Published in Genes Dev on April 01, 1991
Transcriptional activation and chromatin remodeling of the HIV-1 promoter in response to histone acetylation. EMBO J (1996) 5.10
Evidence for eviction and rapid deposition of histones upon transcriptional elongation by RNA polymerase II. Mol Cell Biol (2004) 4.06
Chromatin disruption in the promoter of human immunodeficiency virus type 1 during transcriptional activation. EMBO J (1993) 3.95
Nucleosomal fluctuations govern the transcription dynamics of RNA polymerase II. Science (2009) 3.60
Control of formation of two distinct classes of RNA polymerase II elongation complexes. Mol Cell Biol (1992) 3.60
Ubiquitylation of histone H2B controls RNA polymerase II transcription elongation independently of histone H3 methylation. Genes Dev (2007) 2.81
Dual roles for Spt5 in pre-mRNA processing and transcription elongation revealed by identification of Spt5-associated proteins. Mol Cell Biol (2003) 2.77
ATP-dependent chromatin remodeling by the Cockayne syndrome B DNA repair-transcription-coupling factor. Mol Cell Biol (2000) 2.34
Elongator is a histone H3 and H4 acetyltransferase important for normal histone acetylation levels in vivo. Proc Natl Acad Sci U S A (2002) 2.27
Drosophila Paf1 modulates chromatin structure at actively transcribed genes. Mol Cell Biol (2006) 2.16
Mammalian SWI-SNF complexes contribute to activation of the hsp70 gene. Mol Cell Biol (2000) 2.10
Control of transcriptional elongation. Annu Rev Genet (2013) 1.92
The active site of RNA polymerase II participates in transcript cleavage within arrested ternary complexes. Proc Natl Acad Sci U S A (1994) 1.91
Transcriptional activation of the integrated chromatin-associated human immunodeficiency virus type 1 promoter. Mol Cell Biol (1998) 1.90
Transcription through the roadblocks: the role of RNA polymerase cooperation. EMBO J (2003) 1.89
Characterization of a six-subunit holo-elongator complex required for the regulated expression of a group of genes in Saccharomyces cerevisiae. Mol Cell Biol (2001) 1.87
Mechanism of chromatin remodeling and recovery during passage of RNA polymerase II. Nat Struct Mol Biol (2009) 1.86
Elongation factor SII-dependent transcription by RNA polymerase II through a sequence-specific DNA-binding protein. Proc Natl Acad Sci U S A (1993) 1.79
Mutations in the second largest subunit of RNA polymerase II cause 6-azauracil sensitivity in yeast and increased transcriptional arrest in vitro. J Biol Chem (1996) 1.74
CTD-dependent dismantling of the RNA polymerase II elongation complex by the pre-mRNA 3'-end processing factor, Pcf11. Genes Dev (2005) 1.73
The Swi/Snf complex is important for histone eviction during transcriptional activation and RNA polymerase II elongation in vivo. Mol Cell Biol (2007) 1.72
Distinct activated and non-activated RNA polymerase II complexes in yeast. EMBO J (1996) 1.68
Promoter proximal pausing on genes in metazoans. Chromosoma (2008) 1.64
Native elongating transcript sequencing reveals human transcriptional activity at nucleotide resolution. Cell (2015) 1.60
Histone acetylation facilitates RNA polymerase II transcription of the Drosophila hsp26 gene in chromatin. EMBO J (1998) 1.56
Stimulation of transcription factor binding and histone displacement by nucleosome assembly protein 1 and nucleoplasmin requires disruption of the histone octamer. Mol Cell Biol (1995) 1.55
Stability of Drosophila RNA polymerase II elongation complexes in vitro. Mol Cell Biol (1992) 1.53
Trigger loop dynamics mediate the balance between the transcriptional fidelity and speed of RNA polymerase II. Proc Natl Acad Sci U S A (2012) 1.51
Disruption of downstream chromatin directed by a transcriptional activator. Genes Dev (1997) 1.48
RNA polymerase backtracking in gene regulation and genome instability. Cell (2012) 1.48
Identification of a decay in transcription potential that results in elongation factor dependence of RNA polymerase II. J Biol Chem (1995) 1.44
