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Flexible long-range loops in the VH gene region of the Igh locus facilitate the generation of a diverse antibody repertoire.
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The IgH 3' regulatory region controls somatic hypermutation in germinal center B cells.
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The beta-globin HS4 insulator confers copy-number dependent expression of IgH regulatory elements in stable B cell transfectants.
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6
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The 3' IgH locus control region is sufficient to deregulate a c-myc transgene and promote mature B cell malignancies with a predominant Burkitt-like phenotype.
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J Immunol
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7
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Long-range oncogenic activation of Igh-c-myc translocations by the Igh 3' regulatory region.
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9
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Ig synthesis and class switching do not require the presence of the hs4 enhancer in the 3' IgH regulatory region.
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Immunoglobulin class-switch recombination in mice devoid of any S mu tandem repeat.
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11
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The immunoglobulin heavy-chain locus hs3b and hs4 3' enhancers are dispensable for VDJ assembly and somatic hypermutation.
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1.10
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12
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Premature replacement of mu with alpha immunoglobulin chains impairs lymphopoiesis and mucosal homing but promotes plasma cell maturation.
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1.09
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13
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Polymeric IgA1 controls erythroblast proliferation and accelerates erythropoiesis recovery in anemia.
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1.09
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14
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Transglutaminase is essential for IgA nephropathy development acting through IgA receptors.
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J Exp Med
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1.08
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15
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Interallelic class switch recombination contributes significantly to class switching in mouse B cells.
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J Immunol
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16
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The IgH 3' regulatory region and its implication in lymphomagenesis.
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Eur J Immunol
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17
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Enhancers located in heavy chain regulatory region (hs3a, hs1,2, hs3b, and hs4) are dispensable for diversity of VDJ recombination.
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J Immunol
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20
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Insulators to improve expression of a 3(')IgH LCR-driven reporter gene in transgenic mouse models.
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Crystal-storing histiocytosis with renal Fanconi syndrome: pathological and molecular characteristics compared with classical myeloma-associated Fanconi syndrome.
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Toward understanding renal Fanconi syndrome: step by step advances through experimental models.
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24
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Elucidation of the enigmatic IgD class-switch recombination via germline deletion of the IgH 3' regulatory region.
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0.99
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25
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In vivo redundant function of the 3' IgH regulatory element HS3b in the mouse.
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26
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A defect of the INK4-Cdk4 checkpoint and Myc collaborate in blastoid mantle cell lymphoma-like lymphoma formation in mice.
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27
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AID-driven deletion causes immunoglobulin heavy chain locus suicide recombination in B cells.
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0.96
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28
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Multiple RNA surveillance mechanisms cooperate to reduce the amount of nonfunctional Ig kappa transcripts.
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J Immunol
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0.95
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29
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RNA surveillance down-regulates expression of nonfunctional kappa alleles and detects premature termination within the last kappa exon.
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Proc Natl Acad Sci U S A
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0.94
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A p53 defect sensitizes various stages of B cell development to lymphomagenesis in mice carrying an IgH 3' regulatory region-driven c-myc transgene.
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31
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Immunologic basis for the rare occurrence of true nonsecretory plasma cell dyscrasias.
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0.92
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32
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Germ-line transcription occurs on both the functional and the non-functional alleles of immunoglobulin constant heavy chain genes.
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0.89
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33
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Role of the monoclonal kappa chain V domain and reversibility of renal damage in a transgenic model of acquired Fanconi syndrome.
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0.88
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34
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Transcription-dependent somatic hypermutation occurs at similar levels on functional and nonfunctional rearranged IgH alleles.
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J Immunol
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0.88
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35
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Platelet activation after aortic prosthetic valve surgery.
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36
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Human platelets can activate peripheral blood B cells and increase production of immunoglobulins.
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Cross talk between immunoglobulin heavy-chain transcription and RNA surveillance during B cell development.
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Indolent lymphoplasmacytic and marginal zone B-cell lymphomas: absence of both IRF4 and Ki67 expression identifies a better prognosis subgroup.
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Haematologica
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0.85
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39
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Interallelic class switch recombination can reverse allelic exclusion and allow trans-complementation of an IgH locus switching defect.
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0.85
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40
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The polymorphism of the locus control region lying downstream the human IgH locus is restricted to hs1,2 but not to hs3 and hs4 enhancers.
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Immunol Lett
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41
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A myeloma translocation-like model associating CCND1 with the immunoglobulin heavy-chain locus 3' enhancers does not promote by itself B-cell malignancies.
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Leuk Res
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0.81
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42
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Light chain myeloma plasma cells induce a strong cell-mediated immune response mainly directed against the monoclonal light chain determinants in a murine experimental model.
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0.81
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43
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Glycotranscriptome study reveals an enzymatic switch modulating glycosaminoglycan synthesis during B-cell development and activation.
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44
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B-cell receptor signal strength influences terminal differentiation.
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45
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Combination of 3' and 5' IgH regulatory elements mimics the B-specific endogenous expression pattern of IgH genes from pro-B cells to mature B cells in a transgenic mouse model.
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Biochim Biophys Acta
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0.79
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46
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Genetic background modulates susceptibility to oncogen-driven proliferation and lymphoma occurrence in mice carrying a deregulated c-myc transgene.
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47
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Polyclonal IgG4 hypergammaglobulinemia associated with plasmacytic lymphadenopathy, anemia and nephropathy.
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48
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Anti-CD20 IgA can protect mice against lymphoma development: evaluation of the direct impact of IgA and cytotoxic effector recruitment on CD20 target cells.
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The chicken beta-globin HS4 insulator is not a silver bullet to obtain copy-number dependent expression of transgenes in stable B cell transfectants.
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0.78
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50
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Gammopathy with IgA mesangial deposition provides a monoclonal model of IgA nephritogenicity and offers new insights into its molecular mechanisms.
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A monoclonal V kappa l light chain responsible for incomplete proximal tubulopathy.
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The 5'HS4 insulator element is an efficient tool to analyse the transient expression of an Em mu-GFP vector in a transgenic mouse model.
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Deletion of the α immunoglobulin chain membrane-anchoring region reduces but does not abolish IgA secretion.
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Production of human or humanized antibodies in mice.
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Germ line transcription in mice bearing neor gene downstream of Igamma3 exon in the Ig heavy chain locus.
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Class-specific effector functions of therapeutic antibodies.
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Uncoupling between Ig somatic hypermutation and oncogene mutation in mouse lymphoma.
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Effect of the Emu IgH enhancer on expression of a GFP reporter gene in transfected B cells and transgenic mice.
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Induction of somatic hypermutation by antigen-specific B cell receptors in the human BL2 cell line.
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Similarity of fine specificity of IgA anti-gliadin antibodies between patients with celiac disease and humanized α1KI mice.
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0.75
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Specific impairment of proximal tubular cell proliferation by a monoclonal κ light chain responsible for Fanconi syndrome.
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Nuclear factors, hs1,2 enhancer and IgA nephropathy.
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