Published in J Trace Elem Med Biol on November 17, 2009
Tumorigenic properties of iron regulatory protein 2 (IRP2) mediated by its specific 73-amino acids insert. PLoS One (2010) 1.10
Tumor necrosis factor α inhibits expression of the iron regulating hormone hepcidin in murine models of innate colitis. PLoS One (2012) 0.93
Mice are poor heme absorbers and do not require intestinal Hmox1 for dietary heme iron assimilation. Haematologica (2015) 0.92
Iron and intestinal immunity. Curr Opin Gastroenterol (2011) 0.83
Should we reconsider iron administration based on prevailing ferritin and hepcidin concentrations? Clin Exp Nephrol (2012) 0.81
Alternative splicing and genome complexity. Nat Genet (2001) 7.30
Iron inhibits replication of infectious hepatitis C virus in permissive Huh7.5.1 cells. J Hepatol (2010) 3.04
Regulation of cellular iron metabolism. Biochem J (2011) 3.03
Alcohol metabolism-mediated oxidative stress down-regulates hepcidin transcription and leads to increased duodenal iron transporter expression. J Biol Chem (2006) 2.90
Autocrine formation of hepcidin induces iron retention in human monocytes. Blood (2007) 2.50
Regulation of iron homeostasis in anemia of chronic disease and iron deficiency anemia: diagnostic and therapeutic implications. Blood (2009) 2.41
Interferon-gamma limits the availability of iron for intramacrophage Salmonella typhimurium. Eur J Immunol (2008) 2.25
Erythropoietin contrastingly affects bacterial infection and experimental colitis by inhibiting nuclear factor-κB-inducible immune pathways. Immunity (2011) 2.20
Small-molecule inhibitors of HIF-2a translation link its 5'UTR iron-responsive element to oxygen sensing. Mol Cell (2008) 2.15
The struggle for iron - a metal at the host-pathogen interface. Cell Microbiol (2010) 1.97
Cytokine-mediated regulation of iron transport in human monocytic cells. Blood (2003) 1.93
Association between increased iron stores and impaired endothelial function in patients with hereditary hemochromatosis. J Am Coll Cardiol (2002) 1.65
Pharmacologic inhibition of hepcidin expression reverses anemia of chronic inflammation in rats. Blood (2011) 1.63
MRI-based liver iron content predicts for nonrelapse mortality in MDS and AML patients undergoing allogeneic stem cell transplantation. Clin Cancer Res (2012) 1.58
IRP1 regulates erythropoiesis and systemic iron homeostasis by controlling HIF2α mRNA translation. Blood (2013) 1.53
The co-ordinated regulation of iron homeostasis in murine macrophages limits the availability of iron for intracellular Salmonella typhimurium. Cell Microbiol (2007) 1.51
Increased expression of CCL20 in human inflammatory bowel disease. J Clin Immunol (2004) 1.50
The arachidonic acid metabolome serves as a conserved regulator of cholesterol metabolism. Cell Metab (2014) 1.47
Absence of functional Hfe protects mice from invasive Salmonella enterica serovar Typhimurium infection via induction of lipocalin-2. Blood (2009) 1.40
Regulation of iron transport and the role of transferrin. Biochim Biophys Acta (2011) 1.40
Oxidative stress and iron homeostasis: mechanistic and health aspects. Crit Rev Clin Lab Sci (2008) 1.38
Iron-mediated degradation of IRP2, an unexpected pathway involving a 2-oxoglutarate-dependent oxygenase activity. Mol Cell Biol (2004) 1.37
Lipocalin 2 deactivates macrophages and worsens pneumococcal pneumonia outcomes. J Clin Invest (2013) 1.32
The complex interplay of iron metabolism, reactive oxygen species, and reactive nitrogen species: insights into the potential of various iron therapies to induce oxidative and nitrosative stress. Free Radic Biol Med (2013) 1.30
Iron-dependent degradation of apo-IRP1 by the ubiquitin-proteasome pathway. Mol Cell Biol (2007) 1.25
Nitric oxide-mediated regulation of ferroportin-1 controls macrophage iron homeostasis and immune function in Salmonella infection. J Exp Med (2013) 1.22
In vitro comparison of the vitamin D endocrine system in 1,25(OH)2D3-responsive and -resistant melanoma cells. Cancer Biol Ther (2007) 1.18