Synergistic action of RNA polymerases in overcoming the nucleosomal barrier. Nat Struct Mol Biol (2010) 1.43
Transcription through chromatin by RNA polymerase II: histone displacement and exchange. Mutat Res (2007) 1.38
RNA polymerase complexes cooperate to relieve the nucleosomal barrier and evict histones. Proc Natl Acad Sci U S A (2010) 1.37
Histone chaperone FACT action during transcription through chromatin by RNA polymerase II. Proc Natl Acad Sci U S A (2013) 1.32
Transcriptional activation domains of human heat shock factor 1 recruit human SWI/SNF. Mol Cell Biol (2001) 1.29
The immunoglobulin heavy chain locus control region increases histone acetylation along linked c-myc genes. Mol Cell Biol (1998) 1.28
Positive DNA supercoiling generates a chromatin conformation characteristic of highly active genes. Proc Natl Acad Sci U S A (1991) 1.24
Single-molecule studies of RNA polymerase: one singular sensation, every little step it takes. Mol Cell (2011) 1.21
Gametophytic selection in Arabidopsis thaliana supports the selective model of intron length reduction. PLoS Genet (2005) 1.20
Overcoming the nucleosome barrier during transcript elongation. Trends Genet (2012) 1.19
Mechanism of transcription through a nucleosome by RNA polymerase II. Biochim Biophys Acta (2012) 1.19
The elongation rate of RNA polymerase determines the fate of transcribed nucleosomes. Nat Struct Mol Biol (2011) 1.19
The PARP and VSG genes of Trypanosoma brucei do not resemble RNA polymerase II transcription units in sensitivity to Sarkosyl in nuclear run-on assays. Nucleic Acids Res (1992) 1.15
Structural changes in the RNA polymerase II transcription complex during transition from initiation to elongation. Mol Cell Biol (1998) 1.15
Molecular cloning of an essential subunit of RNA polymerase II elongation factor SIII. Proc Natl Acad Sci U S A (1994) 1.15
Regulation of eukaryotic gene expression by transcriptional attenuation. Mol Biol Cell (1993) 1.15
The Spt4-Spt5 complex: a multi-faceted regulator of transcription elongation. Biochim Biophys Acta (2012) 1.11
BRG1 helps RNA polymerase II to overcome a nucleosomal barrier during elongation, in vivo. EMBO Rep (2010) 1.09
Cooperation between the INO80 complex and histone chaperones determines adaptation of stress gene transcription in the yeast Saccharomyces cerevisiae. Mol Cell Biol (2009) 1.09
Co-transcriptional regulation of alternative pre-mRNA splicing. Biochim Biophys Acta (2012) 1.08
Histone N-terminal tails interfere with nucleosome traversal by RNA polymerase II. J Biol Chem (2008) 1.06
Transcription termination factor Pcf11 limits the processivity of Pol II on an HIV provirus to repress gene expression. Genes Dev (2007) 1.04
Integrator regulates transcriptional initiation and pause release following activation. Mol Cell (2014) 1.04
A key role for Chd1 in histone H3 dynamics at the 3' ends of long genes in yeast. PLoS Genet (2012) 1.02
A polar barrier to transcription can be circumvented by remodeler-induced nucleosome translocation. Nucleic Acids Res (2011) 1.02
In vitro transcription through nucleosomes by T7 RNA polymerase. EMBO J (1992) 1.01
Histone density is maintained during transcription mediated by the chromatin remodeler RSC and histone chaperone NAP1 in vitro. Proc Natl Acad Sci U S A (2012) 1.00
Histone octamer dissociation is not required for transcript elongation through arrays of nucleosome cores by phage T7 RNA polymerase in vitro. Proc Natl Acad Sci U S A (1993) 0.98
Variable pause positions of RNA polymerase II lie proximal to the c-myc promoter irrespective of transcriptional activity. Nucleic Acids Res (1995) 0.98
Basic mechanisms of RNA polymerase II activity and alteration of gene expression in Saccharomyces cerevisiae. Biochim Biophys Acta (2012) 0.98
Nucleosomes are not necessary for promoter-proximal pausing in vitro on the Drosophila hsp70 promoter. Nucleic Acids Res (1998) 0.98
