PubRank

Kjetil Taskén

Author PubWeight™ 98.43‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variant. Nat Genet 2005 6.48
2 Molecular basis of AKAP specificity for PKA regulatory subunits. Mol Cell 2006 2.33
3 Positive and negative regulation of T-cell activation through kinases and phosphatases. Biochem J 2003 1.84
4 PI3K p110delta regulates T-cell cytokine production during primary and secondary immune responses in mice and humans. Blood 2010 1.76
5 AKAP complex regulates Ca2+ re-uptake into heart sarcoplasmic reticulum. EMBO Rep 2007 1.72
6 Cytokine networks are pre-activated in T cells from HIV-infected patients on HAART and are under the control of cAMP. AIDS 2004 1.54
7 Specificity and spatial dynamics of protein kinase A signaling organized by A-kinase-anchoring proteins. J Mol Endocrinol 2010 1.52
8 Diastolic dysfunction in alveolar hypoxia: a role for interleukin-18-mediated increase in protein phosphatase 2A. Cardiovasc Res 2008 1.49
9 Delineation of type I protein kinase A-selective signaling events using an RI anchoring disruptor. J Biol Chem 2006 1.48
10 Enhanced expression of the homeostatic chemokines CCL19 and CCL21 in clinical and experimental atherosclerosis: possible pathogenic role in plaque destabilization. Arterioscler Thromb Vasc Biol 2006 1.47
11 Cyclic AMP-mediated immune regulation--overview of mechanisms of action in T cells. Cell Signal 2010 1.46
12 Molecular mechanisms for protein kinase A-mediated modulation of immune function. Cell Signal 2002 1.45
13 Creating order from chaos: cellular regulation by kinase anchoring. Annu Rev Pharmacol Toxicol 2012 1.44
14 FOXP3+CD4+CD25+ adaptive regulatory T cells express cyclooxygenase-2 and suppress effector T cells by a prostaglandin E2-dependent mechanism. J Immunol 2006 1.43
15 The cAMP-Epac-Rap1 pathway regulates cell spreading and cell adhesion to laminin-5 through the alpha3beta1 integrin but not the alpha6beta4 integrin. J Biol Chem 2004 1.37
16 Generation of highly suppressive adaptive CD8(+)CD25(+)FOXP3(+) regulatory T cells by continuous antigen stimulation. Eur J Immunol 2008 1.28
17 Impaired secretion of IL-10 by T cells from patients with common variable immunodeficiency--involvement of protein kinase A type I. J Immunol 2003 1.25
18 Regulatory T cells in colorectal cancer patients suppress anti-tumor immune activity in a COX-2 dependent manner. Cancer Immunol Immunother 2007 1.24
19 TCR- and CD28-mediated recruitment of phosphodiesterase 4 to lipid rafts potentiates TCR signaling. J Immunol 2004 1.23
20 Haematopoietic protein tyrosine phosphatase (HePTP) phosphorylation by cAMP-dependent protein kinase in T-cells: dynamics and subcellular location. Biochem J 2004 1.20
21 Inhibition of T cell activation by cyclic adenosine 5'-monophosphate requires lipid raft targeting of protein kinase A type I by the A-kinase anchoring protein ezrin. J Immunol 2007 1.19
22 The cyclic AMP-Epac1-Rap1 pathway is dissociated from regulation of effector functions in monocytes but acquires immunoregulatory function in mature macrophages. J Immunol 2006 1.18
23 LPS-activated monocytes suppress T-cell immune responses and induce FOXP3+ T cells through a COX-2-PGE2-dependent mechanism. Int Immunol 2007 1.09
24 Mechanisms of FOXC2- and FOXD1-mediated regulation of the RI alpha subunit of cAMP-dependent protein kinase include release of transcriptional repression and activation by protein kinase B alpha and cAMP. J Biol Chem 2002 1.08
25 Optic atrophy 1 is an A-kinase anchoring protein on lipid droplets that mediates adrenergic control of lipolysis. EMBO J 2011 1.06
26 Reciprocal regulation of SH3 and SH2 domain binding via tyrosine phosphorylation of a common site in CD3epsilon. J Immunol 2007 1.05
27 An exploratory trial of cyclooxygenase type 2 inhibitor in HIV-1 infection: downregulated immune activation and improved T cell-dependent vaccine responses. J Virol 2011 1.05
28 CD7 is a differentiation marker that identifies multiple CD8 T cell effector subsets. J Immunol 2003 1.03
29 Cross talk between phosphatidylinositol 3-kinase and cyclic AMP (cAMP)-protein kinase a signaling pathways at the level of a protein kinase B/beta-arrestin/cAMP phosphodiesterase 4 complex. Mol Cell Biol 2010 1.01
30 CD147 (Basigin/Emmprin) identifies FoxP3+CD45RO+CTLA4+-activated human regulatory T cells. Blood 2011 1.00
31 Monitoring regulatory T cells in clinical samples: consensus on an essential marker set and gating strategy for regulatory T cell analysis by flow cytometry. Cancer Immunol Immunother 2015 0.99
