Analysis of a charge cluster mutation of herpes simplex virus type 1 UL34 and its extragenic suppressor suggests a novel interaction between pUL34 and pUL31 that is necessary for membrane curvature around capsids.

PubWeight™: 1.16‹?› | Rank: Top 10%

🔗 View Article (PMC 2849510)

Published in J Virol on January 27, 2010

Authors

Richard J Roller1, Susan L Bjerke, Alison C Haugo, Sara Hanson

Author Affiliations

1: Department of Microbiology, The University of Iowa, 3-432 Bowen Science Building, Iowa City, IA 52242, USA. richard-roller@uiowa.edu

Articles citing this

Membrane deformation and scission by the HSV-1 nuclear egress complex. Nat Commun (2014) 1.34

Reconstitution of the Kaposi's sarcoma-associated herpesvirus nuclear egress complex and formation of nuclear membrane vesicles by coexpression of ORF67 and ORF69 gene products. J Virol (2011) 1.21

A functional role for TorsinA in herpes simplex virus 1 nuclear egress. J Virol (2011) 1.13

Structural basis of membrane budding by the nuclear egress complex of herpesviruses. EMBO J (2015) 1.09

Dominant negative mutants of the murine cytomegalovirus M53 gene block nuclear egress and inhibit capsid maturation. J Virol (2010) 1.01

A single herpesvirus protein can mediate vesicle formation in the nuclear envelope. J Biol Chem (2015) 1.00

Specific residues of a conserved domain in the N terminus of the human cytomegalovirus pUL50 protein determine its intranuclear interaction with pUL53. J Biol Chem (2012) 0.94

Herpes simplex virus 1 pUL34 plays a critical role in cell-to-cell spread of virus in addition to its role in virus replication. J Virol (2011) 0.93

Structure of a herpesvirus nuclear egress complex subunit reveals an interaction groove that is essential for viral replication. Proc Natl Acad Sci U S A (2015) 0.91

The Herpes Simplex Virus Protein pUL31 Escorts Nucleocapsids to Sites of Nuclear Egress, a Process Coordinated by Its N-Terminal Domain. PLoS Pathog (2015) 0.90

Mapping of sequences in Pseudorabies virus pUL34 that are required for formation and function of the nuclear egress complex. J Virol (2013) 0.89

Crystal Structure of the Herpesvirus Nuclear Egress Complex Provides Insights into Inner Nuclear Membrane Remodeling. Cell Rep (2015) 0.88

Intragenic and extragenic suppression of a mutation in herpes simplex virus 1 UL34 that affects both nuclear envelope targeting and membrane budding. J Virol (2011) 0.85

Functional characterization of nuclear trafficking signals in pseudorabies virus pUL31. J Virol (2014) 0.85

Unexpected features and mechanism of heterodimer formation of a herpesvirus nuclear egress complex. EMBO J (2015) 0.85

Analysis of the early steps of herpes simplex virus 1 capsid tegumentation. J Virol (2013) 0.85

Interactions of the Kaposi's Sarcoma-associated herpesvirus nuclear egress complex: ORF69 is a potent factor for remodeling cellular membranes. J Virol (2013) 0.84

Characterization of conserved region 2-deficient mutants of the cytomegalovirus egress protein pM53. J Virol (2012) 0.84

The Great (Nuclear) Escape: New Insights into the Role of the Nuclear Egress Complex of Herpesviruses. J Virol (2015) 0.84

Identification of conserved amino acids in pUL34 which are critical for function of the pseudorabies virus nuclear egress complex. J Virol (2014) 0.81

Nuclear envelope breakdown induced by herpes simplex virus type 1 involves the activity of viral fusion proteins. Virology (2014) 0.78

Nuclear Exodus: Herpesviruses Lead the Way. Annu Rev Virol (2016) 0.77

Extragenic Suppression of a Mutation in Herpes Simplex Virus 1 UL34 That Affects Lamina Disruption and Nuclear Egress. J Virol (2016) 0.75

Have NEC Coat, Will Travel: Structural Basis of Membrane Budding During Nuclear Egress in Herpesviruses. Adv Virus Res (2016) 0.75

Articles cited by this

Characterization of herpes simplex virus strains differing in their effects on social behaviour of infected cells. J Gen Virol (1968) 26.67

How proteins produce cellular membrane curvature. Nat Rev Mol Cell Biol (2006) 6.90

Two-step red-mediated recombination for versatile high-efficiency markerless DNA manipulation in Escherichia coli. Biotechniques (2006) 5.91

Conditional-lethal mutations that suppress genetic defects in morphogenesis by altering structural proteins. Proc Natl Acad Sci U S A (1975) 4.52

Cytomegalovirus recruitment of cellular kinases to dissolve the nuclear lamina. Science (2002) 4.13

U(L)31 and U(L)34 proteins of herpes simplex virus type 1 form a complex that accumulates at the nuclear rim and is required for envelopment of nucleocapsids. J Virol (2001) 3.56

