|
1
|
Histone deacetylase inhibitors suppress rheumatoid arthritis fibroblast-like synoviocyte and macrophage IL-6 production by accelerating mRNA decay.
|
Ann Rheum Dis
|
2011
|
1.54
|
|
2
|
Histone deacetylase inhibitors suppress inflammatory activation of rheumatoid arthritis patient synovial macrophages and tissue.
|
J Immunol
|
2010
|
1.44
|
|
3
|
The small GTPase Rap1 is required for Mn(2+)- and antibody-induced LFA-1- and VLA-4-mediated cell adhesion.
|
J Biol Chem
|
2002
|
1.39
|
|
4
|
Targeting histone deacetylase activity in rheumatoid arthritis and asthma as prototypes of inflammatory disease: should we keep our HATs on?
|
Arthritis Res Ther
|
2008
|
1.15
|
|
5
|
Signaling through CD70 regulates B cell activation and IgG production.
|
J Immunol
|
2004
|
1.04
|
|
6
|
Function of histone deacetylase inhibitors in inflammation.
|
Crit Rev Immunol
|
2011
|
1.03
|
|
7
|
Rap1 signaling is required for suppression of Ras-generated reactive oxygen species and protection against oxidative stress in T lymphocytes.
|
J Immunol
|
2004
|
1.00
|
|
8
|
Why CCR2 and CCR5 blockade failed and why CCR1 blockade might still be effective in the treatment of rheumatoid arthritis.
|
PLoS One
|
2011
|
0.99
|
|
9
|
Shear stress-dependent downregulation of the adhesion-G protein-coupled receptor CD97 on circulating leukocytes upon contact with its ligand CD55.
|
J Immunol
|
2013
|
0.97
|
|
10
|
Signal transduction pathways and transcription factors as therapeutic targets in inflammatory disease: towards innovative antirheumatic therapy.
|
Curr Pharm Des
|
2005
|
0.93
|
|
11
|
Apoptosis induced by overall metabolic stress converges on the Bcl-2 family proteins Noxa and Mcl-1.
|
Apoptosis
|
2011
|
0.93
|
|
12
|
Deletion of either CD55 or CD97 ameliorates arthritis in mouse models.
|
Arthritis Rheum
|
2010
|
0.91
|
|
13
|
Inflammatory memories: is epigenetics the missing link to persistent stromal cell activation in rheumatoid arthritis?
|
Autoimmun Rev
|
2011
|
0.91
|
|
14
|
A Rac1 inhibitory peptide suppresses antibody production and paw swelling in the murine collagen-induced arthritis model of rheumatoid arthritis.
|
Arthritis Res Ther
|
2010
|
0.91
|
|
15
|
The Ras guanine nucleotide exchange factor RasGRF1 promotes matrix metalloproteinase-3 production in rheumatoid arthritis synovial tissue.
|
Arthritis Res Ther
|
2009
|
0.90
|
|
16
|
Selective involvement of ERK and JNK mitogen-activated protein kinases in early rheumatoid arthritis (1987 ACR criteria compared to 2010 ACR/EULAR criteria): a prospective study aimed at identification of diagnostic and prognostic biomarkers as well as therapeutic targets.
|
Ann Rheum Dis
|
2011
|
0.90
|
|
17
|
Angiopoietin-2 promotes inflammatory activation of human macrophages and is essential for murine experimental arthritis.
|
Ann Rheum Dis
|
2012
|
0.87
|
|
18
|
TOF-secondary ion mass spectrometry imaging of polymeric scaffolds with surrounding tissue after in vivo implantation.
|
Anal Chem
|
2010
|
0.86
|
|
19
|
Brief report: a phase IIa, randomized, double-blind, placebo-controlled trial of apilimod mesylate, an interleukin-12/interleukin-23 inhibitor, in patients with rheumatoid arthritis.
|
Arthritis Rheum
|
2011
|
0.85
|
|
20
|
The ascent of acetylation in the epigenetics of rheumatoid arthritis.
|
Nat Rev Rheumatol
|
2013
|
0.81
|
|
21
|
Histone deacetylases in RA: epigenetics and epiphenomena.
|
Arthritis Res Ther
|
2010
|
0.81
|
|
22
|
The presumed hyporesponsive behavior of rheumatoid arthritis T lymphocytes can be attributed to spontaneous ex vivo apoptosis rather than defects in T cell receptor signaling.
|
J Immunol
|
2009
|
0.80
|
|
23
|
Silencing the expression of Ras family GTPase homologues decreases inflammation and joint destruction in experimental arthritis.
|
Am J Pathol
|
2010
|
0.79
|
|
24
|
Homeostatic intracellular-free Ca2+ is permissive for Rap1-mediated constitutive activation of alpha4 integrins on eosinophils.
|
J Immunol
|
2008
|
0.78
|
|
25
|
The Rho-GEF Trio regulates a novel pro-inflammatory pathway through the transcription factor Ets2.
|
Biol Open
|
2013
|
0.78
|
|
26
|
Sustained T cell Rap1 signaling is protective in the collagen-induced arthritis model of rheumatoid arthritis.
|
Arthritis Rheum
|
2010
|
0.78
|
|
27
|
Local synovial engagement of angiogenic TIE-2 is associated with the development of persistent erosive rheumatoid arthritis in patients with early arthritis.
|
Arthritis Rheum
|
2013
|
0.75
|
|
28
|
Sustained Rap1 activation in autoantigen-specific T lymphocytes attenuates experimental autoimmune encephalomyelitis.
|
J Neuroimmunol
|
2012
|
0.75
|
|
29
|
FMS-related tyrosine kinase 3 ligand (Flt3L)/CD135 axis in rheumatoid arthritis.
|
Arthritis Res Ther
|
2013
|
0.75
|