Potent, transient inhibition of BCR-ABL with dasatinib 100 mg daily achieves rapid and durable cytogenetic responses and high transformation-free survival rates in chronic phase chronic myeloid leukemia patients with resistance, suboptimal response or intolerance to imatinib.

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Published in Haematologica on February 01, 2010

Authors

Neil P Shah1, Dong-Wook Kim, Hagop Kantarjian, Philippe Rousselot, Pedro Enrique Dorlhiac Llacer, Alicia Enrico, Jorge Vela-Ojeda, Richard T Silver, Hanna Jean Khoury, Martin C Müller, Alexandre Lambert, Yousif Matloub, Andreas Hochhaus

Author Affiliations

1: 1Division of Hematology and Oncology, University of California, San Francisco School of Medicine, San Francisco, CA, USA. nshah@medicine.ucsf.edu

Associated clinical trials:

Chronic Myelogenous Leukemia (CML) - Follow on: Study of BMS-354825 in Subjects With CML | NCT00123474

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