32 Dual specificity A-kinase anchoring proteins (AKAPs) contain an additional binding region that enhances targeting of protein kinase A type I. J Biol Chem 2008 0.99
33 Distinct but overlapping domains of AKAP95 are implicated in chromosome condensation and condensin targeting. EMBO Rep 2002 0.99
34 T cell-signaling network analysis reveals distinct differences between CD28 and CD2 costimulation responses in various subsets and in the MAPK pathway between resting and activated regulatory T cells. J Immunol 2011 0.99
35 Characterization of A-kinase-anchoring disruptors using a solution-based assay. Biochem J 2006 0.98
36 Insulin and TNF alpha induce expression of the forkhead transcription factor gene Foxc2 in 3T3-L1 adipocytes via PI3K and ERK 1/2-dependent pathways. Mol Endocrinol 2002 0.97
37 Protein kinase A-anchoring protein AKAP95 interacts with MCM2, a regulator of DNA replication. J Biol Chem 2003 0.97
38 Merlin links to the cAMP neuronal signaling pathway by anchoring the RIbeta subunit of protein kinase A. J Biol Chem 2003 0.95
39 Combined spatial and enzymatic regulation of Csk by cAMP and protein kinase a inhibits T cell receptor signaling. J Biol Chem 2003 0.92
40 Regulation of FynT function by dual domain docking on PAG/Cbp. J Biol Chem 2007 0.91
41 Protein kinase A intersects SRC signaling in membrane microdomains. J Biol Chem 2003 0.91
42 The epidermal growth factor-like growth factor amphiregulin is strongly induced by the adenosine 3',5'-monophosphate pathway in various cell types. Endocrinology 2004 0.91
43 Interleukin-33 drives a proinflammatory endothelial activation that selectively targets nonquiescent cells. Arterioscler Thromb Vasc Biol 2012 0.91
44 High-resolution mapping of prostaglandin E2-dependent signaling networks identifies a constitutively active PKA signaling node in CD8+CD45RO+ T cells. Blood 2010 0.90
45 Activation of C-terminal Src kinase (Csk) by phosphorylation at serine-364 depends on the Csk-Src homology 3 domain. Biochem J 2003 0.90
46 Role for the cAMP-protein kinase A signaling pathway in suppression of antitumor immune responses by regulatory T cells. Crit Rev Oncog 2008 0.89
47 A novel human CD4+ T-cell inducer subset with potent immunostimulatory properties. Eur J Immunol 2010 0.89
48 Reduced Cbl phosphorylation and degradation of the zeta-chain of the T-cell receptor/CD3 complex in T cells with low Lck levels. Eur J Immunol 2008 0.88
49 Reduced PDE4 expression and activity contributes to enhanced catecholamine-induced cAMP accumulation in adipocytes from FOXC2 transgenic mice. FEBS Lett 2006 0.88
50 Immune modulatory effects of cyclooxygenase type 2 inhibitors in HIV patients on combination antiretroviral treatment. AIDS 2006 0.88
51 Spatiotemporal control of cyclic AMP immunomodulation through the PKA-Csk inhibitory pathway is achieved by anchoring to an Ezrin-EBP50-PAG scaffold in effector T cells. FEBS Lett 2010 0.87
52 Proinflammatory and immunoregulatory roles of eicosanoids in T cells. Front Immunol 2013 0.87
53 Mutually exclusive binding of PP1 and RNA to AKAP149 affects the mitochondrial network. Hum Mol Genet 2008 0.86
54 Differentiation of naive CD4+ T cells into CD4+CD25+FOXP3+ regulatory T cells by continuous antigen stimulation. J Leukoc Biol 2008 0.86
55 Splicing factor arginine/serine-rich 17A (SFRS17A) is an A-kinase anchoring protein that targets protein kinase A to splicing factor compartments. J Biol Chem 2009 0.86
56 The potential use of AKAP18delta as a drug target in heart failure patients. Expert Opin Biol Ther 2008 0.85
57 Novel mechanism of signaling by CD28. Immunol Lett 2010 0.85
58 Interplay between the heterotrimeric G-protein subunits Galphaq and Galphai2 sets the threshold for chemotaxis and TCR activation. BMC Immunol 2009 0.85
59 Modulation of T cell immune functions by the prostaglandin E(2) - cAMP pathway in chronic inflammatory states. Br J Pharmacol 2012 0.85
60 The heterotrimeric G-protein alpha-subunit Galphaq regulates TCR-mediated immune responses through an Lck-dependent pathway. Eur J Immunol 2008 0.85
61 Protein kinase A antagonist inhibits β-catenin nuclear translocation, c-Myc and COX-2 expression and tumor promotion in Apc(Min/+) mice. Mol Cancer 2011 0.85
62 T-cell co-stimulation through the CD2 and CD28 co-receptors induces distinct signalling responses. Biochem J 2014 0.84
63 Interactions between the Fyn SH3-domain and adaptor protein Cbp/PAG derived ligands, effects on kinase activity and affinity. FEBS J 2008 0.84
64 Treatment with type-2 selective and non-selective cyclooxygenase inhibitors improves T-cell proliferation in HIV-infected patients on highly active antiretroviral therapy. AIDS 2004 0.84