Ultrastructural localization of the herpes simplex virus type 1 UL31, UL34, and US3 proteins suggests specific roles in primary envelopment and egress of nucleocapsids. J Virol (2002) 3.45

Herpes simplex virus type 1 U(L)34 gene product is required for viral envelopment. J Virol (2000) 3.06

The interacting UL31 and UL34 gene products of pseudorabies virus are involved in egress from the host-cell nucleus and represent components of primary enveloped but not mature virions. J Virol (2002) 2.98

Egress of alphaherpesviruses: comparative ultrastructural study. J Virol (2001) 2.92

Primary envelopment of pseudorabies virus at the nuclear membrane requires the UL34 gene product. J Virol (2000) 2.91

The product of the herpes simplex virus type 1 UL25 gene is required for encapsidation but not for cleavage of replicated viral DNA. J Virol (1998) 2.81

Construction of an excisable bacterial artificial chromosome containing a full-length infectious clone of herpes simplex virus type 1: viruses reconstituted from the clone exhibit wild-type properties in vitro and in vivo. J Virol (2003) 2.59

The herpes simplex virus UL33 gene product is required for the assembly of full capsids. Virology (1991) 2.52

Characterization of a temperature-sensitive mutant of the UL15 open reading frame of herpes simplex virus 1. J Virol (1993) 2.23

The null mutant of the U(L)31 gene of herpes simplex virus 1: construction and phenotype in infected cells. J Virol (1997) 2.22

The herpes simplex virus type 1 U(L)17 gene encodes virion tegument proteins that are required for cleavage and packaging of viral DNA. J Virol (1998) 2.20

Conformational changes in the nuclear lamina induced by herpes simplex virus type 1 require genes U(L)31 and U(L)34. J Virol (2004) 2.11

Herpes simplex virus glycoproteins gB and gH function in fusion between the virion envelope and the outer nuclear membrane. Proc Natl Acad Sci U S A (2007) 2.07

Herpes simplex virus type 1 primary envelopment: UL34 protein modification and the US3-UL34 catalytic relationship. J Virol (2004) 2.01

Herpes simplex virus type 1 infection induces activation and recruitment of protein kinase C to the nuclear membrane and increased phosphorylation of lamin B. J Virol (2006) 1.99

Vesicle formation from the nuclear membrane is induced by coexpression of two conserved herpesvirus proteins. Proc Natl Acad Sci U S A (2007) 1.93

Fate of the inner nuclear membrane protein lamin B receptor and nuclear lamins in herpes simplex virus type 1 infection. J Virol (2001) 1.83

US3 of herpes simplex virus type 1 encodes a promiscuous protein kinase that phosphorylates and alters localization of lamin A/C in infected cells. J Virol (2007) 1.78

Study of herpes simplex virus maturation during a synchronous wave of assembly. J Virol (1997) 1.73

Identification and functional evaluation of cellular and viral factors involved in the alteration of nuclear architecture during herpes simplex virus 1 infection. J Virol (2005) 1.64

BFRF1 of Epstein-Barr virus is essential for efficient primary viral envelopment and egress. J Virol (2005) 1.59

The Epstein-Barr virus BFRF1 and BFLF2 proteins interact and coexpression alters their cellular localization. Virology (2004) 1.54

Roles for herpes simplex virus type 1 UL34 and US3 proteins in disrupting the nuclear lamina during herpes simplex virus type 1 egress. Virology (2006) 1.53

Herpes simplex virus type 2 UL34 protein requires UL31 protein for its relocation to the internal nuclear membrane in transfected cells. J Gen Virol (2001) 1.47

Functional domains of murine cytomegalovirus nuclear egress protein M53/p38. J Virol (2006) 1.41

Emerin is hyperphosphorylated and redistributed in herpes simplex virus type 1-infected cells in a manner dependent on both UL34 and US3. J Virol (2007) 1.41

Effects of charged cluster mutations on the function of herpes simplex virus type 1 UL34 protein. J Virol (2003) 1.38

Phosphorylation of the U(L)31 protein of herpes simplex virus 1 by the U(S)3-encoded kinase regulates localization of the nuclear envelopment complex and egress of nucleocapsids. J Virol (2009) 1.37

Common and specific properties of herpesvirus UL34/UL31 protein family members revealed by protein complementation assay. J Virol (2006) 1.34

Herpes simplex virus infection induces phosphorylation and delocalization of emerin, a key inner nuclear membrane protein. J Virol (2007) 1.28

Herpesvirus gB-induced fusion between the virion envelope and outer nuclear membrane during virus egress is regulated by the viral US3 kinase. J Virol (2009) 1.27

Identification of an essential domain in the herpes simplex virus 1 UL34 protein that is necessary and sufficient to interact with UL31 protein. J Virol (2005) 1.25

The equine herpesvirus 1 UL34 gene product is involved in an early step in virus egress and can be efficiently replaced by a UL34-GFP fusion protein. Virology (2002) 1.21

Identification and characterization of the product encoded by ORF69 of Kaposi's sarcoma-associated herpesvirus. J Virol (2008) 1.04