Neurobiological mechanisms underlying kisspeptin activation of gonadotropin-releasing hormone (GnRH) neurons at puberty.

PubWeight™: 0.92‹?›

🔗 View Article (PMID 20109523)

Published in Mol Cell Endocrinol on January 28, 2010

Authors

Jenny Clarkson1, Seong-Kyu Han, Xinhuai Liu, Kiho Lee, Allan E Herbison

Author Affiliations

1: Centre for Neuroendocrinology, Department of Physiology, School of Medical Sciences, University of Otago, Dunedin 9054, New Zealand.

Articles citing this

Neuroendocrine control by kisspeptins: role in metabolic regulation of fertility. Nat Rev Endocrinol (2011) 1.17

Estradiol signaling in the regulation of reproduction and energy balance. Front Neuroendocrinol (2012) 0.99

Recent discoveries on the control of gonadotrophin-releasing hormone neurones in nonhuman primates. J Neuroendocrinol (2010) 0.98

The Neurosteroid Progesterone Underlies Estrogen Positive Feedback of the LH Surge. Front Endocrinol (Lausanne) (2011) 0.97

Neuroanatomy of the kisspeptin signaling system in mammals: comparative and developmental aspects. Adv Exp Med Biol (2013) 0.94

Alteration in neonatal nutrition causes perturbations in hypothalamic neural circuits controlling reproductive function. J Neurosci (2012) 0.93

Identified GnRH neuron electrophysiology: a decade of study. Brain Res (2010) 0.91

Neuroendocrine control of the transition to reproductive senescence: lessons learned from the female rodent model. Neuroendocrinology (2012) 0.90

Disrupted organization of RFamide pathways in the hypothalamus is associated with advanced puberty in female rats neonatally exposed to bisphenol A. Biol Reprod (2012) 0.87

Kisspeptin and puberty in mammals. Adv Exp Med Biol (2013) 0.86

Synchronous activation of gonadotropin-releasing hormone gene transcription and secretion by pulsatile kisspeptin stimulation. Proc Natl Acad Sci U S A (2013) 0.85

Lesions of the ventral premammillary nucleus disrupt the dynamic changes in Kiss1 and GnRH expression characteristic of the proestrus-estrus transition. Neuroscience (2013) 0.81

Chronic exposure to anabolic androgenic steroids alters activity and synaptic function in neuroendocrine control regions of the female mouse. Neuropharmacology (2011) 0.81

The POU factor ventral veins lacking/Drifter directs the timing of metamorphosis through ecdysteroid and juvenile hormone signaling. PLoS Genet (2014) 0.79

Loss of Fertility in the Absence of Progesterone Receptor Expression in Kisspeptin Neurons of Female Mice. PLoS One (2016) 0.79

Kiss of the mutant mouse: how genetically altered mice advanced our understanding of kisspeptin's role in reproductive physiology. Endocrinology (2012) 0.78

Thyroid Hormone Upregulates Hypothalamic kiss2 Gene in the Male Nile Tilapia, Oreochromis niloticus. Front Endocrinol (Lausanne) (2013) 0.78

Vaginal fold histology reduces the variability introduced by vaginal exfoliative cytology in the classification of mouse estrous cycle stages. Toxicol Pathol (2014) 0.77

A "Timed" Kiss Is Essential for Reproduction: Lessons from Mammalian Studies. Front Endocrinol (Lausanne) (2016) 0.76

Defining a novel leptin-melanocortin-kisspeptin pathway involved in the metabolic control of puberty. Mol Metab (2016) 0.75

Articles by these authors

Activation of gonadotropin-releasing hormone neurons by kisspeptin as a neuroendocrine switch for the onset of puberty. J Neurosci (2005) 4.04

Definition of estrogen receptor pathway critical for estrogen positive feedback to gonadotropin-releasing hormone neurons and fertility. Neuron (2006) 3.04

Postnatal development of kisspeptin neurons in mouse hypothalamus; sexual dimorphism and projections to gonadotropin-releasing hormone neurons. Endocrinology (2006) 2.95

Kisspeptin-GPR54 signaling is essential for preovulatory gonadotropin-releasing hormone neuron activation and the luteinizing hormone surge. J Neurosci (2008) 2.38

Critical in vivo roles for classical estrogen receptors in rapid estrogen actions on intracellular signaling in mouse brain. Endocrinology (2004) 2.26