Conditional derepression of ferritin synthesis in cells expressing a constitutive IRP1 mutant. Mol Cell Biol (2002) 1.18
Dysregulated monocyte iron homeostasis and erythropoietin formation in patients with anemia of chronic disease. Blood (2006) 1.18
Iron inactivates the RNA polymerase NS5B and suppresses subgenomic replication of hepatitis C Virus. J Biol Chem (2005) 1.17
A phosphomimetic mutation at Ser-138 renders iron regulatory protein 1 sensitive to iron-dependent degradation. Mol Cell Biol (2003) 1.17
Peroxisome proliferator-activated receptors (PPARs) and the human skin: importance of PPARs in skin physiology and dermatologic diseases. Am J Clin Dermatol (2008) 1.16
Activation of iron regulatory protein-1 by oxidative stress. Methods Enzymol (2002) 1.16
Slc11a1 limits intracellular growth of Salmonella enterica sv. Typhimurium by promoting macrophage immune effector functions and impairing bacterial iron acquisition. Cell Microbiol (2009) 1.15
Role of IL-10 for induction of anemia during inflammation. J Immunol (2002) 1.13
Hfe and Hjv exhibit overlapping functions for iron signaling to hepcidin. J Mol Med (Berl) (2015) 1.13
Pathways for the regulation of interferon-gamma-inducible genes by iron in human monocytic cells. J Leukoc Biol (2003) 1.12
Overexpression of iron regulatory protein 1 suppresses growth of tumor xenografts. Carcinogenesis (2006) 1.10
Tumorigenic properties of iron regulatory protein 2 (IRP2) mediated by its specific 73-amino acids insert. PLoS One (2010) 1.10
The prolyl 4-hydroxylase inhibitor ethyl-3,4-dihydroxybenzoate generates effective iron deficiency in cultured cells. FEBS Lett (2002) 1.09
Characterization of the vitamin D endocrine system in human sebocytes in vitro. J Steroid Biochem Mol Biol (2008) 1.08
Copper availability contributes to iron perturbations in human nonalcoholic fatty liver disease. Gastroenterology (2008) 1.07
Nramp1 functionality increases inducible nitric oxide synthase transcription via stimulation of IFN regulatory factor 1 expression. J Immunol (2003) 1.05
Thromboembolic complications after splenectomy for hematologic diseases. Am J Hematol (2004) 1.04
Pathogenesis and treatment of anemia in inflammatory bowel disease. Haematologica (2010) 1.04
Growth differentiation factor 15 in anaemia of chronic disease, iron deficiency anaemia and mixed type anaemia. Br J Haematol (2009) 1.03
Activation of vitamin D receptor (VDR)- and peroxisome proliferator-activated receptor (PPAR)-signaling pathways through 1,25(OH)(2)D(3) in melanoma cell lines and other skin-derived cell lines. Dermatoendocrinol (2009) 1.03
Identification of a common variant in the TFR2 gene implicated in the physiological regulation of serum iron levels. Hum Mol Genet (2010) 1.03
Mechanisms of iron mediated regulation of the duodenal iron transporters divalent metal transporter 1 and ferroportin 1. Blood Cells Mol Dis (2003) 1.03
In vivo tumor growth is inhibited by cytosolic iron deprivation caused by the expression of mitochondrial ferritin. Blood (2006) 1.02
High-fat diet causes iron deficiency via hepcidin-independent reduction of duodenal iron absorption. J Nutr Biochem (2012) 1.02
HO-1-mediated macroautophagy: a mechanism for unregulated iron deposition in aging and degenerating neural tissues. J Neurochem (2009) 1.01
Mass spectrometry analysis of hepcidin peptides in experimental mouse models. PLoS One (2011) 1.00
Disorders associated with systemic or local iron overload: from pathophysiology to clinical practice. Metallomics (2011) 1.00
The macrophage: a cellular factory at the interphase between iron and immunity for the control of infections. Biometals (2005) 0.99
The pleiotropic effects of erythropoietin in infection and inflammation. Microbes Infect (2011) 0.99
Pathways for the regulation of hepcidin expression in anemia of chronic disease and iron deficiency anemia in vivo. Haematologica (2011) 0.99
Unregulated brain iron deposition in transgenic mice over-expressing HMOX1 in the astrocytic compartment. J Neurochem (2012) 0.98
