Published in J Med Chem on February 25, 2010
Targeting essential pathways in trypanosomatids gives insights into protozoan mechanisms of cell death. Parasit Vectors (2010) 1.22
The diamidine diminazene aceturate is a substrate for the high-affinity pentamidine transporter: implications for the development of high resistance levels in trypanosomes. Mol Pharmacol (2011) 0.91
The 8-aminoquinoline analogue sitamaquine causes oxidative stress in Leishmania donovani promastigotes by targeting succinate dehydrogenase. Antimicrob Agents Chemother (2011) 0.90
The double-edged sword in pathogenic trypanosomatids: the pivotal role of mitochondria in oxidative stress and bioenergetics. Biomed Res Int (2014) 0.85
Reversed-Polarity Synthesis of Diaryl Ketones through Palladium-Catalyzed Direct Arylation of 2-Aryl-1,3-dithianes. Adv Synth Catal (2014) 0.83
Cell death and ultrastructural alterations in Leishmania amazonensis caused by new compound 4-Nitrobenzaldehyde thiosemicarbazone derived from S-limonene. BMC Microbiol (2014) 0.82
Phosphonium lipocations as antiparasitic agents. Bioorg Med Chem Lett (2012) 0.81
Trypanocidal action of bisphosphonium salts through a mitochondrial target in bloodstream form Trypanosoma brucei. Int J Parasitol Drugs Drug Resist (2015) 0.81
Enterocin AS-48 as Evidence for the Use of Bacteriocins as New Leishmanicidal Agents. Antimicrob Agents Chemother (2017) 0.80
Novel Gallate Triphenylphosphonium Derivatives with Potent Antichagasic Activity. PLoS One (2015) 0.78
SAR Studies of Diphenyl Cationic Trypanocides: Superior Activity of Phosphonium over Ammonium Salts. ACS Med Chem Lett (2014) 0.76
Mechanisms of action of substituted β-amino alkanols on Leishmania donovani. Antimicrob Agents Chemother (2014) 0.75
Impaired virulence and in vivo fitness of colistin-resistant Acinetobacter baumannii. J Infect Dis (2011) 3.43
The cost of resistance to colistin in Acinetobacter baumannii: a proteomic perspective. Proteomics (2009) 1.83
Dendritic cell (DC)-specific intercellular adhesion molecule 3 (ICAM-3)-grabbing nonintegrin (DC-SIGN, CD209), a C-type surface lectin in human DCs, is a receptor for Leishmania amastigotes. J Biol Chem (2002) 1.61
Subcutaneous abdominal artificial tears pump-reservoir for severe dry eye. Orbit (2003) 1.41
Adaptive mutations in NEP compensate for defective H5N1 RNA replication in cultured human cells. Nat Commun (2012) 1.41
Multi-slice CT angiography for arterial evaluation in the injured lower extremity. J Trauma (2006) 1.30
Regulated expression of the pathogen receptor dendritic cell-specific intercellular adhesion molecule 3 (ICAM-3)-grabbing nonintegrin in THP-1 human leukemic cells, monocytes, and macrophages. J Biol Chem (2004) 1.28
Temporins, small antimicrobial peptides with leishmanicidal activity. J Biol Chem (2004) 1.07
Activity of cecropin A-melittin hybrid peptides against colistin-resistant clinical strains of Acinetobacter baumannii: molecular basis for the differential mechanisms of action. Antimicrob Agents Chemother (2006) 1.07
New bis(2-aminoimidazoline) and bisguanidine DNA minor groove binders with potent in vivo antitrypanosomal and antiplasmodial activity. J Med Chem (2008) 1.06
Human antimicrobial peptide histatin 5 is a cell-penetrating peptide targeting mitochondrial ATP synthesis in Leishmania. FASEB J (2008) 1.06
The dendritic cell receptor DC-SIGN discriminates among species and life cycle forms of Leishmania. J Immunol (2004) 1.02
Appraisal of a Leishmania major strain stably expressing mCherry fluorescent protein for both in vitro and in vivo studies of potential drugs and vaccine against cutaneous leishmaniasis. PLoS Negl Trop Dis (2012) 1.00
Prospective evaluation of screening multislice helical computed tomographic angiography in the initial evaluation of penetrating neck injuries. J Trauma (2006) 0.99
A cutaneous gene therapy approach to treat infection through keratinocyte-targeted overexpression of antimicrobial peptides. FASEB J (2004) 0.98
Tafenoquine, an antiplasmodial 8-aminoquinoline, targets leishmania respiratory complex III and induces apoptosis. Antimicrob Agents Chemother (2010) 0.97