65 The adaptor protein EBP50 is important for localization of the protein kinase A-Ezrin complex in T-cells and the immunomodulating effect of cAMP. Biochem J 2009 0.84
66 Kinetics and activation requirements of contact-dependent immune suppression by human regulatory T cells. J Immunol 2012 0.84
67 Interleukin-10-secreting T cells define a suppressive subset within the HIV-1-specific T-cell population. Eur J Immunol 2009 0.83
68 CD147 in regulatory T cells. Cell Immunol 2013 0.83
69 A human whole blood model of LPS-mediated suppression of T cell activation. Med Sci Monit 2003 0.82
70 CD8+ regulatory T cells-A distinct T-cell lineage or a transient T-cell phenotype? Hum Immunol 2008 0.82
71 Activated regulatory and memory T-cells accumulate in malignant ascites from ovarian carcinoma patients. Cancer Immunol Immunother 2014 0.81
72 Quantitative proteome analysis of detergent-resistant membranes identifies the differential regulation of protein kinase C isoforms in apoptotic T cells. Proteomics 2010 0.81
73 Role of cAMP phosphodiesterase 4 in regulation of T-cell function. Crit Rev Immunol 2006 0.81
74 Analysing phosphorylation-based signalling networks by phospho flow cytometry. Cell Signal 2010 0.81
75 Modulation of proximal signaling in normal and transformed B cells by transmembrane adapter Cbp/PAG. Exp Cell Res 2012 0.81
76 Mice with disrupted type I protein kinase A anchoring in T cells resist retrovirus-induced immunodeficiency. J Immunol 2011 0.80
77 Effect of activated platelets on expression of cytokines in peripheral blood mononuclear cells - potential role of prostaglandin E2. Thromb Haemost 2004 0.80
78 Design of proteolytically stable RI-anchoring disruptor peptidomimetics for in vivo studies of anchored type I protein kinase A-mediated signalling. Biochem J 2009 0.80
79 Endosome-to-Golgi transport is regulated by protein kinase A type II alpha. J Biol Chem 2002 0.79
80 Aggressive treatment of patients with metastatic colorectal cancer increases survival: a scandinavian single-center experience. HPB Surg 2013 0.79
81 Hypophosphorylated TCR/CD3zeta signals through a Grb2-SOS1-Ras pathway in Lck knockdown cells. Eur J Immunol 2007 0.78
82 A winged helix forkhead (FOXD2) tunes sensitivity to cAMP in T lymphocytes through regulation of cAMP-dependent protein kinase RIalpha. J Biol Chem 2003 0.78
83 A kinase anchoring protein (AKAP) interaction and dimerization of the RIalpha and RIbeta regulatory subunits of protein kinase a in vivo by the yeast two hybrid system. J Mol Biol 2003 0.78
84 Phosphodiesterases as targets for modulating T-cell responses. Handb Exp Pharmacol 2011 0.78
85 Cell signalling analyses in the functional genomics era. N Biotechnol 2013 0.78
86 USF2 inhibits C/EBP-mediated transcriptional regulation of the RIIbeta subunit of cAMP-dependent protein kinase. BMC Mol Biol 2002 0.77
87 Electrical muscle activity pattern and transcriptional and posttranscriptional mechanisms regulate PKA subunit expression in rat skeletal muscle. Mol Cell Neurosci 2002 0.77
88 Regulatory T-cell-mediated inhibition of antitumor immune responses is associated with clinical outcome in patients with liver metastasis from colorectal cancer. Cancer Immunol Immunother 2011 0.77
89 Stereoselective preparation of (RP)-8-hetaryladenosine-3',5'-cyclic phosphorothioic acids. Org Biomol Chem 2007 0.77
90 Inhibition of protein kinase A improves effector function of monocytes from HIV-infected patients. AIDS Res Hum Retroviruses 2008 0.76
91 A phenotypic screening approach to identify anticancer compounds derived from marine fungi. Assay Drug Dev Technol 2014 0.76
92 The RIAD peptidomimetic inhibits HIV-1 replication in humanized NSG mice. Eur J Clin Invest 2013 0.76
93 Quantitative profiling of tyrosine phosphorylation revealed changes in the activity of the T cell receptor signaling pathway upon cisplatin-induced apoptosis. J Proteomics 2013 0.76
94 Stereoselective synthesis of (RP)-8-substituted-N⁶-acylated and N⁶-alkylated adenosine-3',5'-cyclic phosphorothioic acids as cAMP antagonists. Eur J Med Chem 2011 0.75
95 Plasma IP-10 Is Increased in Immunological NonResponders and Associated With Activated Regulatory T Cells and Persisting Low CD4 Counts. J Acquir Immune Defic Syndr 2016 0.75
96 EGF signalling and rapamycin-mediated mTOR inhibition in glioblastoma multiforme evaluated by phospho-specific flow cytometry. J Neurooncol 2013 0.75
97 A fast and sensitive method for isolation of detergent-resistant membranes from T cells. J Immunol Methods 2005 0.75