Molecular and clinical aspects of iron homeostasis: From anemia to hemochromatosis. Wien Klin Wochenschr (2006) 0.97
Expression of the subgenomic hepatitis C virus replicon alters iron homeostasis in Huh7 cells. J Hepatol (2007) 0.97
Increase of haemoglobin levels by anti-retroviral therapy is associated with a decrease in immune activation. Eur J Haematol (2003) 0.96
Impact of iron treatment on immune effector function and cellular iron status of circulating monocytes in dialysis patients. Nephrol Dial Transplant (2010) 0.96
Distinct clinical and immunologic profiles in severe malarial anemia and cerebral malaria in Zambia. J Infect Dis (2011) 0.95
Nramp1-functionality increases iNOS expression via repression of IL-10 formation. Eur J Immunol (2008) 0.95
1,25-dihydroxyvitamin D(3) protects human keratinocytes against UV-B-induced damage: In vitro analysis of cell viability/proliferation, DNA-damage and -repair. Dermatoendocrinol (2009) 0.94
Differences in activation of mouse hepcidin by dietary iron and parenterally administered iron dextran: compartmentalization is critical for iron sensing. J Mol Med (Berl) (2012) 0.94
Human endogenous retrovirus HERV-K(HML-2) proviruses with Rec protein coding capacity and transcriptional activity. Virology (2004) 0.94
Oxidation-induced ferritin turnover in microglial cells: role of proteasome. Free Radic Biol Med (2005) 0.93
eIF2{alpha} Kinase PKR modulates the hypoxic response by Stat3-dependent transcriptional suppression of HIF-1{alpha}. Cancer Res (2010) 0.92
Slc11a1 (Nramp1) impairs growth of Salmonella enterica serovar typhimurium in macrophages via stimulation of lipocalin-2 expression. J Leukoc Biol (2012) 0.92
Clinical Consequences of New Insights in the Pathophysiology of Disorders of Iron and Heme Metabolism. Hematology Am Soc Hematol Educ Program (2000) 0.92
Cross-talk between vitamin D receptor (VDR)- and peroxisome proliferator-activated receptor (PPAR)-signaling in melanoma cells. Anticancer Res (2009) 0.92
Adaptation of iron transport and metabolism to acute high-altitude hypoxia in mountaineers. Hepatology (2013) 0.92
Redox control of iron regulatory proteins. Redox Rep (2002) 0.91
Conditional disruption of mouse HFE2 gene: maintenance of systemic iron homeostasis requires hepatic but not skeletal muscle hemojuvelin. Hepatology (2011) 0.91
Human endogenous retrovirus HERV-K(HML-2) Rec expression and transcriptional activities in normal and rheumatoid arthritis synovia. J Rheumatol (2006) 0.91
Pitfalls in the diagnosis and therapy of infections in elderly patients--a mini-review. Gerontology (2009) 0.91
Vitamin D(3) metabolism in human glioblastoma multiforme: functionality of CYP27B1 splice variants, metabolism of calcidiol, and effect of calcitriol. Clin Cancer Res (2005) 0.90
Short term protective effects of iron in a murine model of ischemia/reperfusion. Biometals (2006) 0.90
Cutaneous photosynthesis of vitamin D: an evolutionary highly-conserved endocrine system that protects against environmental hazards including UV-radiation and microbial infections. Anticancer Res (2006) 0.89
Sustained hydrogen peroxide induces iron uptake by transferrin receptor-1 independent of the iron regulatory protein/iron-responsive element network. J Biol Chem (2007) 0.89
Modulation of macrophage iron transport by Nramp1 (Slc11a1). Immunobiology (2007) 0.89
Sodium nitroprusside promotes IRP2 degradation via an increase in intracellular iron and in the absence of S nitrosylation at C178. Mol Cell Biol (2006) 0.88
Nitric oxide inhibits the degradation of IRP2. Mol Cell Biol (2005) 0.88
IRP1 Ser-711 is a phosphorylation site, critical for regulation of RNA-binding and aconitase activities. Biochem J (2005) 0.88
Impact of oral iron challenges on circulating non-transferrin-bound iron in healthy Guatemalan males. Ann Nutr Metab (2012) 0.88
The late endosomal adaptor p14 is a macrophage host-defense factor against Salmonella infection. J Cell Sci (2012) 0.87
Expression analysis of CYP27B1 in tumor biopsies and cell cultures. Anticancer Res (2006) 0.87