Activities of polymyxin B and cecropin A-,melittin peptide CA(1-8)M(1-18) against a multiresistant strain of Acinetobacter baumannii. Antimicrob Agents Chemother (2002) 0.95
Novel computed tomography scan scoring system predicts the need for intervention after splenic injury. J Trauma (2006) 0.94
Miltefosine (hexadecylphosphocholine) inhibits cytochrome c oxidase in Leishmania donovani promastigotes. Antimicrob Agents Chemother (2007) 0.94
Fungus-elicited metabolites from plants as an enriched source for new leishmanicidal agents: antifungal phenyl-phenalenone phytoalexins from the banana plant (Musa acuminata) target mitochondria of Leishmania donovani promastigotes. Antimicrob Agents Chemother (2004) 0.90
In vitro bactericidal activity of the antiprotozoal drug miltefosine against Streptococcus pneumoniae and other pathogenic streptococci. Antimicrob Agents Chemother (2007) 0.90
Multi-analytical platform metabolomic approach to study miltefosine mechanism of action and resistance in Leishmania. Anal Bioanal Chem (2014) 0.90
The 8-aminoquinoline analogue sitamaquine causes oxidative stress in Leishmania donovani promastigotes by targeting succinate dehydrogenase. Antimicrob Agents Chemother (2011) 0.90
Effect of natural L- to D-amino acid conversion on the organization, membrane binding, and biological function of the antimicrobial peptides bombinins H. Biochemistry (2006) 0.90
Crystal structure of a trypanocidal 4,4'-bis(imidazolinylamino)diphenylamine bound to DNA. Biochemistry (2009) 0.89
Prospective evaluation of multislice computed tomography versus plain radiographic cervical spine clearance in trauma patients. J Trauma (2007) 0.88
6-phosphogluconate dehydrogenase: a target for drugs in African trypanosomes. Curr Med Chem (2004) 0.88
Identification of influenza virus inhibitors which disrupt of viral polymerase protein-protein interactions. Methods (2011) 0.87
Synthesis and antiprotozoal activity of N-alkoxy analogues of the trypanocidal lead compound 4,4'-bis(imidazolinylamino)diphenylamine with improved human blood-brain barrier permeability. J Med Chem (2010) 0.86
Characterization of the leishmanicidal activity of antimicrobial peptides. Methods Mol Biol (2010) 0.86
Identification of new leishmanicidal peptide lead structures by automated real-time monitoring of changes in intracellular ATP. Biochem J (2003) 0.86
Kahalalide F, an antitumor depsipeptide in clinical trials, and its analogues as effective antileishmanial agents. Mol Pharm (2009) 0.85
The N-terminal segment of pulmonary surfactant lipopeptide SP-C has intrinsic propensity to interact with and perturb phospholipid bilayers. Biochem J (2004) 0.85
Therapeutic index of gramicidin S is strongly modulated by D-phenylalanine analogues at the beta-turn. J Med Chem (2009) 0.84
Solid-phase synthesis of the cyclic lipononadepsipeptide [N-Mst(Ser1), d-Ser4, L-Thr6, L-Asp8, L-Thr9]syringotoxin. Chemistry (2003) 0.84
Antimicrobial peptide action on parasites. Curr Drug Targets (2012) 0.84
CE-ESI-MS metabolic fingerprinting of Leishmania resistance to antimony treatment. Electrophoresis (2012) 0.83
Visceral torso computed tomography for clearance of the thoracolumbar spine in trauma: a review of the literature. J Trauma (2006) 0.82
Role of the C-type lectins DC-SIGN and L-SIGN in Leishmania interaction with host phagocytes. Immunobiology (2005) 0.82
Defeating Leishmania resistance to miltefosine (hexadecylphosphocholine) by peptide-mediated drug smuggling: a proof of mechanism for trypanosomatid chemotherapy. J Control Release (2012) 0.81
Enhanced leishmanicidal activity of cryptopeptide chimeras from the active N1 domain of bovine lactoferrin. Amino Acids (2012) 0.81
Comparative study of limbal stem cell deficiency diagnosis methods: detection of MUC5AC mRNA and goblet cells in corneal epithelium. Ophthalmology (2012) 0.81
Synthesis of BODIPY-labeled alkylphosphocholines with leishmanicidal activity, as fluorescent analogues of miltefosine. Bioorg Med Chem Lett (2008) 0.81
Synthesis and structure-activity analysis of new phosphonium salts with potent activity against African trypanosomes. J Med Chem (2012) 0.81