Estrogen receptor beta mediates rapid estrogen actions on gonadotropin-releasing hormone neurons in vivo. J Neurosci (2003) 1.58

Kisspeptin excites gonadotropin-releasing hormone neurons through a phospholipase C/calcium-dependent pathway regulating multiple ion channels. Endocrinology (2008) 1.51

Postnatal development of an estradiol-kisspeptin positive feedback mechanism implicated in puberty onset. Endocrinology (2009) 1.44

RFamide-related peptide-3, a mammalian gonadotropin-inhibitory hormone ortholog, regulates gonadotropin-releasing hormone neuron firing in the mouse. Endocrinology (2009) 1.41

NMDA receptors regulate developmental gap junction uncoupling via CREB signaling. Nat Neurosci (2005) 1.37

Flavonoids purified from Rhus verniciflua Stokes actively inhibit cell growth and induce apoptosis in human osteosarcoma cells. Biochim Biophys Acta (2005) 1.35

Leptin indirectly regulates gonadotropin-releasing hormone neuronal function. Endocrinology (2009) 1.33

Postnatal remodeling of dendritic structure and spine density in gonadotropin-releasing hormone neurons. Endocrinology (2006) 1.27

Effect of GABA on GnRH neurons switches from depolarization to hyperpolarization at puberty in the female mouse. Endocrinology (2002) 1.21

Dendro-dendritic bundling and shared synapses between gonadotropin-releasing hormone neurons. Proc Natl Acad Sci U S A (2009) 1.20

Biocytin filling of adult gonadotropin-releasing hormone neurons in situ reveals extensive, spiny, dendritic processes. Endocrinology (2004) 1.19

Dependence of fertility on kisspeptin-Gpr54 signaling at the GnRH neuron. Nat Commun (2013) 1.17

Endogenous GABA release inhibits the firing of adult gonadotropin-releasing hormone neurons. Endocrinology (2003) 1.15

Gonadotropin-releasing hormone neurons extend complex highly branched dendritic trees outside the blood-brain barrier. Endocrinology (2011) 1.14

Critical role for estrogen receptor alpha in negative feedback regulation of gonadotropin-releasing hormone mRNA expression in the female mouse. Neuroendocrinology (2003) 1.14

Nonclassical estrogen modulation of presynaptic GABA terminals modulates calcium dynamics in gonadotropin-releasing hormone neurons. Endocrinology (2008) 1.11

Cells expressing RFamide-related peptide-1/3, the mammalian gonadotropin-inhibitory hormone orthologs, are not hypophysiotropic neuroendocrine neurons in the rat. Endocrinology (2008) 1.11

Production of biallelic CMP-Neu5Ac hydroxylase knock-out pigs. Sci Rep (2013) 1.08

An intact sialoadhesin (Sn/SIGLEC1/CD169) is not required for attachment/internalization of the porcine reproductive and respiratory syndrome virus. J Virol (2013) 1.08

Neurokinin B activates arcuate kisspeptin neurons through multiple tachykinin receptors in the male mouse. Endocrinology (2013) 1.07

Definition of brainstem afferents to gonadotropin-releasing hormone neurons in the mouse using conditional viral tract tracing. Endocrinology (2007) 1.06

Frequency-dependent recruitment of fast amino acid and slow neuropeptide neurotransmitter release controls gonadotropin-releasing hormone neuron excitability. J Neurosci (2011) 1.04

Two slow calcium-activated afterhyperpolarization currents control burst firing dynamics in gonadotropin-releasing hormone neurons. J Neurosci (2010) 1.04

Projections of arcuate nucleus and rostral periventricular kisspeptin neurons in the adult female mouse brain. Endocrinology (2011) 1.04

Prolactin regulation of gonadotropin-releasing hormone neurons to suppress luteinizing hormone secretion in mice. Endocrinology (2007) 1.03

Small-conductance calcium-activated potassium channels control excitability and firing dynamics in gonadotropin-releasing hormone (GnRH) neurons. Endocrinology (2008) 1.03

GnRH neurons elaborate a long-range projection with shared axonal and dendritic functions. J Neurosci (2013) 1.03

Antitumor activity of cytokine-induced killer cells against human lung cancer. Int Immunopharmacol (2007) 1.01

