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1
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Hypoxia-inducible factor 1alpha (HIF-1alpha)-mediated hypoxia increases BACE1 expression and beta-amyloid generation.
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J Biol Chem
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2007
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1.91
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2
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Antidiabetic drug metformin (GlucophageR) increases biogenesis of Alzheimer's amyloid peptides via up-regulating BACE1 transcription.
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Proc Natl Acad Sci U S A
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2009
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1.76
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3
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Presenilin/gamma-secretase-dependent processing of beta-amyloid precursor protein regulates EGF receptor expression.
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Proc Natl Acad Sci U S A
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2007
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1.61
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4
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Phosphorylation of tau antagonizes apoptosis by stabilizing beta-catenin, a mechanism involved in Alzheimer's neurodegeneration.
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Proc Natl Acad Sci U S A
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2007
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1.41
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5
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NO signaling and S-nitrosylation regulate PTEN inhibition in neurodegeneration.
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Mol Neurodegener
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2010
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1.23
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6
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Chemically programmed antibodies: endothelin receptor targeting CovX-Bodies.
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Bioorg Med Chem Lett
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2006
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1.22
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7
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Suppression of cyclin-dependent kinase 5 activation by amyloid precursor protein: a novel excitoprotective mechanism involving modulation of tau phosphorylation.
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J Neurosci
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2005
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1.21
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8
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Differential regulation of BACE1 expression by oxidative and nitrosative signals.
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Mol Neurodegener
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2011
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1.06
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9
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Tumor-suppressor PTEN affects tau phosphorylation, aggregation, and binding to microtubules.
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FASEB J
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2006
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0.99
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10
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Appoptosin is a novel pro-apoptotic protein and mediates cell death in neurodegeneration.
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J Neurosci
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2012
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0.99
|
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11
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Metabolic stress modulates Alzheimer's β-secretase gene transcription via SIRT1-PPARγ-PGC-1 in neurons.
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Cell Metab
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2013
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0.98
|
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12
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Alzheimer's presenilin 1 modulates sorting of APP and its carboxyl-terminal fragments in cerebral neurons in vivo.
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J Neurochem
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2007
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0.97
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13
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Functional interaction of phosphatase and tensin homologue (PTEN) with the E3 ligase NEDD4-1 during neuronal response to zinc.
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J Biol Chem
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2010
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0.96
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14
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Statin's excitoprotection is mediated by sAPP and the subsequent attenuation of calpain-induced truncation events, likely via rho-ROCK signaling.
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J Neurosci
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2009
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0.96
|
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15
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Upregulation of the E3 ligase NEDD4-1 by oxidative stress degrades IGF-1 receptor protein in neurodegeneration.
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J Neurosci
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2012
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0.96
|
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16
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Hsp90 chaperone inhibitor 17-AAG attenuates Aβ-induced synaptic toxicity and memory impairment.
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J Neurosci
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2014
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0.95
|
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17
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Intracellular trafficking of presenilin 1 is regulated by beta-amyloid precursor protein and phospholipase D1.
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J Biol Chem
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2009
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0.94
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18
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A functional mouse retroposed gene Rps23r1 reduces Alzheimer's beta-amyloid levels and tau phosphorylation.
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Neuron
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2009
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0.91
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19
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Nedd4 haploinsufficient mice display moderate insulin resistance, enhanced lipolysis, and protection against high-fat diet-induced obesity.
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Endocrinology
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2015
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0.87
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20
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The Rps23rg gene family originated through retroposition of the ribosomal protein s23 mRNA and encodes proteins that decrease Alzheimer's beta-amyloid level and tau phosphorylation.
|
Hum Mol Genet
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2010
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0.83
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21
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Tumor suppressor PTEN affects tau phosphorylation: deficiency in the phosphatase activity of PTEN increases aggregation of an FTDP-17 mutant Tau.
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Mol Neurodegener
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2006
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0.82
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22
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Synaptic protein α1-takusan mitigates amyloid-β-induced synaptic loss via interaction with tau and postsynaptic density-95 at postsynaptic sites.
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J Neurosci
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2013
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0.79
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23
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Homocysteine disrupts outgrowth of microvascular endothelium by an iNOS-dependent mechanism.
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Microcirculation
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2014
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0.78
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24
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APP regulates NGF receptor trafficking and NGF-mediated neuronal differentiation and survival.
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PLoS One
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2013
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0.78
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