Chem Int Ed Engl (2010) 0.76
Pellasoren: structure elucidation, biosynthesis, and total synthesis of a cytotoxic secondary metabolite from Sorangium cellulosum. Angew Chem Int Ed Engl (2012) 0.76
Success in tubulysin D synthesis. Nat Chem Biol (2007) 0.75
Mode of action of epoxyphomalins A and B and characterization of related metabolites from the marine-derived fungus Paraconiothyrium sp. J Nat Prod (2010) 0.75
Chivosazoles A and F, cytostatic macrolides from myxobacteria, interfere with actin. Chembiochem (2009) 0.75
Modification of uptake and subcellular distribution of doxorubicin by N-acylhydrazone residues as visualised by intrinsic fluorescence. Cancer Chemother Pharmacol (2011) 0.75