PubRank

William R Ewing

Author PubWeight™ 10.87‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Potent and selective biphenyl azole inhibitors of adipocyte fatty acid binding protein (aFABP). Bioorg Med Chem Lett 2006 1.43
2 Discovery of pyrazine carboxamide CB1 antagonists: the introduction of a hydroxyl group improves the pharmaceutical properties and in vivo efficacy of the series. Bioorg Med Chem Lett 2007 1.32
3 Molecular structures of human factor Xa complexed with ketopiperazine inhibitors: preference for a neutral group in the S1 pocket. J Med Chem 2003 0.99
4 Eleven amino acid glucagon-like peptide-1 receptor agonists with antidiabetic activity. J Med Chem 2009 0.86
5 Dual angiotensin II and endothelin A receptor antagonists: synthesis of 2'-substituted N-3-isoxazolyl biphenylsulfonamides with improved potency and pharmacokinetics. J Med Chem 2005 0.83
6 Discovery of a tetrazole-based growth hormone secretagogue: 4-(hydroxybutyl)carbamic acid 2-{5-[1-(2-amino-2-methylpropionylamino)-2- benzyloxyethyl]tetrazol-1-yl}ethyl ester (BMS-317180). J Med Chem 2007 0.79
7 Cannabinoid CB(1) receptor ligand binding and function examined through mutagenesis studies of F200 and S383. Eur J Pharmacol 2010 0.79
8 Discovery of a potent and novel motilin agonist. J Med Chem 2004 0.79
9 Identification of potent 11mer glucagon-like peptide-1 receptor agonist peptides with novel C-terminal amino acids: Homohomophenylalanine analogs. Peptides 2010 0.79
10 Design and SAR of selective T-type calcium channel antagonists containing a biaryl sulfonamide core. Bioorg Med Chem Lett 2007 0.77
11 Potent biphenyl- and 3-phenyl pyridine-based inhibitors of acetyl-CoA carboxylase. Bioorg Med Chem Lett 2009 0.77
12 Solid phase synthesis of 1,5-diarylpyrazole-4-carboxamides: discovery of antagonists of the CB-1 receptor. ACS Comb Sci 2012 0.77
13 Exploration of structure-activity relationships at the two C-terminal residues of potent 11mer Glucagon-Like Peptide-1 receptor agonist peptides via parallel synthesis. Peptides 2010 0.77
14 Characterization of a novel and selective CB1 antagonist as a radioligand for receptor occupancy studies. Bioorg Med Chem Lett 2011 0.75
15 Reductions in log P improved protein binding and clearance predictions enabling the prospective design of cannabinoid receptor (CB1) antagonists with desired pharmacokinetic properties. J Med Chem 2013 0.75
16 Reduction of site-specific CYP3A-mediated metabolism for dual angiotensin and endothelin receptor antagonists in various in vitro systems and in cynomolgus monkeys. Drug Metab Dispos 2007 0.75
17 Design and synthesis of tetrazole-based growth hormone secretagogue: the SAR studies of the O-benzyl serine side chain. Bioorg Med Chem Lett 2008 0.75
18 Discovery of a parenteral small molecule coagulation Factor XIa inhibitor clinical candidate (BMS-962212). J Med Chem 2017 0.75
19 (D)-2-tert-Butoxycarbonylamino-5,5-difluoro-5-phenyl-pentanoic acid: synthesis and incorporation into the growth hormone secretagogues. Bioorg Med Chem Lett 2008 0.75