Reduction in synaptic GABA release contributes to target-selective elevation of PVN neuronal activity in rats with myocardial infarction. Am J Physiol Regul Integr Comp Physiol (2010) 1.01

Development of GABA and glutamate signaling at the GnRH neuron in relation to puberty. Mol Cell Endocrinol (2006) 0.99

Dendritic action potential initiation in hypothalamic gonadotropin-releasing hormone neurons. Endocrinology (2008) 0.98

Enhanced permeability of the antimicrobial agent 2,5-bis(4-amidinophenyl)furan across Caco-2 cell monolayers via its methylamidoidme prodrug. Pharm Res (2002) 0.98

Electrical and morphological characteristics of anteroventral periventricular nucleus kisspeptin and other neurons in the female mouse. Endocrinology (2010) 0.97

Inhibitory effect of 4-O-methylhonokiol on lipopolysaccharide-induced neuroinflammation, amyloidogenesis and memory impairment via inhibition of nuclear factor-kappaB in vitro and in vivo models. J Neuroinflammation (2012) 0.96

Improvement of high-fat diet-induced obesity by a mixture of red grape extract, soy isoflavone and L-carnitine: implications in cardiovascular and non-alcoholic fatty liver diseases. Food Chem Toxicol (2011) 0.96

Cell type-specific expression of a genetically encoded calcium indicator reveals intrinsic calcium oscillations in adult gonadotropin-releasing hormone neurons. J Neurosci (2007) 0.96

LW6, a novel HIF-1 inhibitor, promotes proteasomal degradation of HIF-1alpha via upregulation of VHL in a colon cancer cell line. Biochem Pharmacol (2010) 0.96

Inhibition of human ovarian tumor growth by cytokine-induced killer cells. Arch Pharm Res (2007) 0.95

Spontaneous kisspeptin neuron firing in the adult mouse reveals marked sex and brain region differences but no support for a direct role in negative feedback. Endocrinology (2012) 0.95

Somatostatin inhibition of gonadotropin-releasing hormone neurons in female and male mice. Endocrinology (2010) 0.94

Anti-tumor activity of ex vivo expanded cytokine-induced killer cells against human hepatocellular carcinoma. Int Immunopharmacol (2007) 0.94

C5-Modified nucleosides exhibiting anticancer activity. Bioorg Med Chem Lett (2009) 0.94

Disruption of ephrin signaling associates with disordered axophilic migration of the gonadotropin-releasing hormone neurons. J Neurosci (2005) 0.94

Glutamate regulation of GnRH neuron excitability. Brain Res (2010) 0.91

A lipid-soluble red ginseng extract inhibits the growth of human lung tumor xenografts in nude mice. J Med Food (2010) 0.90

Expression of mRNAs encoding receptors that mediate stress signals in gonadotropin-releasing hormone neurons of the mouse. Neuroendocrinology (2006) 0.90

Distribution of prolactin-responsive neurons in the mouse forebrain. J Comp Neurol (2010) 0.89

Low dose estrogen supplementation reduces mortality of mice in estrogen-dependent human tumor xenograft model. Biol Pharm Bull (2009) 0.89

Sex differences in the regulation of tyrosine hydroxylase gene transcription by estrogen in the locus coeruleus of TH9-LacZ transgenic mice. Brain Res Mol Brain Res (2002) 0.89

Direct regulation of GnRH neuron excitability by arcuate nucleus POMC and NPY neuron neuropeptides in female mice. Endocrinology (2012) 0.89

Inhibition of atopic dermatitis by topical application of silymarin in NC/Nga mice. Int Immunopharmacol (2008) 0.89

In vivo recordings of GnRH neuron firing reveal heterogeneity and dependence upon GABAA receptor signaling. J Neurosci (2013) 0.89

Calcium dynamics in gonadotropin-releasing hormone neurons. Front Neuroendocrinol (2010) 0.88

Protein structure modeling for CASP10 by multiple layers of global optimization. Proteins (2013) 0.88

NELL-1 promotes cell adhesion and differentiation via Integrinβ1. J Cell Biochem (2012) 0.88

A novel benzimidazole analogue inhibits the hypoxia-inducible factor (HIF)-1 pathway. Biochem Biophys Res Commun (2009) 0.88

Estrogen-negative feedback and estrous cyclicity are critically dependent upon estrogen receptor-α expression in the arcuate nucleus of adult female mice. Endocrinology (2014) 0.88

