PubRank

Shi-Quan Hu

Author PubWeight™ 16.65‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Structural resolution of a tandem hormone-binding element in the insulin receptor and its implications for design of peptide agonists. Proc Natl Acad Sci U S A 2010 1.36
2 Decoding the cryptic active conformation of a protein by synthetic photoscanning: insulin inserts a detachable arm between receptor domains. J Biol Chem 2009 1.16
3 How insulin binds: the B-chain alpha-helix contacts the L1 beta-helix of the insulin receptor. J Mol Biol 2004 1.15
4 Diabetes-associated mutations in insulin: consecutive residues in the B chain contact distinct domains of the insulin receptor. Biochemistry 2004 1.07
5 Toward the active conformation of insulin: stereospecific modulation of a structural switch in the B chain. J Biol Chem 2006 1.06
6 Chiral mutagenesis of insulin. Foldability and function are inversely regulated by a stereospecific switch in the B chain. Biochemistry 2005 1.06
7 Chiral mutagenesis of insulin. Contribution of the B20-B23 beta-turn to activity and stability. J Biol Chem 2006 1.05
8 Enhancing the activity of a protein by stereospecific unfolding: conformational life cycle of insulin and its evolutionary origins. J Biol Chem 2009 1.02
9 A conserved histidine in insulin is required for the foldability of human proinsulin: structure and function of an ALAB5 analog. J Biol Chem 2006 0.97
10 Enhancing the activity of insulin at the receptor interface: crystal structure and photo-cross-linking of A8 analogues. Biochemistry 2004 0.92
11 An Achilles' heel in an amyloidogenic protein and its repair: insulin fibrillation and therapeutic design. J Biol Chem 2010 0.91
12 Diabetes-associated mutations in insulin identify invariant receptor contacts. Diabetes 2004 0.88
13 Diabetes-associated mutations in human insulin: crystal structure and photo-cross-linking studies of a-chain variant insulin Wakayama. Biochemistry 2005 0.88
14 The structure of a mutant insulin uncouples receptor binding from protein allostery. An electrostatic block to the TR transition. J Biol Chem 2008 0.87
15 Contribution of residue B5 to the folding and function of insulin and IGF-I: constraints and fine-tuning in the evolution of a protein family. J Biol Chem 2009 0.85
16 Supramolecular protein engineering: design of zinc-stapled insulin hexamers as a long acting depot. J Biol Chem 2010 0.82
17 Deciphering the hidden informational content of protein sequences: foldability of proinsulin hinges on a flexible arm that is dispensable in the mature hormone. J Biol Chem 2010 0.79