Characterization of a novel RNA polymerase II arrest site which lacks a weak 3' RNA-DNA hybrid. Nucleic Acids Res (2004) 0.97
ATR-like kinase Mec1 facilitates both chromatin accessibility at DNA replication forks and replication fork progression during replication stress. Genes Dev (2013) 0.96
Sarkosyl block of transcription reinitiation by RNA polymerase II as visualized by the colliding polymerases reinitiation assay. Nucleic Acids Res (1994) 0.92
Structural analysis of nucleosomal barrier to transcription. Proc Natl Acad Sci U S A (2015) 0.91
Deposition of histone H1 onto reconstituted nucleosome arrays inhibits both initiation and elongation of transcripts by T7 RNA polymerase. Nucleic Acids Res (1995) 0.90
The Roles of the Paf1 Complex and Associated Histone Modifications in Regulating Gene Expression. Genet Res Int (2011) 0.90
Recognition of CpG island chromatin by KDM2A requires direct and specific interaction with linker DNA. Mol Cell Biol (2011) 0.89
The Elp3 subunit of human Elongator complex is functionally similar to its counterpart in yeast. Mol Genet Genomics (2005) 0.88
Epigenomic and RNA structural correlates of polyadenylation. RNA Biol (2011) 0.87
Template topology and transcription: chromatin templates relaxed by localized linearization are transcriptionally active in yeast. Mol Cell Biol (1997) 0.87
Suppression of intragenic transcription requires the MOT1 and NC2 regulators of TATA-binding protein. Nucleic Acids Res (2014) 0.86
Mechanisms of HIV Transcriptional Regulation and Their Contribution to Latency. Mol Biol Int (2012) 0.86
Experimental analysis of the mechanism of chromatin remodeling by RNA polymerase II. Methods Enzymol (2012) 0.84
Dynamical analysis on gene activity in the presence of repressors and an interfering promoter. Biophys J (2008) 0.83
A positioned +1 nucleosome enhances promoter-proximal pausing. Nucleic Acids Res (2015) 0.82
The mechanism of nucleosome traversal by RNA polymerase II: roles for template uncoiling and transcript elongation factors. RNA Biol (2011) 0.81
Modeling exon expression using histone modifications. PLoS One (2013) 0.80
The Xenopus 9 bp ribosomal terminator (T3 box) is a pause signal for the RNA polymerase I elongation complex. Nucleic Acids Res (1995) 0.80
Coming to terms with chromatin structure. Chromosoma (2015) 0.79
PHD and TFIIS-Like domains of the Bye1 transcription factor determine its multivalent genomic distribution. PLoS One (2014) 0.77
Chromatin structure and pre-mRNA processing work together. Transcription (2016) 0.75
Nucleosomal Barrier to Transcription: Structural Determinants and Changes in Chromatin Structure. Biochem Mol Biol J (2016) 0.75
Regulation of chaperone binding and nucleosome dynamics by key residues within the globular domain of histone H3. Epigenetics Chromatin (2016) 0.75
Nucleosomal arrangement affects single-molecule transcription dynamics. Proc Natl Acad Sci U S A (2016) 0.75
Histone availability as a strategy to control gene expression. RNA Biol (2016) 0.75
Selective and accurate initiation of transcription at the Ad2 major late promotor in a soluble system dependent on purified RNA polymerase II and DNA. Cell (1979) 19.98
Accurate transcription initiation on a purified mouse beta-globin DNA fragment in a cell-free system. Cell (1980) 8.02
Transcription of the beta-like globin genes and pseudogenes of the goat in a cell-free system. Nucleic Acids Res (1981) 6.63
FACT, a factor that facilitates transcript elongation through nucleosomes. Cell (1998) 4.91
The RNA polymerase II ternary complex cleaves the nascent transcript in a 3'----5' direction in the presence of elongation factor SII. Genes Dev (1992) 2.93
The presence of nucleosomes on a DNA template prevents initiation by RNA polymerase II in vitro. Cell (1986) 2.88
Factor-stimulated RNA polymerase II transcribes at physiological elongation rates on naked DNA but very poorly on chromatin templates. J Biol Chem (1992) 2.53
