PubRank

Peter H G M Willems

Author PubWeight™ 90.09‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Mitochondrial function and morphology are impaired in parkin-mutant fibroblasts. Ann Neurol 2008 2.34
2 Monogenic mitochondrial disorders. N Engl J Med 2012 2.30
3 Mammalian mitochondrial complex I: biogenesis, regulation, and reactive oxygen species generation. Antioxid Redox Signal 2010 2.26
4 Inhibition of complex I of the electron transport chain causes O2-. -mediated mitochondrial outgrowth. Am J Physiol Cell Physiol 2005 1.82
5 Mitochondrial complex I deficiency: from organelle dysfunction to clinical disease. Brain 2009 1.71
6 Functional expression of mutations in the human NaCl cotransporter: evidence for impaired routing mechanisms in Gitelman's syndrome. J Am Soc Nephrol 2002 1.65
7 Effects of chemical chaperones on partially retarded NaCl cotransporter mutants associated with Gitelman's syndrome in a mouse cortical collecting duct cell line. Nephrol Dial Transplant 2004 1.59
8 Identification of mitochondrial complex I assembly intermediates by tracing tagged NDUFS3 demonstrates the entry point of mitochondrial subunits. J Biol Chem 2007 1.56
9 Cytosolic signaling protein Ecsit also localizes to mitochondria where it interacts with chaperone NDUFAF1 and functions in complex I assembly. Genes Dev 2007 1.53
10 Inherited complex I deficiency is associated with faster protein diffusion in the matrix of moving mitochondria. Am J Physiol Cell Physiol 2008 1.51
11 Mitochondrial network complexity and pathological decrease in complex I activity are tightly correlated in isolated human complex I deficiency. Am J Physiol Cell Physiol 2005 1.49
12 Simultaneous quantitative measurement and automated analysis of mitochondrial morphology, mass, potential, and motility in living human skin fibroblasts. Cytometry A 2006 1.38
13 Activated leukocyte cell adhesion molecule (ALCAM/CD166/MEMD), a novel actor in invasive growth, controls matrix metalloproteinase activity. Cancer Res 2005 1.36
14 OXPHOS mutations and neurodegeneration. EMBO J 2012 1.33
15 The coxsackievirus 2B protein suppresses apoptotic host cell responses by manipulating intracellular Ca2+ homeostasis. J Biol Chem 2004 1.23
16 Determinants for membrane association and permeabilization of the coxsackievirus 2B protein and the identification of the Golgi complex as the target organelle. J Biol Chem 2002 1.22
17 Reconstruction of the complete ouabain-binding pocket of Na,K-ATPase in gastric H,K-ATPase by substitution of only seven amino acids. J Biol Chem 2005 1.20
18 The structural unit of the thiazide-sensitive NaCl cotransporter is a homodimer. J Biol Chem 2003 1.19
19 Superoxide production is inversely related to complex I activity in inherited complex I deficiency. Biochim Biophys Acta 2007 1.18
20 Functional analysis of picornavirus 2B proteins: effects on calcium homeostasis and intracellular protein trafficking. J Virol 2008 1.15
21 Computer-assisted live cell analysis of mitochondrial membrane potential, morphology and calcium handling. Methods 2008 1.11
22 Depletion of PINK1 affects mitochondrial metabolism, calcium homeostasis and energy maintenance. J Cell Sci 2011 1.11
23 Multimerization reactions of coxsackievirus proteins 2B, 2C and 2BC: a mammalian two-hybrid analysis. J Gen Virol 2002 1.09
24 Life cell quantification of mitochondrial membrane potential at the single organelle level. Cytometry A 2008 1.09
25 Subunits of mitochondrial complex I exist as part of matrix- and membrane-associated subcomplexes in living cells. J Biol Chem 2008 1.09
26 Mitochondrial processes are impaired in hereditary inclusion body myopathy. Hum Mol Genet 2008 1.05
27 Enterovirus protein 2B po(u)res out the calcium: a viral strategy to survive? Trends Microbiol 2005 1.02
28 Detection and manipulation of mitochondrial reactive oxygen species in mammalian cells. Biochim Biophys Acta 2010 1.01
29 Inhibition of mitochondrial Na+-Ca2+ exchange restores agonist-induced ATP production and Ca2+ handling in human complex I deficiency. J Biol Chem 2004 1.01
30 Cellular and animal models for mitochondrial complex I deficiency: a focus on the NDUFS4 subunit. IUBMB Life 2013 1.01