Induction of atopic eczema/dermatitis syndrome-like skin lesions by repeated topical application of a crude extract of Dermatophagoides pteronyssinus in NC/Nga mice. Int Immunopharmacol (2006) 0.88

Tonic extrasynaptic GABA(A) receptor currents control gonadotropin-releasing hormone neuron excitability in the mouse. Endocrinology (2011) 0.88

Angelan isolated from Angelica gigas Nakai induces dendritic cell maturation through toll-like receptor 4. Int Immunopharmacol (2006) 0.87

A novel delta-lactam-based histone deacetylase inhibitor, KBH-A42, induces cell cycle arrest and apoptosis in colon cancer cells. Biochem Pharmacol (2009) 0.87

Antiinflammatory activity of methanol extract isolated from stem bark of Magnolia kobus. Phytother Res (2008) 0.87

In vitro inhibitory effects of Polygonum cuspidatum on bacterial viability and virulence factors of Streptococcus mutans and Streptococcus sobrinus. Arch Oral Biol (2006) 0.86

Kisspeptin neurons co-express met-enkephalin and galanin in the rostral periventricular region of the female mouse hypothalamus. J Comp Neurol (2011) 0.86

Discovery of N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-2-fluoroaniline (EW-7197): a highly potent, selective, and orally bioavailable inhibitor of TGF-β type I receptor kinase as cancer immunotherapeutic/antifibrotic agent. J Med Chem (2014) 0.86

Oyster shell as substitute for aggregate in mortar. Waste Manag Res (2004) 0.85

Structure and property based design, synthesis and biological evaluation of γ-lactam based HDAC inhibitors: part II. Bioorg Med Chem Lett (2012) 0.85

Gamma-aminobutyric acid and glutamate differentially regulate intracellular calcium concentrations in mouse gonadotropin-releasing hormone neurons. Endocrinology (2009) 0.85

Effects of neuron-specific estrogen receptor (ER) α and ERβ deletion on the acute estrogen negative feedback mechanism in adult female mice. Endocrinology (2014) 0.85

Prevention of arthritic inflammation using an oriental herbal combination BDX-1 isolated from Achyranthes bidentata and Atractylodes japonica. Arch Pharm Res (2005) 0.85

Dopamine regulation of gonadotropin-releasing hormone neuron excitability in male and female mice. Endocrinology (2012) 0.85

Widdrol induces apoptosis via activation of AMP-activated protein kinase in colon cancer cells. Oncol Rep (2012) 0.85

Glabridin suppresses intercellular adhesion molecule-1 expression in tumor necrosis factor-alpha-stimulated human umbilical vein endothelial cells by blocking sphingosine kinase pathway: implications of Akt, extracellular signal-regulated kinase, and nuclear factor-kappaB/Rel signaling pathways. Mol Pharmacol (2005) 0.84

Inhibition of atopic dermatitis-like skin lesions by topical application of a novel ceramide derivative, K6PC-9p, in NC/Nga mice. Exp Dermatol (2008) 0.84

Gap junctions between neuronal inputs but not gonadotropin-releasing hormone neurons control estrous cycles in the mouse. Endocrinology (2011) 0.84

Equol inhibits nitric oxide production and inducible nitric oxide synthase gene expression through down-regulating the activation of Akt. Int Immunopharmacol (2007) 0.84

Estrous cycle plasticity in the hyperpolarization-activated current ih is mediated by circulating 17β-estradiol in preoptic area kisspeptin neurons. J Neurosci (2013) 0.84

Inhibition of human cervical carcinoma growth by cytokine-induced killer cells in nude mouse xenograft model. Int Immunopharmacol (2008) 0.84

Pectic polysaccharide isolated from Angelica gigas Nakai inhibits melanoma cell metastasis and growth by directly preventing cell adhesion and activating host immune functions. Cancer Lett (2006) 0.84

In vitro effects of a fraction separated from Polygonum cuspidatum root on the viability, in suspension and biofilms, and biofilm formation of mutans streptococci. J Ethnopharmacol (2007) 0.84

Topical application of silymarin reduces chemical-induced irritant contact dermatitis in BALB/c mice. Int Immunopharmacol (2007) 0.83

GnRH neuron firing and response to GABA in vitro depend on acute brain slice thickness and orientation. Endocrinology (2012) 0.83