cis-acting elements that confer lung epithelial cell expression of the CC10 gene. J Biol Chem (1992) 2.18
The increment of SII-facilitated transcript cleavage varies dramatically between elongation competent and incompetent RNA polymerase II ternary complexes. J Biol Chem (1993) 1.98
Transcription initiation by RNA polymerase II in vitro. Properties of preinitiation, initiation, and elongation complexes. J Biol Chem (1987) 1.93
The active site of RNA polymerase II participates in transcript cleavage within arrested ternary complexes. Proc Natl Acad Sci U S A (1994) 1.91
Promoter-proximal pausing by RNA polymerase II in vitro: transcripts shorter than 20 nucleotides are not capped. Proc Natl Acad Sci U S A (1983) 1.87
SII-facilitated transcript cleavage in RNA polymerase II complexes stalled early after initiation occurs in primarily dinucleotide increments. J Biol Chem (1993) 1.54
Promoter clearance by RNA polymerase II is an extended, multistep process strongly affected by sequence. Mol Cell Biol (2001) 1.50
Transcription initiation by RNA polymerase II in vitro. At least two nucleotides must be added to form a stable ternary complex. J Biol Chem (1987) 1.49
The lung-specific CC10 gene is regulated by transcription factors from the AP-1, octamer, and hepatocyte nuclear factor 3 families. Mol Cell Biol (1993) 1.44
The H3/H4 tetramer blocks transcript elongation by RNA polymerase II in vitro. J Biol Chem (1997) 1.31
RNA polymerase II elongation complexes paused after the synthesis of 15- or 35-base transcripts have different structures. Mol Cell Biol (1991) 1.29
Assembly of RNA polymerase II preinitiation complexes before assembly of nucleosomes allows efficient initiation of transcription on nucleosomal templates. Mol Cell Biol (1988) 1.23
Translocation and transcriptional arrest during transcript elongation by RNA polymerase II. J Biol Chem (1996) 1.22
Amanitin greatly reduces the rate of transcription by RNA polymerase II ternary complexes but fails to inhibit some transcript cleavage modes. J Biol Chem (1996) 1.18
Structural changes in the RNA polymerase II transcription complex during transition from initiation to elongation. Mol Cell Biol (1998) 1.15
Two members of the HNF-3 family have opposite effects on a lung transcriptional element; HNF-3 alpha stimulates and HNF-3 beta inhibits activity of region I from the Clara cell secretory protein (CCSP) promoter. J Biol Chem (1994) 1.07
Variations in template protection by the RNA polymerase II transcription complex during the initiation process. Mol Cell Biol (1987) 1.02
Purification and characterization of ternary complexes containing accurately initiated RNA polymerase II and less than 20 nucleotides of RNA. J Mol Biol (1984) 1.00
RNA polymerase II ternary complexes may become arrested after transcribing to within 10 bases of the end of linear templates. J Biol Chem (1995) 1.00
Initially transcribed sequences strongly affect the extent of abortive initiation by RNA polymerase II. J Biol Chem (1999) 1.00
Abortive initiation is increased only for the weakest members of a set of down mutants of the adenovirus 2 major late promoter. J Biol Chem (1991) 0.87
RNA polymerase II promoter strength in vitro may be reduced by defects at initiation or promoter clearance. J Biol Chem (1994) 0.86
GAL4-VP16 stimulates two RNA polymerase II promoters primarily at the preinitiation complex assembly step. Gene Expr (1996) 0.77
Differential expression of mouse beta/goat beta c, mouse beta/goat beta F, and mouse beta/goat epsilon II hybrid globin genes in murine erythroleukemia cells. Mol Cell Biol (1986) 0.75
In vitro transcription of Drosophila ribosomal genes using Drosophila RNA polymerases. Biochem Biophys Res Commun (1978) 0.75
Selective in situ transcription of Drosophila polytene chromosomes by Drosophila RNA polymerases. Exp Cell Res (1977) 0.75