31 Homomultimerization of the coxsackievirus 2B protein in living cells visualized by fluorescence resonance energy transfer microscopy. J Virol 2002 0.99
32 Human Golgi antiapoptotic protein modulates intracellular calcium fluxes. Mol Biol Cell 2009 0.99
33 C. elegans ATAD-3 is essential for mitochondrial activity and development. PLoS One 2009 0.98
34 Human NADH:ubiquinone oxidoreductase deficiency: radical changes in mitochondrial morphology? Am J Physiol Cell Physiol 2007 0.94
35 Mutational analysis of different regions in the coxsackievirus 2B protein: requirements for homo-multimerization, membrane permeabilization, subcellular localization, and virus replication. J Biol Chem 2004 0.94
36 Cell biological consequences of mitochondrial NADH: ubiquinone oxidoreductase deficiency. Curr Neurovasc Res 2004 0.93
37 The antioxidant Trolox restores mitochondrial membrane potential and Ca2+ -stimulated ATP production in human complex I deficiency. J Mol Med (Berl) 2009 0.93
38 Mitochondrial and cytosolic thiol redox state are not detectably altered in isolated human NADH:ubiquinone oxidoreductase deficiency. Biochim Biophys Acta 2007 0.92
39 Two technetium-99m-labeled cholecystokinin-8 (CCK8) peptides for scintigraphic imaging of CCK receptors. Bioconjug Chem 2004 0.92
40 Decreased intracellular ATP content and intact mitochondrial energy generating capacity in human cystinotic fibroblasts. Pediatr Res 2006 0.92
41 Subunit-specific incorporation efficiency and kinetics in mitochondrial complex I homeostasis. J Biol Chem 2012 0.92
42 Primary fibroblasts of NDUFS4(-/-) mice display increased ROS levels and aberrant mitochondrial morphology. Mitochondrion 2012 0.92
43 Phe783, Thr797, and Asp804 in transmembrane hairpin M5-M6 of Na+,K+-ATPase play a key role in ouabain binding. J Biol Chem 2003 0.92
44 Mouse models for nuclear DNA-encoded mitochondrial complex I deficiency. J Inherit Metab Dis 2010 0.90
45 Trolox-sensitive reactive oxygen species regulate mitochondrial morphology, oxidative phosphorylation and cytosolic calcium handling in healthy cells. Antioxid Redox Signal 2012 0.90
46 Ca2+-mobilizing agonists increase mitochondrial ATP production to accelerate cytosolic Ca2+ removal: aberrations in human complex I deficiency. Am J Physiol Cell Physiol 2006 0.89
47 Solute diffusion is hindered in the mitochondrial matrix. Proc Natl Acad Sci U S A 2011 0.89
48 Clinical spectrum of the pseudotumor cerebri complex in children. Childs Nerv Syst 2009 0.89
49 A mutation in the FAM36A gene, the human ortholog of COX20, impairs cytochrome c oxidase assembly and is associated with ataxia and muscle hypotonia. Hum Mol Genet 2012 0.88
50 Complex I disorders: causes, mechanisms, and development of treatment strategies at the cellular level. Dev Disabil Res Rev 2010 0.88
51 Simultaneous quantification of oxidative stress and cell spreading using 5-(and-6)-chloromethyl-2',7'-dichlorofluorescein. Cytometry A 2006 0.88
52 Interactions between mitochondrial reactive oxygen species and cellular glucose metabolism. Arch Toxicol 2015 0.88
53 The non-gastric H,K-ATPase is oligomycin-sensitive and can function as an H+,NH4(+)-ATPase. J Biol Chem 2005 0.87
54 The non-gastric H,K-ATPase as a tool to study the ouabain-binding site in Na,K-ATPase. Pflugers Arch 2008 0.86
55 Metabolic consequences of NDUFS4 gene deletion in immortalized mouse embryonic fibroblasts. Biochim Biophys Acta 2012 0.86
56 The creatine kinase system is essential for optimal refill of the sarcoplasmic reticulum Ca2+ store in skeletal muscle. J Biol Chem 2001 0.85
57 Defective mitochondrial translation differently affects the live cell dynamics of complex I subunits. Biochim Biophys Acta 2011 0.85
58 A conformation-specific interhelical salt bridge in the K+ binding site of gastric H,K-ATPase. J Biol Chem 2004 0.85
59 Mitigation of NADH: ubiquinone oxidoreductase deficiency by chronic Trolox treatment. Biochim Biophys Acta 2008 0.85
60 Modeling mitochondrial dysfunctions in the brain: from mice to men. J Inherit Metab Dis 2011 0.84