Synthesis, biological assessment and molecular modeling of new dihydroquinoline-3-carboxamides and dihydroquinoline-3-carbohydrazide derivatives as cholinesterase inhibitors, and Ca channel antagonists. Eur J Med Chem (2010) 0.80
Studies on the antimicrobial activity of cecropin A-melittin hybrid peptides in colistin-resistant clinical isolates of Acinetobacter baumannii. J Antimicrob Chemother (2006) 0.80
Role of positional hydrophobicity in the leishmanicidal activity of magainin 2. Antimicrob Agents Chemother (2004) 0.80
A BODIPY-embedding miltefosine analog linked to cell-penetrating Tat(48-60) peptide favors intracellular delivery and visualization of the antiparasitic drug. Amino Acids (2014) 0.80
Autologous serum eye drops diluted with sodium hyaluronate: clinical and experimental comparative study. Acta Ophthalmol (2013) 0.80
Synthesis and biological evaluation of fluorescent leishmanicidal analogues of hexadecylphosphocholine (miltefosine) as probes of antiparasite mechanisms. J Med Chem (2007) 0.79
The antitumoral depsipeptide IB-01212 kills Leishmania through an apoptosis-like process involving intracellular targets. Mol Pharm (2010) 0.79
The induction of NOS2 expression by the hybrid cecropin A-melittin antibiotic peptide CA(1-8)M(1-18) in the monocytic line RAW 264.7 is triggered by a temporary and reversible plasma membrane permeation. Biochim Biophys Acta (2005) 0.79
Leishmania donovani: thionins, plant antimicrobial peptides with leishmanicidal activity. Exp Parasitol (2009) 0.79
Structural framework for the modulation of the activity of the hybrid antibiotic peptide cecropin A-melittin [CA(1-7)M(2-9)] by Nε-lysine trimethylation. Chembiochem (2011) 0.78
Validation of novel fluorescence assays for the routine screening of drug susceptibilities of Trichomonas vaginalis. J Antimicrob Chemother (2012) 0.78
AM3 modulates dendritic cell pathogen recognition capabilities by targeting DC-SIGN. Antimicrob Agents Chemother (2007) 0.78
Conjugation of quinones with natural polyamines: toward an expanded antitrypanosomatid profile. J Med Chem (2012) 0.78
Lysine N(epsilon)-trimethylation, a tool for improving the selectivity of antimicrobial peptides. J Med Chem (2010) 0.77
Phosphorylation of the N-terminal and C-terminal CD3-epsilon-ITAM tyrosines is differentially regulated in T cells. Biochem Biophys Res Commun (2002) 0.77
Discovery of nitroheterocycles active against African trypanosomes. In vitro screening and preliminary SAR studies. Bioorg Med Chem Lett (2012) 0.76
Effects of Autologous Serum Eye Drops on Conjunctival Expression of MUC5AC in Patients With Ocular Surface Disorders. Cornea (2016) 0.76
Synthetic peptides representing the N-terminal segment of surfactant protein C modulate LPS-stimulated TNF-alpha production by macrophages. Innate Immun (2009) 0.76
Influence of lysine N(ε)-trimethylation and lipid composition on the membrane activity of the cecropin A-melittin hybrid peptide CA(1-7)M(2-9). J Phys Chem B (2010) 0.76
Sequence inversion and phenylalanine surrogates at the beta-turn enhance the antibiotic activity of gramicidin S. J Med Chem (2010) 0.75
Influence of ornithine decarboxylase antizymes and antizyme inhibitors on agmatine uptake by mammalian cells. Amino Acids (2015) 0.75
Fluorescent labeling of Acanthamoeba assessed in situ from corneal sectioned microscopy. Biomed Opt Express (2012) 0.75
Observation of diastereotopic signals in (15) N NMR spectroscopy. Angew Chem Int Ed Engl (2015) 0.75
Antiprotozoal activity and DNA binding of dicationic acridones. J Med Chem (2015) 0.75
Computed tomographic angiography in the initial assessment of penetrating extremity injuries. J Trauma (2007) 0.75
The nonoperative management of penetrating internal jugular vein injury. J Vasc Surg (2006) 0.75
The lacunar sulci: a new test to measure the shrinkage of ocular surface, and its relation with the number of goblet cells. Adv Exp Med Biol (2002) 0.75
Synthesis of 16-mercaptohexadecylphosphocholine, a miltefosine analog with leishmanicidal activity. Bioorg Med Chem Lett (2006) 0.75
Morphogenesis of the human laryngeal ventricles. Head Neck (2012) 0.75
Amniotic membrane transplantation in acute toxic epidermal necrolysis: histopathologic changes and ocular surface features after 1-year follow-up. Eur J Ophthalmol (2014) 0.75