61 Calcium and ATP handling in human NADH:ubiquinone oxidoreductase deficiency. Biochim Biophys Acta 2009 0.84
62 Conversion of the low affinity ouabain-binding site of non-gastric H,K-ATPase into a high affinity binding site by substitution of only five amino acids. J Biol Chem 2006 0.84
63 Partial complex I inhibition decreases mitochondrial motility and increases matrix protein diffusion as revealed by fluorescence correlation spectroscopy. Biochim Biophys Acta 2007 0.83
64 Cytoskeletal restraints regulate homotypic ALCAM-mediated adhesion through PKCalpha independently of Rho-like GTPases. J Cell Sci 2004 0.83
65 Inhibition of protein kinase CbetaII increases glucose uptake in 3T3-L1 adipocytes through elevated expression of glucose transporter 1 at the plasma membrane. Mol Endocrinol 2003 0.83
66 Impaired routing of wild type FXYD2 after oligomerisation with FXYD2-G41R might explain the dominant nature of renal hypomagnesemia. Biochim Biophys Acta 2007 0.83
67 Functional expression of the human thiazide-sensitive NaCl cotransporter in Madin-Darby canine kidney cells. J Am Soc Nephrol 2003 0.82
68 Pharmacological targeting of mitochondrial complex I deficiency: the cellular level and beyond. Mitochondrion 2011 0.82
69 Isolated mitochondrial complex I deficiency: explorative data analysis of patient cell parameters. Curr Pharm Des 2011 0.81
70 Quantitative glucose and ATP sensing in mammalian cells. Pharm Res 2011 0.80
71 The human non-gastric H,K-ATPase has a different cation specificity than the rat enzyme. Biochim Biophys Acta 2006 0.80
72 Phenotypic knock out of heparan sulfates in myotubes impairs excitation-induced calcium spiking. FASEB J 2003 0.80
73 Function and regulation of the Na+-Ca2+ exchanger NCX3 splice variants in brain and skeletal muscle. J Biol Chem 2014 0.80
74 Asn792 participates in the hydrogen bond network around the K+-binding pocket of gastric H,K-ATPase. J Biol Chem 2005 0.80
75 R-Ras alters Ca2+ homeostasis by increasing the Ca2+ leak across the endoplasmic reticular membrane. J Biol Chem 2003 0.79
76 Native LDL potentiate TNF alpha and IL-8 production by human mononuclear cells. J Lipid Res 2002 0.79
77 Regulation and quantification of cellular mitochondrial morphology and content. Curr Pharm Des 2014 0.79
78 Regulation of GLUT1-mediated glucose uptake by PKClambda-PKCbeta(II) interactions in 3T3-L1 adipocytes. Biochem J 2004 0.78
79 Decreased agonist-stimulated mitochondrial ATP production caused by a pathological reduction in endoplasmic reticulum calcium content in human complex I deficiency. Biochim Biophys Acta 2005 0.78
80 Sustained accumulation of prelamin A and depletion of lamin A/C both cause oxidative stress and mitochondrial dysfunction but induce different cell fates. Nucleus 2015 0.78
81 Parenteral medium-chain triglyceride-induced neutrophil activation is not mediated by a Pertussis Toxin sensitive receptor. Clin Nutr 2008 0.78
82 FXYD2 and Na,K-ATPase expression in isolated human proximal tubular cells: disturbed upregulation on renal hypomagnesemia? J Membr Biol 2009 0.78
83 Prompt inhibition of fMLP-induced Ca2+ mobilization by parenteral lipid emulsions in human neutrophils. J Lipid Res 2002 0.78
84 The E1/E2-preference of gastric H,K-ATPase mutants. Ann N Y Acad Sci 2003 0.78
85 Upregulation of Ca2+ removal in human skeletal muscle: a possible role for Ca2+-dependent priming of mitochondrial ATP synthesis. Am J Physiol Cell Physiol 2003 0.77
86 Reduction of phospholipase D activity during coxsackievirus infection. J Gen Virol 2007 0.76
87 Live-cell assessment of mitochondrial reactive oxygen species using dihydroethidine. Methods Mol Biol 2015 0.76
88 Exploring levels of hexosamine biosynthesis pathway intermediates and protein kinase C isoforms in muscle and fat tissue of Zucker Diabetic Fatty rats. Endocrine 2003 0.75
89 Amplitude modulation of nuclear Ca2+ signals in human skeletal myotubes: a possible role for nuclear Ca2+ buffering. Cell Calcium 2005 0.75
90 The role of Lys791 and Asn792 in gastric H,K-ATPase. Ann N Y Acad Sci 2003 0.75
91 Disturbed Ca2+ kinetics in N-deacetylase/N-sulfotransferase-1 defective myotubes. J Cell Sci 2003 0.75